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ORIGINAL RESEARCH

Role of Endothelial Chemokines and Their Receptors during Inflammation

, PhD &
Pages 18-27 | Received 27 Aug 2010, Accepted 01 Sep 2010, Published online: 28 Jan 2011

REFERENCES

  • Yoshimura T, Matsushima K, Tanaka S, Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A. 1987;84:9233–9237.
  • Murphy PM. International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol Rev. 2002;54:227–229.
  • Abe Y, Fornage M, Yang CY, L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis 2007;192:56–66.
  • Bazan JF, Bacon KB, Hardiman G, A new class of membrane-bound chemokine with a CX3C motif. Nature 1997;385:640–644.
  • Beck GC, Yard BA, Breedijk AJ, Release of CXC-chemokines by human lung microvascular endothelial cells (LMVEC) compared with macrovascular umbilical vein endothelial cells. Clin Exp Immunol. 1999;118:298–303.
  • Christopherson KW, 2nd, Hromas RA. Endothelial chemokines in autoimmune disease. Curr Pharm Des. 2004;10:145–154.
  • Goebeler M, Yoshimura T, Toksoy A, The chemokine repertoire of human dermal microvascular endothelial cells and its regulation by inflammatory cytokines. J Invest Dermatol. 1997;108:445–451.
  • Guessous F, Marcinkiewicz M, Polanowska-Grabowska R, Shiga toxin 2 and lipopolysaccharide induce human microvascular endothelial cells to release chemokines and factors that stimulate platelet function. Infect Immun. 2005;73:8306–8316.
  • Guo M, Sahni SK, Sahni A, Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004;92:858–866.
  • Laudes IJ, Chu JC, Huber-Lang M, Expression and function of C5a receptor in mouse microvascular endothelial cells. J Immunol. 2002;169:5962–5970.
  • Raju R, Malloy A, Shah T, Alloimmune induction of endothelial cell-derived interferon-gamma-inducible chemokines. Transplantation 2003;75:1072–1074.
  • Speyer CL, Neff TA, Warner RL, Regulatory effects of iNOS on acute lung inflammatory responses in mice. Am J Pathol. 2003;163:2319–2328.
  • Weber KS, von Hundelshausen P, Clark-Lewis I, Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flow. Eur J Immunol. 1999;29:700–712.
  • Yamaoka-Tojo M, Yamaguchi S, Nitobe J, Dual response to Fas ligation in human endothelial cells: apoptosis and induction of chemokines, interleukin-8 and monocyte chemoattractant protein-1. Coron Artery Dis. 2003;14:89–94.
  • Boisvert WA, Santiago R, Curtiss LK, A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient mice. J Clin Invest. 1998;101:353–363.
  • Combadiere C, Potteaux S, Gao JL, Decreased atherosclerotic lesion formation in CX3CR1/ apolipoprotein E double knockout mice. Circulation 2003;107:1009–1016.
  • Engelhardt E, Toksoy A, Goebeler M, Chemokines IL-8, GROalpha, MCP-1, IP-10, and Mig are sequentially and differentially expressed during phase-specific infiltration of leukocyte subsets in human wound healing. Am J Pathol. 1998;153:1849–1860.
  • Lesnik P, Haskell CA, Charo IF. Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesis. J Clin Invest. 2003;111:333–340.
  • Addison CL, Daniel TO, Burdick MD, The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity. J Immunol. 2000;165:5269–5277.
  • Dzenko KA, Andjelkovic AV, Kuziel WA, The chemokine receptor CCR2 mediates the binding and internalization of monocyte chemoattractant protein-1 along brain microvessels. J Neurosci. 2001;21:9214–9223.
  • Gupta SK, Lysko PG, Pillarisetti K, Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem. 1998;273:4282–4287.
  • Gupta SK, Singh JP. Inhibition of endothelial cell proliferation by platelet factor-4 involves a unique action on S phase progression. J Cell Biol. 1994;127:1121–1127.
  • Salcedo R, Ponce ML, Young HA, Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression. Blood 2000;96:34–40.
  • Salcedo R, Resau JH, Halverson D, Differential expression and responsiveness of chemokine receptors (CXCR1–3) by human microvascular endothelial cells and umbilical vein endothelial cells. FASEB J. 2000;14:2055–2064.
  • Salcedo R, Wasserman K, Young HA, Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol. 1999;154:1125–1135.
  • Veillard NR, Braunersreuther V, Arnaud C, Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2006;188:51–58.
  • Weber KS, Nelson PJ, Grone HJ, Expression of CCR2 by endothelial cells: implications for MCP-1 mediated wound injury repair and In vivo inflammatory activation of endothelium. Arterioscler Thromb Vasc Biol. 1999;19:2085–2093.
  • Ganju RK, Brubaker SA, Meyer J, The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J Biol Chem. 1998;273:23169–23175.
  • Li Z, Jiang H, Xie W, Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science 2000;287:1046–1049.
  • Majka M, Ratajczak J, Kowalska MA, Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT. Eur J Haematol. 2000;64:164–172.
  • Wang JF, Park IW, Groopman JE. Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C. Blood 2000;95:2505–2513.
  • Daaka Y, Luttrell LM, Ahn S, Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J Biol Chem. 1998;273: 685–688.
  • Hayashi H, Kume T. Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration. Biochem Biophys Res Commun. 2008;367:584–589.
  • Chaudhuri A, Nielsen S, Elkjaer ML, Detection of Duffy antigen in the plasma membranes and caveolae of vascular endothelial and epithelial cells of nonerythroid organs. Blood 1997;89:701–712.
  • Hadley TJ, Peiper SC. From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen. Blood 1997;89:3077–3091.
  • Kuschert GS, Coulin F, Power CA, Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses. Biochemistry 1999;38:12959–12968.
  • Hub E, Rot A. Binding of RANTES, MCP-1, MCP-3, and MIP-1alpha to cells in human skin. Am J Pathol. 1998;152:749–757.
  • Patterson AM, Siddall H, Chamberlain G, Expression of the duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium. J Pathol. 2002;197:108–116.
  • Ebnet K, Kaldjian EP, Anderson AO, Orchestrated information transfer underlying leukocyte endothelial interactions. Annu Rev Immunol. 1996;14:155–177.
  • Middleton J, Neil S, Wintle J, Transcytosis and surface presentation of IL-8 by venular endothelial cells. Cell 1997;91:385–395.
  • Baekkevold ES, Yamanaka T, Palframan RT, The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med. 2001;193:1105–1112.
  • Middleton J, Patterson AM, Gardner L, Leukocyte extravasation: chemokine transport and presentation by the endothelium. Blood 2002;100:3853–3860.
  • Burns AR, Bowden RA, MacDonell SD, Analysis of tight junctions during neutrophil transendothelial migration. J Cell Sci. 2000;113(Pt 1):45–57.
  • Feng D, Nagy JA, Pyne K, Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med. 1998;187:903–915.
  • Thureson-Klein A, Hedqvist P, Lindbom L. Leukocyte diapedesis and plasma extravasation after leukotriene B4: lack of structural injury to the endothelium. Tissue Cell. 1986;18:1–12.
  • Gunn MD, Tangemann K, Tam C, A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci USA. 1998;95:258–263.
  • Strieter RM, Polverini PJ, Kunkel SL, The functional role of the ELR motif in CXC chemokine-mediated angiogenesis. J Biol Chem. 1995;270:27348–27357.
  • Jouan V, Canron X, Alemany M, Inhibition of in vitro angiogenesis by platelet factor-4-derived peptides and mechanism of action. Blood 1999;94:984–993.
  • Yoshimura T, Takeya M, Ogata H, Molecular cloning of the guinea pig GRO gene and its rapid expression in the tissues of lipopolysaccharide-injected guinea pigs. Int Arch Allergy Immunol. 1999;119:101–111.
  • Lasagni L, Francalanci M, Annunziato F, An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med. 2003;197:1537–1549.
  • Kemeny L, Ruzicka T, Dobozy A, Role of interleukin-8 receptor in skin. Int Arch Allergy Immunol. 1994;104:317–322.
  • Belperio JA, Keane MP, Arenberg DA, CXC chemokines in angiogenesis. J Leukoc Biol. 2000;68:1–8.
  • Devalaraja RM, Nanney LB, Du J, Delayed wound healing in CXCR2 knockout mice. J Invest Dermatol. 2000;115:234–244.
  • Feil C, Augustin HG. Endothelial cells differentially express functional CXC-chemokine receptor-4 (CXCR-4/fusin) under the control of autocrine activity and exogenous cytokines. Biochem Biophys Res Commun. 1998;247:38–45.
  • Sima AV, Stancu CS, Simionescu M. Vascular endothelium in atherosclerosis. Cell Tissue Res. 2009;335:191–203.
  • Han KH, Tangirala RK, Green SR, Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes. A regulatory role for plasma LDL. Arterioscler Thromb Vasc Biol. 1998;18:1983–1991.
  • Gerszten RE, Garcia-Zepeda EA, Lim YC, MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 1999;398:718–723.
  • Boisvert WA, Rose DM, Johnson KA, Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression. Am J Pathol. 2006;168:1385–1395.
  • Imai T, Hieshima K, Haskell C, Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 1997;91:521–530.
  • Volin MV, Woods JM, Amin MA, Fractalkine: a novel angiogenic chemokine in rheumatoid arthritis. Am J Pathol. 2001;159:1521–1530.
  • Ruth JH, Volin MV, Haines GK, 3rd, Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritis. Arthritis Rheum. 2001;44:1568–1581.
  • Szekanecz Z, Kim J, Koch AE. Chemokines and chemokine receptors in rheumatoid arthritis. Semin Immunol. 2003;15:15–21.
  • Pablos JL, Santiago B, Galindo M, Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J Immunol. 2003;170:2147–2152.
  • Homey B, Alenius H, Muller A, CCL27-CCR10 interactions regulate T cell-mediated skin inflammation. Nat Med. 2002;8:157–165.
  • Homey B, Wang W, Soto H, Cutting edge: the orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J Immunol. 2000;164:3465–3470.
  • Campbell JJ, Haraldsen G, Pan J, The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 1999;400:776–780.
  • Christopherson KW, 2nd, Hood AF, Travers JB, Endothelial induction of the T-cell chemokine CCL21 in T-cell autoimmune diseases. Blood 2003;101:801–806.
  • Heidenreich R, Rocken M, Ghoreschi K. Angiogenesis drives psoriasis pathogenesis. Int J Exp Pathol. 2009;90: 232–248.
  • Pietrzak AT, Zalewska A, Chodorowska G, Cytokines and anticytokines in psoriasis. Clin Chim Acta. 2008;394:7–21.
  • Creamer D, Sullivan D, Bicknell R, Angiogenesis in psoriasis. Angiogenesis 2002;5:231–236.
  • Heidenreich R, Rocken M, Ghoreschi K. Angiogenesis: the new potential target for the therapy of psoriasis? Drug News Perspect. 2008;21:97–105.
  • Ozawa M, Terui T, Tagami H. Localization of IL-8 and complement components in lesional skin of psoriasis vulgaris and pustulosis palmaris et plantaris. Dermatology 2005;211:249–255.
  • Teunissen MB, Koomen CW, de Waal Malefyt R, Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol. 1998;111:645–649.
  • Duan H, Koga T, Kohda F, Interleukin-8-positive neutrophils in psoriasis. J Dermatol Sci. 2001;26:119–124.
  • Scapini P, Lapinet-Vera JA, Gasperini S, The neutrophil as a cellular source of chemokines. Immunol Rev. 2000;177:195–203.
  • van Beelen AJ, Teunissen MB, Kapsenberg ML, Interleukin-17 in inflammatory skin disorders. Curr Opin Allergy Clin Immunol. 2007;7:374–381.
  • Witowski J, Ksiazek K, Jorres A. Interleukin-17: a mediator of inflammatory responses. Cell Mol Life Sci. 2004;61: 567–579.
  • Maertzdorf J, Osterhaus AD, Verjans GM. IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts. J Immunol. 2002;169:5897–5903.
  • Wilson NJ, Boniface K, Chan JR, Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol. 2007;8:950–957.
  • Fossiez F, Djossou O, Chomarat P, T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J Exp Med. 1996;183:2593–2603.
  • Numasaki M, Fukushi J, Ono M, Interleukin-17 promotes angiogenesis and tumor growth. Blood 2003;101: 2620–2627.
  • Gong JH, Ratkay LG, Waterfield JD, An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse model. J Exp Med. 1997;186:131–137.
  • Podolin PL, Bolognese BJ, Foley JJ, A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbit. J Immunol. 2002;169:6435–6444.
  • Huang S, Mills L, Mian B, Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am J Pathol. 2002;161:125–134.
  • Haringman JJ, Kraan MC, Smeets TJ, Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62:715–721.

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