Advanced search
Publication Cover
Journal of Investigative Surgery Volume 29, 2016 - Issue 6
Submit an article Journal homepage
323
Views
3
CrossRef citations to date
0
Altmetric
Original Articles

Glaucarubinone Combined with Gemcitabine Improves Pancreatic Cancer Survival in an Immunocompetent Orthotopic Murine Model

Dannel YeoDepartment of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
,
Nhi HuynhDepartment of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
,
John A. BeutlerMolecular Targets Laboratory, National Cancer Institute, Frederick, MD
,
Graham S. BaldwinDepartment of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
,
Hong HeDepartment of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, Australia
&
Mehrdad NikfarjamDepartment of Surgery, University of Melbourne, Austin Health, Melbourne, Victoria, AustraliaCorrespondence[email protected]
Pages 366-372 | Received 20 Dec 2015, Accepted 26 Feb 2016, Published online: 30 Mar 2016

REFERENCES

  • Rahib L, Smith BD, Aizenberg R, et al. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913–21.
  • Sun C, Ansari D, Andersson R, et al. Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer? World J Gastroenterol. 2012;18(35):4944–58.
  • Waddell N, Pajic M, Patch AM, et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 2015;518(7540):495–501.
  • Ryan DP, Hong TS, Bardeesy N. Pancreatic adenocarcinoma. N Engl J Med. 2014;371(11):1039–49.
  • Collins MA, Pasca di Magliano M. Kras as a key oncogene and therapeutic target in pancreatic cancer. Front Physiol. 2013;4:407.
  • Yeo D, He H, Baldwin GS, et al. The Role of p21-Activated Kinases in Pancreatic Cancer. Pancreas. 2015;44(3): 363–9.
  • He H, Huynh N, Liu KH, et al. P-21 activated kinase 1 knockdown inhibits beta-catenin signalling and blocks colorectal cancer growth. Cancer Lett. 2012;317(1):65–71.
  • Huynh N, Liu KH, Baldwin GS, et al. P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways. Biochimica et biophysica acta. 2010;1803(9):1106–13.
  • Yeo D, Huynh N, Beutler JA, et al. Glaucarubinone and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases. Cancer Lett. 2014;346(2):264–72.
  • Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58(3):621–81.
  • Nikfarjam M, Yeo D, He H, et al. Comparison of two syngeneic orthotopic murine models of pancreatic adenocarcinoma. J Investigat Surg. 2013;26(6):352–9.
  • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul. 1984;22:27–55.
  • Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013;369(18):1691–703.
  • Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011;364(19):1817–25.
  • Monjour L, Rouquier F, Alfred C, et al. Therapeutic trials of experimental murine malaria with the quassinoid, glaucarubinone. Comptes rendus de l'Academie des sciences Serie III, Sciences de la vie. 1987;304(6):129–32.
  • Valeriote FA, Corbett TH, Grieco PA, et al. Anticancer activity of glaucarubinone analogues. Oncol Res. 1998;10(4):201–8.
  • Fiaschetti G, Grotzer MA, Shalaby T, et al. Quassinoids: From traditional drugs to new cancer therapeutics. Curr Med Chem. 2011;18(3):316–28.
  • Sicard A, Semblat JP, Doerig C, et al. Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes. Cell Microbiol. 2011;13(6):836–45.
  • Campbell PJ, Yachida S, Mudie LJ, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature. 2010;467(7319):1109–13.
  • Biankin AV, Waddell N, Kassahn KS, et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012;491(7424):399–405.
  • Wang Y, Zhang Y, Yang J, et al. Genomic sequencing of key genes in mouse pancreatic cancer cells. Curr Mol Med. 2012;12(3):331–41.
  • Tseng WW, Winer D, Kenkel JA, et al. Development of an orthotopic model of invasive pancreatic cancer in an immunocompetent murine host. Clin Cancer Res. 2010;16(14):3684–95.
  • Huynh N, Beutler JA, Shulkes A, et al. Glaucarubinone inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1alpha and beta-catenin via a p-21 activated kinase 1-dependent pathway. Biochimica et Biophysica Acta 2015;1853(1):157–65.
  • Ide T, Kitajima Y, Miyoshi A, et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol. 2007;14(9):2600–7.
  • Ye LY, Zhang Q, Bai XL, et al. Hypoxia-inducible factor 1alpha expression and its clinical significance in pancreatic cancer: a meta-analysis. Pancreatology. 2014;14(5):391–7.
  • Qin R, Smyrk TC, Reed NR, et al. Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1alpha pathway to predict survival in resectable pancreatic cancer. Br J Cancer 2015;112(3):514–22.
  • Moon SU, Kim JW, Sung JH, et al. p21-Activated Kinase 4 (PAK4) as a predictive marker of gemcitabine sensitivity in pancreatic cancer cell lines. Cancer Res Treat. 2015;47(3): 501–8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.