Pulmonary and cardiovascular effects of traffic-related particulate matter: 4-week exposure of rats to roadside and diesel engine exhaust particles

References

• ACGIH. 1991. Documentation of the threshold limit values and biological exposure indices. 6th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
   Google Scholar
• Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE. 2008. Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circ Res 102:589–596.
   PubMed Web of Science ®Google Scholar
• Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Giacomini S, Bonzini M, Lanzani G, Mannucci PM, Bertazzi PA, Schwartz J. 2007. Effects of exposure to air pollution on blood coagulation. J Thromb Haemost 5:252–260.
   PubMed Web of Science ®Google Scholar
• Bagate K, Meiring JJ, Gerlofs-Nijland ME, Vincent R, Cassee FR, Borm PJ. 2004. Vascular effects of ambient particulate matter instillation in spontaneous hypertensive rats. Toxicol Appl Pharmacol 197:29–39.
   PubMed Web of Science ®Google Scholar
• Beelen R, Hoek G, Houthuijs D, van den Brandt PA, Goldbohm RA, Fischer P, Schouten LJ, Armstrong B, Brunekreef B. 2009. The joint association of air pollution and noise from road traffic with cardiovascular mortality in a cohort study. Occup Environ Med 66:243–250.
   PubMed Web of Science ®Google Scholar
• Bhalla DK. 1999. Ozone-induced lung inflammation and mucosal barrier disruption: toxicology, mechanisms, and implications. J Toxicol Environ Health B Crit Rev 2:31–86.
   PubMed Web of Science ®Google Scholar
• Bonzini M, Tripodi A, Artoni A, Tarantini L, Marinelli B, Bertazzi PA, Apostoli P, Baccarelli A. 2010. Effects of inhalable particulate matter on blood coagulation. J Thromb Haemost 8:662–668.
   PubMed Web of Science ®Google Scholar
• Brunekreef B, Holgate ST. 2002. Air pollution and health. Lancet 360:1233–1242.
   PubMed Web of Science ®Google Scholar
• Brüske I, Hampel R, Socher MM, Rückerl R, Schneider A, Heinrich J, Oberdörster G, Wichmann HE, Peters A. 2010. Impact of ambient air pollution on the differential white blood cell count in patients with chronic pulmonary disease. Inhal Toxicol 22:245–252.
   PubMed Web of Science ®Google Scholar
• Carlsten C, Kaufman JD, Trenga CA, Allen J, Peretz A, Sullivan JH. 2008. Thrombotic markers in metabolic syndrome subjects exposed to diesel exhaust. Inhal Toxicol 20:917–921.
   PubMed Web of Science ®Google Scholar
• Cassee FR, Boere AJ, Fokkens PH, Leseman DL, Sioutas C, Kooter IM, Dormans JA. 2005. Inhalation of concentrated particulate matter produces pulmonary inflammation and systemic biological effects in compromised rats. J Toxicol Environ Health Part A 68:773–796.
   PubMed Web of Science ®Google Scholar
• Chen JX, Berry LC, Christman BW, Meyrick B. 2003. Glutathione mediates LPS-stimulated COX-2 expression via early transient p42/44 MAPK activation. J Cell Physiol 197:86–93.
   PubMedGoogle Scholar
• Chen LC, Hwang JS. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart-rate variability. Inhal Toxicol 17:209–216.
   PubMed Web of Science ®Google Scholar
• Chen LC, Nadziejko C. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. V. CAPs exacerbate aortic plaque development in hyperlipidemic mice. Inhal Toxicol 17:217–224.
   PubMed Web of Science ®Google Scholar
• Delfino RJ, Sioutas C, Malik S. 2005. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ Health Perspect 113:934–946.
   PubMed Web of Science ®Google Scholar
• Dormans JA, Rombout PJ, van Loveren H. 1990. Surface morphology and morphometry of rat alveolar macrophages after ozone exposure. J Toxicol Environ Health 31:53–70.
   PubMed Web of Science ®Google Scholar
• Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. 2007. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol 19:1–12.
   PubMed Web of Science ®Google Scholar
• Frampton MW, Boscia J, Roberts NJ Jr, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ. 2002. Nitrogen dioxide exposure: effects on airway and blood cells. Am J Physiol Lung Cell Mol Physiol 282:L155–L165.
   PubMed Web of Science ®Google Scholar
• Franchini M, Mannucci PM. 2008. Von Willebrand factor: another janus-faced hemostasis protein. Semin Thromb Hemost 34:663–669.
   PubMed Web of Science ®Google Scholar
• Frederix K, Kooter IM, van Oerle R, Fens D, Hamulyak K, Gerlofs-Nijland ME, Ten Cate H, Spronk HM. 2008. A new method to determine tissue specific tissue factor thrombomodulin activities: endotoxin and particulate air pollution induced disbalance. Thromb J 6:14.
   PubMedGoogle Scholar
• Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. 2005. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology 16:737–743.
   PubMed Web of Science ®Google Scholar
• Gehring U, Heinrich J, Krämer U, Grote V, Hochadel M, Sugiri D, Kraft M, Rauchfuss K, Eberwein HG, Wichmann HE. 2006. Long-term exposure to ambient air pollution and cardiopulmonary mortality in women. Epidemiology 17:545–551.
   PubMed Web of Science ®Google Scholar
• Geiser M, Kreyling WG. 2010. Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7:2.
   PubMed Web of Science ®Google Scholar
• Gerlofs-Nijland ME, Boere AJ, Leseman DL, Dormans JA, Sandström T, Salonen RO, van Bree L, Cassee FR. 2005. Effects of particulate matter on the pulmonary and vascular system: time course in spontaneously hypertensive rats. Part Fibre Toxicol 2:2.
   PubMed Web of Science ®Google Scholar
• Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, Leseman DL, John A, Boere F, Kelly FJ, Mudway IS, Jimenez AA, Donaldson K, Guastadisegni C, Janssen NA, Brunekreef B, Sandström T, van Bree L, Cassee FR. 2007. Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol 19:1055–1069.
   PubMed Web of Science ®Google Scholar
• Gerlofs-Nijland ME, Campbell A, Miller MR, Newby DE, Cassee FR. 2009a. Toxicity of inhaled traffic related particulate matter. J Phys Conf Ser 151:012049.
   Google Scholar
• Gerlofs-Nijland ME, Rummelhard M, Boere AJ, Leseman DL, Duffin R, Schins RP, Borm PJ, Sillanpää M, Salonen RO, Cassee FR. 2009b. Particle induced toxicity in relation to transition metal and polycyclic aromatic hydrocarbon contents. Environ Sci Technol 43:4729–4736.
   PubMed Web of Science ®Google Scholar
• Gong H Jr, Sioutas C, Linn WS. 2003. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient particles in metropolitan Los Angeles. Res Rep Health Eff Inst 1–36; discussion 37.
   PubMedGoogle Scholar
• Hildebrandt K, Rückerl R, Koenig W, Schneider A, Pitz M, Heinrich J, Marder V, Frampton M, Oberdörster G, Wichmann HE, Peters A. 2009. Short-term effects of air pollution: a panel study of blood markers in patients with chronic pulmonary disease. Part Fibre Toxicol 6:25.
   PubMed Web of Science ®Google Scholar
• Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. 2002. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 360:1203–1209.
   PubMed Web of Science ®Google Scholar
• Hoffmann B, Moebus S, Dragano N, Möhlenkamp S, Memmesheimer M, Erbel R, Jöckel KH. Heinz Nixdorf Recall Investigative Group. 2009. Residential traffic exposure and coronary heart disease: results from the Heinz Nixdorf Recall Study. Biomarkers 14 Suppl 1:74–78.
   PubMedGoogle Scholar
• Hwang JS, Nadziejko C, Chen LC. 2005. Effects of subchronic exposures to concentrated ambient particles (CAPs) in mice. III. Acute and chronic effects of CAPs on heart rate, heart-rate fluctuation, and body temperature. Inhal Toxicol 17:199–207.
   PubMed Web of Science ®Google Scholar
• Kim S, Jaques PA, Chang M, Froines JR, Sioutas C. 2001a. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles Part I: Development and laboratory characterization. J Aerosol Sci 32:1281–1297.
   Web of Science ®Google Scholar
• Kim S, Jaques PA, Chang M, Barone T, Xiong C, Friedlander SK, Sioutas C. 2001b. Versatile aerosol concentration enrichment system (VACES) for simultaneous in vivo and in vitro evaluation of toxic effects of ultrafine, fine and coarse ambient particles Part II: Field Evaluation. J Aerosol Sci 32:1299–1314.
   Web of Science ®Google Scholar
• Kleinman MT, Hamade A, Meacher D, Oldham M, Sioutas C, Chakrabarti B, Stram D, Froines JR, Cho AK. 2005. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. J Air Waste Manag Assoc 55:1277–1288.
   PubMedGoogle Scholar
• Knol AB, de Hartog JJ, Boogaard H, Slottje P, van der Sluijs JP, Lebret E, Cassee FR, Wardekker JA, Ayres JG, Borm PJ, Brunekreef B, Donaldson K, Forastiere F, Holgate ST, Kreyling WG, Nemery B, Pekkanen J, Stone V, Wichmann HE, Hoek G. 2009. Expert elicitation on ultrafine particles: likelihood of health effects and causal pathways. Part Fibre Toxicol 6:19.
   PubMed Web of Science ®Google Scholar
• Kooter IM, Boere AJ, Fokkens PH, Leseman DL, Dormans JA, Cassee FR. 2006. Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study. Part Fibre Toxicol 3:7.
   PubMed Web of Science ®Google Scholar
• Lai CH, Liou SH, Lin HC, Shih TS, Tsai PJ, Chen JS, Yang T, Jaakkola JJ, Strickland PT. 2005. Exposure to traffic exhausts and oxidative DNA damage. Occup Environ Med 62:216–222.
   PubMed Web of Science ®Google Scholar
• Lippmann M, Hwang JS, Maciejczyk P, Chen LC. 2005a. PM source apportionment for short-term cardiac function changes in ApoE-/- mice. Environ Health Perspect 113:1575–1579.
   PubMed Web of Science ®Google Scholar
• Lippmann M, Gordon T, Chen LC. 2005b. Effects of subchronic exposures to concentrated ambient particles in mice. IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhal Toxicol 17:255–261.
   PubMed Web of Science ®Google Scholar
• Lippmann M, Chen LC. 2009. Health effects of concentrated ambient air particulate matter (CAPs) and its components. Crit Rev Toxicol 39:865–913.
   PubMed Web of Science ®Google Scholar
• Lucking AJ, Lundback M, Mills NL, Faratian D, Barath SL, Pourazar J, Cassee FR, Donaldson K, Boon NA, Badimon JJ, Sandstrom T, Blomberg A, Newby DE. 2008. Diesel exhaust inhalation increases thrombus formation in man. Eur Heart J 29:3043–3051.
   PubMed Web of Science ®Google Scholar
• Marra M, Rombout PJA. 1990. Design and performance of an inhalation chamber for exposing laboratory animals to oxidant air pollutants. Inhal Toxicol 2:187–204.
   Google Scholar
• McCreanor J, Cullinan P, Nieuwenhuijsen MJ, Stewart-Evans J, Malliarou E, Jarup L, Harrington R, Svartengren M, Han IK, Ohman-Strickland P, Chung KF, Zhang J. 2007. Respiratory effects of exposure to diesel traffic in persons with asthma. N Engl J Med 357:2348–2358.
   PubMed Web of Science ®Google Scholar
• Miller MR, Borthwick SJ, Shaw CA, McLean SG, McClure D, Mills NL, Duffin R, Donaldson K, Megson IL, Hadoke PW, Newby DE. 2009. Direct impairment of vascular function by diesel exhaust particulate through reduced bioavailability of endothelium-derived nitric oxide induced by superoxide free radicals. Environ Health Perspect 117:611–616.
   PubMed Web of Science ®Google Scholar
• Mills NL, Törnqvist H, Robinson SD, Gonzalez M, Darnley K, MacNee W, Boon NA, Donaldson K, Blomberg A, Sandstrom T, Newby DE. 2005. Diesel exhaust inhalation causes vascular dysfunction and impaired endogenous fibrinolysis. Circulation 112:3930–3936.
   PubMed Web of Science ®Google Scholar
• Mills NL, Törnqvist H, Gonzalez MC, Vink E, Robinson SD, Söderberg S, Boon NA, Donaldson K, Sandström T, Blomberg A, Newby DE. 2007. Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. N Engl J Med 357:1075–1082.
   PubMed Web of Science ®Google Scholar
• Mills NL, Robinson SD, Fokkens PH, Leseman DL, Miller MR, Anderson D, Freney EJ, Heal MR, Donovan RJ, Blomberg A, Sandström T, MacNee W, Boon NA, Donaldson K, Newby DE, Cassee FR. 2008. Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ Health Perspect 116:709–715.
   PubMed Web of Science ®Google Scholar
• O’Neill MS, Veves A, Sarnat JA, Zanobetti A, Gold DR, Economides PA, Horton ES, Schwartz J. 2007. Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med 64:373–379.
   PubMed Web of Science ®Google Scholar
• Pope CA 3rd, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. 2004. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:71–77.
   PubMed Web of Science ®Google Scholar
• Rudez G, Janssen NA, Kilinc E, Leebeek FW, Gerlofs-Nijland ME, Spronk HM, ten Cate H, Cassee FR, de Maat MP. 2009. Effects of ambient air pollution on hemostasis and inflammation. Environ Health Perspect 117:995–1001.
   PubMed Web of Science ®Google Scholar
• Schikowski T, Sugiri D, Ranft U, Gehring U, Heinrich J, Wichmann HE, Krämer U. 2005. Long-term air pollution exposure and living close to busy roads are associated with COPD in women. Respir Res 6:152.
   PubMed Web of Science ®Google Scholar
• Schlesinger RB, Cassee F. 2003. Atmospheric secondary inorganic particulate matter: the toxicological perspective as a basis for health effects risk assessment. Inhal Toxicol 15:197–235.
   PubMed Web of Science ®Google Scholar
• Schulz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, Radykewicz R, Stampfl A, Thorand B, Peters A. 2005. Cardiovascular effects of fine and ultrafine particles. J Aerosol Med 18:1–22.
   PubMedGoogle Scholar
• Schwarze PE, Ovrevik J, Låg M, Refsnes M, Nafstad P, Hetland RB, Dybing E. 2006. Particulate matter properties and health effects: consistency of epidemiological and toxicological studies. Hum Exp Toxicol 25:559–579.
   PubMed Web of Science ®Google Scholar
• Seagrave J, McDonald JD, Bedrick E, Edgerton ES, Gigliotti AP, Jansen JJ, Ke L, Naeher LP, Seilkop SK, Zheng M, Mauderly JL. 2006. Lung toxicity of ambient particulate matter from southeastern U.S. sites with different contributing sources: relationships between composition and effects. Environ Health Perspect 114:1387–1393.
   PubMed Web of Science ®Google Scholar
• Sioutas C, Koutrakis P, Godleski J, Ferguson S, Kim C, Burton RM. 1997. Harvard/EPA ambient fine particle concentrators for human and animal exposures. J Aerosol Sci 28:1057–1071.
   Web of Science ®Google Scholar
• Spronk HM, Dielis AW, De Smedt E, van Oerle R, Fens D, Prins MH, Hamulyák K, ten Cate H. 2008. Assessment of thrombin generation II: Validation of the Calibrated Automated Thrombogram in platelet-poor plasma in a clinical laboratory. Thromb Haemost 100:362–364.
   PubMed Web of Science ®Google Scholar
• Sun Q, Wang A, Jin X, Natanzon A, Duquaine D, Brook RD, Aguinaldo JG, Fayad ZA, Fuster V, Lippmann M, Chen LC, Rajagopalan S. 2005. Long-term air pollution exposure and acceleration of atherosclerosis and vascular inflammation in an animal model. JAMA 294:3003–3010.
   PubMed Web of Science ®Google Scholar
• Sun Q, Yue P, Kirk RI, Wang A, Moatti D, Jin X, Lu B, Schecter AD, Lippmann M, Gordon T, Chen LC, Rajagopalan S. 2008. Ambient air particulate matter exposure and tissue factor expression in atherosclerosis. Inhal Toxicol 20:127–137.
   PubMed Web of Science ®Google Scholar
• Thrane EV, Refsnes M, Thoresen GH, Låg M, Schwarze PE. 2001. Fluoride-induced apoptosis in epithelial lung cells involves activation of MAP kinases p38 and possibly JNK. Toxicol Sci 61:83–91.
   PubMed Web of Science ®Google Scholar
• van Bree L, Dormans JA, Boere AJ, Rombout PJ. 2001. Time study on development and repair of lung injury following ozone exposure in rats. Inhal Toxicol 13:703–718.
   PubMed Web of Science ®Google Scholar
• van Bree L, Dormans JA, Koren HS, Devlin RB, Rombout PJ. 2002. Attenuation and recovery of pulmonary injury in rats following short-term, repeated daily exposure to ozone. Inhal Toxicol 14:883–900.
   PubMed Web of Science ®Google Scholar
• Veronesi B, Makwana O, Pooler M, Chen LC. 2005. Effects of subchronic exposures to concentrated ambient particles. VII. Degeneration of dopaminergic neurons in Apo E-/- mice. Inhal Toxicol 17:235–241.
   PubMed Web of Science ®Google Scholar
• Ying Z, Kampfrath T, Thurston G, Farrar B, Lippmann M, Wang A, Sun Q, Chen LC, Rajagopalan S. 2009. Ambient particulates alter vascular function through induction of reactive oxygen and nitrogen species. Toxicol Sci 111:80–88.
   PubMed Web of Science ®Google Scholar
• Yue W, Schneider A, Stölzel M, Rückerl R, Cyrys J, Pan X, Zareba W, Koenig W, Wichmann HE, Peters A. 2007 Aug 1. Ambient source-specific particles are associated with prolonged repolarization and increased levels of inflammation in male coronary artery disease patients. Mutat Res 621(1–2):50–60.
   PubMedGoogle Scholar