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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 3
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Research Article

Susceptibility of adult and senescent Brown Norway rats to repeated ozone exposure: an assessment of behavior, serum biochemistry and cardiopulmonary function

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Pages 141-159 | Received 18 Sep 2012, Accepted 07 Jan 2013, Published online: 19 Feb 2013

References

  • Arito H, Takahashi M, Iwasaki T, Uchiyama I. (1997). Age-related changes in ventilatory and heart rate responses to acute ozone exposure in the conscious rat. Ind Health 35:78–86
  • Avila-Costa MR, Colin-Barenque L, Fortoul TI, et al. (2001). Motor impairments in an oxidative stress model and its correlation with cytological changes on rat striatum and prefrontal cortex. Int J Neurosci 108:193–200
  • Balasubramanian P, Sirivelu MP, Weiss KA, et al. (2012). Differential effects of inhalation exposure to PM2.5 on hypothalamic monamines and corticotrophin releasing hormone in lean and obese rats. NeuroToxicology preprint [Epub available 7 March 2012]
  • Cho HY, Morgan DL, Bauer AK, Kleeberger SR. (2007). Signal transduction pathways of tumor necrosis factor-mediated lung injury induced by ozone in mice. Am J Respir Crit Care Med 175:829–39
  • Chuang GC, Yang Z, Westbrook DG, et al. (2009). Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol 297:L209–16
  • Ciencewicki J, Trivedi S, Kleeberger SR. (2008). Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol 122:456–68
  • Del Turco S, Basta G. (2012). An update on advanced glycation endproducts and atherosclerosis. Biofactors 38:266–74
  • Dong CC, Yin XJ, Ma JY, et al. (2005). Effect of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats. Toxicol Sci 88:202–12
  • Dorado-Marinez C, Paredes-Carbajal C, Mascher D, et al. (2001). Effects of different ozone doses on memory, motor activity and lipid peroxidation levels in rats. Int J Neurosci 108:149–61
  • Dormans JA, van Bree L, Boere AJ, et al. (1999). Interspecies differences in time course of pulmonary toxicity following repeated exposure to ozone. Inhal Toxicol 11:309–29
  • Federal Interagency Forum on Aging-Related Statistics. (2010). Older Americans 2010: key indicators of well-being. federal interagency forum on aging-related statistics. Washington, DC: U.S. Government Printing Office
  • Gordon CJ. (2008). Cardiac and thermal homeostasis in the aging Brown Norway rat. J Gerontol A Biol Sci Med Sci 63:1307–13
  • Gordon CJ, Bishop BL, Rowsey PJ, et al. (2011). Serum biomarkers of aging in the Brown Norway rat. Exper Gerontol 46:953–7
  • Gordon CJ, Gottipolu RR, Kenyon EM, et al. (2010). Aging and susceptibility to toluene in rats: a pharmacokinetic, biomarker, and physiological approach. J Toxicol Env Health 73:301–18
  • Gordon CJ, Ward WO. (2009). A multi-analyte profile of serum proteins to screen for toxicological effects of anticholinesterase insecticides in the rat. Neurotoxicology 30:377–81
  • Hammelmann E, Schwarze K, Takeda A, et al. (1997). Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am J Crit Care Med 156:766–75
  • Hampel R, Breitner S, Zareba W, et al. (2012). Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals. Occup Environ Med 69:428–36
  • Hollingsworth JW, Kleeberger SR, Foster WM. (2007). Ozone and pulmonary innate immunity. Proc Am Thorac Soc 4:240–6
  • Jang Y, Lee JH, Wang Y, Sweeney G. (2012). Emerging clinical and experimental evidence for the role of lipocalin-2 in metabolic syndrome. Clin Exp Pharmacol Physiol 39:194–9
  • Joseph PM. (2007). Paradoxical ozone associations could be due to methyl nitrite from combustion of methyl ethers or esters in engine fuels. Environ Int 33:1090–106
  • Kim JH, Hong YC. (2012). GSTM1, GSTT1, and GSTP1 polymorphisms and associations between air pollutants and markers of insulin resistance in elderly Koreans. Environ Health Perspect 120:1378–84
  • Kodavanti UP, Thomas R, Ledbetter AD, et al. (2011). Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles. Environ Health Persp 119:312–18
  • Kooter IM, Frederix K, Spronk HM, et al. (2008). Lung inflammation and thrombogenic responses in a time course study of Csb mice exposed to ozone. J Appl Toxicol 28:779–87
  • Kulle TJ, Sauder LR, Kerr HD, et al. (1982). Duration of pulmonary function adaptation to ozone in humans. Am Ind Hyg Assoc J 43:832–7
  • Lutz W, Sanderson W, Scherbov S. (2008). The coming acceleration of global population ageing. Nature 451:716–19
  • MacPhail RC. (2001). Episodic exposures to chemicals: what relevance to chemical intolerance? Ann NY Acad Sci 933:103–11
  • Mustafic H, Jabre P, Caussin C, et al. (2012). Main air pollutants and myocardial infarction: a systematic review and meta-analysis. JAMA 307:713–21
  • Nadon NL. (2006). Gerontology and age-associated lesions. In: Sucknow MA, Weisbroth SH, Franklin CL. The laboratory rat. 2nd ed. New York: Academic Press, 761–72
  • National Academies of Science. (2011). Guide for the care and use of laboratory animals. 8th ed. Washington, DC: The National Academies Press
  • National Research Council (NRC). (1993). Pesticides in the diets of infants and children. Washington, DC: National Academy Press
  • National Research Council (NRC). (2009). Science and decisions: advancing risk assessment. Washington, DC: The National Academy Press
  • Plopper CG, Hyde DM. (2008). The non-human primate as a model for studying COPD and asthma. Pulm Pharmacol Ther 21:755–66
  • Rivas-Arancibia S, Dorado-Martinez C, Colin-Barenque L, et al. (2003). Effect of acute ozone exposure on locomotor behavior and striatal function. Pharmacol Biochem Behav 74:891–900
  • Rivas-Arancibia S, Guevara-Guzman R, Lopez-Vidal Y, et al. (2010). Oxidative stress caused by ozone exposure induces loss of brain repair in the hippocampus of adult rats. Toxicol Sci 113:187–97
  • Russell JC, Amy RM, Dolphin PJ. (1991). Effect of dietary n-3 fatty acids on atherosclerosis prone JCR:LA-corpulent rats. Exp Mol Pathol 55:285–93
  • Shi S, Klotz U. (2011). Age-related changes in pharmacokinetics. Current Drug Metab 12:601–10
  • Shannahan JH, Alzate O, Winnik WM, et al. (2012). Acute phase response, inflammation and metabolic syndrome biomarkers of Libby asbestos exposure. Toxicol Appl Pharmacol 260:105–14
  • Shore SA, Williams ES, Chen L, et al. (2011). Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1. Inhal Toxicol 23:878–88
  • Skrha J Jr, Kalousová M, Svarcová J, et al. (2012). Relationship of soluble RAGE and RAGE ligands HMGB1 and EN-RAGE to endothelial dysfunction in type 1 and type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes 120:277–81
  • Sun Q, Yue P, Deiuliis JA, et al. (2009). Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119:538–46
  • Tanner CM, Kamel F, Ross GW, et al. (2011). Rotenone, paraquat, and Parkinson’s disease. Environ Health Perspect 119:866–72
  • Tepper JL, Weiss B, Cox C. (1982). Microanalysis of ozone depression of motor activity. Toxicol Appl Pharmacol 64:317–26
  • Tepper JS, Weiss B, Wood R. (1985). Alterations in behavior produced by inhaled ozone or ammonia. Fund Appl Toxicol 5:1110–18
  • Tesfaigzi Y, McDonald JD, Reed MD, et al. (2005). Low-level subchronic exposure to wood smoke exacerbates inflammatory responses in allergic rats. Toxicol Sci 88:505–13
  • Turturro A, Witt WW, Lewis S, et al. (1999). Growth curves and survival characteristics of the animals used in the biomarkers of aging program. J Gerontol A Biol Sci Med Sci 54:B492–501
  • Uchiyama I, Simomura Y, Yokoyama E. (1986). Effects of acute exposure to ozone on heart rate and blood pressure of the conscious rat. Environ Res 41:529–37
  • Uysal N, Schapira RM. (2003). Effects of ozone on lung function and lung diseases. Curr Opin Pulm Med 9:144–50
  • van Bree L, Dormans JA, Koren HS, et al. (2002). Attenuation and recovery of pulmonary injury in rats following short-term, repeated daily exposure to ozone. Inhal Toxicol 14:883–900
  • Vancza EM, Galdanes K, Gunnison A, et al. (2009). Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone. Toxicol Sci 107:535–43
  • Watkinson WP, Wiester MJ, Highfill JW. (1995). Ozone toxicity in the rat. I. Effect of changes in ambient temperature on extrapulmonary physiological parameters. J Appl Physiol 78:1108–20
  • Xu X, Liu C, Xu Z, et al. (2011). Long-term exposure to ambient fine particulate pollution induces insulin resistance and mitochondrial alteration in adipose tissue. Toxicol Sci 124:88–98

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