In vitro and ex vivo toxicological testing of sildenafil-loaded solid lipid nanoparticles

References

• Antoniu SA. (2006). Sildenafil for pulmonary arterial hypertension: when blue turns into white. Expert Opin Pharmacother 7:1801–10
   PubMed Web of Science ®Google Scholar
• Arab Tehrany E, Kahn CJ, Baravian C, et al. (2012). Elaboration and characterization of nanoliposome made of soya; rapeseed and salmon lecithins: application to cell culture. Colloid Surf B: Biointerfaces 95:75–81
   PubMed Web of Science ®Google Scholar
• Azarmi S, Roa WH, Löbenberg R. (2008). Targeted delivery of nanoparticles for the treatment of lung diseases: clinical developments in drug delivery nanotechnology. Adv Drug Deliv Rev 60:863–75
   PubMed Web of Science ®Google Scholar
• Badesch DB. (2010). Pulmonary arterial hypertension baseline characteristics from the REVEAL Registry. Chest 137:376
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Gauss J, Packhaeuser CB, et al. (2009). Pulmonary drug delivery with aerosolizable nanoparticles in an ex vivo lung model. Int J Pharm 367:169–78
   PubMed Web of Science ®Google Scholar
• Beck-Broichsitter M, Kleimann P, Gessler T, et al. (2012). Nebulization performance of biodegradable sildenafil-loaded nanoparticles using the Aeroneb® Pro: formulation aspects and nanoparticle stability to nebulization. Int J Pharm 422:398–408
   PubMed Web of Science ®Google Scholar
• Bussek A, Schmidt M, Bauriedl J, et al. (2012). Cardiac tissue slices with prolonged survival for in vitro drug safety screening. J Pharmacol Toxicol Methods 66:145–51
   PubMed Web of Science ®Google Scholar
• Bussek A, Wettwer E, Christ T, et al. (2009). Tissue slices from adult mammalian hearts as a model for pharmacological drug testing. Cell Physiol Biochem 24:527–36
   PubMed Web of Science ®Google Scholar
• Dupuis J, Hoeper MM. (2008). Endothelin receptor antagonists in pulmonary arterial hypertension. Eur Respir J 31:407–15
   PubMed Web of Science ®Google Scholar
• Finke J, Schur J, Richter C, et al. (2012). The influence of customized geometries and process parameters on nanoemulsion and solid lipid nanoparticle production in microsystems. Chem Eng J 209:126–37
   Web of Science ®Google Scholar
• Galie N, Manes A, Branzi A. (2003). Prostanoids for pulmonary arterial hypertension. Am J Respir Med 2:123–37
   PubMedGoogle Scholar
• Goris K, Uhlenbruck S, Schwegmann-Wessels C, et al. (2009). Differential sensitivity of differentiated epithelial cells to respiratory viruses reveals different viral strategies of host infection. J Virol 83:1962–68
   PubMed Web of Science ®Google Scholar
• Harms M, Mueller-Goymann CC. (2011). Solid lipid nanoparticles for drug delivery (invited review). J Drug Deliv Sci Technol 21:89–99
   Web of Science ®Google Scholar
• Huddleston AJ, Knodoerer CA, Morris JL, Ebenroth ES. (2009). Sildenafil for treatment of pulmonary hypertension in pediatric patients. Pediatr Cardiol 30:871–82
   PubMed Web of Science ®Google Scholar
• Jawad H, Boccaccini AR, Ali NN, Harding SE. (2011). Assessment of cellular toxicity of TiO2 nanoparticles for cardiac tissue engineering applications. Nanotoxicology 5:372–80
   PubMed Web of Science ®Google Scholar
• Jung S-Y, Seo Y-G, Kim GK, et al. (2011). Comparison of the solubility and pharmacokinetics of sildenafil salts. Arch Pharm Res 34:451–4
   PubMed Web of Science ®Google Scholar
• Kaneko MR, Coppen S. (2012). Histological validation of heart slices as a model in cardiac research. J Cell Sci Ther 3:126. doi: 10.4172/2157-7013.1000126
   Google Scholar
• Köhler M, Gothsch T, Finke JH, et al. (2011). Effect of microchannel geometry on high-pressure dispersion and emulsification. Chem Eng Technol 34:335–43
   Web of Science ®Google Scholar
• Labiris NR, Dolovich MB. (2003). Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications. Br J Clin Pharmacol 56:588–99
   PubMed Web of Science ®Google Scholar
• Melnikov P, Corbi PP, Cuin A, et al. (2003). Physicochemical properties of sildenafil citrate (Viagra) and sildenafil base. J Pharm Sci 92:2140–3
   PubMed Web of Science ®Google Scholar
• Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55–63
   PubMed Web of Science ®Google Scholar
• Muller RH, Mader K, Gohla S. (2000). Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art. Eur J Pharm Biopharm 50:161–77
   PubMed Web of Science ®Google Scholar
• Nanjwade BK, Adichwal SA, Gaikwad KR, et al. (2011). Pulmonary drug delivery: novel pharmaceutical technologies breathe new life into the lungs. PDA J Pharm Sci Technol 65:513–34
   PubMedGoogle Scholar
• Nassimi M, Schleh C, Lauenstein HD, et al. (2009). Low cytotoxicity of solid lipid nanoparticles in in vitro and ex vivo lung models. Inhal Toxicol 21:104–9
   PubMedGoogle Scholar
• Nassimi M, Schleh C, Lauenstein HD, et al. (2010). A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung. Eur J Pharm Biopharm 75:107–16
   PubMed Web of Science ®Google Scholar
• Nishiyama T, Mishima K, Ide F, et al. (2007). Functional analysis of an established mouse vascular endothelial cell line. J Vasc Res 44:138–48
   PubMed Web of Science ®Google Scholar
• Oberdörster G, Stone V, Donaldson K. (2007). Toxicology of nanoparticles: a historical perspective. Nanotoxicology 1:2–25
   Web of Science ®Google Scholar
• Rang HP, Dale MM, Ritter JM, Flower RJ. (2007). Pharmacology. 6th ed. New York: Churchill Livingstone. xiii, 829
   Google Scholar
• Revatio®, Revatio website source, Roteliste-Fachinformation, Pfizer Deutschland GmbH, Berlin, Germany
   Google Scholar
• Roggen EL, Soni NK, Verheyen GR. (2006). Respiratory immunotoxicity: an in vitro assessment. Toxicol In Vitro 20:1249–64
   PubMed Web of Science ®Google Scholar
• Sakagami M. (2006). In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drug Deliv Rev 58:1030–60
   PubMed Web of Science ®Google Scholar
• Scherließ R. (2011). The MTT assay as tool to evaluate and compare excipient toxicity in vitro on respiratory epithelial cells. Int J Pharm 411:98–105
   PubMed Web of Science ®Google Scholar
• Sung JC, Pulliam BL, Edwards DA. (2007). Nanoparticles for drug delivery to the lungs. Trends Biotechnol 25:563–70
   PubMed Web of Science ®Google Scholar
• Viagra®, Viagra website source, Roteliste-Fachinformation, Pfizer Deutschland GmbH, Berlin, Germany
   Google Scholar