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Inhalation Toxicology
International Forum for Respiratory Research
Volume 1, 1989 - Issue 1
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Research Article

Repeated Inhalation Exposures to 1-Nitropyrene (NP) or Benzo[a]Pyrene (BaP) in Association with Ca2O3 Particles and SO2: Tissue Distribution, Binding, and Metabolism of [14C]NP and [14C]BaP

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Pages 79-94 | Received 06 Jul 1988, Accepted 26 Aug 1988, Published online: 27 Sep 2008

References

  • Bond J. A., Mauderly J. L. Metabolism and macromolecular covalent binding of 14C-1-nitropyrene in isolated perfused and ventilated rat lungs. Cancer Res. 1984; 44: 3924–3929
  • Bond J. A., Mauderly J. L., Henderson R. F., McClellan R. O. Metabolism of I-14C-nitropyrene in respiratory tract tissue of rats exposed to diesel exhaust. Toxicol. Appl. PharmaCol. 1985; 79: 461–470
  • Bond J. A., Sun J. D., Medinsky M. A., Jones R. K., Yeh H. C. Deposition, metabolism and excretion of 14C-l-nitropyrene coated on diesel exhaust particles as influenced by exposure concentration. Toxicol. Appl. Pharmacol. 1986a; 65: 102–117
  • Bond J. A., Sun J. D., Mitchell C. E., Dutcher J. S., Wolff R. K., McClellan R. O. Biological fate of inhaled organic compounds associated with particulate matter. Aerosols, S. D. Lee, T. Schneider, L. D. Grant, P. J. Verker. Lewis Publisher., Chelsea, Mich. 1986b; 579–592
  • Creasia D. A., Poggenburg J. K., Nettesheim P. Elution of benzo[a]pyrene from carbon particles in the respiratory tract of mice. J. Toxicol. Environ. Health 1976; 1: 967–975
  • BMDP Statistical Software., W. J. Dixon. University of California, Berkeley 1983
  • Farrell R. L., Davis G. W. Effect of particulate benzo[a]pyrene carrier on carcinogenesis in the respiratory tract of hamsters. Experimental Lung Cancer: Carcinogenesis and Bioassay, R. Karbe, J. F. Park. Springer-Verlag., New York 1974; 186–198
  • Henry M. C., Kaufman D. G. Clearance of benzo[a]pyrene from hamster lungs after administration on coated particles. J. Natl. Cancer lnst. 1973; 51: 1961–1964
  • Howard A. J., Mitchell C. E., Dutcher J. S., Henderson T. R., McClellan R. O. Binding of nitropyrenes and benzo[a]pyrene to mouse lung deoxyribonucleic acid after pretreatment with inducing agents. Biochem. Pharmacol. 1986; 35: 2129–2134
  • Laskin S., Kuschner M., Sellakumar A., Katz G. V. Combined carcinogen-irritant animal inhalation studies. Air Pollution and the Lung, E. Aharonson, A. Ben-David, M. Klingberg. Wiley, New York 1975; 190–213
  • Mauderly J. L. Respiration of F344 rats in nose-only inhalation exposure tubes. J. Appl. Toxicol. 1986; 6: 25–30
  • Medinsky M. A., Shelton H., Bond J. A., McClellan R. O. Biliary excretion and enterohe-patic circulation of I-nitropyrene metabolites in Fischer-344 rats. Biochem. Pharmacol. 1985; 34: 2325–2330
  • Mitchell C. E. Effect of aryl hydrocarbon hydroxylase induction on the in vivo covalent binding of 1-nitropyrene, benzo[a]pyrene, 2-aminoanthracene, and phenanthridone to mouse lung deoxyribonucleic acid. Biochem. Pharmacol. 1985; 34: 545–551
  • Pylev L. N., Roe F. J.C., Warwick G. P. Elimination of radioactivity after intratracheal instillation of 3,4-benzopyrene in hamsters. Br. J. Cancer 1969; 23: 103–115
  • Raabe O. G., Bennick J. E., Light M. E., Hobbs C. H., Thomas R. L., Tillery M. I. An improved apparatus for acute inhalation exposure of rodents to radioactive aerosols. Toxicol. Appl. Pharmacol. 1973; 26: 264–273
  • Saffiotti U., Borg S. A., Grote M. I., Karp D. S. Retention rates of particulate carcinogens in lungs. Chicago Med. School Q. 1964; 24: 10–17
  • Saffiotti U., Cefin F., Kolb L. H., Shubik P. Experimental studies of the conditions of exposure to carcinogens for lung cancer induction. J. Air Pollut. Control Assoc. 1965; 15: 23–25
  • Sun J. D., Dent J. G. A new method for measuring covalent binding fo chemicals to cellular macromolecules. Chem.-Biol. Interact. 1980; 32: 41–61
  • Sun J. D., Wolff R. K., Kanapilly G. M. Deposition, retention and biological fate of inhaled benzo[a]pyrene adsorbed onto ultrafine particles and as a pure aerosol. Toxicol. Appl. Pharmacol. 1982; 65: 231–244
  • Sun J. D., Wolff T. K., Aberman H. M., McClellan R. O. Inhalation of 1-nitropyrene associated with ultrafine insoluble particles or as a pure aerosol: A comparison of deposition and biological fate. Toxicol. Appl. fharrnacol. 1983; 69: 185–198
  • Sun J. D., Wolff R. K., Kanapilly C. M., McClellan R. O. Lung retention and metabolic fate of inhaled benzo[a]pyrene associated with diesel exhaust particles. roxicol. Appl. fharrnacol. 1984; 73: 48–59
  • Vahakungas K., Nebert D. W., Pelkonen O. The DNA binding of benzo[a]pyrene metabolites catalyzed by rat lung microsornes in vitro and in isolated perfused rat lung. Chern.-Biol. Interact. 1979; 24: 167–176
  • Warshawsky D., Niemeier R., Bingham E. Influence of sulfur dioxide on metabolism and distribution of benzo[a]pyrene in isolated perfused rabbit lung. 1. Toxicol. Environ. Health 1981; 7: 1001–1024
  • Warshawsky D., Bingham E., Nierneier R. W. Influence of airborne particulate on the metabolism of benzo[a]pyrene in the isolated perfused lung. I. Toxicol. Environ. Health 1983; 11: 503–517
  • Warshawsky D., Bingham E., Niemeier R. W. The effects of a cocarcinogen, ferric oxide on the metabolism of benzo[a]pyrene in the isolated perfused lung. J. Toxicol. Environ. Health 1984; 14: 191–209
  • Wolff R. K., Kanapilly G. M., Denee P. B., McClellan R. O. Deposition of 0.1 μm chain aggregate aerosols in beagle dogs. J. Aerosol Sci. 1981; 12: 119–129
  • Wolff R. K., Lopez J. A., Wolf I., Beierman W. F., Hoover M. D., McClellan R. O. Combined unit for housing and noseonly exposures. Toxicologist 1984a; 4503
  • Wolff R. K., Kanapilly G. M., Gray R. H., McClellan R. O. Deposition and retention of inhaled aggregate 67Ga2O3 particles in beagle dogs, Fischer-344 rats, and CD-1 mice. Am. Ind. Hyg. Assoc. J. 1984b; 45: 377–381
  • Wolff R. K., Henderson R. F., Eidson A. F., Pickrell J. A., Rothenberg S. J., Hahn F. F. 1988, Toxicity of gallium oxide particles following a 4week inhalation exposure. J. Appl. Toxicol., in press
  • Wong D., Mitchell C. E., Wolff R. K., Mauderly J. L., Jeffrey A. M. Identification of DNA damage as a result of exposure of rats to diesel engine exhaust. Carcinogenesis 1986; 7: 1595–1597

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