42
Views
22
CrossRef citations to date
0
Altmetric
Original Article

The Sequential Activation and Repression of the Human PDGF-B Gene During Chronic Hypoxia Reveals Antagonistic Roles for the Depletion of Oxygen and Glucose

, , &
Pages 233-245 | Published online: 11 Jul 2009

References

  • Bae S. K., Bae M. H., Ahn M. Y., Son M. J., Lee Y. M., Bae M. K., Lee O. H., Park B. C., Kim K. W. Egr-1 mediates transcriptional activation of IGF-II gene in response to hypoxia. Cancer Res. 1999; 59: 5989–5994
  • Bandyopadhyay R. S., Phelan M., Faller D. V. Hypoxia induces AP-1–regulated genes and AP-1 transcription factor binding in human endothelial and other cell types. Biochim Biophys. Acta 1995; 1264: 72–78
  • Carmeliet P., Jain R. K. Angiogenesis in cancer and other diseases. Nature 2000; 407: 249–257
  • Carmeliet P., Dor Y., Herbert J. M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C. J., Ratcliffe P., Moons L., Jain R. K., Collen D., Keshet E. Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998; 394: 485–490
  • Dang C. V., Semenza G. L. Oncogenic alterations of metabolism. Trends Biochem Sci. 1999; 24: 68–72
  • Di Paolo S., Gesualdo L., Ranieri E., Grandaliano G., Schena F. P. High glucose concentration induces the over-expression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells. Am. J. Pathol. 1996; 149: 2095–2106
  • Forsberg K., Valyi-Nagy I., Heldin C. H., Herlyn M., Westermark B. Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB. Proc. Natl Acad. Sci. USA 1993; 90: 393–397
  • Forsythe J. A., Jiang B. H., Iyer N. V., Agani F., Leung S. W., Koos R. D., Semenza G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor l. Mol. Cell. Biol. 1996; 16: 4604–4613
  • Franklin G. C., Donovan M., Adam G. I., Holmgren L., Pfeifer-Ohlsson S., Ohlsson R. Expression of the human PDGF-B gene is regulated by both positively and negatively acting cell type-specific regulatory elements located in the first intron. EMBO J. 1991; 10: 1365–1373
  • Gleadle J. M., Ebert B. L., Firth J. D., Ratcliffe P. J. Regulation of angiogenic growth factor expression by hypoxia, transition metals and chelating agents. Am. J. Physiol. 1995; 268: 1362–1368
  • Heldin C. H., Westermark B. Mechanism of action and in vivo role of platelet-denved growth factor. Physiol. Rev 1999; 79: 1283–1316
  • Iyer N. V., Kotch L. E., Agani F., Leung S. W., Laughner E., Wenger R. H., Gassmann M., Gearhart J. D., Lawler A. M., Yu A. Y., Semenza G. L. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev. 1998; 12: 149–162
  • Jones S. C., Saunders H. J., Qi W., Pollock C. A. Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells. Diabeto-logia 1999; 42: 1113–1119
  • Khachigian L. M., Fries J. W.U., Benz M. W., Bonthron D. T., Collins T. Novel cis-acting elements in the human plateletderived growth factor B-chain core promoter that mediate gene expression in cultured vascular endothelial cells. J. Biol. Chem 1994; 269: 22647–22656
  • Khachigian L. M., Linder V., Williams A. J., Collins T. Egr-1–induced endothelial gene expression: a common theme in vascular injury. Science 1996; 1427–1431
  • Kietzmann T., Roth U., Jungermaun K. Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood 1999; 94: 4177–4185
  • Kimura H., Weisz A., Ogura T., Hitomi Y., Kurashima Y., Hashimoto K., D'Acquisto F., Makuuchi M., Esumi H. Identification of hypoxia-inducible factor-1 (HIF-1) ancillary sequence and its function in vascular endothelia growth factor gene induction by hypoxia and nitric oxide. J. Biol. Chem 2000
  • Kourembanas S., Hannan R. L., Faller D. V. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J. Clin. Invest. 1990; 86: 670–674
  • Kuwabara K., Ogawa S., Matsumoto M., Koga S., Clauss M., Pinsky D. J., Lyn P., Leavy J., Witte L., Joseph-Silverstein J., et al. Hypoxia-mediated induction of acidichasic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc. Natl Acad. Sci. USA 1995; 92: 4606–4610
  • Lee P. J., Jiang B. H., Chin B. Y., Iyer N. V., Alam J., Semenza G. L., Choi A. M. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 1997; 272: 5375–5381
  • Levy A. P., Levy N. S., Goldberg M. A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem 1996; 271: 2746–2753
  • Maltepe E., Schmidt J. V., Baunoch D., Bradfield C. A., Simon M. C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 1997; 386: 403–407
  • Morita T., Kourembanas S. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J. Clin. Invest. 1995; 96: 2676–2682
  • Nakanishi K., Hiroi S., Kawai T., Torikata C. Expression of platelet-derived growth-factor B-chain mRNA and tumor angiogenesis in invasive transitional cell carcinoma of the upper urinary tract. Mod. Pathol. 1997; 10: 341–347
  • Nakayama M., Takahashi K., Kitamuro T., Yasumoto K., Katayose D., Shirato K., Fujii-Kuriyama Y., Shibahara S. Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells. Biochem. Biophys. Res. Commun. 2000; 271: 665–671
  • Okuda Y., Adrogue H. J., Nakajima T., Mizutani M., Asano M., Tachi Y., Suzuki S., Yamashita K. Increased production of PDGF by angiotensin and high glucose in human vascular endothelium. Life Sci. 1996; 59: 1455–1461
  • Press R. D., Samols D., Goldthwait D. A. Expression and stability of c-sis mRNA in human glioblastoma cells. Biochemistry 1988; 27: 5736–5741
  • Rafty L. A., Khachigian L. M. Novel negative regulatory element in the platelet-derived growth factor B chain promoter that mediates ERK-dependent transcriptional repression. J. Biol. Chem. 2000; 275: 11478–11483
  • Ratner L. Regulation of expression of the c-sis proto-oncogene. Nucleic Acids Res. 1989; 17: 4101–4115
  • Rofstad E. K. Microenvironment-induced cancer metastasis. Int. J. Radiat. Biol. 2000; 76: 589–605
  • Ryan H E., Poloni M., McNulty W., Elson D., Gassmann M., Arbeit J. M., Johnson R. S. Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth. Cancer Res. 2000; 60: 4010–4015
  • Satake S., Kuzuya M., Miura H., Asai T., Ramos M. A., Muraguchi M., Ohmoto Y., Iguchi A. Up-regulation of vascular endothelial growth factor in response to glucose deprivation. Biol. Cell 1998; 90: 161–168
  • Semenza G. L. Regulation of mammalian O2 homeostasis by hypoxia-inducible factor l. Annu. Rev. Cell Dev. Biol. 1999; 15: 551–578
  • Semenza G. L., Wang G. L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol. Cell Biol. 1992; 12: 547–5454
  • Semenza G. L., Jiang B. H., Leung S. W., Passantino R., Concordet J. P., Maire P., Giallongo A. Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor l. J. Biol. Chem. 1996; 271: 32529–32537
  • Shweiki D., Neeman M., Itin A., Keshet E. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis. Proc. Natl Acad. Sci. USA 1995; 92: 768–772
  • Stein I., Neeman M., Shweiki D., Itin A., Keshet E. Stabilization of vascular endothelial growth factor mRNA by hypoxia and hypoglycemia and coregulation with other ischemia-induced genes. Mol. Cell Biol. 1995; 15: 5363–5368
  • Tsai T. F., Yauk Y. K., Chou C. K., Ting L. P., Chang C., Hu C. P., Han S. H., Su T. S. Evidence of autocrine regulation in human hepatoma cell lines. Biochem. Biophys. Res. Commun. 1988; 153: 39–45
  • Vaulont S., Vasseur-Cognet M., Kahn A. Glucose regulation of gene transcription. J. Biol. Chem. 2000; 275: 31555–31558, in process citation
  • Westermark B., Heldin C. H., Nister M. Platelet-derived growth factor in human glioma. Glia 1995; 15: 257–263
  • Wood S. M., Gleadle J. M., Pugh C. W., Hankinson O., Ratcliffe P. J. The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT-deficient cells. J. Biol. Chem. 1996; 271: 15117–15123
  • Wood S. M., Wiesener M. S., Yeates K. M., Okada N., Pugh C. W., Maxwell P. H., Ratcliffe P. J. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha-subunit (HIF-1 alpha). Characterization of HIF-1 alpha-dependent and -independent hypoxia-inducible gene expression. J. Biol. Chem. 1998; 273: 8360–8368

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.