286
Views
18
CrossRef citations to date
0
Altmetric
Articles

Coordinated age-dependent and pancreatic-specific expression of mouse Reg2Reg3α, and Reg3β genes

, , , , , , , & show all
Pages 72-81 | Received 23 Dec 2010, Accepted 10 Feb 2011, Published online: 16 Mar 2011

References

  • Baeza N, Moriscot C, Figarella C, Guy-Crotte O, Vialettes B. 1996. Reg protein: A potential beta-cell-specific growth factor?. Diabetes Metab. 22:229–234.
  • Bartoli C, Gharib B, Giorgi D, Sansonetti A, Dagorn JC, Berge-Lefranc JL. 1993. A gene homologous to the reg gene is expressed in the human pancreas. FEBS Lett. 327:289–293.
  • Bimmler D, Schiesser M, Perren A, Scheele G, Angst E, Meili S, Ammann R, Graf R. 2004. Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis. J Surg Res. 118:122–135.
  • Bluth M, Mueller CM, Pierre J, Callender G, Kandil E, Viterbo D, Fu SL, Sugawara A, Okamoto H, Zenilman ME. 2008. Pancreatic regenerating protein I in chronic pancreatitis and aging: Implications for new therapeutic approaches to diabetes. Pancreas. 37:386–395.
  • Boulet AM, Erwin CR, Rutter WJ. 1986. Cell-specific enhancers in the rat exocrine pancreas. Proc Natl Acad Sci USA. 83:3599–3603.
  • Castellarin ML, Petropavlovskaia M, Lipsett MA, Rosenberg L. 2007. The identification and sequence analysis of a new Reg3gamma and Reg2 in the Syrian golden hamster. Biochim Biophys Acta. 1769:579–585.
  • Cavard C, Terris B, Grimber G, Christa L, Audard V, Radenen-Bussiere B, Simon MT, Renard CA, Buendia MA, Perret C. 2006. Overexpression of regenerating islet-derived 1 alpha and 3 alpha genes in human primary liver tumors with [beta]-catenin mutations. Oncogene. 25:599–608.
  • Chakraborty C, Katsumata N, Myal Y, Schroedter IC, Brazeau P, Murphy LJ, Shiu RP, Friesen HG. 1995. Age-related changes in peptide-23/pancreatitis-associated protein and pancreatic stone protein/reg gene expression in the rat and regulation by growth hormone-releasing hormone. Endocrinology. 136:1843–1849.
  • Christa L, Carnot F, Simon MT, Levavasseur F, Stinnakre MG, Lasserre C, Thepot D, Clement B, Devinoy E, Brechot C. 1996. HIP/PAP is an adhesive protein expressed in hepatocarcinoma, normal Paneth, and pancreatic cells. Am J Physiol. 271:G993–G1002.
  • Christa L, Simon MT, Brezault-Bonnet C, Bonte E, Carnot F, Zylberberg H, Franco D, Capron F, Roskams T, Brechot C. 1999. Hepatocarcinoma-intestine-pancreas/pancreatic associated protein (HIP/PAP) is expressed and secreted by proliferating ductules as well as by hepatocarcinoma and cholangiocarcinoma cells. Am J Pathol. 155:1525–1533.
  • Cui W, De Jesus K, Zhao H, Takasawa S, Shi B, Srikant CB, Liu JL. 2009. Overexpression of Reg3alpha increases cell growth and the levels of cyclin D1 and CDK4 in insulinoma cells. Growth Factors. 27:195–202.
  • De Leon DD, Farzad C, Crutchlow MF, Brestelli J, Tobias J, Kaestner KH, Stoffers DA. 2006. Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment. Physiol Genomics. 24:133–143.
  • Egan JM, Bulotta A, Hui H, Perfetti R. 2003. GLP-1 receptor agonists are growth and differentiation factors for pancreatic islet beta cells. Diabetes Metab Res Rev. 19:115–123.
  • Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U, Perfetti R. 2002. Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology. 143:4397–4408.
  • Flores LE, Garcia ME, Borelli MI, Del Zotto H, Alzugaray ME, Maiztegui B, Gagliardino JJ. 2003. Expression of islet neogenesis-associated protein in islets of normal hamsters. J Endocrinol. 177:243–248.
  • Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF. 2000. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem. 275:1226–1232.
  • Gigoux V, Clerc P, Sanchez D, Coll MG, Corominola H, Leung-Theung-Long S, Penicaud L, Gomis R, Seva C, Fourmy D, Dufresne M. 2008. Reg genes are CCK2 receptor targets in ElasCCK2 mice pancreas. Regul Pept. 146:88–98.
  • Gurr W, Shaw M, Li Y, Sherwin R. 2007. RegII is a {beta}-cell protein and autoantigen in diabetes of NOD mice. Diabetes. 56:34–40.
  • Hervieu V, Christa L, Gouysse G, Bouvier R, Chayvialle JA, Brechot C, Scoazec JY. 2006. HIP/PAP, a member of the reg family, is expressed in glucagon-producing enteropancreatic endocrine cells and tumors. Hum Pathol. 37:1066–1075.
  • Iovanna JL, Keim V, Bosshard A, Orelle B, Frigerio JM, Dusetti N, Dagorn JC. 1993. PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine. Am J Physiol Gastrointest Liver Physiol. 265:G611–G618.
  • Itoh T, Teraoka H. 1993. Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP). Biochim Biophys Acta. 1172:184–186.
  • Lasserre C, Christa L, Simon MT, Vernier P, Brechot C. 1992. A novel gene (HIP) activated in human primary liver cancer. Cancer Res. 52:5089–5095.
  • Lasserre C, Simon MT, Ishikawa H, Diriong S, Nguyen VC, Christa L, Vernier P, Brechot C. 1994. Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer. Eur J Biochem. 224:29–38.
  • Liu JL, Cui W. 2007. Which gene, Reg2 or Reg3beta, was targeted that affected liver regeneration?. Hepatology. 45:1584–1585.
  • Liu JL, Patel YC. 1995. Glucocorticoids inhibit somatostatin gene expression through accelerated degradation of somatostatin messenger ribonucleic acid in human thyroid medullary carcinoma (TT) cells. Endocrinology. 136:2389–2396.
  • Liu JL, Cui W, Li B, Lu Y. 2008. Possible roles of reg family proteins in pancreatic islet cell growth. Endocr Metab Immune Disord Drug Targets. 8:1–10.
  • Liu L, Liu JL, Srikant CB. 2010. Reg2 protects mouse insulinoma cells from streptozotocin-induced mitochondrial disruption and apoptosis. Growth Factors. 28:370–378.
  • Lu Y, Ponton A, Okamoto H, Takasawa S, Herrera PL, Liu J-L. 2006. Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas. Am J Physiol Endocrinol Metab. 291:E50–E58.
  • Mally MI, Otonkoski T, Lopez AD, Hayek A. 1994. Developmental gene expression in the human fetal pancreas. Pediatr Res. 36:537–544.
  • Meister A, Weinrich SL, Nelson C, Rutter WJ. 1989. The chymotrypsin enhancer core. Specific factor binding and biological activity. J Biol Chem. 264:20744–20751.
  • Miyashita H, Yonekura H, Unno M, Suzuki Y, Watanabe T, Moriizumi S, Takasawa S, Okamoto H. 1994. Characterization of the 5′-regulatory region of rat Reg I gene. Biochim Biophys Acta. 1219:241–243.
  • Narushima Y, Unno M, Nakagawara K, Mori M, Miyashita H, Suzuki Y, Noguchi N, Takasawa S, Kumagai T, Yonekura H, Okamoto H. 1997. Structure, chromosomal localization and expression of mouse genes encoding type III Reg, RegIII alpha, RegIII beta, RegIII gamma. Gene. 185:159–168.
  • Okamoto H, Takasawa S. 2002. Recent advances in the Okamoto model: The CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)–Reg receptor system in beta-cells. Diabetes. 51 Suppl. 3: S462–S473.
  • Perfetti R, Raygada M, Wang Y, Zenilman ME, Egan JM, Denno KM, Sadler TW, Shuldiner AR. Regenerating (reg) and insulin genes are expressed in prepancreatic mouse embryos. J Mol Endocrinol. 1996a; 17:79–88.
  • Perfetti R, Egan JM, Zenilman ME, Shuldiner AR. Differential expression of reg-I and reg-II genes during aging in the normal mouse. J Gerontol A Biol Sci Med Sci. 1996b; 51:B308–B315.
  • Rafaeloff R, Pittenger GL, Barlow SW, Qin XF, Yan B, Rosenberg L, Duguid WP, Vinik AI. 1997. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J Clin Invest. 99:2100–2109.
  • Rosenberg L, Lipsett M, Yoon JW, Prentki M, Wang R, Jun HS, Pittenger GL, Taylor-Fishwick D, Vinik AI. 2004. A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice. Ann Surg. 240:875–884.
  • Sasahara K, Yamaoka T, Moritani M, Yoshimoto K, Kuroda Y, Itakura M. 2000. Molecular cloning and tissue-specific expression of a new member of the regenerating protein family, islet neogenesis-associated protein-related protein. Biochim Biophys Acta. 1500:142–146.
  • Simon MT, Pauloin A, Normand G, Lieu HT, Mouly H, Pivert G, Carnot F, Tralhao JG, Brechot C, Christa L. 2003. HIP/PAP stimulates liver regeneration after partial hepatectomy and combines mitogenic and anti-apoptotic functions through the PKA signaling pathway. Faseb J. 17:1441–1450.
  • Takasawa S, Ikeda T, Akiyama T, Nata K, Nakagawa K, Shervani NJ, Noguchi N, Murakami-Kawaguchi S, Yamauchi A, Takahashi I, Tomioka-Kumagai T, Okamoto H. 2006. Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration. FEBS Lett. 580:585–591.
  • Taylor-Fishwick DA, Bowman A, Hamblet N, Bernard P, Harlan DM, Vinik AI. 2006. Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin. J Endocrinol. 190:729–737.
  • Taylor-Fishwick DA, Bowman A, Korngiebel-Rosique M, Vinik AI. 2008. Pancreatic islet immunoreactivity to the Reg protein INGAP. J Histochem Cytochem. 56:183–191.
  • Treisman R. 1992. The serum response element. Trends Biochem Sci. 17:423–426.
  • Unno M, Yonekura H, Nakagawara K, Watanabe T, Miyashita H, Moriizumi S, Okamoto H, Itoh T, Teraoka H. 1993. Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 268:15974–15982.
  • Xiong X, Wang X, Li B, Chowdhury S, Lu Y, Srikant CB, Ning N, Liu J-L. 2011. Pancreatic islet-specific overexpression of Reg3β protein induced the expression of pro-islet genes and protected mice against streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab. 300 4 (in press).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.