307
Views
4
CrossRef citations to date
0
Altmetric
Research Paper

Intrabody application of eptotermin alpha enhances bone formation in osteoporotic fractures of the lumbar spine; however, fails to increase biomechanical stability – results of an experimental sheep model

, , , , , , & show all
Pages 290-297 | Received 14 Jul 2015, Accepted 26 Jul 2015, Published online: 12 Sep 2015

References

  • Amanat N, Brown R, Bilston LE, Little DG. 2005. A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. J Orthop Res 23:1029–1034
  • Aspenberg P. 2005. Drugs and fracture repair. Acta Orthop 76:741–748
  • Büyükkurt CD, Bülbül M, Ayanoğlu S, Esenyel CZ, Oztürk K, Gürbüz H. 2012. The effects of osteoporosis on functional outcome in patients with distal radius fracture treated with plate osteosynthesis. Acta Orthop Traumatol Turc 46:89–95
  • Chen D, Zhao M, Mundy GR. 2004. Bone morphogenetic proteins. Growth Factors 22:233–241
  • Cook SD. 1999. Preclinical and clinical evaluation of osteogenic protein-1 (BMP-7) in bony sites. Orthopedics 22:669–671
  • Delawi D, Dhert WJ, Rillardon L, Gay E, Prestamburgo D, Garcia-Fernandez C, Guerado E, et al. 2010. A prospective, randomized, controlled, multicenter study of osteogenic protein-1 in instrumented posterolateral fusions: Report on safety and feasibility. Spine (PA 1976) 35:1185–1191
  • Einhorn TA. 2010. Can an anti-fracture agent heal fractures? Clin Cases Miner Bone Metab 7:11–14
  • Ekrol I, Hajducka C, Court-Brown C, McQueen MM. 2008. A comparison of RhBMP-7 (OP-1) and autogenous graft for metaphyseal defects after osteotomy of the distal radius. Injury 39:73–82
  • Eom KS, Kim TY. 2012. Percutaneous vertebroplasty-induced adjacent vertebral compression fracture. Pain Physician 15:527–532
  • Eschler A, Ender SA, Schiml K, Mittlmeier T, Gradl G. 2015a. Bony healing of unstable thoracolumbar burst fractures in the elderly using percutaneously applied titanium mesh cages and a transpedicular fixation system with expandable screws. PLoS One 10:0117122
  • Eschler A, Ender SA, Ulmar B, Herlyn P, Mittlmeier T, Gradl G. 2014. Cementless fixation of osteoporotic VCFs using titanium mesh implants (OsseoFix): Preliminary results. Biomed Res Int 2014:853897
  • Eschler A, Roepenack P, Herlyn P, Roesner J, Pille K, Büsing K, Vollmar B, et al. 2015b. The standardized creation of a lumbar spine vertebral compression fracture in a sheep osteoporosis model induced by ovariectomy, corticosteroid therapy and calcium-/phosphorus/vitamin D-deficient diet. Under review, submitted 2015 Apr
  • Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, et al. 2001. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 83:151–158
  • Garrison KR, Donell S, Ryder J, Shemilt I, Mugford M, Harvey I, Song F. 2007. Clinical effectiveness and cost-effectiveness of bone morphogenetic proteins in the non-healing of fractures and spinal fusion: A systematic review. Health Technol Assess 11:1–150
  • Garrison KR, Shemilt I, Donell S, Ryder JJ, Mugford M, Harvey I, Song F, Alt V. 2010. Bone morphogenetic protein (BMP) for fracture healing in adults. Cochrane Database Syst Rev 16:CD006950
  • Gerstenfeld LC, Cullinane DM, Barnes GL, Graves DT, Einhorn TA. 2003. Fracture healing as a post-natal developmental process: Molecular, spatial, and temporal aspects of its regulation. J Cell Biochem 88:873–884
  • Ghofrani H, Nunn T, Robertson C, Mahar A, Lee Y, Garfin S. 2010. An evaluation of fracture stabilization comparing kyphoplasty and titanium mesh repair techniques for vertebral compression fractures: Is bone cement necessary? Spine (PA 1976) 35:768–773
  • Goldhahn J, Suhm N, Goldhahn S, Blauth M, Hanson B. 2008. Influence of osteoporosis on fracture fixation – A systematic literature review. Osteoporos Int 19:761–772
  • Goldhahn S, Kralinger F, Rikli D, Marent M, Goldhahn J. 2010. Does osteoporosis increase complication risk in surgical fracture treatment? A protocol combining new endpoints for two prospective multicentre open cohort studies. BMC Musculoskelet Disord 11:256
  • Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R, Aro H, et al.; BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. 2002. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: A prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 84:2123–2134
  • Han S, Wan S, Ning L, Tong Y, Zhang J, Fan S. 2011. Percutaneous vertebroplasty versus balloon kyphoplasty for treatment of osteoporotic vertebral compression fracture: A meta-analysis of randomised and non-randomised controlled trials. Int Orthop 35:1349–1358
  • Hao YJ, Zhang G, Wang YS, Qin L, Hung WY, Leung K, Pei FX. 2007. Changes of microstructure and mineralized tissue in the middle and late phase of osteoporotic fracture healing in rats. Bone 41:631–638
  • Hartmann F, Griese M, Dietz SO, Kuhn S, Rommens PM, Gercek E. 2014. Two-year results of vertebral body stenting for the treatment of traumatic incomplete burst fractures. Minim Invasive Ther Allied Technol 29:1–6
  • Hoang-Kim A, Gelsomini L, Luciani D, Moroni A, Giannini S. 2009. Fracture healing and drug therapies in osteoporosis. Clin Cases Miner Bone Metab 6:136–143
  • Hulme PA, Krebs J, Ferguson SJ, Berlemann U. 2006. Vertebroplasty and kyphoplasty: A systematic review of 69 clinical studies. Spine (PA 1976) 31:1983–2001
  • Jones AL, Bucholz RW, Bosse MJ, Mirza SK, Lyon TR, Webb LX, Pollak AN, et al. 2006. BMP-2 Evaluation in Surgery for Tibial Trauma-Allgraft (BESTT-ALL) Study Group. Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 88:1431–1441
  • Korovessis P, Vardakastanis K, Repantis T, Vitsas V. 2013. Transpedicular vertebral body augmentation reinforced with pedicle screw fixation in fresh traumatic A2 and A3 lumbar fractures: Comparison between two devices and two bone cements. Eur J Orthop Surg Traumatol 24:183–191
  • Kubo T, Shiga T, Hashimoto J, Yoshioka M, Honjo H, Urabe M, Kitajima I, et al. 1999. Osteoporosis influences the late period of fracture healing in a rat model prepared by ovariectomy and low calcium diet. J Steroid Biochem Mol Biol 68:197–202
  • Lee HM, Park SY, Lee SH, Suh SW, Hong JY. 2012. Comparative analysis of clinical outcomes in patients with osteoporotic vertebral compression fractures (OVCFs): Conservative treatment versus balloon kyphoplasty. Spine J 12:998–1005
  • Li Y, Cheng H, Liu ZC, Wu JW, Yu L, Zang Y, He Q, et al. 2013. In vivo study of pedicle screw augmentation using bioactive glass in osteoporosis sheep. J Spinal Disord Tech 26:118–123
  • Lill CA, Hesseln J, Schlegel U, Eckhardt C, Goldhahn J, Schneider E. 2003. Biomechanical evaluation of healing in a non-critical defect in a large animal model of osteoporosis. J Orthop Res 21:836–842
  • Lin EP, Ekholm S, Hiwatashi A, Westesson PL. 2004. Vertebroplasty: Cement leakage into the disc increases the risk of new fracture of adjacent vertebral body. Am J Neuroradiol 25:175–180
  • Lovi A, Teli M, Ortolina A, Costa F, Fornari M, Brayda-Bruno M. 2009. Vertebroplasty and kyphoplasty: Complementary techniques for the treatment of painful osteoporotic vertebral compression fractures: A prospective non-randomised study on 154 patients. Eur Spine J 18:95–101
  • Mittra E, Rubin C, Qin YX. 2005. Interrelationship of trabecular mechanical and microstructural properties in sheep trabecular bone. J Biomech 38:1229–1237
  • Movrin I. 2012. Adjacent level fracture after osteoporotic vertebral compression fracture: A nonrandomized prospective study comparing balloon kyphoplasty with conservative therapy. Wien Klin Wochenschr 124:304–311
  • Namkung-Matthai H, Appleyard R, Jansen J, Hao Lin J, Maastricht S, Swain M, et al. 2001. Osteoporosis influences the early period of fracture healing in a rat osteoporotic model. Bone 28:80–86
  • Omidi-Kashani F, Samini F, Hasankhani EG, Kachooei AR, Toosi KZ, Golhasani-Keshtan F. 2013. Does percutaneous kyphoplasty have better functional outcome than vertebroplasty in single level osteoporotic compression fractures? A comparative prospective study. J Osteoporos 2013:690329
  • Paik H, Dmitriev AE, Lehman RA Jr, Gaume RE, Ambati DV, Kang DG, Lenke LG. 2012. The biomechanical effect of pedicle screw hubbing on pullout resistance in the thoracic spine. Spine J 12:417–424
  • Peter CP, Cook WO, Nunamaker DM, Provost MT, Seedor JG, Rodan GA. 1996. Effect of alendronate on fracture healing and bone remodeling in dogs. J Orthop Res 14:74–79
  • Phillips FM, Turner AS, Seim HB 3rd, MacLeay J, Toth CA, Pierce AR, Wheeler DL. 2006. In vivo BMP-7 (OP-1) enhancement of osteoporotic vertebral bodies in an ovine model. Spine J 6:500–506
  • S3-Leitlinie des Dachverbands der Deutschsprachigen Wissenschaftlichen Osteologischen Gesellschaften e.V. (DVO). 2014. Prophylaxe, diagnostik und therapie der osteoporose. Available from: http://www.dv-osteologie.org/uploads/Leitlinie%202014/DVO-Leitlinie%20Osteoporose%202014%20Kurzfassung%20und%20Langfassung%2018.%2009.%202014.pdf [Accessed 15 June 2015]
  • Saeed M, Khan BA, Wazir Z, Inam M, Satar A. 2014. The use of locally harvested bone chips as a graft in spine fusion surgery. J Pak Med Assoc 64:87–90
  • Upasani VV, Robertson C, Lee D, Tomlinson T, Mahar AT. 2010. Biomechanical comparison of kyphoplasty versus a titanium mesh implant with cement for stabilization of vertebral compression fractures. Spine 35:1783–1788
  • Walter J, Haciyakupoglu E, Waschke A, Kalff R, Ewald C. 2012. Cement leakage as a possible complication of balloon kyphoplasty – Is there a difference between osteoporotic compression fractures (AO type A1) and incomplete burst fractures (AO type A3.1)? Acta Neurochir 154:313–319
  • White AP, Vaccaro AR, Hall JA, Whang PG, Friel BC, McKee MD. 2007. Clinical applications of BMP-7/OP-1 in fractures, nonunions and spinal fusion. Int Orthop 31:735–741
  • World Health Organisation. 1994. Assessment of fracture risk and its implication to screening for postmenopausal osteoporosis: Technical report series 843. Geneva: WHO
  • Zou J, Mei X, Zhu X, Shi Q, Yang H. 2012. The long-term incidence of subsequent vertebral body fracture after vertebral augmentation therapy: A systemic review and meta-analysis. Pain Physician 15:515–522

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.