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Original Article

The Effects of TGFβ on Haemopoietic Cells

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Pages 193-202 | Received 15 Sep 1988, Accepted 18 Oct 1988, Published online: 11 Jul 2009

References

  • Assoian R. K., Komoriya A., Meyers C. A., Miller D. M., Sporn M. B. Transforming growth factor-beta in human platelets. J. Biol. Chem. 1983; 258: 7155–7160
  • Baird A., Durkin T. Inhibition of endothelial cell proliferation by type-beta transforming growth factor: interactions with acidic and basic fibroblast growth factors. Biochem. Biophys. Res. Commun. 1986; 138: 476–482
  • Bazill G. W., Haynes M., Garland J., Dexter T. M. Characterisation and partial purification of a haemopoietic cell growth factor in Wehi 3 cell conditioned medium. Biochem. J 1983; 210: 747–759
  • Centrella M., McCarthy T. L., Canalis E. Transforming growth factor β is a bifunctional regulator of replication and collagen synthesis in osteoblast enriched cell cultures from fetal rat bone. J. Biol. Chem. 1987; 262: 2869–2874
  • Cheifetz S., Like B., Massague J. Cellular distribution of type I and type II receptors for transforming growth factor-β. J. Biol. Chem. 1986; 261: 9972–9978
  • Cheifetz S., Weatherbee J. A., Tsang M. L. S., Anderson J. K., Mole J. E., Lucas R., Massague J. The transforming growth factor β system, a complex pattern fo cross reactive ligands and receptors. Cell 1987; 48: 409–415
  • Derynck R., Jarrett E. A., Chen E. Y., Eaton D. H., Bell J. R., Assoian R. K., Roberts A. B., Sporn M. B., Goeddel D. V. Human transforming growth factor-β complementary DNA sequence and expression in tumor cell lines. Nature 1985; 316: 701–705
  • Dexter T. M., Garland J., Scott D., Scolnick E., Metcalf D. Growth factor dependent haemopoietic precursor cell lines. J. Exp. Med. 1980; 152: 1036–1047
  • Ellingsworth L. R., Brennan J. E., Fok K., Rosen D. M., Bentz H., Piez K. A., Seyedin S. M. Antibodies to the N-terminal portion of cartilage-inducing factor A and transforming growth factor β. J. Biol. Chem. 1986; 261: 12362–12367
  • Fine A., Goldstein R. H. The effect of transforming growth factor-beta on cell proliferation and collagen formation by lung fibroblasts. J. Biol. Chem. 1987; 262: 3897–3902
  • Frater-Schroder M., Muller G., Birchmeier W., Bohlen P. Transforming growth factor-beta inhibits endothelial cell proliferation. Biochem. Biophys. Res. Commun. 1986; 137: 295–392
  • Frolik C. A., Dart L. L., Meyers C. A., Smith D. M., Sporn M. B. Purification and initial characterisation of a type beta transforming growth factor from human platelets. Proc. Natl. Acad. Sci. USA 1983; 80: 3676–3680
  • Frolik C. A., Wakefield L. A., Smith D. M., Sporn M. B. Characterisation of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J. Biol. Chem. 1984; 259: 10995–11000
  • Fung M. C., Hapel A. J., Ymer S., Cohen D. R., Johnson R. M., Campbell H. D., Young I. G. Molecular cloning of cDNA for murine interleukin-3. Nature 1984; 307: 233–237
  • Gough N. M., Gough J., Metcalf D., Kelso A., Grail D., Nicola N. A., Burgess A. W., Dunn A. R. Molecular cloning of cDNA encoding a murine haemopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature 1984; 309: 763–767
  • Heimark R. L., Twardzik D. R., Schwartz S. M. Inhibition of endothelial regeneration by type-beta transforming growth factor from platelets. Science 1986; 233: 1078–1080
  • Heyworth C. M., Ponting I. L. O., Dexter T. M. The response of haemopoietic cells to growth factors: developmental implications of synergistic interactions. J. Cell Sci. 1988; 91: 239–247
  • Hino M., Arinobu T., Mihyazono K., Urabe A., Takaku F. Effects of type β transforming growth factors on haemopoietic progenitor cells. Br. J. Haematol. 1988; 70: 143–147
  • Ihle J. N., Keller J., Oroszland S., Henderson L. E., Copeland T. D., Fitch F., Prystowsky M. B., Goldwasser E., Schrader J. W., Palaszynski E., Dy M., Lebel B. Biologic properties of homogeneous interleukin 3: I. Demonstration of WEHI-3 growth factor activity, mast cell growth activity, P cell-stimulating factor activity. J. Immunol. 1983; 131: 282–287
  • Ignotz R. A., Massague J. Type β transforming growth factor controls the adipogenic differentiation of 3T3 fibroblats. Proc. Natl. Acad. Sci. USA 1985; 82: 8530–8534
  • Ignotz R. A., Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J. Biol. Chem. 1986; 261: 4337–4345
  • Kehrl J. H., Roberts A. B., Wakefield L. M., Jakowlew S. B., Sporn M. B., Fauci A. S. Transforming growth factor beta is an important immunomodulatory protein for human B-lvmphocytes. J. Immunol. 1986a; 137: 3855–3860
  • Kehrl J. H., Wakefield L., Roberts A. B., Jakowlew S. B., Alvarez-Mon M., Derynck R., Sporn M. B., Fauci A. S. Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J. Exp. Med. 1986b; 163: 1037–1050
  • Keller J. R., Mantel C., Sing G. K., Ellingsworth L. R., Ruscetti S. K., Ruscetti F. W. Transforming growth factor β1 selectively regulates early murine haemopoietic progenitors. and inhibits the growth of IL-3-dependent myeloid leukemia cell lines. J. Exp. Med. 1988; 168: 737–750
  • Lord B. I., Spooncer E. Isolation of haemopoietic spleen colony forming cells. Lymphokine Res. 1986; 5: 59–72
  • Massague J. The TGFβ family of growth and differentiation factors. Cell 1987; 49: 437–438
  • Massague J., Cheifetz S., Endo T., Nadal-Ginard B. Type β transforming growth factor is an inhibitor of myogenic differentiations. Proc. Natl. Acad. Sci. USA 1986; 83: 8206–8210
  • Massague J., Like B. Cellular receptors for type β transforming growth factor: ligand binding and affinity labeling in human and rodent cell lines. J. Biol. Chem. 1985; 260: 2636–2645
  • Masui T., Wakefield L. M., Lechner J. F., LaVeck M. A., Sporn M. B., Harris C. C. Type β transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. USA 1986; 83: 2438–2442
  • McMahon J. B., Richards W. L., del Campo A. A., Song M.-K. H., Thorgeirsson S. S. Differential effects of transforming growth factor-β on proliferation of normal and malignant rat liver epithelial cells in cutlure. Cancer Res. 1986; 46: 4665–4671
  • Metcalf D. The granulocyte-marcrophage colony stimulating factors. Science 1985; 229: 16–22
  • Moses H. L., Tucker R. F., Leof E. B., Coffey R. J., Hapler J., Shipley G. D. Type-beta transforming growth factor is a growth stimulator and a growth inhibitor. Cancer cells, J. Feramisco, B. Ozanne, C. Stiles. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 1985; 65–71
  • Nicola N. A., Metcalt M., Matsumoto M., Johnson G. R. Purification of a factor inducing differentiation in murine myelomonocytic leukaemia cells: identification of granulocyte colony-stimulating factor. J. Biol. Chem. 1983; 258: 9017–9023
  • Ohta M., Greenberger J. S., Aklesaria P., Bassols A., Massague J. Two forms of transforming growth factor β distinguished by multipotential haemopoietic progenitor cells. Nature 1987; 329: 539–541
  • Ottmann O. G., Pelus L. M. Differential proliferative effects of transforming growth factor-β on human hemopoietic progenitor cells. J. Immunol. 1988; 140: 2661–2665
  • Ranchalis J. E., Gentry L., Ogawa Y., Seyedin S. M., McPherson J., Purchis A., Twardzik D. R. Bone-derived and recombinant transforming growth factor β's are potent inhibitors of tumor cell growth. Biochem. Biophys. Res. Commun. 1987; 124: 783–789
  • Ranges G. E., Figari I. S., Espervik T., Palladino M. A. Inhibition of cytotoxic T cell development by transforming growth factor β and reversal by recombinant tumor necrosis factor α. J. Exp. Med. 1987; 166: 991–998
  • Roberts A. B., Anzano M. A., Lamb L. C., Smith J. M., Sporn M. B. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc. Null. Acad. Sci. USA 1981; 78: 5339–5343
  • Roberts A. B., Anzano M. A., Meyers C. A., Wideman J., Blacker R., Pan Y.-C. E., Stein S., Lehrman R., Smith J. M., Lamb L. C., Sporn M. B. Purification and properties of type beta transforming growth factor from bovine kidney. Biochemistry 1983; 22: 5692–5698
  • Roberts A. B., Sporn M. B., Assoian R. K., Smith J. M., Roche N. S., Wakefield L. M., Heine U. I., Liotta L. A., Falanga V., Kehrl J. H., Fauci A. S. Transforming growth factor type-beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation. Proc. Natl. Acad. Sci. USA 1986; 83: 4167–4171
  • Robey P. G., Young M. F., Flanders K. C., Roche N. S., Kondaioh P., Reddi A. H., Termine J. D., Sporn M. B., Roberts A. B. Osteoblasts synthesize and respond to transforming growth factor-type β (TGFβ) in vitro. J. Cell Biol. 1987; 105: 457–463
  • Rook A. M., Kehrl J. H., Wakefield L. M., Roberts A. B., Sporn M. B., Burlington D. B., Lane H. C., Fauci A. S. Effects of transforming growth factor-β on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J. Immunol. 1986; 136: 3916–3920
  • Rosen D. M., Stempien S. A., Thompson A. Y., Brennan J. E., Ellingsworth L. R., Seyedin S. M. Differentiation of rat mesenchymal cells by cartilage-inducing factor. Enhanced expression of dihydrocytochalasin B. Exp. Cell Res. 1986; 165: 127–138
  • Rossi P., Karsenty G., Roberts A. B., Roche N. S., Sporn M. B., de Crombrugghe B. A nuclear factor I binding site mediates the transcriptional activation of type I collagen promoter by transforming growth factor B. Cell 1988; 52: 405–414
  • Scatchard G. The attractions of proteins for small molecules and ions. Ann. NY Acad. Sci. 1949; 51: 660–672
  • Seyedin S. M., Segarini P. R., Rosen D. M., Thompson A. Y., Bentz H., Graycar J. Cartilage-inducing factor B is a unique protein structurally and functionally related to transforming growth factor β. J. Biol. Chem. 1987; 262: 1946–1949
  • Seyedin D. M., Thompson A. Y., Bentz H., Rosen D. M., McPherson J., Conti A., Siegel N. R., Galluppi G. R., Piez K. A. Cartilage inducing factor A. Apparent identity to transforming growth factor-β. J. Biol. Chem. 1986; 261: 5693–5695
  • Shipley G. D., Pittelkow M. R., Wille J. J., Scott R. E., Moses H. Reversible inhibition of normal human prokeratinocyte proliferation by type beta transforming growth factor-growth inhibitor in serum free medium. Cancer Res. 1986; 46: 2068–2071
  • Solberg L. A., Tucker R. F., Grant B. W., Mann K. G., Moses H. L. Transforming growth factor β inhibits colony formation from human megakaryocytic, erythroid and multipotent stem cells. The inhibitors of haemopoiesis, A. Najman, M. Guigon. Colloque INSERM/John Libby Eurotext. 1987; 111–121
  • Spooncer E., Heyworth C. M., Dunn A., Dexter T. M. Self-renewal and differentiation of interleukin 3 dependent multipotent stem cells are modulated by stromal cells and serum factors. Differentiation 1986; 31: 111–118
  • Sporn M. B., Roberts A. B. Peptide growth factors are multifunctional. Nature 1988; 332: 217–219
  • Sporn M. B., Roberts A. B., Wakefield L. M., Assoian R. K. TGF/J-biological function and chemical structure. Science 1986; 233: 532–534
  • Stanley E. R., Heard P. M. Factors regulating macrophage production and growth: purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. J. Biol. Chem. 1977; 252: 4305–4312
  • Till J. E., McCulloch E. A. A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat. Res. 1961; 14: 213–222
  • Varga J., Rosenbloom J., Jimenez S. A. Transforming growth factor β (TGFβ) causes a persistent increase in steady state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem. J. 1987; 247: 597–604
  • Visser J. W. M., Buman J. G. J., Mulder A. H. M., Eliason J. F., Leeuw A. M. Isolation of murine pluripotent haemopoietic stem cells. J. Exp. Med. 1984; 159: 1576–1590
  • Waheed A., Shadduck R. K. Purification and properties of L-cell derived colony stimulating factor. J. Lab. Clin. Med. 1979; 94: 180–194
  • Wahl S. M., Hunt D. A., Wakefield L. M., McCartney-Francis N., Wahl L. M., Roberts A. B., Sporn M. B. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc. Natl. Acad. Sci. USA 1987; 84: 5788–5792
  • Williams D. E., Straneva J. E., Shen R. N., Broxmeyer H. E. Purification of murine bone-marrow-derived granulocyte-macrophage colony-forming cells. Exp. Haematol. 1987; 15: 243–250
  • Yaeger A. M., Levin F. C., Levin J. Effects of cyclophosphamide on murine bone marrow and splenic megakaryocyte-CFC, granulocyte-macrophage-CFC and peripheral blood cell levels. J. Cell Physiol. 1982; 112: 222–228

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