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Original Article

Cloning and Overexpression of TGF-β1 cDNA in a Mammary Adenocarcinoma: In Vitro and In Vivo Effects

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Pages 305-316 | Received 11 Apr 1991, Accepted 13 Jun 1991, Published online: 11 Jul 2009

References

  • Antonelli‐Orlidge A., Saunders K. B., Smith S. R., D'Amore P. A. An activated form of transforming growth factor β is produced by cocultures of endothelial cells and pericytes. Proc. Natl. Acad. Sci. USA 1989; 86: 4544–4548
  • Anzano M. A., Roberts A. B., De Larco J. E., Wakefield L. M., Assoin R. K., Roche N. S., Smith J. M., Lazarus J. E., Sporn M. B. Increased secretion of type β transforming growth factor accompanies viral transformation of cells. Mol. Cell. Biol 1985; 5: 242–247
  • Arteaga C. L., Coffey R. J., Jr., Dugger T. C., McCutchen C. M., Moses H. L., Lyons R. M. Growth stimulation of human breast cancer cells with anti‐transforming growth factor β antibodies: evidence for negative autocrine regulation by transforming growth factor β. Cell Growth & Differentiation 1990; 1: 367–374
  • Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A., Struhl K. Current Protocols in Molecular Biology. Wiley and Sons, New York 1988
  • Aviv H., Leder P. Purification of biologically active globin messenger RNA by chromatography on oligo‐thymidylic acid cellulose. Proc. Natl. Acad. Sci. (USA) 1972; 69: 1408–2412
  • Barnard J. A., Lyons R. M., Moses H. L. The cell biology of transforming growth factor β. Bioch. Biophys. Accta 1990; 1032: 79–87
  • Brown P. D., Wakefield L. M., Levinson A. D., Sporn M. B. Physiochemical activation of recombinant latent transforming growth factor‐betas 1, 2, and 3. Growth Factors 1990; 3: 35–43
  • Brunner A. M., Gentry L. E., Cooper J. A., Purcho A. F. Recombinant type 1 transforming growth factor β precursor produced in Chinese hamster ovary cells is glycosylated and phosphorylated. Mol. Cell Biol 1988; 8: 2229–2232
  • Carlow D. A., Kerbel R. S., Feltis J. T., Elliott B. E. Enhanced expression of class 1 MHC (Dk) gene products on immunogenic variants of a spontaneous murine carcinoma. JNCI 1985; 75: 291–301
  • Chirgwin J. M., Przybyla A. E., MacDonald R. J., Rutter W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 18: 5294–5299
  • Cleveland D. W., Lopata M. A., MacDonald R. J., Cowan N. J., Rutter W. J., Kirschner M. W. Number and evolutionary conservation of alpha‐ and beta‐tubulin and cytoplasmic beta‐ and gamma‐actin genes using specific cloned cDNA probes. Cell 1980; 20: 95–105
  • Colletta A. A., Wakefield L. M., Howell F. V., Danielpour D., Baum M., Sporn M. B. The growth induction of human breast cancer cells by a novel synthetic progestin involves the induction of transforming growth factor beta. J. Clin. Invest 1991; 87: 277–283
  • DeLarco J. E., Todaro G. J. Growth factors from murine sarcoma virus‐transformed cells. Proc. Natl. Acad. Sci. (USA) 1978; 75: 4001–4005
  • Derynck R., Jarrett J. A., Chen E. Y., Eaton D. H., Bell J. R., Assoian R. K., Roberts A. B., Sporn M. B., Goeddel D. V. Human transforming growth factor‐β complementary DNA sequence and expression in normal and transformed cells. Nature 1985; 316: 701–705
  • Dickson R. B., Kasid A., Huff K. K., Bates S. E., Knabbe C., Bronzert D., Gelmann E. P., Lippman M. E. Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17β‐estradiol or V‐Ha‐ras onco‐gene. Proc. Natl. Acad. Sci. (USA) 1987; 84: 837–841
  • Gentry L. E., Lioubin M. N., Purchio A. F., Marquardt H. Molecular events in the processing of recombi‐nant type 1 pre‐pro‐transforming growth factor β to the mature polypeptide. Mol. Cell. Biol 1988; 8: 4162–4168
  • Gluzman Y. SV40‐transformed simian cell support the replication of early SV40 mutants. Cell 1981; 23: 175–182
  • Gorman C. M., Merlino G. T., Willingham M. C., Pastan I., Howard B. H. The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eucaryotic cells by DNA‐mediated transfection. Proc. Natl. Acad. Sci. (USA) 1982; 79: 6777–6781
  • Kerbel R. S. Growth dominance of the metastatic cancer cell: cellular and molecular aspects. Adv. Cancer Res 1990; 55: 87–132
  • Keski‐Oja J., Moses H. L. Growth inhibitory poly‐peptides in the regulation of cell proliferation. Med. Biol 1987; 65: 13–20
  • Kim S. J., Denhez F., Kim K. Y., Holt J. T., Sporn M. B., Roberts A. B. Activation of the second promoter of the transforming growth factor pl gene by transforming growth factor β1 and phorbol ester occurs through the same target sequences. J. Biol. Chem 1989a; 264: 19373–19378
  • Kim S. J., Jeang K. T., Glick A. B., Sporn M. B., Roberts A. B. Promoter sequences of the human transforming growth factor β1 gene responsive to transforming growth factor β1 autoinduction. J. Biol. Chem 1989b; 264: 7041–7045
  • Kim S. J., Glick A., Sporn M. B., Roberts A. B. Characterization of the promoter region of the human transforming growth factor β1 gene. J. Biol. Chem 1989c; 264: 402–408
  • Kimchi A., Wang X. ‐F., Weinberg R. A., Cheifetz S., Massague J. Absence of TGF‐β receptors and growth inhibitory responses in retinoblastoma cells. Science 1988; 240: 196–198
  • Knabbe C., Lippman M. E., Wakefield L. M., Flanders K. C., Kasid A., Derynck R., Dickson R. B. Evidence that transforming growth factor‐β is a hormonally regulated negative growth factor in human breast cancer cells. Cell 1987; 48: 417–428
  • Knabbe C., Zugmaier G., Dickson R. B., Lippman M. E. 3rd Proc. Int. Cong. Horm. Cancer. Hamburg 1988
  • Lawrence D. A., Pircher R., Jullien P. Conversion of a high molecular weight latent β‐TGF from chicken embryo fibroblasts into a low molecular weight active β‐TGF under acidic conditions. Biochem. Biophys. Res. Commun 1985; 133: 1026–1034
  • Lyons R. M., Keski‐Oja J., Moses H. L. Proteolytic activation of latent transforming growth factor‐β from fibroblast‐conditioned medium. J. Cell Biol 1988; 106: 1659–1665
  • Masui T., Wakefield L. M., Lechner J. F., LaVeck M. A., Sporn M. B., Harris C. C. Type β transforming growth factor is the primary differentiation‐inducing serum factor for normal human bronchial epithelial cells. Proc. Natl. Acad. Sci. (USA) 1986; 83: 2438–2442
  • Miyazono K., Hellman U., Wernstedt C., Heldin C. ‐H. Latent high molecular weight complex of transforming growth factor β1. J. Biol. Chem 1988; 263: 6407–6415
  • Moses H. L., Tucker R. F., Leof E. B., Coffey R. J., Jr., Halper J., Shipley G. D. Type‐β transforming growth factor is a growth stimulator and a growth inhibitor. Cancer Cells, J. Feramisco, B. Ozanne, C. Stiles. Cold Spring Harbor Laboratory, New York 1985; 65–71
  • Hoda K., Umeda M., Ono T. Transforming growth factor activity in human colostrum. Gann 1984; 75: 109–112
  • Nowell P. C. The clonal evolution of tumor cell populations. Science 1976; 194: 23–28
  • Pfarr D. S., Sathe G., Reff M. E. A highly modular cloning vector for the analysis of eucaryotic genes and gene regulatory elements. DNA 1985; 4: 461–467
  • Roberts A. B., Anzano M. A., Wakefield L. M., Roche N. S., Stern D. F., Sporn M. B. Type β transforming growth factor: a bifunctional regulation of cellular growth. Proc. Natl. Acad. Sci. (USA) 1985; 82: 119–123
  • Roberts A. B., Sporn M. B. Transforming growth factor‐β. Adv. Cancer Res 1988; 51: 107–145
  • Rosenthal A., Lindquist P. B., Bringman T. S., Goeddel D. V., Derynck R. Expression in rat fibroblasts of a human transforming growth factor‐α cDNA results in transformation. Cell 1986; 46: 301–309
  • Ruscetti C. CIBA Foundation Symposium 1991; 113: 212–231
  • Sanger F., Nicklen S., Coulson A. R. DNA sequencing with chain‐terminating inhibitors. Prac. Natl. Acad. Sci. (USA) 1977; 74: 5463–5467
  • Sato Y., Rifkin D. B. Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor‐β1‐like molecule by plasmin during co‐culture. J. Cell. Biol 1989; 109: 309–315
  • Schwarz L. C., Gingras M. ‐C., Goldberg G., Greenberg A. H., Wright J. A. Loss of growth factor dependence and conversion of transforming growth factor‐β inhibition to stimulation in metastatic H‐ras‐transformed murine fibroblasts. Cancer Res 1988; 48: 6999–7003
  • Schwarz L. C., Wright J. A., Gingras M. ‐C., Kondaiaif P., Danielpour D., Pimentel M., Sporn M. G., Greenberg A. H. Aberrant TGF‐β production and regulation in metastatic malignancy. Growth Factors 1990; 3: 115–127
  • Schor S. L., Schor A. M., Durning P., Rushton G. Skin fibroblasts obtained from cancer patients display fetal‐like behavior on collagen gels. J. Cell Science 1985; 73: 235–244
  • Sha X., Bruuner A. M., Purchio A. F., Gentry L. E. Transforming growth factor β1: importance of glycosylation and acidic proteases for processing and secretion. Mol. Endocrinol 1989; 3: 1090–1098
  • Silberstein G. B., Daniel C. W. Reversible inhibition of mammary gland growth by transforming growth factor‐beta. Science 1987; 237: 291–295
  • Simonsen C. C., Levinson A. D. Isolation and expression of an altered mouse dihydrofolate reductase cDNA. Proc. Natl. Acad. Sci. (USA) 1983; 80: 2495–2499
  • Southern P. J., Berg P. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under the control of the SV40 early region promoter. J. Mol. Appl. Gen 1982; 1: 327–341
  • Sporn M. B., Roberts A. B. Autocrine growth factors and cancer. Nature 1985; 303: 745–747
  • Stern D. F., Hare D. L., Cecchini M. A., Weinberg R. A. Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor. Science 1987; 235: 321–324
  • Theodorescu D., Fernandez B., Cornil I., Kerbel R. S. Overexpression of normal and mutated forms of c‐Ha‐ras induce orthotopic bladder invasion in a human superficial transitional cell carcinoma. Proc. Natl. Acad. Sci. (USA) 1990; 87: 9047–9051
  • Theodorescu D., Caltabiano M., Greig R., Rieman D., Waghorne C., Kerbel R. S. Reduction of TGF‐beta activity abrogates growth promoting tumor cell‐cell interactions in vivo. J. Cell Physiol 1991a, in press
  • Theodorescu D., Cornil I., Sheehan C., Man S., Kerbel R. S. Dominance of metastatically competent cells in primary murine breast neoplasms is necessary for distant metastatic spread. Int. J. Cancer 1991b; 47: 118–123
  • Tsuji T., Okada F., Yamaguchi K., Nakamura T. Molecular cloning of the large subunit of transforming growth factor type betas masking protein and expression of the mRNA in various rat tissues. Proc. Natl. Acad. Sci 1990; 87: 8835–8839
  • Valverius E. M., Walker‐Jones D., Bates S. E., Stampfer M. R., Clark R., McCormick F., Dickson R. B., Lippman M. E. Production of and responsiveness to transforming growth factor‐β in normal and oncogene‐transformed human mammary epithelial cells. Cancer Res 1989; 49: 19203–6274
  • Vonderhaar B. K. Breast Cancer: Cellular and Molecular Biology, M. E. Lippman, R. B. Dickson. Kluwer, Boston 1988; 251–266
  • Wakefield L. M., Smith D. M., Masui T., Harris C. C., Sporn M. B. Distribution and modulation of the cellular receptor for transforming growth factor‐beta. J. Cell Biol 1987; 105: 965–975
  • Wakefield L. M., Smith D. M., Broz S., Jackson M., Levison A. D., Sporn M. B. Recombinant TGF‐β1 is synthesized as a two component latent complex that shares some structural features with the native platelet latent TGF‐β1 complex. Growth Factors 1989; 263: 6407–6415
  • Walker‐Jones D., Valverius E. M., Stampfer M. S., Clarke R., McCormick F., Lippman M. E., Dickson R. B. Proc. Ann. Meet. Assoc. Cancer Res 1988; 249, (Abstract)
  • Wang J. L., Hsu Y. M. Isolation and characterization of a growth regulatory factor from 3T3 cells. Prog. Clin. Biol. Res 1986; 217A: 393–396
  • Wood W. I., Gitschier J., Lasky L. A., Lawn R. M. Base composition‐independent hybridization in tetro‐methylammonium chloride: A method for oligonucleotide screening of highly complex gene libraries. Proc. Natl. Acad. Sci. (USA) 1985; 82: 1585–1588

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