10
Views
6
CrossRef citations to date
0
Altmetric
Original Article

Differential Effects of PDGF Isoforrns on Proliferation of Normal Rat Kidney Cells

, , &
Pages 329-339 | Received 20 Jun 1993, Accepted 13 Aug 1993, Published online: 03 Aug 2009

References

  • Anderson M., Östman A., Backstrom G., Hellman U., George-Nascimento C., Westermark B., Heldin C. H. Assignment of interchain disulfide bonds in platelet-derived growth factor (PDGF) and evidence for agonist activity of monomeric PDGF. J. Biol. Chem. 1992; 267: 11260–11266
  • Baisch H., Gohde W., Linden W. A. Mathematical analysis of ICP-data to determine the fraction of cells in the various phases of the cell cycle. Pulse-Cytophotometry, C. A. M. Haanen, H. F. P. Hillen, J. M. C. Wessels. European Press, Ghent 1975; 68–76, part 1
  • Bishayee S., Majumdar S., Mire J., Das M. Ligand-induced dimerization of the platelet-derived growth factor receptor. Monomer-dimer interconversion occurs independent of receptor phosphorylation. J. Biol. Chem. 1989; 264: 11699–11705
  • Drozdoff V., Pledger W. J. Cellular response to platelet-derived growth factor (PDGF)-AB after down-regulation of PDGF a-receptors. Evidence that functional binding does not require a-receptors. J. Biol. Chem. 1991; 266: 17165–17172
  • Folkman J., Moscona A. Role of cell shape in growth control. Nature 1978; 273: 345–349
  • Gronwald R. G. K., Seifert R. A., Bowen-Pope D. F. Differential regulation of expression of two platelet-derived growth factor receptor subunits by transforming growth factor-β. J. Biol. Chem. 1989; 264: 8120–8125
  • Hammacher A., Hellman U., Johnsson A., Östman A., Gun-Narsson K., Westermark B., Wasteson A., Heldm C. H. A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain. J. Biol. Chem. 1988; 263: 16493–16498
  • Hammacher A., Mellstrom K., Heldin C. H., Westermark B. Isoform-specific induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J. 1989; 8: 2489–2495
  • Hart C. E., Bailey M., Curtis D. A., Osbom S., Raines E., Ross R., Forstrom J. W. Purification of PDGF-AB and PDGF-BB from human platelet extracts and identification of all three PDGF dimers in human platelets. Biochem. 1990; 29: 166–172
  • Heidaran M. A., Pierce J. H., Yu J. C., Lombardi D., Artrip J. E., Fleming T. P., Thomason A., Aaronson S. A. Role of α β receptor heterodimer formation in β platelet-derived growth factor (PDGF) receptor activation by PDGF-AB. J. Biol. Chem. 1991; 266: 20232–20237
  • Heldin C. H., Bäckström G., Östman A., Hammacher A., Ronnstrand L., Rubin K., Nister M., Westermark B. Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types. EMBO J. 1988; 7: 1387–1393
  • Heldin C. H., Emlund A., Rorsman C., Rönnstrand L. Dimerization of β-type platelet-derived growth factor receptors occurs after ligand binding and is closely associated with receptor kinase activation. J. Biol. Chem. 1989; 264: 8905–8912
  • Heldin C. H., Westermark B. Platelet-derived growth factor: mechanism of action and possible in vivo function. Cell Regul. 1990; 1: 555–566
  • Hoppe J., Weich H A, Eichner W., Tatje D. Preparation of biologically active platelet-derived growth factor isoforms AA and AB. Preferential formation of AB het-erodimers. Eur. J. Biochem. 1990; 187: 207–214
  • Labarca C., Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 1980; 102: 344–352
  • Matsui T., Pierce J. H., Fleming T. P., Greenberger J. S., La-Rochelle W. J., Ruggiero M., Aaronson S. A. Independent expression of human α or β platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathways. Proc. Natl Acad. Sci. USA 1989; 86: 8314–8318
  • Ostman A., Bäckstrdm G., Fong N., Betsholtz C., Wernstedt C., Hellman U., Westermark B., Valenzuela P., Heldin C. H. Expression of three recombinant homodimeric forms of PDGF in Saccharomyces cerevisiae: evidence for difference in receptor binding and functional activities. Growth Factors 1989; 1: 271–281
  • Raines E. W., Bowen-Pope D. F., Ross R. Platelet-derived growth factor. Handbook of Experimental Pharmacology. Peptide Growth Factors and their Receptors, M. B. Sporn, A. B. Roberts. Springer Verlag, Heidelberg 1991; volume 95: 176–262, part I
  • Sachinidis A., Locher R., Vetter W., Tatje D., Hoppe J. Different effects of platelet-derived growth factor isoforms on rat vascular smooth muscle cells. J. Biol. Chem. 1990; 265: 10238–10243
  • Scatchard G. The attraction of proteins for small molecules and ions. Ann. NY Acad. Sci. 1949; 51: 660–672
  • Seifert R. A., Hart C. E., Phillip P. E., Forstrom J. W., Ross R., Murray M. J., Bowen-Pope D. F. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J. Biol. Chem. 1989; 264: 8771–8778
  • Sorkin A., Westermark B., Heldin C. H., Claesson-Welsh L. Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF P-receptor. J. Cell Biol. 1991; 112: 469–478
  • Tiesman J., Rizzino A. Recent developments in the structure, function and regulation of platelet-derived growth factors and its receptors. Cytotechnology 1989; 2: 333–350
  • Van den Eijnden-Van Raaij A. J. M., Koomneef I., Van Oost-Waard T. M. J., Feijen A., Kruijer W., De Laat S. W., Van Zoelen E. J. J. Purification of a growth factor related to platelet-derived growth factor and a type β transforming growth factor secreted by mouse neuroblastoma cells. A general strategy for purification of basic polypeptide growth factors. Biochem. J. 1989; 257: 375–382
  • Van Erp P. E. J., Brons P. P. T., Boezeman J. B. M., De Jongh G. J., Bauer F. W. A rapid flow cytometric method for bivariate bromodeoxyuridine/DNA analysis using simultaneous proteolytic enzyme digestion and acid denaturation. Cytometry 1988; 9: 627–630
  • Van Zoelen E. J. J., Van Oostwaard T. M. J., Van der Saag P. T., De Laat S. W. Phenotypic transformation of normal rat kidney cells in a growth factor defined medium: Induction by a neuroblastoma-derived transforming growth factor independently of the EGF receptor. J. Cell. Physiol. 1985; 123: 151–160
  • Van Zoelen E. J. J., Van Oostwaard T. M. J., De Laat S. W. Transforming growth factor-β and retinoic acid modulate phenotypic transformation of normal rat kidney cells induced by epidermal growth factor and platelet-derived growth factor. J. Biol. Chem. 1986; 261: 5003–5009
  • Van Zoelen E. J. J., Van Oostwaard T. M. J., De Laat S. W. PDGF-like growth factor induces EGF-potentiated phenotypic transformation of normal rat kidney cells in the absence of TGF β. Biochem. Biophys. Res. Commun. 1986; 141: 1229–1235
  • Van Zoelen E. J. J., Van Oostwaard T. M. J., De Laat S. W. The role of polypeptide growth factors in phenotypic transformation of normal rat kidney cells. J. Biol. Chem. 1988; 263: 64–68
  • Van Zoelen E. J. J. Receptor-ligand interaction: a new method for determining binding parameters without a priori assumptions on non-specific binding. Biochem. J. 1989; 262: 549–556
  • Van Zoelen E. J. J. Phenotypic transformation of normal rat kidney cells: A model for studying cellular alterations in oncogenesis. CRC Reviews in Oncogenesis 1991; 2: 311–333
  • Van Zoelen E. J. J., Van Rotterdam W., Ward-Van Oostwaard T. M. J., Feijen A. Phenotypic transformation of normal rat kidney cells by transforming growth factor β is not paralleled by enhanced production of a platelet-derived growth factor. Eur. I. Biochem. 1992; 209: 89–94

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.