The Vascular Endothelial Growth Factor Family: Signalling for Vascular Development

References

• Achen M. G., Gad J. M., Stacker S. A., Wilks A. F. Placenta growth factor and vascular endothelial growth factor are co-expressed during early embryonic development. Growth Factors 1997; 15: 69–80
   PubMed Web of Science ®Google Scholar
• Achen M. G., Jeltsch M., Kukk E., Mäkinen T., Vitali A., Wilks A. F., Alitalo K., Stacker S. A. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk-1) and VEGF receptor 3 (Flt-4). Proc. Natl. Acad. Sci. USA 1998; 95: 548–553
   PubMed Web of Science ®Google Scholar
• Alon T., Hemo I., Itin A., Pe'er J., Stone J., Keshet E. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1995; 1: 1024–1028
   PubMed Web of Science ®Google Scholar
• Avantaggiato V., Orlandini M., Acampora D., Oliviero S., Simeone A. Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family. Mech. Dev. 1998; 73: 221–224
   PubMed Web of Science ®Google Scholar
• Benjamin L. E., Keshet E. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal. Proc. Natl. Acad. Sci. USA 1997; 94: 8761–8766
   PubMed Web of Science ®Google Scholar
• Breier G., Albrecht U., Sterrer S., Risau W. Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. Development 1992; 114: 521–532
   PubMed Web of Science ®Google Scholar
• Cao Y., Chen H., Zhou L., Chiang M., Anand-Apte B., Weatherbee J. A., Wang Y., Fang F., Flanagan J. G., Tsang M. L.-S. Heterodimers of placenta growth factor/vascular endothelial growth factor. Endothelial activity, tumor cell expression, and high affinity binding to Flk-1/KDR. J. Biol. Chem. 1996a; 271: 3154–3162
   PubMed Web of Science ®Google Scholar
• Cao Y., Linden P., Shima D., Browne F., Folkman J. In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J. Clin. Invest. 1996b; 98: 2507–2511
   PubMed Web of Science ®Google Scholar
• Cao Y., Ji W. R., Qi P., Rosin A., Cao Y. Y. Placenta growth factor: identification and characterization of a novel isoform generated by RNA alternative splicing. Biochem. Biophys. Res. Commun. 1997; 235: 493–498
   PubMed Web of Science ®Google Scholar
• Cao Y., Linden P., Farnebo J., Cao R., Eriksson A., Kumar V., Qi J. H., Claesson-Welsh L., Alitalo K. Vascular endothelial growth factor C., induces angiogenesi. in vivo. Proc. Natl. Acad. Sci. USA 1998; 95: 14389–14394
   PubMed Web of Science ®Google Scholar
• Carmeliet P., Ferreira V., Breier G., Pollofeyt S., Keickens L., Gertenstein M., Fahrig M., Vandenhoeck A., Harpal K., Eberhardt C., Declerq C., Pawling J., Moons L., Collen D., Risau W., Nagy A. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435–439
   PubMed Web of Science ®Google Scholar
• Damert A., Machein M., Breier G., Fujita M. Q., Hanahan D., Risau W., Plate K. H. Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms. Cancer Res. 1997; 57: 3860–3864
   PubMed Web of Science ®Google Scholar
• de Vries C., Escobedo J. A., Ueno H., Houck K., Ferrara N., Williams L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992; 255: 989–991
   PubMed Web of Science ®Google Scholar
• DiSalvo J., Bayne M. L., Conn G., Kwok P. W., Trivedi P. G., Soderman D. D., Palisi T. M., Sullivan K. A., Thomas K. A. Purification and characterization of a naturally occurring vascular endothelial growth factor placenta growth factor heterodimer. J. Biol. Chem. 1995; 270: 7717–7723
   PubMed Web of Science ®Google Scholar
• Dougher-Vermazen M., Hulmes J. D., Bohlen P., Terman B. I. Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGF-receptor. Biochem. Biophys. Res. Commun. 1994; 205: 728–738
   PubMed Web of Science ®Google Scholar
• Dumont D. J., Fong G. H., Puri M. C., Gradwohl G., Alitalo K., Breitman M. L. Vascularization of the mouse embryo: a study of flk-1, tek, tie, and vascular endothelial growth factor expression during development. Dev. Dyn. 1995; 203: 80–92
   PubMed Web of Science ®Google Scholar
• Dumont D. J., Jussila L., Taipale J., Lymboussaki A., Mustonen T., Pajusola K., Breitman M., Alitalo K. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 1998; 282: 946–949
   PubMed Web of Science ®Google Scholar
• Dvorak H. F., Orenstein N. S., Carvalho A. C., Churchill W. H., Dvorak A. M., Galli S. J., Feder J., Bitzer A. M., Rypysc J., Giovinco P. Induction of a fibrin-gel investment: an early event in line 10 hepatocarcinoma growth mediated by tumor-secreted products. J. Immunol. 1979; 122: 166–174
   PubMed Web of Science ®Google Scholar
• Feng D., Nagy J. A., Hipp J., Dvorak H. F., Dvorak A. M. Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine and serotonin. J. Exp. Med. 1996; 183: 1981–1986
   PubMed Web of Science ®Google Scholar
• Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L. O., Shea K. S., Powel-Braxton L., Hillan K. J., Moore M. W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380: 439–443
   PubMed Web of Science ®Google Scholar
• Fong G. H., Rossant J., Gertsenstein M., Breitman M. L. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376: 66–70
   PubMed Web of Science ®Google Scholar
• Gerber H. P., McMurtrey A., Kowalski J., Yan M., Keyt B. A., Dixit V., Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for the flk-1/kdr activation. J. Biol. Chem. 1998; 273: 30336–30343
   PubMed Web of Science ®Google Scholar
• Grimmond S., Lagercrantz J., Drinkwater C., Silins G., Townson S., Pollock P., Gotley D., Carson E., Rakar S., Nordenskjöld M., Ward L., Hayward N., Weber G. Cloning and characterization of a novel human gene related to vascular endothelial growth factor. Genome Res. 1996; 6: 124–131
   PubMed Web of Science ®Google Scholar
• Groves R. W., Wilson-Jones E., MacDonald D. M. Human orf and milkers' nodule: a clinicopathologic study. J. Am. Acad. Dermatol. 1991; 25: 706–711
   PubMed Web of Science ®Google Scholar
• Hauser S., Weich H. A heparin-binding form of placenta growth factor (PIGF-2) is expressed in human umbilical vein endothelial cells and in placenta. Growth Factors 1993; 9: 259–268
   PubMed Web of Science ®Google Scholar
• He Z., Tessier-Lavigne M. Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 1997; 90: 739–751
   PubMed Web of Science ®Google Scholar
• Hiratsuka S., Minowa O., Kuno J., Noda T., Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. USA 1998; 95: 9349–9354
   PubMed Web of Science ®Google Scholar
• Houck K. A., Ferrara N., Winer J., Cachianes G., Li B., Leung D. W. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol. Endocrinol. 1991; 5: 1806–1814
   PubMed Web of Science ®Google Scholar
• Houck K. A., Leung D. W., Rowland A. M., Winer J., Ferrara N. Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms. J. Biol. Chem. 1992; 267: 26031–26037
   PubMed Web of Science ®Google Scholar
• Ikeda E., Achen M. G., Breier G., Risau W. Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells. J. Biol. Chem. 1995; 270: 19761–19766
   PubMed Web of Science ®Google Scholar
• Jeltsch M., Kaipainen A., Joukov V., Meng X., Lakso M., Rauvala H., Swartz M., Fukumura D., Jain R. K., Alitalo K. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. Science 1997; 276: 1423–1425
   PubMed Web of Science ®Google Scholar
• Joukov V., Pajusola K., Kaipainen A., Chilov D., Lahtinen I., Kukk E., Saksela O., Kalkkinen N., Alitalo K. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt-4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 1996; 15: 290–298
   PubMed Web of Science ®Google Scholar
• Joukov V., Sorsa Kumar T. V., Jeltsch M., Claesson-Welsh L., Cao Y., Saksela O., Kalkkinen N., Alitalo K. Proteolytic processing regulates receptor specificity and activity of VEGF-C. EMBO J. 1997; 16: 3898–3911
   PubMed Web of Science ®Google Scholar
• Joukov V., Kumar V., Sorsa T., Arighi E., Weich H., Saksela O., Alitalo K. A recombinant mutant vascular endothelial growth factor-C that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities. J. Biol. Chem. 1998; 273: 6599–6602
   PubMed Web of Science ®Google Scholar
• Kaipainen A., Korhonen J., Mustonen T., van Hinsbergh V. W., Fang G. H., Dumont D., Breitman M., Alitalo K. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc. Natl. Acad. Sci. USA 1995; 92: 3566–3570
   PubMed Web of Science ®Google Scholar
• Keck P. J., Hauser S. D., Krivi G., Sanzo K., Warren T., Feder J., Connolly D. T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 1989; 246: 1309–1312
   PubMed Web of Science ®Google Scholar
• Kim K. J., Li B., Winer J., Armanini M., Gillett N., Phillips H. S., Ferrara N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growt. in vivo. Nature 1993; 362: 841–844
   PubMed Web of Science ®Google Scholar
• Kitsukawa T., Shimono A., Kawakami A., Kondoh H., Fujisawa H. Overexpression of a membrane protein, neuropilin, in chimeric mice causes anomalies in the cardiovascular system, nervous system and limbs. Development 1995; 121: 4309–4318
   PubMed Web of Science ®Google Scholar
• Kitsukawa T., Shimizu M., Sanbo M., Hirata T., Taniguchi M., Bekku Y., Yagi T., Fujisawa H. Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron 1997; 19: 995–1005
   PubMed Web of Science ®Google Scholar
• Kolodkin A. L., Levengood D. V., Rowe E. G., Tai Y.-T., Giger R. J., Ginty D. D. Neuropilin is a semaphorin III receptor. Cell 1997; 90: 753–762
   PubMed Web of Science ®Google Scholar
• Kroll J., Waltenberger J. The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. J. Biol. Chem. 1997; 272: 32521–32527
   PubMed Web of Science ®Google Scholar
• Kukk E., Lymboussaki A., Taira S., Kaipainen A., Jeltsch M., Joukov V., Alitalo K. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. Development 1996; 122: 3829–3837
   PubMed Web of Science ®Google Scholar
• Kurz H., Wilting J., Sandau K., Christ B. Automated evaluation of angiogenic effects mediated by VEGF and PIGF homo- and heterodimers. Microvasc. Res. 1998; 55: 92–102
   PubMed Web of Science ®Google Scholar
• Lee J., Gray A., Yuan J., Luoh S. M., Avraham H., Wood W. I. Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4. Proc. Natl. Acad. Sci. USA 1996; 93: 1988–1992
   PubMed Web of Science ®Google Scholar
• Leung D. W., Cachianes G., Kuang W. J., Goeddel D. V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 1989; 246: 1306–1309
   PubMed Web of Science ®Google Scholar
• Levy A. P., Levy N. S., Wegner S., Goldberg M. A. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J. Biol. Chem. 1995; 270: 13333–13340
   PubMed Web of Science ®Google Scholar
• Lymboussaki A., Partanen T. A., Olofsson B., Thomas-Crusells J., Fletcher C. D.M., de Waal R. M.W., Kaipainen A., Alitalo K. Expression of the vascular endothelial growth factor C receptor VEGFR-3 in lymphatic endothelium of the skin and in vascular tumors. Am. J. Pathol. 1998; 153: 395–403
   PubMed Web of Science ®Google Scholar
• Lyttle D. J., Fraser K. M., Fleming S. B., Mercer A. A., Robinson A. J. Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus. J. Virol. 1994; 68: 84–92
   PubMed Web of Science ®Google Scholar
• Maglione D., Guerriero V., Viglietto G., Delli Bovi P., Persico M. G. Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor. Proc. Natl. Acad. Sci. USA 1991; 88: 9267–9271
   PubMed Web of Science ®Google Scholar
• Maglione D., Guerriero V., Viglietto G., Ferraro M., Aprelikova A., Alitalo K., Del Vecchio S., Lei K., Chou J. Y., Persico M. G. Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PIGF), are transcribed from a single gene of chromosome 14. Oncogene 1993; 8: 925–931
   PubMed Web of Science ®Google Scholar
• McDonald N. Q., Hendrickson W. A. A structural superfamily of growth factors containing a cystine knot motif. Cell 1993; 73: 421–424
   PubMed Web of Science ®Google Scholar
• Migdal M., Huppertz B., Tessler S., Comforti A., Shibuya M., Reich R., Baumann H., Neufeld G. Neuropilin-1 is a placenta growth factor-2 receptor. J. Biol. Chem. 1998; 273: 22272–22278
   PubMed Web of Science ®Google Scholar
• Millauer B., WizigmannVoos S., Schnürch H., Martinez R., Moller N. P., Risau W., Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 1993; 72: 835–846
   PubMed Web of Science ®Google Scholar
• Millauer B., Shawver L. K., Plate K. H., Risau W., Ullrich A. Glioblastoma growth inhibited in vivo by a dominant negative Flk-1 mutant. Nature 1994; 367: 576–579
   PubMed Web of Science ®Google Scholar
• Millauer B., Longhi M. P., Plate K. H., Shawver L. K., Risau W., Ullrich A., Strawn L. M. Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor type. in vivo. Cancer Res. 1996; 56: 1615–1620
   PubMed Web of Science ®Google Scholar
• Muller Y. A., Christinger H. W., Keyt B. A., de Vos A. M. The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 Å resolution: multiple copy flexibility and receptor binding. Structure 1997a; 5: 1325–1338
   PubMed Web of Science ®Google Scholar
• Muller Y. A., Li B., Christinger H. W., Wells J. A., Cunningham B. C., de Vos A. M. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc. Natl. Acad. Sci. USA 1997b; 94: 7192–7197
   PubMed Web of Science ®Google Scholar
• Ogawa S., Oku A., Sawano A., Yamaguchi S., Yazaki Y., Shibuya M. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain. J. Biol. Chem. 1998; 273: 31273–31282
   PubMed Web of Science ®Google Scholar
• Oh S., Jeltsch M. M., Birkenhäger R., McCarthy J. E.G., Weich H. A., Christ B., Alitalo K., Wilting J. VEGF and VEGF-C: specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane. Dev. Biol. 1997; 188: 96–109
   PubMed Web of Science ®Google Scholar
• Olofsson B., Pajusola K., Kaipainen A., von Euler G., Joukov V., Saksela O., Orpana A., Pettersson R. F., Alitalo K., Eriksson U. Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc. Natl. Acad. Sci. USA 1996a; 93: 2576–2581
   PubMed Web of Science ®Google Scholar
• Olofsson B., Pajusola K., von Euler G., Chilov D., Alitalo K., Eriksson U. Genomic organization of the mouse and human genes for vascular endothelial growth factor B (VEGF-B) and characterization of a second splice isoform. J. Biol. Chem. 1996b; 271: 19310–19317
   PubMed Web of Science ®Google Scholar
• Olofsson B., Korpelainen E., Pepper M. S., Mandriota S. J., Aase K., Kumar V., Gunji Y., Jeltsch M. M., Shibuya M., Alitalo K., Eriksson U. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells. Proc. Natl. Acad. Sci. USA 1998; 95: 11709–11714
   PubMed Web of Science ®Google Scholar
• Orlandini M., Marconcini L., Ferruzzi R., Oliviero S. Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family. Proc. Natl. Acad. Sci. USA 1996; 93: 11675–11680
   PubMed Web of Science ®Google Scholar
• Pajusola K., Aprelikova O., Pelicci G., Weich H., Claesson-Welsh L., Alitalo K. Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors. Oncogene 1994; 9: 3545–3555
   PubMed Web of Science ®Google Scholar
• Park J. E., Chen H. H., Winer J., Houck K. A., Ferrara N. Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 1994; 269: 25646–25654
   PubMed Web of Science ®Google Scholar
• Peters K. G., DeVries C., Williams L. T. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc. Natl. Acad. Sci. USA 1993; 90: 8915–8919
   PubMed Web of Science ®Google Scholar
• Plate K. H., Breier G., Weich H. A., Risau W. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human glioma. in vivo. Nature 1992; 359: 845–848
   PubMed Web of Science ®Google Scholar
• Plate K. H., Breier G., Millauer A., Ullrich A., Risau W. Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumour angiogenesis. Cancer Res. 1993; 53: 5822–5827
   PubMed Web of Science ®Google Scholar
• Poltorak Z., Cohen T., Sivan R., Kandelis Y., Spira G., Vlodavsky I., Keshet E., Neufeld G. VEGF145 a secreted vascular endothelial growth factor isoform that binds to extracellular matrix. J. Biol. Chem. 1997; 272: 7151–7158
   PubMed Web of Science ®Google Scholar
• Quinn T. P., Peters KG., DeVries C., Ferrara N., Williams L. T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA 1993; 90: 7533–7537
   PubMed Web of Science ®Google Scholar
• Risau W. Mechanisms of angiogenesis. Nature 1997; 386: 671–674
   PubMed Web of Science ®Google Scholar
• Roberts W. G., Palade G. E. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res. 1997; 57: 765–772
   PubMed Web of Science ®Google Scholar
• Saleh M., Stacker S. A., Wilks A. F. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence. Cancer Res. 1996; 56: 393–401
   PubMed Web of Science ®Google Scholar
• Sawano A., Takahashi T., Yamaguchi S., Aonuma M., Shibuya M. Flt-1 but not KDR/Flk-1 tyrosine kinase is a receptor for placenta growth factor, which is related to vascular endothelial growth factor. Cell Growth and Differentiation 1996; 7: 213–221
   PubMedGoogle Scholar
• Seetharam L., Gotoh N., Maru Y., Neufeld G., Yamaguchi S., Shibuya M. A unique signal transduction from FLT tyrosine kinase, a receptor for vascular endothelial growth factor VEGF. Oncogene 1995; 10: 135–147
   PubMed Web of Science ®Google Scholar
• Semenza G. L. Transcriptional regulation by hypoxia-inducible factor 1 - molecular mechanisms of oxygen homeostasis. Trends Cardiovasc. Med. 1996; 6: 151–157
   PubMed Web of Science ®Google Scholar
• Senger D. R., Galli S. J., Dvorak A. M., Perruzzi C. A., Harvey V. S., Dvorak H. F. Tumour cells secrete a vascular permeability factor that promotes accumulation of ascities fluid. Science 1983; 219: 983–985
   PubMed Web of Science ®Google Scholar
• Shalaby F., Rossant J., Yamaguchi T. P., Gertsenstein M., Wu X. F., Breitman M. L., Schuh A. C. Failure of blood-island formation and vasculogenesis in flk-1 -deficient mice. Nature 1995; 376: 62–66
   PubMed Web of Science ®Google Scholar
• Shweiki D., Itin A., Soffer D., Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 1992; 359: 843–845
   PubMed Web of Science ®Google Scholar
• Soker S., Takashima S., Miao H. Q., Neufeld G., Klagsbrun M. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 1998; 92: 735–745
   PubMed Web of Science ®Google Scholar
• Stacker S. A., Stenvers K., Caesar C., Vitali A., Roufail S., Simpson R. J., Moritz R., Domagala T., Nice E., Alitalo K., Achen M. G. Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers. J. Biol. Chem. 1999a, submitted
   Web of Science ®Google Scholar
• Stacker S. A., Vitali A., Caesar C., Domagala T., Groenen L., Nice E., Achen M. G., Wilks A. F. A mutant form of vascular endothelial growth factor which lacks VEGFR-2 activation but retains the ability to induce vascular permeability (to be published). 1999b
   Google Scholar
• Takahashi T., Shibuya M. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene 1997; 14: 2079–2089
   PubMed Web of Science ®Google Scholar
• Takeshita S., Zheng L. P., Brogi E., Kearney M., Pu L. Q., Bunting S., Ferrara N., Symes J. F., Isner J. M. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 1994; 93: 662–670
   PubMed Web of Science ®Google Scholar
• Tischer E., Mitchell R., Hartman T., Silva M., Gospodarowicz D., Fiddes J. C., Abraham J. A. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J. Biol. Chem. 1991; 266: 11947–11954
   PubMed Web of Science ®Google Scholar
• Waltenberger J., Claesson-Welsh L., Siegbahn A., Shibuya M., Heldin C. H. Different signal transduction properties of KDR and Fltl, two receptors for vascular endothelial growth factor. J. Biol. Chem. 1994; 269: 26988–26995
   PubMed Web of Science ®Google Scholar
• Wise L. M., Veikkola T., Mercer A. A., Savory L. J., Fleming S. B., Caesar C., Vitali A., Makinen T., Alitalo K., Stacker S. A. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1. Proc. Natl. Acad. Sci. USA 1999; 96: 3071–3076
   PubMed Web of Science ®Google Scholar
• Witzenbichler B., Asahara T., Murohara T., Silver M., Spyridopoulos I., Magner M., Principe N., Kearney M., Hu J.-S., Isner J. M. Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia. Am. J. Pathol. 1998; 153: 381–394
   PubMed Web of Science ®Google Scholar
• Yamada Y., Nezu J., Shimane M., Hirata Y. Molecular cloning of a novel vascular endothelial growth factor, VEGF-. Genomics 1997; 42: 483–488
   PubMed Web of Science ®Google Scholar