32
Views
15
CrossRef citations to date
0
Altmetric
Review Article

Targeting of Drugs to Solid Tumors Using Anti-Her2 Immunoliposomes

, , , , , , & show all
Pages 425-442 | Published online: 28 Sep 2008

References

  • Papahadjopoulos D. 30-Year progress for liposomes: from serendipity to molecular design. J Liposome Res 1995; 5: ix–xiv
  • Lasic D. D., Papahadjopoulos D. Liposomes revisited. Science 1995; 267: 1275–1276
  • Leserman L., Machy P. Ligand targeting of liposomes. Liposomes: From Biophysics to Therapeutics, M. J. Ostro. Marcel Dekker, New York 1987; 157–194
  • Ranade V. V. Drug delivery systems: Site-specific drug delivery using liposomes as carriers. J Clin Pharmacol 1989; 29: 685–694
  • Straubinger R. M., Lopez N. G., Debs R. J., Hong K., Papahadjopoulos D. Liposome-based therapy of human ovarian cancer: parameters determining potency of negatively charged and antibody-targeted liposomes. Cancer Res 1988; 48: 5237–5245
  • Allen T. M., Chonn A. Large unilamellar liposomes with low uptake into the reticuloendothelial system. FEBS Lett 1987; 223: 42–46
  • Gabizon A., Papahadjopoulos D. Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors. Proc Natl Acad Sci USA 1988; 85: 6949–6953
  • Blume G., Cevc G. Liposomes for the sustained drug release in vivo. Biochim Biophys Acta 1990; 1029: 91–97
  • Klibanov A. L., Maruyama K., Torchilin V. P., Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990; 268: 235–237
  • Papahadjopoulos D., Allen T., Gabizon A., Mayhew E., Matthay K., Huang S. K., Lee K.-D., Woodle M. C., Lasic D. D., Redemann C., Martin F. J. Sterically stabilized liposomes: Improvements in pharmacokinetics and anti-tumor therapeutic efficacy. Proc Natl Acad Sci USA 1991; 88: 11460–11464
  • Torchilin V. P., Klibanov A. L., Huang L., O'Donnell S., Nossiff N. D., Khaw B. A. Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J 1992; 6: 2716–2719
  • Klibanov A. L., Maruyama K., Beckerleg A. M., Torchilin V. P., Huang L. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation lifetime of liposomes depends on the liposome size and is unfavorable for immunoli-posome binding to target. Biochim Biophys Acta 1991; 1062: 142–148
  • Torchilin V. P., Papisov M. I., Bogdanov A. A., Trubetskoy V. S., Omelyanenko V. G. Molecular mechanism of liposome and immunoliposome steric protection with poly(ethylene glycol). Stealth Liposomes, D. Lasic, F. Martin. CRC Press, Boca Raton, FL 1995; 51–62
  • Allen T. M., Brandeis E., Hansen C. B., Kao G. Y., Zalipsky S. A new strategy for attachment of antibodies to sterically stabilized liposomes resulting in efficient targeting to cancer cells. Biochim Biophys Acta 1995; 1237: 99–108
  • Hansen C. B., Kao G. Y., Moase E. H., Zalipsky S., Allen T. M. Attachment of antibodies to sterically stabilized liposomes: evaluation, comparison and optimization of coupling procedures. Biochim Biophys Acta 1995; 1239: 133–144
  • Zalipsky S., Hansen C. B., Lopes de Menezes D.E, Allen T. M. Long-circulating, polyethylene glycol-grafted immunoliposomes. J Controlled Release 1996; 39: 153–161
  • Kirpotin D., Park J. W., Hong K., Zalipsky S., Li W.-L., Carter P., Benz C. C., Papahadjopoulos D. Sterically stabilized anti-HER2 immunoliposomes: desin and targeting to human breast cancer cells in vitro. Biochemistry 1997; 36: 66–75
  • Park J. W., Hong K., Carter P., Asgari H., Guo L. Y., Wirth C., Shalaby R., Kotts C., Keller G. A., Wood W. I., Papahadjopoulos D, Benz C. C. Development of anti-p185HER2 immunoliposomes for cancer therapy. Proc Natl Acad Sci USA 1995; 92: 1327–1331
  • Park J. W., Hong K., Kirpotin D. B., Papahadjopoulos D., Benz C. C. Immunoliposomes for cancer treatment. Adv Pharmacol 1997; 40: 399–436
  • Park J. W., Hong K., Kirpotin D. B., Meyer O., Papahadjopoulos D., Benz C. C. Anti-HER2 immunoliposomes for targeted therapy of human tumors. Cancer Lett 1997; 118: 153–160
  • Park J. W., Colbern G., Hong K., Kirpotin D., Shao Y., Baselga J., Moore D., Papahadjopoulos D., Benz C. C. Targeted intracellular drug delivery via anti-HER2 immunoliposomes yields superior antitumor efficacy. Proc ASCO 1997; 16: 430a
  • Meyer O., Kirpotin D., Hong K., Sternberg B., Park J. W., Woodle M. C., Papahadjopoulos D. Poly(ethylene glycol)-coated cationic liposomes as carriers for cellular delivery of antisense oligonucleotides. J Biol Chem 1998; 283: 15261–15267
  • Hynes N. E., Stern D. F. The biology of erbB-2/neu/HER2 and its role in cancer. Biochim Biophys Acta 1994; 1198: 165–184
  • Carraway K. L., Cantley L. C. A neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling. Cell 1994; 78: 5–8
  • Slamon D. J., Clark G. M., Wong S. G., Levin W. J., Ullrich A., McGuire W. L. Human breast cancer: correlation of relapse and survival with amplification of HER2/neu oncogene. Science 1987; 235: 177–182
  • Slamon D. J., Godolphin W., Jones L. A., Holt J. A., Wong S. G., Keith D. E., Levin W. J., Stuart S. G., Udove J., Ullrich A., Press M. Studies of the HER2/neu proto-oncogene in human breast and ovarian cancer. Science 1989; 244: 707–712
  • Berchuck A., Kamel A., Whitaker R., Kerns B., Olt G., Kinney R., Soper J. T., Dodge R., Clarke-Pearson D. L., Marks P., McKenzie S., Yin S., Bast R. C. Overexpression of HER2/neu is associated with poor survival in advanced epithelial ovarian cancer. Cancer Res 1990; 50: 4087–4091
  • Berchuck A., Rodriguez G., Kinney R. B., Soper J. T., Dodge R. K., Clarke-Pearson D. L., Bast R. C. Overexpression of HER2/neu in endometrial cancer is associated with advanced stage disease. Am J Obstetrics Gynecol 1991; 164: 15–21
  • Kern J. A., Schwartz D. A., Nordberg J. E., Weiner D. B., Greene M. I., Torney L., Robinson R. A. p185neu expression in human lung adenocarcinomas predict shortened survival. Cancer Res 1990; 50: 5184–5191
  • Yokota J., Yamamoto T., Miyajima N., Toyoshima K., Nomura N., Sakamoto H., Yoshida T., Terada M., Sugimura T. Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of v-erbA homologue. Oncogene 1988; 2: 283–287
  • Park J. B., Rhim J. S., Park S. C., Kimm S. W., Kraus M. H. Amplification, overexpression and rearrangement of the erbB-2 proto-oncogene in primary human stomach carcinomas. Cancer Res 1989; 49: 6605–6609
  • Lei A., Appert H. E., Nakata B., Domenico D. R., Kim K., Howard J. M. Overexpression of HER2/neu oncogene in pancreatic cancer correlates with shortened survival. In. J Pancreatology 1995; 17: 15–21
  • Zhau H. E., Zhang X., Von Eschenbach A. C., Scorsone K., Babaian R. J., Ro J. Y., Hung M. C. Amplification and expression of the c-erbB-2/neu proto-oncogene in human bladder cancer. Molec Carcinogenesis 1990; 3: 254–257
  • Gu K., Mes-Masson A.-M., Gauthier J, Saad F. Overexpression of her-2/neu, in human prostate cancer and benign hyperplasia. Cancer Lett 1996; 99: 185–189
  • VandeVijver M. J., Peterse M. L., Mooi W. J., Wisman O., Lomans J., Dalesio O., Nusse R. Neu-protein expression in breast cancer. New Engl J Med 1988; 319: 1239–1245
  • Liu E., Thor A., He M., Barcos M., Ljung B. M., Benz C. C. The HER2 (c-erbB-2) oncogene is frequently amplified in in situ, carcinomas of the breast. Oncogene 1992; 7: 1027–1032
  • Lewis G. D., Figari I., Fendly B. M., Wong W.-L., Carter P., Gorman C., Shepard H. M. Differential responses of human tumor cell lines to anti-p185HER2 monoclonal antibodies. Cancer Immunol Immunother 1993; 37: 255–263
  • Press M. F., Cordon-Cardo C., Slamon D. J. Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene 1990; 5: 953–962
  • Niehans G. A., Singleton T. P., Dykoski D., Kiang D. T. Stability of HER-2/neu expression over time and at multiple metastatic sites. J Natl Cancer Inst 1993; 85: 1230–1235
  • Tagliabue E., Centis P., Campiglio M., Mastroiannini A., Martignone S, Pellegrini R., Casalani P., Lanzi C., Menard S., Colnaghi M. I. Selecion of monoclonal antibodies which induce internalization and phosphorylation of p185HER2 and growth inhibition of cells with HER2/neu gene amplification. Int J Cancer 1991; 47: 933–937
  • Sarup J. C., Johnson R. M., King K. L., Fendly B. M., Lipari M. T., Napier M. A., Ullrich A., Shepard H. M. Characterization of an anti-p185HER2 monoclonal antibody that stimulated receptor function and inhibits tumor cell growth. Growth Regulation 1991; 37: 72–82
  • Hurwitz E., Stancovski I., Sela M., Yarden Y. Suppression and promotion of tumor growth by monoclonal antibodies to ErbB-2 differentially correlate with cellular uptake. Proc Natl Acad Sci USA 1995; 92: 3553–3557
  • Fendly B. M., Winget M., Hudziak R. M., Lipari M. T., Napier M. A., Ullrich A. Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. Cancer Res 1990; 50: 1550–1558
  • Schier R., Marks J. D., Wolf E. J., Apell G., Wong C., McCartney J. E., Bookman M. A., Huston J. A., Houston L. L., Weiner L. M., Adams G. P. In vitro, and in vivo, characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology 1995; 1: 73–81
  • Schier R., McCal A., Adams G. P., Marshall K. W., Merritt H., Yim M., Craford R. S., Weiner L. M., Marks C., Marks J. D. Isolation of picomolar affinity anti-c-erbB-2 single chain Fv by molecular evolution of the complementary determining regions in the center of the antibody binding site. J Mol Biol 1996; 263: 551–567
  • Park J. W., Stagg R., Lewis G. D., Carter P., Maneval D., Slamon D. J., Jaffe H., Shepard H. M. Anti-p185HER2 monoclonal antibodies: biological properties and potential for immunotherapy. Genes, Oncogenes, and Hormones: Advances in Cellular and Molecular Biology of Breast Cancer, R. B. Dickson, M. E. Lippman. Kluwer, Boston, MA 1992; 193–211
  • Carter P., Presta L., Gorman C. M., Ridgway J. B.B., Henner D., Wong W. L.T., Rowland A. M., Kotts C., Carver M. E., Shepard H. M. Humanization of an anti-p185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992; 89: 4285–4289
  • Baselga J., Tripathy D., Mendelsohn J., Baughman S., Benz C. C., Dantis L., Sklarin N. T., Seidman A. D., Hudis C. A., Moore J., Rosen P. P., Twaddell T., Henderson I. C., Norton L. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neuoverexpressing metastatic breast cancer. J Clin Oncol. 1996; 14: 737–744
  • Papahadjopoulos D., Jacobson K., Nir S., Isac T. Phase transitions in phospholipid vesicles, fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. Biochim Biophys Acta 1973; 311: 330–348
  • Olson F., Hunt C. A., Szoka F. C., Vail W. J., Papahadjopoulos D. Preparation of liposomes of defined size distribution by extrusion through polycarbonate membranes. Biochim Biophys Acta 1979; 557: 9–23
  • Martin F., Papahadjopoulos D. Irreversible coupling of immunoglobulin fragments to preformed vesicles. An improved method for liposome targeting. J Biol Chem 1982; 257: 286–288
  • Shahinian S., Silvius J. R. A novel strategy affords high-yield coupling of antibody Fab′ fragments to liposomes. Biochim Biophys Acta 1995; 1239: 157–167
  • Loughrey H. C., Choi L. S., Cullis P. R., Bally M. B. Optimized procedures for the coupling of proteins to liposomes. J Immunol Methods 1990; 132: 25–35
  • Bredehorst R., Ligler F. S., Kusterbeck A. W., Chang E. L., Gaber B. P., Vogel C.-W. Effect of covalent attachment of immunoglobulin fragments on liposomal integrity. Biochemistry 1986; 25: 5693–5698
  • Hristova K., Needham D. Physical properties of polymer-grafted bilayers. Stealth Liposomes, D. Lasic, F. Martin. CRC Press, Boca Raton, FL 1995; 35–49
  • Mori A., Klibanov A. L., Torchilin V. P., Huang L. Influence of the steric barrier activity of amphipathic poly(ethylene glycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett 1991; 284: 263–266
  • Huang S. K., Mayhew E., Gilani S., Lasic D. D., Martin F. J., Papahadjopoulos D. Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma. Cancer Res 1992; 52: 6774–6781
  • Working P. W., Newman M., Huang S. K., Vaage J., Mayhew E., Lasic D. D. Pharmacokinetics, biodistribution and therapeutic efficacy of doxorubicin encapsulated in Stealth liposomes. J Liposome Res 1994; 4: 667–675
  • Bogner J. R., Goebel F.-D. Efficacy of Dox-SL (Stealth liposomal doxorubicin) in the treatment of advanced AIDS-related Kaposi's sarcoma. Stealth Liposomes, D. Lasic, F. Martin. CRC Press, Boca Raton, FL 1995; 267–278
  • Haran G., Cohen R., Bar L. K., Barenholz Y. Transmembrane ammonium sulfate gradients in liposomes produce efficient and stable entrapment of amphipathic weak bases. Biochim Biophys Acta 1993; 1149: 180–184
  • Daleke D. L., Hong K., Papahadjopoulos D. Endocytosis of liposomes by macrophages: binding, acidification, and leakage of liposomes monitored by a new fluorescence assay. Biochim Biophys Acta 1990; 1024: 352–366
  • Maruyama K., Takizawa T., Yuda T., Kennel S. J., Huang L., Iwatsuru M. Targetability of novel immunoliposomes modified with amphipathic poly(ethylene glycol)s conjugated at their distal terminals to monoclonal antibodies. Biochim Biophys Acta 1995; 1234: 74–80
  • Nezlin R. C. Structure and biosynthesis of antibodies. Consultants Bureau, New York, NY 1977; 174
  • Kenworthy A. K., Simon S. A., McIntosh T. J. Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol). Biophys J 1995; 68: 1903–1920
  • Lee K.-D., Nir S., Papahadjopoulos D. Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes. Biochemistry 1993; 32: 889–899
  • Goren D., Horowitz A. T., Zalipsky S., Woodle M. C., Yarden Y., Gabizon A. Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro, and in vivo, studies. Br J Cancer 1996; 74: 1749–1756
  • Suzuki S., Uno S., Fukuda Y., Aoki Y., Masuko T., Hashimoto Y. Cytotoxicity of anti-c-erbB-2 immunoliposomes containing doxorubicin on human cancer cells. Br J Cancer 1995; 72: 663–668
  • Gabizon A., Huberty J., Straubinger R., Price D. C., Papahadjopoulos D. An improved method for in vivo, tracing and imaging of liposomes using Gallium-67- deferoxamine complex. J Liposome Res 1988; 1: 123–135
  • Heitjan D. F. Generalized Norton-Simon models of tumor growth. Statistics in Medicine 1991; 10: 1075–1088
  • Kirpotin D B, Park J W, Hong K, Shao Y, Shalaby R, Colbern G, Benz C C, Papahadjopoulos D. Targeting of liposomes to solid tumors: The case of the sterically stabilized anti-HER2 immunoliposomes. Forum on Liposomes targeting in animal models. J Lipo Res 1997; 7(4)391–417
  • Kirpotin D. B., Park J. W., Hong K, Shao Y, Colbern G, Zheng W, Meyer O, Benz C C, Papahadjopoulos D. Targeting of Sterically Stabilized Liposomes to Cancers Overexpressing HER2/neu Proto-oncogene. Medical Applications of Liposomes, D Lasic, D Papahadjopoulos. Elsevier Publishers, AmsterdamThe Netherlands 1998
  • Matzku S., Krempel H., Weckenmann H.-P., Schirrmacher V., Sinn H., Stricker H. Tumour targeting with antibody-coupled liposomes: failure to achieve accumulation in xenografts and spontaneous liver metastases. Cancer Immunol Immunother 1990; 31: 285–291
  • Hong K., Friend D. S., Glabe C. G., Papahadjopoulos D. Liposomes containing colloidal gold are a useful probe of liposome-cell interactions. Biochim Biophys Acta 1983; 732: 320–323
  • Huang S. K., Lee K.-D., Hong K., Friend D. S., Papahadjopoulos D. Microscopic localization of sterically stabilized liposomes in colon-carcinoma bearing mice. Cancer Res 1992; 52: 5135–5143
  • Madden T. D., Harrigan P. R., Tai L. C., Bally M. B., Mayer L. D., Redelmeier T. E., Loughrey H. C., Tilcock C. P., Reinish L. W., Cullis P. R. The accumulation of drugs within large unilamellar vesicles exhibiting a proton gradient: a survey. Chem Phys Lipids 1990; 53: 37–46
  • Janknegt R. Liposomal formulations of cytotoxic drugs. Supportive Care Cancer 1996; 4: 298–304

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.