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Original Article

Nephropathy in Type 1 diabetes is associated with increased circulating activated platelets and platelet hyperreactivity

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Pages 513-519 | Received 08 Jun 2009, Accepted 30 Jul 2009, Published online: 26 Oct 2009

References

  • Consensus development conference on the diagnosis of coronary heart disease in people with diabetes: 10–11 February 1998, Miami, Florida. American Diabetes Association. Diabetes Care 1998;21:1551–1559
  • Astrup AS, Tarnow L, Rossing P, Pietraszek L, Riis HP, Parving HH. Improved prognosis in type 1 diabetic patients with nephropathy: A prospective follow-up study. Kidney Int 2005; 68: 1250–1257
  • Angiolillo DJ, Bernardo E, Sabate M, Jimenez-Quevedo P, Costa MA, Palazuelos J, Hernandez-Antolin R, Moreno R, Escaned J, Alfonso F, et al. Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol 2007; 50: 1541–1547
  • Tschoepe D. The activated megakaryocyte platelet-system in vascular-disease–focus on diabetes. Sem Thromb Hemost 1995; 21: 152–160
  • Tschoepe D, Roesen P, Schwippert B, Gries FA. Platelets in diabetes–the role in the hemostatic regulation in atherosclerosis. Sem Thromb Hemost 1993; 19: 122–128
  • Yngen M, Ostenson CG, Hu H, Li N, Hjemdahl P, Wallen NH. Enhanced P-selectin expression and increased soluble CD40 Ligand in patients with Type 1 diabetes mellitus and microangiopathy: Evidence for platelet hyperactivity and chronic inflammation. Diabetologia 2004; 47: 537–540
  • Tschoepe D, Ostermann H, Huebinger A, Ziegler D, Wiefels K, Gries FA. Elevated platelet activation in Type-I diabetics with chronic complications under long-term near-normoglycemic control. Haemostasis 1990; 20: 93–98
  • Tschoepe D, Rauch U, Schwippert B. Platelet-leukocyte-cross-talk in diabetes mellitus. Horm Metab Res 1997; 29: 631–635
  • Kaplar M, Kappelmayer J, Veszpremi A, Szabo K, Udvardy M. The possible association of in vivo leukocyte-platelet heterophilic aggregate formation and the development of diabetic angiopathy. Platelets 2001; 12: 419–422
  • Hu H, Li N, Yngen M, Ostenson CG, Wallen NH, Hjemdahl P. Enhanced leukocyte-platelet cross-talk in Type 1 diabetes mellitus: relationship to microangiopathy. J Thromb Haemost 2004; 2: 58–64
  • Odonnell MJ, Leguen CA, Lawson N, Gyde OHB, Barnett AH. Platelet behavior and hemostatic variables in Type-1 (insulin-dependent) diabetic-patients with and without albuminuria. Diabet Med 1991; 8: 624–628
  • Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H, Birjiniuk V, Ouimet H, Pasche B, Nelson MJ, et al. The platelet-function defect of cardiopulmonary bypass. Blood 1993; 82: 107–117
  • Gurbel PA, Becker RC, Mann KG, Steinhubl SR, Michelson AD. Platelet function monitoring in patients with coronary artery disease. J Am Coll Cardiol 2007; 50: 1822–1834
  • Michelson AD, Linden MD, Barnard MR, Furman MI, Frelinger III. Michelson ALFlow cytometry. A. D. Platelets, 2nd. Elsevier/Academic Press, San Diego 2007; 545–563
  • Rauch U, Schwippert B, Schultheiss HP, Tschoepe D. Platelet activation in diabetic microangiopathy. Platelets 1998; 9: 237–240
  • Li Y, Woo V, Bose R. Platelet hyperactivity and abnormal Ca2+ homeostasis in diabetes mellitus. Am J Physiol 2001; 280: H1480–H1489
  • Assert R, Scherk G, Bumbure A, Pirags V, Schatz H, Pfeiffer AFH. Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro. Diabetologia 2001; 44: 188–195
  • Baynes JW. Role of Oxidative stress in development of complications in diabetes. diabetes 1991; 40: 405–412
  • Jain SK, Krueger KS, Mcvie R, Jaramillo JJ, Palmer M, Smith T. Relationship of blood thromboxane-B-2 (TxB(2)) with lipid peroxides and effect of vitamin E and placebo supplementation on TxB(2) and lipid peroxide levels in Ttype 1 diabetic patients. Diabetes Care 1998; 21: 1511–1516
  • Rabini RA, Staffolani R, Fumelli P, Mutus B, Curatola G, Mazzanti L. Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients. Diabetologia 1998; 41: 101–104
  • Roshan B, Tofler GH, Weinrauch LA, Gleason RE, Keough JA, Lipinska I, Lee AT, D'Elia JA. Improved glycemic control and platelet function abnormalities in diabetic patients with microvascular disease. Metabolism 2000; 49: 88–91
  • Tschoepe D, Driesch E, Schwippert B, Nieuwenhuis HK, Gries FA. Exposure of adhesion molecules on activated platelets in patients with newly-diagnosed Iddm is not normalized by near-normoglycemia. Diabetes 1995; 44: 890–894
  • Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, Raskin P, Zinman B. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005; 353: 2643–2653

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