Advances in monitoring of aspirin therapy

References

• Patrono C, Andreotti F, Arnesen H, Badimon L, Baigent C, Collet JP, De Caterina R, Gulba D, Huber K, Husted S, et al. Antiplatelet agents for the treatment and prevention of atherothrombosis. Eur Heart J 2011; 32: 2922–2932
   PubMed Web of Science ®Google Scholar
• Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H, Caso P, Dudek D, Gielen S, Huber K, et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 2011; 32: 2999–3054
   PubMed Web of Science ®Google Scholar
• Smith SC, Jr, Benjamin EJ, Bonow RO, Braun LT, Creager MA, Franklin BA, Gibbons RJ, Grundy SM, Hiratzka LF, Jones DW, et al. AHA/ACCF secondary prevention and risk reduction therapy for patients with coronary and other atherosclerotic vascular disease: 2011 update: A guideline from the American Heart Association and American College of Cardiology Foundation. Circulation 2011; 124: 2458–2473
   PubMed Web of Science ®Google Scholar
• Wright RS, Anderson JL, Adams CD, Bridges CR, Casey DE, Jr, Ettinger SM, Fesmire FM, Ganiats TG, Jneid H, Lincoff AM, et al. 2011 ACCF/AHA focused update of the guidelines for the management of patients with unstable Angina/Non-ST-elevation myocardial infarction (Updating the 2007 guideline): A report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation 2011; 123: 2022–2060
   PubMed Web of Science ®Google Scholar
• Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, Meade T, et al. Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009; 373: 1849–1860
   PubMed Web of Science ®Google Scholar
• Fuster V, Sweeny JM. Aspirin: A historical and contemporary therapeutic overview. Circulation 2011; 123: 768–778
   PubMed Web of Science ®Google Scholar
• Jack DB. One hundred years of aspirin. Lancet 1997; 350: 437–439
   PubMed Web of Science ®Google Scholar
• The NHS, Information Centre. 2011. Prescriptions dispensed in the community: England, statistics for 2000 to 2010. Available from http://www.ic.nhs.uk/statistics-and-data-collections/primary-care/prescriptions/prescriptions-dispensed-in-the-community-england-statistics-for-2000-to-2010 (Accessed on 20 April 2012)
   Google Scholar
• Hernandez-Diaz S, Garcia Rodriguez LA. Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications. BMC Med 2006; 4: 22
   PubMed Web of Science ®Google Scholar
• Eikelboom JW, Hirsh J, Spencer FA, Baglin TP, Weitz JI. Antiplatelet drugs: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141: e89S–e119S
   PubMed Web of Science ®Google Scholar
• Awtry EH, Loscalzo J. Aspirin. Circulation 2000; 101: 1206–1218
   PubMed Web of Science ®Google Scholar
• Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971; 231: 232–235
   PubMedGoogle Scholar
• Roth GJ, Majerus PW. The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein. J Clin Invest 1975; 56: 624–632
   PubMed Web of Science ®Google Scholar
• Bjornsson TD, Schneider DE, Berger H, Jr. Aspirin acetylates fibrinogen and enhances fibrinolysis. Fibrinolytic effect is independent of changes in plasminogen activator levels. J Pharmacol Exp Ther 1989; 250: 154–161
   PubMed Web of Science ®Google Scholar
• Pinckard RN, Hawkins D, Farr RS. In vitro acetylation of plasma proteins, enzymes and DNA by aspirin. Nature 1968; 219: 68–69
   PubMed Web of Science ®Google Scholar
• Roth GJ, Stanford N, Majerus PW. Acetylation of prostaglandin synthase by aspirin. Proc Natl Acad Sci USA 1975; 72: 3073–3076
   PubMed Web of Science ®Google Scholar
• Patrignani P, Filabozzi P, Patrono C. Selective cumulative inhibition of platelet thromboxane production by low-dose aspirin in healthy subjects. J Clin Invest 1982; 69: 1366–1372
   PubMed Web of Science ®Google Scholar
• Laine L. Review article: Gastrointestinal bleeding with low-dose aspirin – what's the risk?. Aliment Pharmacol Ther 2006; 24: 897–908
   PubMed Web of Science ®Google Scholar
• Lanas A. Gastrointestinal bleeding associated with low-dose aspirin use: Relevance and management in clinical practice. Expert Opin Drug Saf 2011; 10: 45–54
   PubMed Web of Science ®Google Scholar
• Wallace JL. Prostaglandins, NSAIDs, and gastric mucosal protection: Why doesn’t the stomach digest itself?. Physiol Rev 2008; 88: 1547–1565
   PubMed Web of Science ®Google Scholar
• Bertrand OF, Larose E, Rodes-Cabau J, Gleeton O, Taillon I, Roy L, Poirier P, Costerousse O, Larochelliere RD. Incidence, predictors, and clinical impact of bleeding after transradial coronary stenting and maximal antiplatelet therapy. Am Heart J 2009; 157: 164–169
   PubMedGoogle Scholar
• Suh JW, Mehran R, Claessen BE, Xu K, Baber U, Dangas G, Parise H, Lansky AJ, Witzenbichler B, Grines CL, et al. Impact of in-hospital major bleeding on late clinical outcomes after primary percutaneous coronary intervention in acute myocardial infarction the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trial. J Am Coll Cardiol 2011; 58: 1750–1756
   PubMed Web of Science ®Google Scholar
• Wijns W, Kolh P, Danchin N, Di Mario C, Falk V, Folliguet T, Garg S, Huber K, James S, Knuuti J, et al. Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur Heart J 2010; 31: 2501–2555
   PubMed Web of Science ®Google Scholar
• Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, et al. 2011 ACCF/AHA/SCAI Guideline for percutaneous coronary intervention: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. Circulation 2011; 124: e574–e651
   PubMed Web of Science ®Google Scholar
• Michelson AD, Cattaneo M, Eikelboom JW, Gurbel P, Kottke-Marchant K, Kunicki TJ, Pulcinelli FM, Cerletti C, Rao AK, Committee of the International Society on Thrombosis, Platelet Physiology Subcommittee of the Scientific and Standardization, et al. Aspirin resistance: Position paper of the Working Group on Aspirin Resistance. J Thromb Haemost 2005; 3: 1309–1311
   PubMed Web of Science ®Google Scholar
• Feldman M, Cryer B. Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution. Am J Cardiol 1999; 84: 404–409
   PubMed Web of Science ®Google Scholar
• Benedek IH, Joshi AS, Pieniaszek HJ, King SY, Kornhauser DM. Variability in the pharmacokinetics and pharmacodynamics of low dose aspirin in healthy male volunteers. J Clin Pharmacol 1995; 35: 1181–1186
   PubMed Web of Science ®Google Scholar
• Patrono C, Coller B, FitzGerald GA, Hirsh J, Roth G. Platelet-active drugs: The relationships among dose, effectiveness, and side effects: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126: 234S–264S
   PubMed Web of Science ®Google Scholar
• Cox D, Maree AO, Dooley M, Conroy R, Byrne MF, Fitzgerald DJ. Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteers. Stroke 2006; 37: 2153–2158
   PubMed Web of Science ®Google Scholar
• Maree AO, Curtin RJ, Dooley M, Conroy RM, Crean P, Cox D, Fitzgerald DJ. Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease. J Am Coll Cardiol 2005; 46: 1258–1263
   PubMed Web of Science ®Google Scholar
• Vanags D, Rodgers SE, Lloyd JV, Bochner F. The antiplatelet effect of daily low dose enteric-coated aspirin in man: A time course of onset and recovery. Thromb Res 1990; 59: 995–1005
   PubMedGoogle Scholar
• Tang M, Mukundan M, Yang J, Charpentier N, LeCluyse EL, Black C, Yang D, Shi D, Yan B. Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol. J Pharmacol Exp Ther 2006; 319: 1467–1476
   PubMed Web of Science ®Google Scholar
• Pedersen AK, FitzGerald GA. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N Engl J Med 1984; 311: 1206–1211
   PubMed Web of Science ®Google Scholar
• Patrono C, Ciabattoni G, Patrignani P, Pugliese F, Filabozzi P, Catella F, Davì G, Forni L. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation 1985; 72: 1177–1184
   PubMed Web of Science ®Google Scholar
• Di Minno G, Silver MJ, Murphy S. Monitoring the entry of new platelets into the circulation after ingestion of aspirin. Blood 1983; 61: 1081–1085
   PubMed Web of Science ®Google Scholar
• Henry P, Vermillet A, Boval B, Guyetand C, Petroni T, Dillinger JG, Sideris G, Sollier CB, Drouet L. 24-hour time dependent aspirin efficacy in patients with stable coronary artery disease. Thromb Haemost 2010; 105: 336–344
   PubMedGoogle Scholar
• Lordkipanidze M, Pharand C, Schampaert E, Palisaitis DA, Diodati JG. Heterogeneity in platelet cyclooxygenase inhibition by aspirin in coronary artery disease. Int J Cardiol 2011; 150: 39–44
   PubMed Web of Science ®Google Scholar
• Pascale S, Petrucci G, Dragani A, Habib A, Zaccardi F, Pagliaccia F, Pocaterra D, Ragazzoni E, Rolandi G, Rocca B, et al. Aspirin-insensitive thromboxane biosynthesis in essential thrombocythemia is explained by accelerated renewal of the drug target. Blood 2012; 119: 3595–3603
   PubMed Web of Science ®Google Scholar
• Rocca B, Santilli F, Pitocco D, Mucci L, Petrucci G, Vitacolonna E, Lattanzio S, Mattoscio D, Zaccardi F, Liani R, et al. The recovery of platelet cyclooxygenase activity explains interindividual variability of responsiveness to low-dose aspirin in patients with and without diabetes. J Thromb Haemost 2012; 10: 1220–30
   PubMed Web of Science ®Google Scholar
• Frelinger AL, 3rd, Li Y, Linden MD, Barnard MR, Fox ML, Christie DJ, Furman MI, Michelson AD. Association of cyclooxygenase-1-dependent and -independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization. Circulation 2009; 120: 2586–2596
   PubMed Web of Science ®Google Scholar
• Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 2002; 105: 1650–1655
   PubMed Web of Science ®Google Scholar
• Eikelboom JW, Hankey GJ, Thom J, Bhatt DL, Steg PG, Montalescot G, Johnston SC, Steinhubl SR, Mak KH, Easton JD, et al. Incomplete inhibition of thromboxane biosynthesis by acetylsalicylic acid: Determinants and effect on cardiovascular risk. Circulation 2008; 118: 1705–1712
   PubMed Web of Science ®Google Scholar
• Breet NJ, van Werkum JW, Bouman HJ, Kelder JC, Ten Berg JM, Hackeng CM. High on-aspirin platelet reactivity as measured with aggregation based, COX-1 inhibition sensitive platelet function tests is associated with the occurrence of atherothrombotic events. J Thromb Haemost 2010; 8: 2140–2148
   PubMed Web of Science ®Google Scholar
• Crescente M, Di Castelnuovo A, Iacoviello L, de Gaetano G, Cerletti C. PFA-100 closure time to predict cardiovascular events in aspirin-treated cardiovascular patients: A meta-analysis of 19 studies comprising 3003 patients. Thromb Haemost 2008; 99: 1129–1131
   PubMedGoogle Scholar
• Cattaneo M. Aspirin and clopidogrel: Efficacy, safety, and the issue of drug resistance. Arterioscler Thromb Vasc Biol 2004; 24: 1980–1987
   PubMed Web of Science ®Google Scholar
• Nakahata N. Thromboxane A2: Physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther 2008; 118: 18–35
   PubMed Web of Science ®Google Scholar
• Patrono C, Ciabattoni G, Pinca E, Pugliese F, Castrucci G, De Salvo A, Satta MA, Peskar BA. Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. Thromb Res 1980; 17: 317–327
   PubMed Web of Science ®Google Scholar
• Patrono C, Ciabattoni G, Pugliese F, Pierucci A, Blair IA, FitzGerald GA. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest 1986; 77: 590–594
   PubMedGoogle Scholar
• Catella F, Healy D, Lawson JA, FitzGerald GA. 11-Dehydrothromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc Natl Acad Sci USA 1986; 83: 5861–5865
   PubMed Web of Science ®Google Scholar
• Li C, Hirsh J, Xie C, Johnston MA, Eikelboom JW. Reversal of the anti-platelet effects of aspirin and clopidogrel. J Thromb Haemost 2012; 10: 521–528
   PubMed Web of Science ®Google Scholar
• Santilli F, Rocca B, De CR, Lattanzio S, Pietrangelo L, Habib A, Pettinella C, Recchiuti A, Ferrante E, Ciabattoni G, et al. Platelet cyclooxygenase inhibition by low-dose aspirin is not reflected consistently by platelet function assays: Implications for aspirin “resistance”. J Am Coll Cardiol 2009; 53: 667–677
   PubMed Web of Science ®Google Scholar
• Harrison P, Frelinger AL, III, Furman MI, Michelson AD. Measuring antiplatelet drug effects in the laboratory. Thromb Res 2007; 120: 323–336
   PubMed Web of Science ®Google Scholar
• Michelson AD. Platelet function testing in cardiovascular diseases. Circulation 2004; 110: e489–e493
   PubMed Web of Science ®Google Scholar
• FitzGerald GA. Mechanisms of platelet activation: Thromboxane A2 as an amplifying signal for other agonists. Am J Cardiol 1991; 68: 11B–15B
   PubMed Web of Science ®Google Scholar
• Chan MV, Armstrong PC, Papalia F, Kirkby NS, Warner TD. Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Platelets 2011; 22: 485–494
   PubMed Web of Science ®Google Scholar
• Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG. A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 2007; 28: 1702–1708
   PubMed Web of Science ®Google Scholar
• Tantry US, Bliden KP, Gurbel PA. Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation. J Am Coll Cardiol 2005; 46: 1705–1709
   PubMed Web of Science ®Google Scholar
• Gurbel PA, Bliden KP, DiChiara J, Newcomer J, Weng W, Neerchal NK, Gesheff T, Chaganti SK, Etherington A, Tantry US. Evaluation of dose-related effects of aspirin on platelet function: Results from the Aspirin-Induced Platelet Effect (ASPECT) study. Circulation 2007; 115: 3156–3164
   PubMed Web of Science ®Google Scholar
• Faraday N, Yanek LR, Mathias R, Herrera-Galeano JE, Vaidya D, Moy TF, Fallin MD, Wilson AF, Bray PF, Becker LC, et al. Heritability of platelet responsiveness to aspirin in activation pathways directly and indirectly related to cyclooxygenase-1. Circulation 2007; 115: 2490–2496
   PubMed Web of Science ®Google Scholar
• Harrison P, Segal H, Blasbery K, Furtado C, Silver L, Rothwell PM. Screening for aspirin responsiveness after transient ischemic attack and stroke: Comparison of 2 point-of-care platelet function tests with optical aggregometry. Stroke 2005; 36: 1001–1005
   PubMed Web of Science ®Google Scholar
• Frelinger AL, 3rd, Furman MI, Linden MD, Li Y, Fox ML, Barnard MR, Michelson AD. Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent pathway: A 700-patient study of aspirin resistance. Circulation 2006; 113: 2888–2896
   PubMed Web of Science ®Google Scholar
• Snoep JD, Hovens MM, Eikenboom JC, van der Bom JG, Huisman MV. Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: A systematic review and meta-analysis. Arch Intern Med 2007; 167: 1593–1599
   PubMed Web of Science ®Google Scholar
• Krasopoulos G, Brister SJ, Beattie WS, Buchanan MR. Aspirin “resistance” and risk of cardiovascular morbidity: Systematic review and meta-analysis. BMJ 2008; 336: 195–198
   PubMed Web of Science ®Google Scholar
• Lordkipanidzé M, Pharand C, Palisaitis DA, Diodati JG. Aspirin resistance: Truth or dare. Pharmacol Ther 2006; 112: 733–743
   PubMed Web of Science ®Google Scholar
• Rocca B, Petrucci G. Variability in the responsiveness to low-dose aspirin: Pharmacological and disease-related mechanisms. Thrombosis 2012; 2012: 376721
   PubMedGoogle Scholar
• Yusuf S, Islam S, Chow CK, Rangarajan S, Dagenais G, Diaz R, Gupta R, Kelishadi R, Iqbal R, Avezum A, et al. Use of secondary prevention drugs for cardiovascular disease in the community in high-income, middle-income, and low-income countries (the PURE Study): A prospective epidemiological survey. Lancet 2011; 378: 1231–1243
   PubMed Web of Science ®Google Scholar
• Cotter G, Shemesh E, Zehavi M, Dinur I, Rudnick A, Milo O, Vered Z, Krakover R, Kaluski E, Kornberg A. Lack of aspirin effect: Aspirin resistance or resistance to taking aspirin?. Am Heart J 2004; 147: 293–300
   PubMed Web of Science ®Google Scholar
• Peace A, McCall M, Tedesco T, Kenny D, Conroy RM, Foley D, Cox D. The role of weight and enteric coating on aspirin response in cardiovascular patients. J Thromb Haemost 2010; 8: 2323–2325
   PubMed Web of Science ®Google Scholar
• Katona E, Kovacs EG, Bereczky Z, Balogh L, Homorodi N, Haramura G, Toth E, Csapo J, Edes I, Muszbek L, et al. Development of reference methods for evaluating the effect of aspirin and for comparison with routinely used methods; the lack of aspirin resistance in healthy volunteers. J Thromb Haemost 2011; 9: 15–16
   Web of Science ®Google Scholar
• Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Tournier B, Vyas SN, FitzGerald GA. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med 2001; 345: 1809–1817
   PubMed Web of Science ®Google Scholar
• Capone ML, Sciulli MG, Tacconelli S, Grana M, Ricciotti E, Renda G, Di Gregorio P, Merciaro G, Patrignani P. Pharmacodynamic interaction of naproxen with low-dose aspirin in healthy subjects. J Am Coll Cardiol 2005; 45: 1295–1301
   PubMed Web of Science ®Google Scholar
• Wilner KD, Rushing M, Walden C, Adler R, Eskra J, Noveck R, Vargas R. Celecoxib does not affect the antiplatelet activity of aspirin in healthy volunteers. J Clin Pharmacol 2002; 42: 1027–1030
   PubMed Web of Science ®Google Scholar
• van Ryn J, Kink-Eiband M, Kuritsch I, Feifel U, Hanft G, Wallenstein G, Trummlitz G, Pairet M. Meloxicam does not affect the antiplatelet effect of aspirin in healthy male and female volunteers. J Clin Pharmacol 2004; 44: 777–784
   PubMed Web of Science ®Google Scholar
• Rao GH, Johnson GG, Reddy KR, White JG. Ibuprofen protects platelet cyclooxygenase from irreversible inhibition by aspirin. Arteriosclerosis 1983; 3: 383–388
   PubMedGoogle Scholar
• Goodman T, Sharma P, Ferro A. The genetics of aspirin resistance. Int J Clin Pract 2007; 61: 826–834
   PubMed Web of Science ®Google Scholar
• Goodman T, Ferro A, Sharma P. Pharmacogenetics of aspirin resistance: A comprehensive systematic review. Br J Clin Pharmacol 2008; 66: 222–232
   PubMed Web of Science ®Google Scholar
• Anger K, Kempfert J, Kostelka M, Mohr FW, Dhein S. Platelet hyporesponsiveness to acetylsalicylic acid can be transferred by plasma in humans. Pharmacology 2010; 85: 241–247
   PubMedGoogle Scholar
• Adebayo GI, Williams J, Healy S. Aspirin esterase activity – Evidence for skewed distribution in healthy volunteers. Eur J Intern Med 2007; 18: 299–303
   PubMedGoogle Scholar
• Hubbard RE, O’Mahony MS, Calver BL, Woodhouse KW. Plasma esterases and inflammation in ageing and frailty. Eur J Clin Pharmacol 2008; 64: 895–900
   PubMed Web of Science ®Google Scholar
• Abou-Hatab K, O’Mahony MS, Patel S, Woodhouse K. Relationship between age and plasma esterases. Age Ageing 2001; 30: 41–45
   PubMed Web of Science ®Google Scholar
• Gum PA, Kottke-Marchant K, Poggio ED, Gurm H, Welsh PA, Brooks L, Sapp SK, Topol EJ. Profile and prevalence of aspirin resistance in patients with cardiovascular disease. Am J Cardiol 2001; 88: 230–235
   PubMed Web of Science ®Google Scholar
• Jedlitschky G, Greinacher A, Kroemer HK. Transporters in human platelets: Physiologic function and impact for pharmacotherapy. Blood 2012; 119: 3394–3402
   PubMed Web of Science ®Google Scholar
• Jedlitschky G, Tirschmann K, Lubenow LE, Nieuwenhuis HK, Akkerman JW, Greinacher A, Kroemer HK. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage. Blood 2004; 104: 3603–3610
   PubMed Web of Science ®Google Scholar
• Jedlitschky G, Cattaneo M, Lubenow LE, Rosskopf D, Lecchi A, Artoni A, Motta G, Niessen J, Kroemer HK, Greinacher A. Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: Evidence from patients with delta-storage pool deficiencies. Am J Pathol 2010; 176: 1097–1103
   PubMed Web of Science ®Google Scholar
• Russel FG, Koenderink JB, Masereeuw R. Multidrug resistance protein 4 (MRP4/ABCC4): A versatile efflux transporter for drugs and signalling molecules. Trends Pharmacol Sci 2008; 29: 200–207
   PubMed Web of Science ®Google Scholar
• Mattiello T, Guerriero R, Lotti LV, Trifiro E, Felli MP, Barbarulo A, Pucci B, Gazzaniga P, Gaudio C, Frati L, et al. Aspirin extrusion from human platelets through multidrug resistance protein-4-mediated transport: Evidence of a reduced drug action in patients after coronary artery bypass grafting. J Am Coll Cardiol 2011; 58: 752–761
   PubMed Web of Science ®Google Scholar
• Zimmermann N, Wenk A, Kim U, Kienzle P, Weber AA, Gams E, Schrör K, Hohlfeld T. Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery. Circulation 2003; 108: 542–547
   PubMed Web of Science ®Google Scholar
• Arazi HC, Doiny DG, Torcivia RS, Grancelli H, Waldman SV, Nojek C, Fornari MC, Badimon JJ. Impaired anti-platelet effect of aspirin, inflammation and platelet turnover in cardiac surgery. Interact Cardiovasc Thorac Surg 2010; 10: 863–867
   PubMed Web of Science ®Google Scholar
• Buchanan MR, Schwartz L, Bourassa M, Brister SJ, Peniston CM. Results of the BRAT study–a pilot study investigating the possible significance of ASA nonresponsiveness on the benefits and risks of ASA on thrombosis in patients undergoing coronary artery bypass surgery. Can J Cardiol 2000; 16: 1385–1390
   PubMed Web of Science ®Google Scholar
• Golanski J, Chlopicki S, Golanski R, Gresner P, Iwaszkiewicz A, Watala C. Resistance to aspirin in patients after coronary artery bypass grafting is transient: Impact on the monitoring of aspirin antiplatelet therapy. Ther Drug Monit 2005; 27: 484–490
   PubMed Web of Science ®Google Scholar
• Davi G, Vazzana N, Sestili S. Variability in the response to antiplatelet treatment in diabetes mellitus. Prostaglandins Other Lipid Mediat 2012 doi: 10.1016/j.prostaglandins.2012.01.008
   PubMedGoogle Scholar
• Grove EL, Gregersen S, Antiplatelet therapy in patients with diabetes mellitus. Curr Vasc Pharmacol 2012:10: 494–505
   Google Scholar
• El Haouari M, Rosado JA. Platelet signalling abnormalities in patients with type 2 diabetes mellitus: A review. Blood Cells Mol Dis 2008; 41: 119–123
   PubMed Web of Science ®Google Scholar
• Angiolillo DJ. Antiplatelet therapy in type 2 diabetes mellitus. Curr Opin Endocrinol Diabetes Obes 2007; 14: 124–131
   PubMedGoogle Scholar
• DiChiara J, Bliden KP, Tantry US, Hamed MS, Antonino MJ, Suarez TA, Bailon O, Singla A, Gurbel PA. The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: An analysis from the aspirin-induced platelet effect (ASPECT) study. Diabetes 2007; 56: 3014–3019
   PubMed Web of Science ®Google Scholar
• Watala C, Boncler M, Gresner P. Blood platelet abnormalities and pharmacological modulation of platelet reactivity in patients with diabetes mellitus. Pharmacol Rep 2005; 57: 42–58
   PubMed Web of Science ®Google Scholar
• Watala C, Golanski J, Pluta J, Boncler M, Rozalski M, Luzak B, Kropiwnicka A, Drzewoski J. Reduced sensitivity of platelets from type 2 diabetic patients to acetylsalicylic acid (aspirin) – its relation to metabolic control. Thromb Res 2004; 113: 101–113
   PubMed Web of Science ®Google Scholar
• Pulcinelli FM, Biasucci LM, Riondino S, Giubilato S, Leo A, Di Renzo L, Trifirò E, Mattiello T, Pitocco D, Liuzzo G, et al. COX-1 sensitivity and thromboxane A2 production in type 1 and type 2 diabetic patients under chronic aspirin treatment. Eur Heart J 2009; 30: 1279–1286
   PubMed Web of Science ®Google Scholar
• Watala C, Pluta J, Golanski J, Rozalski M, Czyz M, Trojanowski Z, Drzewoski J. Increased protein glycation in diabetes mellitus is associated with decreased aspirin-mediated protein acetylation and reduced sensitivity of blood platelets to aspirin. J Mol Med 2005; 83: 148–158
   PubMed Web of Science ®Google Scholar
• Kobzar G, Mardla V, Samel N. Short-term exposure of platelets to glucose impairs inhibition of platelet aggregation by cyclooxygenase inhibitors. Platelets 2011; 22: 338–344
   PubMed Web of Science ®Google Scholar
• Hovens MM, Snoep JD, Groeneveld Y, Tamsma JT, Eikenboom JC, Huisman MV. High levels of low-density lipoprotein cholesterol and triglycerides and suboptimal glycemic control predict diminished ex vivo aspirin responsiveness in patients with Type 2 diabetes. J Thromb Haemost 2007; 5: 1562–1564
   PubMed Web of Science ®Google Scholar
• Brown AS, Hong Y, de Belder A, Beacon H, Beeso J, Sherwood R, Edmonds M, Martin JF, Erusalimsky JD. Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis. Arterioscler Thromb Vasc Biol 1997; 17: 802–807
   PubMed Web of Science ®Google Scholar
• Mylotte D, Kavanagh GF, Peace AJ, Tedesco AF, Carmody D, O’Reilly M, Foley DP, Thompson CJ, Agha A, Smith D, et al. Platelet reactivity in type 2 diabetes mellitus: A comparative analysis with survivor of myocardial infarction and the role of glycaemic control. Platelets 2011 doi: 10.3109/09537104.2011.634932
   PubMedGoogle Scholar
• Santilli F, Davi G, Consoli A, Cipollone F, Mezzetti A, Falco A, Taraborelli T, Devangelio E, Ciabattoni G, Basili S, et al. Thromboxane-dependent CD40 ligand release in type 2 diabetes mellitus. J Am Coll Cardiol 2006; 47: 391–397
   PubMed Web of Science ®Google Scholar
• Capodanno D, Patel A, Dharmashankar K, Ferreiro JL, Ueno M, Kodali M, Tomasello SD, Capranzano P, Seecheran N, Darlington A, et al. Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery disease. Circ Cardiovasc Interv 2011; 4: 180–187
   PubMed Web of Science ®Google Scholar
• Spectre G, Arnetz L, Ostenson CG, Brismar K, Li N, Hjemdahl P. Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complications. Thromb Haemost 2011; 106: 491–499
   PubMed Web of Science ®Google Scholar
• Dillinger JG, Sideris G, Henry P, Bal dit Sollier C, Ronez E, Drouet L. Twice daily aspirin to improve biological aspirin efficacy in patients with essential thrombocytemia. Thromb Res 2012; 129: 91–94
   PubMed Web of Science ®Google Scholar
• Dragani A, Pascale S, Recchiuti A, Mattoscio D, Lattanzio S, Petrucci G, Mucci L, Ferrante E, Habib A, Ranelletti FO, et al. The contribution of cyclooxygenase −1 and −2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: Implications for antiplatelet therapy. Blood 2010; 115: 1054–1061
   PubMed Web of Science ®Google Scholar
• Perneby C, Wallen NH, Rooney C, Fitzgerald D, Hjemdahl P. Dose- and time-dependent antiplatelet effects of aspirin. Thromb Haemost 2006; 95: 652–658
   PubMed Web of Science ®Google Scholar
• Minno Di G. Aspirin resistance and platelet turnover: A 25-year old issue. Nutr Metab Cardiovasc Dis 2011; 21: 542–545
   PubMedGoogle Scholar
• Grove EL, Hvas AM, Mortensen SB, Larsen SB, Kristensen SD. Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease. J Thromb Haemost 2011; 9: 185–191
   PubMed Web of Science ®Google Scholar
• Neubauer H, Kaiser AF, Endres HG, Krüger JC, Engelhardt A, Lask S, Pepinghege F, Kusber A, Mügge A. Tailored antiplatelet threapy can overcome clopidogrel and aspirin resistance – the BOchum CLopidogrel and Aspirin Plan (BOCLA-Plan) to improve antiplatelet therapy. BMC Med 2011; 9: 3
   PubMed Web of Science ®Google Scholar
• Pettersen AA, Seljeflot I, Abdelnoor M, Arnesen H. Unstable angina, stroke, myocardial infarction and death in aspirin non-responders. A prospective, randomized trial. The ASCET (ASpirin non-responsiveness and Clopidogrel Endpoint Trial) design. Scand Cardiovasc J 2004; 38: 353–356
   PubMed Web of Science ®Google Scholar
• Nainggolan L, 2010. ASCET: Single antiplatelet therapies compared in stable CAD. Available from http://www.theheart.org/article/1157257.do (Accessed on 7 May 2012)
   Google Scholar
• Collet JP, Cayla G, Cuisset T, Elhadad S, Rangé G, Vicaut E, Montalescot G. Randomized comparison of platelet function monitoring to adjust antiplatelet therapy versus standard of care: Rationale and design of the assessment with a double randomization of (1) a fixed dose versus a monitoring-guided dose of aspirin and clopidogrel after DES implantation, and (2) treatment interruption versus continuation, 1 year after stenting (ARCTIC) study. Am Heart J 2011; 161: 5.e5–12.e5
   Google Scholar