Hinokitiol is a novel glycoprotein VI antagonist on human platelets

References

• Jackson SP, Nesbitt WS, Kulkarni S. Signaling events underlying thrombus formation. J Thromb Haemost 2003;1:1602–1612
   PubMed Web of Science ®Google Scholar
• Phillips DR, Nannizzi-Alaimo L, Prasad KS. Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling. Thromb Haemost 2001;86:246–258
   PubMedGoogle Scholar
• Clemetson KJ, Clemetson JM. Platelet collagen receptors. Thromb Haemost 2001;86:189–197
   PubMed Web of Science ®Google Scholar
• Schulz C, Leuschen NV, Frohlich T, Lorenz M, Pfeiler S, Gleissner CA, Kremmer E, Kessler M, Khandoga AG, Engelmann B, et al. Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: Implications for thrombus formation. Blood 2010;115:4102–4110
   PubMed Web of Science ®Google Scholar
• Inamori Y, Tsujibo H, Ohishi H, Ishii F, Mizugaki M, Aso H, Ishida N. Cytotoxic effect of hinokitiol and tropolone on the growth of mammalian cells and on blastogenesis of mouse splenic T cells. Biol Pharm Bull 1993;16:521–523
   PubMedGoogle Scholar
• Muto N, Dota A, Tanaka T, Itoh N, Okabe M, Inada A, Nakanishi T, Tanaka K. Hinokitiol induces differentiation of teratocarcinoma F9 cells. Biol Pharm Bull 1995;18:1576–1579
   PubMedGoogle Scholar
• Baba T, Nakano H, Tamai K, Sawamura D, Hanada K, Hashimoto I, Arima Y. Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. J Invest Dermatol 1998;110:24–28
   PubMed Web of Science ®Google Scholar
• Yamato M, Ando J, Sakaki K, Hashigaki K, Wataya Y, Tsukagoshi S, Tashiro T, Tsuruo T. Synthesis and antitumor activity of tropolone derivatives. 7. Bistropolones containing connecting methylene chains. J Med Chem 1992;35:267–273
   PubMedGoogle Scholar
• Liu S, Yamauchi H. Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. Biochem Biophys Res Commun 2006;351:26–32
   PubMed Web of Science ®Google Scholar
• Byeon SE, Lee YG, Kim JC, Han JG, Lee HY, Cho JY. Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB. Planta Med 2008;74:828–833
   PubMed Web of Science ®Google Scholar
• Lin KH, Kuo JR, Lu WJ, Chung CL, Chou DS, Huang SY, Lee HC, Sheu JR. Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. Biochem Pharmacol 2013;85:1478–1485
   PubMed Web of Science ®Google Scholar
• Sheu JR, Lee CR, Lin CH, Hsiao G, Ko WC, Chen YC, Yen MH. Mechanisms involved in the antiplatelet activity of Staphylococcus aureus lipoteichoic acid in human platelets. Thromb Haemost 2000;83:777–784
   PubMed Web of Science ®Google Scholar
• Hsu YF, Sheu JR, Lin CH, Yang DS, Hsiao G, Ou G, Chiu PT, Huang YH, Kuo WH, Hsu MJ. Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells. Biochim Biophys Acta 2012;1820:104–115
   PubMedGoogle Scholar
• Niedergang F, Alcover A, Knight CG, Farndale RW, Barnes MJ, Francischetti IM, Bon C, Leduc M. Convulxin binding to platelet receptor GPVI: Competition with collagen related peptides. Biochem Biophys Res Commun 2000;273:246–250
   PubMed Web of Science ®Google Scholar
• Huang TF, Liu CZ, Yang SH. Aggretin, a novel platelet-aggregation inducer from snake (Calloselasma rhodostoma) venom, activates phospholipase C by acting as a glycoprotein Ia/IIa agonist. Biochem J 1995;309:1021–1027
   PubMedGoogle Scholar
• Singer WD, Brown HA, Sternweis PC. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D. Annu Rev Biochem 1997;66:475–509
   PubMedGoogle Scholar
• Hughes PE, Renshaw MW, Pfaff M, Forsyth J, Keivens VM, Schwartz MA, Ginsberg MH. Suppression of integrin activation: A novel function of a Ras/Raf-initiated MAP kinase pathway. Cell 1997;88:521–530
   PubMed Web of Science ®Google Scholar
• Bugaud F, Nadal-Wollbold F, Levy-Toledano S, Rosa JP, Bryckaert M. Regulation of c-jun-NH2 terminal kinase and extracellular-signal regulated kinase in human platelets. Blood 1999;94:3800–3805
   PubMed Web of Science ®Google Scholar
• Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995;81:727–736
   PubMed Web of Science ®Google Scholar
• Stegner D, Nieswandt B. Platelet receptor signaling in thrombus formation. J Mol Med (Berl) 2011;89:109–121
   PubMed Web of Science ®Google Scholar
• Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, et al. Cloning, characterization, and functional studies of human and mouse glycoprotein VI: A platelet-specific collagen receptor from the immunoglobulin superfamily. Blood 2000;96:1798–1807
   PubMed Web of Science ®Google Scholar
• Moroi M, Jung SM. Platelet glycoprotein VI: Its structure and function. Thromb Res 2004;114:221–233
   PubMed Web of Science ®Google Scholar
• Chang CH, Chung CH, Kuo HL, Hsu CC, Huang TF. The highly specific platelet glycoprotein (GP) VI agonist trowaglerix impaired collagen-induced platelet aggregation ex vivo through matrix metalloproteinase-dependent GPVI shedding. J Thromb Haemost 2008;6:669–676
   PubMed Web of Science ®Google Scholar
• Ezumi Y, Shindoh K, Tsuji M, Takayama H. Physical and functional association of the Src family kinases Fyn and Lyn with the collagen receptor glycoprotein VI-Fc receptor gamma chain complex on human platelets. J Exp Med 1998;188:267–276
   PubMed Web of Science ®Google Scholar
• Suzuki-Inoue K, Tulasne D, Shen Y, Bori-Sanz T, Inoue O, Jung SM, Moroi M, Andrews RK, Berndt MC, Watson SP. Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling. J Biol Chem 2002;277:21561–21566
   PubMed Web of Science ®Google Scholar
• Chung CH, Wu WB, Huang TF. Aggretin, a snake venom-derived endothelial integrin alpha 2 beta 1 agonist, induces angiogenesis via expression of vascular endothelial growth factor. Blood 2004;103:2105–2113
   PubMedGoogle Scholar
• He L, Pappan LK, Grenache DG, Li Z, Tollefsen DM, Santoro SA, Zutter MM. The contributions of the alpha 2 beta 1 integrin to vascular thrombosis in vivo. Blood 2003;102:3652–3657
   PubMed Web of Science ®Google Scholar
• Nieswandt B, Watson SP. Platelet-collagen interaction: Is GPVI the central receptor? Blood 2003;102:449–461
   PubMed Web of Science ®Google Scholar
• Moroi M, Jung SM, Okuma M, Shinmyozu K. A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion. J Clin Invest 1989;84:1440–1445
   PubMed Web of Science ®Google Scholar
• Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhofer D, Heinzmann U, Nieswandt B. A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 2003;197:41–49
   PubMed Web of Science ®Google Scholar
• Stephens G, Yan Y, Jandrot-Perrus M, Villeval JL, Clemetson KJ, Phillips DR. Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen. Blood 2005;105:186–191
   PubMed Web of Science ®Google Scholar
• Ikeda U, Yamamoto K, Shimada K. Biochemical markers of coagulation activation in mitral stenosis, atrial fibrillation, and cardiomyopathy. Clin Cardiol 1997;20:7–10
   PubMedGoogle Scholar
• Yusuf S, Zhao F, Mehta SR, Chrolavicius S, Tognoni G, Fox KK. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. New Engl J Med 2001;345:494–502
   PubMed Web of Science ®Google Scholar