Strawberry extract presents antiplatelet activity by inhibition of inflammatory mediator of atherosclerosis (sP-selectin, sCD40L, RANTES, and IL-1β) and thrombus formation

References

• Gregg D, Goldschmidt-Clermont PJ. Cardiology patient page. Platelets and cardiovascular disease. Circulation 2003;108:e88–e90
   PubMed Web of Science ®Google Scholar
• Collins B, Hollidge C. Antithrombotic drug market. Nat Rev Drug Discov 2003;2:11–12
   PubMed Web of Science ®Google Scholar
• Palomo I, Toro C, Alarcon M. The role of platelets in the pathophysiology of atherosclerosis (Review). Mol Med Rep 2008;1:179–184
   PubMed Web of Science ®Google Scholar
• Harrington RA, Hodgson PK, Larsen RL. Cardiology patient page. Antiplatelet therapy. Circulation 2003;108:e45–e47
   Google Scholar
• Smart S, Aragola S, Hutton P. Antiplatelet agents and anaesthesia. Continuing Education in Anaesthesia, Critical Care & Pain 2007;7:157–161
   Google Scholar
• Barrett NE, Holbrook L, Jones S, Kaiser WJ. Future innovations in anti-platelet therapies. Br J Pharmacol 2008;154:918–939
   PubMed Web of Science ®Google Scholar
• Badimon L, Vilahur G. Coronary atherothrombotic disease: Progress in antiplatelet therapy. Rev Esp Cardiol 2008;61:501–513
   PubMed Web of Science ®Google Scholar
• Massaro M, Scoditti E, Carluccio MA, De Caterina R. Nutraceuticals and prevention of atherosclerosis: Focus on omega-3 polyunsaturated fatty acids and Mediterranean diet polyphenols. Cardiovasc Ther 2010;28:e13–e19
   PubMed Web of Science ®Google Scholar
• Willett WC. The Mediterranean diet: Science and practice. Public Health Nutr 2006;9:105–110
   PubMed Web of Science ®Google Scholar
• Estruch R, Martinez-Gonzalez MA, Corella D, Salas-Salvado J. Effects of a Mediterranean-style diet on cardiovascular risk factors: A randomized trial. Ann Intern Med 2006;145:1–11
   PubMed Web of Science ®Google Scholar
• Liu S, Manson JE, Lee IM, Cole SR. Fruit and vegetable intake and risk of cardiovascular disease: The Women's Health Study. Am J Clin Nutr 2000;72:922–928
   PubMed Web of Science ®Google Scholar
• Pierre S, Crosbie L, Duttaroy AK. Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro. Platelets 2005;16:469–473
   PubMed Web of Science ®Google Scholar
• Torres-Urrutia C, Guzman L, Schmeda-Hirschmann G, Moore-Carrasco R. Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables. Blood Coagul Fibrinolysis 2011;22:197–205
   PubMed Web of Science ®Google Scholar
• Sabha D, Hiyasat B, Grotzinger K, Hennig L. Allium ursinum L.: Bioassay-guided isolation and identification of a galactolipid and a phytosterol exerting antiaggregatory effects. Pharmacology 2012;89:260–269
   PubMedGoogle Scholar
• Hiyasat B, Sabha D, Grotzinger K, Kempfert J. Antiplatelet activity of Allium ursinum and Allium sativum. Pharmacology 2009;83:197–204
   PubMed Web of Science ®Google Scholar
• Panayiotou A, Samartzis D, Nomikos T, Fragopoulou E. Lipid fractions with aggregatory and antiaggregatory activity toward platelets in fresh and fried cod (Gadus morhua): Correlation with platelet-activating factor and atherogenesis. J Agric Food Chem 2000;48:6372–6379
   PubMedGoogle Scholar
• Zunino SJ, Parelman MA, Freytag TL, Stephensen CB. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr 2012;108:900–909
   PubMed Web of Science ®Google Scholar
• Sesso HD, Gaziano JM, Jenkins DJ, Buring JE. Strawberry intake, lipids, C-reactive protein, and the risk of cardiovascular disease in women. J Am Coll Nutr 2007;26:303–310
   PubMed Web of Science ®Google Scholar
• Burton-Freeman B, Linares A, Hyson D, Kappagoda T. Strawberry modulates LDL oxidation and postprandial lipemia in response to high-fat meal in overweight hyperlipidemic men and women. J Am Coll Nutr 2010;29:46–54
   PubMed Web of Science ®Google Scholar
• Fuentes E, Castro R, Astudillo L, Carrasco G. Bioassay-guided isolation and HPLC determination of bioactive compound that relate to the anti-platelet activity (adhesion, secretion and aggregation) from Solanum lycopersicum. Evid-Based Complement Alternat Med 2012;2012:1–10
   Google Scholar
• Harrison P, Mackie I, Mumford A, Briggs C. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol 2011;155:30–44
   PubMed Web of Science ®Google Scholar
• Born GV, Cross MJ. The aggregation of blood platelets. J Physiol 1963;168:178–195
   PubMed Web of Science ®Google Scholar
• Przyklenk K, Whittaker P. Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals. Lasers Med Sci 2007;22:42–45
   PubMedGoogle Scholar
• Naemura A, Mitani T, Ijiri Y, Tamura Y. Anti-thrombotic effect of strawberries. Blood Coagul Fibrinolysis 2005;16:501–509
   PubMed Web of Science ®Google Scholar
• Fuentes EJ, Astudillo LA, Gutierrez MI, Contreras SO. Fractions of aqueous and methanolic extracts from tomato (Solanum lycopersicum L.) present platelet antiaggregant activity. Blood Coagul Fibrinolysis 2012;23:109–117
   PubMed Web of Science ®Google Scholar
• Aukrust P, Muller F, Ueland T, Berget T. Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes. Circulation 1999;100:614–620
   PubMed Web of Science ®Google Scholar
• Nurden AT. Platelets, inflammation and tissue regeneration. Thromb Haemost 2011;105:S13–S33
   PubMed Web of Science ®Google Scholar
• Lievens D, Zernecke A, Seijkens T, Soehnlein O. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 2010;116:4317–4327
   PubMed Web of Science ®Google Scholar
• Koh SJ, Kim JY, Hyun YJ, Park SH. Association of serum RANTES concentrations with established cardiovascular risk markers in middle-aged subjects. Int J Cardiol 2009;132:102–108
   PubMedGoogle Scholar
• Hawrylowicz CM, Howells GL, Feldmann M. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med 1991;174:785–790
   PubMed Web of Science ®Google Scholar
• Ellis CL, Edirisinghe I, Kappagoda T, Burton-Freeman B. Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake. A randomized placebo-controlled trial. J Atheroscler Thromb 2011;18:318–327
   PubMed Web of Science ®Google Scholar
• Angiolillo DJ, Capodanno D, Goto S. Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J 2010;31:17–28
   PubMed Web of Science ®Google Scholar
• Schror K. Aspirin and platelets: The antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin Thromb Hemost 1997;23:349–356
   PubMed Web of Science ®Google Scholar
• Remijn JA, Wu YP, Jeninga EH, MJ IJ. Role of ADP receptor P2Y(12) in platelet adhesion and thrombus formation in flowing blood. Arterioscler Thromb Vasc Biol 2002;22:686–691
   PubMed Web of Science ®Google Scholar
• Penz SM, Reininger AJ, Toth O, Deckmyn H. Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. Thromb Haemost 2007;97:435–443
   PubMed Web of Science ®Google Scholar
• Fuentes E, Palomo I. Antiplatelet effects of natural bioactive compounds by multiple targets: Food and drug interactions. J Funct Foods 2014;6:73–81
   Google Scholar
• Fuentes E, Fuentes F, Palomo I. Mechanism of the anti-platelet effect of natural bioactive compounds: Role of peroxisome proliferator-activated receptors activation. 2013 Nov 18 [Epub ahead of print]
   Google Scholar
• Violi F, Pignatelli P, Basili S. Nutrition, supplements, and vitamins in platelet function and bleeding. Circulation 2010;121:1033–1044
   PubMedGoogle Scholar
• Naemura A, Ohira H, Ikeda M, Koshikawa K. An experimentally antithrombotic strawberry variety is also effective in humans. Pathophysiol Haemost Thromb 2006;35:398–404
   PubMedGoogle Scholar
• Raju NC, Eikelboom JW. The aspirin controversy in primary prevention. Curr Opin Cardiol 2012;27:499–507
   PubMed Web of Science ®Google Scholar
• Fuentes E, Pereira J, Alarcon M, Valenzuela C. Protective mechanisms of S. lycopersicum aqueous fraction (Nucleosides and Flavonoids) on platelet activation and thrombus formation: In vitro, ex vivo and in vivo studies. Evid Based Complement Alternat Med 2013;2013:1–13
   Google Scholar