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Case Report

Spontaneous heparin-induced thrombocytopenia syndrome without any proximate heparin exposure, infection, or inflammatory condition: Atypical clinical features with heparin-dependent platelet activating antibodies

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Pages 602-607 | Received 07 Aug 2014, Accepted 18 Oct 2014, Published online: 10 Nov 2014

References

  • Warkentin TE. HIT paradigms and paradoxes. J Thromb Haemost 2011;9 Suppl 1:105–117
  • Warkentin TE, Sheppard JA, Moore JC, Cook RJ, Kelton JG. Studies of the immune response in heparin-induced thrombocytopenia. Blood 2009;113:4963–4969
  • Warkentin TE, Kelton JG. Temporal aspects of heparin-induced thrombocytopenia. N Engl J Med 2001;344:1286–1292
  • Warkentin TE, Makris M, Jay RM, Kelton JG. A spontaneous prothrombotic disorder resembling heparin-induced thrombocytopenia. Am J Med 2008;121:632–636
  • Jay RM, Warkentin TE. Fatal heparin-induced thrombocytopenia (HIT) during warfarin thromboprophylaxis following orthopedic surgery: Another example of ‘spontaneous' HIT? J Thromb Haemost 2008;6:1598–1600
  • Pruthi RK, Daniels PR, Nambudiri GS, Warkentin TE. Heparin-induced thrombocytopenia (HIT) during postoperative warfarin thromboprophylaxis: A second example of postorthopedic surgery ‘spontaneous' HIT. J Thromb Haemost 2009;7:499–501
  • Mallik A, Carlson KB, DeSancho MT. A patient with ‘spontaneous' heparin-induced thrombocytopenia and thrombosis after undergoing knee replacement. Blood Coagul Fibrin 2011;22:73–75
  • Olah Z, Kerenyi A, Kappelmayer J, Schlammadinger A, Razso K, Boda Z. Rapid-onset heparin-induced thrombocytopenia without previous heparin exposure. Platelets 2012;23:495–498
  • Greinacher A. Me or not me? The danger of spontaneity. Blood 2014;123:3536–3538
  • Warkentin TE, Basciano PA, Knopman J, Bernstein RA. Spontaneous heparin-induced thrombocytopenia syndrome: Two new cases and a proposal for defining this disorder. Blood 2014;123:3651--3654
  • Perrin J, Barraud D, Toussaint-Hacquard M, Bollaert PE, Lecompte T. Rapid onset heparin-induced thrombocytopenia (HIT) without history of heparin exposure: A new case of so-called ‘spontaneous' HIT. Thromb Haemost 2012;107:795–797
  • Ketha S, Smithedajkul P, Vella A, Pruthi R, Wysokinski W, McBane R. Adrenal haemorrhage due to heparin-induced thrombocytopenia. Thromb Haemost 2013;109:669–675
  • Krauel K, Potschke C, Weber C, Kessler W, Furll B, Ittermann T, Maier S, Hammerschmidt S, Broker BM, Greinacher A. Platelet factor 4 binds to bacteria-inducing antibodies cross-reacting with the major antigen in heparin-induced thrombocytopenia. Blood 2011;117:1370–1378
  • Jaax ME, Krauel K, Marschall T, Brandt S, Gansler J, Furll B, Appel B, Fischer S, Block S, Helm CA, et al. Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4. Blood 2013;122:272–281
  • Maeda T, Noguchi T, Saito S, Yoshioka R, Horibe E, Miyanaga S, Seguchi S, Kanaumi Y, Kawai T, Okazaki H, Miyata S. Impact of heparin-induced thrombocytopenia on acute coronary artery thrombosis in patients undergoing PCI. Thromb Haemost 2014;112:624–626
  • Greinacher A, Gopinadhan M, Gunther JU, Omer-Adam MA, Strobel U, Warkentin TE, Papastavrou G, Weitschies W, Helm CA. Close approximation of two platelet factor 4 tetramers by charge neutralization forms the antigens recognized by HIT antibodies. Arterioscler Thromb Vasc Biol 2006;26:2386–2393
  • Hughes M, Hayward CP, Warkentin TE, Horsewood P, Chorneyko KA, Kelton JG. Morphological analysis of microparticle generation in heparin-induced thrombocytopenia. Blood 2000;96:188–194
  • Warkentin TE, Kelton JG. A 14-year study of heparin-induced thrombocytopenia. Am J Med 1996;101:502–507
  • Warkentin TE, Sheppard JA. Serological investigation of patients with a previous history of heparin-induced thrombocytopenia who are reexposed to heparin. Blood 2014;123:2485–2493
  • Greinacher A, Holtfreter B, Krauel K, Gatke D, Weber C, Ittermann T, Hammerschmidt S, Kocher T. Association of natural anti-platelet factor 4/heparin antibodies with periodontal disease. Blood 2011;118:1395–1401

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