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Review Article

The Platelet in Asthma

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Pages 293-303 | Published online: 07 Jul 2009

References

  • Copley A L. Roles of platelets in physiological defense mechanisms and pathological conditions. Folia Haematol 1979; 106: 732–764
  • Capron A, Joseph M, Ameisen J-C, Capron M, Pancre V, Auriault C. Platelets as effectors in immune and hypersensitivity reactions. Int Arch Allergy Appl Immunol 1987; 82: 307–312
  • Gresele P, Ribaldi E, Grasselli S, Todisco T, Nenci G G. Evidence for platelet activation in asthma. Platelets, platelet activating factor and asthma. Agents and actions supplement, M Schmitz-Schumann, G Menz, C P Page. Birkhauser Verlag, Basel 1987; 21: 119–128
  • Page C P. The involvement of platelets in non-thrombotic processes. Tren Pharmacol Sci 1988; 9: 66–71
  • Lowenhaupt R W. Human platelet chemotaxis can be induced by low molecular weight substance(s) derived from the interaction of plasma and collagen. Interaction of platelets and tumour cells, G A Jamieson, A R Scipio. Alan R Liss Inc, New York 1982; 269–279
  • Mustard J F, Packham M A. The reaction of the blood to injury. Inflammation, immunity and hypersensitivity, H Z Movat. Harper & Row, New York 1979; 61
  • Weksler B B. Platelets. Inflammation: Basic principles and clinical correlates, J I Gallin, I M Goldstein, R Snyderman. Raven Press Ltd, New York 1983
  • Majno G, Palade G E. Studies on inflammation I The effect of histamine and serotonin on vascular permeability: an electron microscope study. J Biophys Biochem Cytol 1961; 11: 571–605
  • Boucek R J, Alvarez T R. 5-Hydroxytryptamine: A cytospecific growth stimulator of cultured fibroblasts. Science 1970; 167: 898–899
  • Humphrey J H, Jacques R. The histamine and serotonin content of platelets and polymorphonuclear leukocytes of various species. J Physiol 1954; 124: 305–310
  • Knauer K A, Kagey-Sobotka A, Adkinson N F, Lichtenstein L M. Platelet augmentation of IgE-dependent histamine release from human basophils and mast cells. Int Arch Allergy Appl Immunol 1984; 74: 29–35
  • Orchard M A, Waddell K A, Lewis P J, Blair I A. Thromboxane synthase inhibition causes re-direction of prostaglandin endoperoxides to prostaglandin D2 during collagen stimulated aggregation of human platelet rich plasma. Thromb Res 1985; 39: 701–710
  • Metzger W J, Henriksen R A, Atkinson L B, Wirfel-Svet K L, Fisher R H. Bronchial challenge with platelet derived histamine releasing factor (PD-HRF) induces a pulmonary eosinophilic infiltrate. J Allergy Clin Immunol 1990; 85: 262A
  • Holgate S T, Church M K, Polosa R. Adenosine: a positive modulator of airway inflammation in asthma. Ann NY Acad Sci 1991; 629: 227–236
  • Mustafa S J, Ali S, Metzger W J. Adenosine induced bronchoconstriction in allergic rabbits: evidence for receptor involvement. Jap J Pharmacol 1991; 52: 113
  • Nachman R L, Weksler B, Ferris B. Characterization of human platelet vascular-permeability-enhancing activity. J Clin Invest 1972; 51: 549–556
  • Weksler B, Coupal C E. Platelet dependent generation of chemotactic activity in serum. J Exp Med 1973; 137: 1419–1430
  • Brindley L L, Sweet J M, Goetzl E J. Stimulation of histamine release from human basophils by human platelet factor 4. J Clin Invest 1983; 72: 1218–1223
  • Deuel T F, Senior R M, Chang D, Griffin G L, Heinrickson R L, Kaiser E T. Platelet factor 4 is chemotactic for neutrophils and monocytes. Proc Natl Acad Sci USA 1981; 78: 4584–4587
  • Chihara J, Fukuda K, Yasuba H. Platelet factor 4 enhances eosinophil IgG and IgEFc receptors and has eosinophil chemotactic activity. Am Rev Respir Dis 1988; 137: A421
  • Frigas E, Gleich G J. The eosinophil and the pathophysiology of asthma. J Allergy Clin Immunol 1986; 77: 527–537
  • Katz I R, Hoffman M K, Thorbecke G J. Lymphoma related immunosuppression in mice is abolished by factors in normal mouse serum. Fed Proc 1983; 42: 466
  • Katz I R, Hoffman M K, Zucker M B, Bell M K, Thorbecke G J. A platelet-derived immunoregulatory serum factor with Tcell affinity. J Immunol 1985; 134: 3199–3203
  • Katz I R, Thorbecke G J, Bell M K, Yin J Z, Clarke D, Zucker M B. Protease-induced immunoregulatory activity of platelet factor 4. Proc Natl Acad Sci USA 1986; 83: 3491–3495
  • Katz I R, Zucker M B, Thorbecke G J. Platelet factor 4 (PF4) and its C-terminal peptides reverse the suppressor effect of Con A-induced blast cells on antibody production in vitro. FASEB J 1989; 3: A1082
  • Zucker M B, Katz I R, Thorbecke G J, Milot D C, Holt J. Immunoregulatory activity of peptides related to platelet factor 4. Proc Natl Acad Sci USA 1989; 86: 7571–7574
  • Schall T J, Bacon K, Toy K J, Goeddel D V. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature 1990; 347: 669–671
  • Kameyoshi Y, Dorschner A, Mallet A I, Christophers E, Schroder J M. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J Exp Med 1992; 176: 587–592
  • Berk B C, Alexander R W, Brock T A, Gimbrone M A, Webb R C. Vasoconstriction: a new activity for platelet-derived growth factor. Science 1986; 232: 87–90
  • Deuel T F, Senior R M, Huang J-S, Griffin G L. Chemotaxis of monocytes and neutrophils to platelet derived growth factor. J Clin Invest 1982; 69: 1046–1049
  • Grotendorst G R, Seppa H E J, Kleinman H K. Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci USA 1981; 78: 3669–3672
  • Tzeng D Y, Deuel T F, Huang J S, Boehner R L. Platelet-derived growth factor promotes human peripheral monocyte activation. Blood 1985; 66: 179–183
  • Wahl S M, Hunt D A, Wakefield L M. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 1987; 63: 943–945
  • Ross R, Raines E W, Bowen-Poke D F. The biology of platelet derived growth factor. Cell 1986; 5: 169
  • Hirst S J, Barnes P J, Twort C H C. Quantifying proliferation of cultured human and rabbit airway smooth muscle cells in response to serum and platelet-derived growth factor. Am J Respir Cell Mol Biol 1992; 7: 574–581
  • Samuelsson B, Dahlen S-E, Lindgren J A. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 1987; 237: 1171–1176
  • Goetzl E J, Woods J M, Gorman R R. Stimulation of human eosinophil and neutrophil polymorphonuclear leukocyte chemotaxis and random migration by 12-L-hydroxy-5,8,10,14-eicosatetraenoic acid. J Clin Invest 1977; 59: 179–183
  • Marcus A J, Safier L B, Ullman H L. 12S,20Dihydroxyeicosatetraenoic acid: A new icosanoid synthesised by neutrophils from 12S-hydroxyeicosatetraenoic acid produced by thrombin- or collagen-stimulated platelets. Proc Natl Acad Sci USA 1984; 81: 903–907
  • Marcus A J, Saifer L B, Ullman H L, Broekman M J, von Schacky C. Studies on the mechanism of omega-hydroxylation of platelet 12-hydroxyeicosaenoic acid (12-HETE) by unstimulated neutrophils. J Clin Invest 1987; 79: 179–187
  • Marcus A J, Saner L B, Ullman H L. Platelet neutrophil interactions. J Biol Chem 1988; 263: 2223–2229
  • Maclouf J, Fruteau de Laclos B, Borgeat P. Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet derived 12-hydroperoxy-icosatetraenoicacid. Proc Natl Acad Sci USA 1982; 79: 6042–6046
  • Marcus A J, Broekman M J, Safier L B. Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun 1982; 109: 130–137
  • Ford-Hutchinson A W. Leukotriene B4 in inflammation. CRC Crit Rev Immunol 1990; 10: 1–12
  • Lin A H, Morton D R, Gorman R R. Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4. synthesis in human polymorphonuclear leukocytes. J Clin Invest 1982; 70: 1058–1065
  • Maclouf J A, Murphy R C. Transcellular metabolism of neutrophil-derived leukotriene A4 by human platelets. A potential source of leukotriene C4. J Biol Chem 1988; 263: 174–181
  • Piacentini G L, Kaliner M A. The potential roles of leukotrienes in bronchial asthma. Am Rev Respir Dis 1991; 143: S96–S99
  • Coeffier E, Chignard M, Delautier D, Benveniste J. Cooperation between platelets and neutrophils for Paf-acether formation. Fed Proc 1984; 43: 781
  • Cotran R S. The delayed and prolonged vascular leakage in inflammation. II. An electron microscopic study of the vascular response after thermal injury. Am J Pathol 1965; 46: 589–620
  • Kravis T, Henson P M. Accumulation of platelets at sites of antigen-antibody-mediated injury. J Immunol 1977; 118: 1569–1573
  • Kulka J P, Booking D, Ropes M W, Bauer W. Early joint lesions of rheumatoid arthritis. Arch Pathol 1955; 59: 129–150
  • Schumacher H R. Synovial membrane and fluid morphologic alterations in early rheumatoid arthritis: microvascular injury and virus-like particles. Ann N Y Acad Sci 1975; 256: 39–64
  • Braunstein P W, Cuenard H F, Joris I, Majno G. Platelets, fibroblasts and inflammation. Am J Pathol 1980; 99: 53–60
  • Day R P, Behrmann S, Dolovich J, Hargreave F E. Inflammatory effects of leukocytes and platelets. J Allergy Clin Immunol 1975; 55: 87
  • Tvedten H W, Till G O, Ward P A. Mediators of lung injury in mice following systemic activation of complement. Am J Pathol 1985; 119: 92–100
  • Ward P A, Till G O, Johnson K J. Role of platelets in neutrophil dependent, oxygen radical mediated damage of the microvasculature. Fed Proc 1986; 45: 380
  • Cines D B, van der Keyl H, Levinson A I. In vitro binding of an IgE protein to human platelets. J Immunol 1986; 136: 3433–3440
  • Joseph M, Capron A, Ameisen J-C. The receptor for IgE on blood platelets. Eur J Immunol 1986; 16: 306–312
  • Joseph M, Auriault C, Capron A, Vorng H, Viens P. A new function for platelets: IgE-dependent killing of schistosomes. Nature 1983; 303: 810–812
  • Capron M, Jouault T, Prin L. Functional study of a monoclonal antibody to IgE Fc receptor (FceR2) of eosinophils, platelets and macrophages. J Exp Med 1986; 164: 72–89
  • Maccia C A, Gallagher J S, Ataman G, Gluek H I, Brooks S M, Bernstein I L. Platelet thrombopathy in asthmatic patients with elevated immunoglobulin E. J Allergy Clin Immunol 1977; 59: 101–108
  • Haque A, Cuna W, Bonnel B, Capron A, Joseph M. Platelet mediated killing of larvae from different filarial species in the presence of Dipetalonema viteae stimulated IgE antibodies. Parasite Immunol 1985; 7: 517–526
  • Ameisen J-C, Capron A, Joseph M. Aspirin sensitive asthma: Abnormal platelet response to drugs inducing asthmatic attacks. Diagnostic and pathophysiological implications. Int Arch Allergy Appl Immunol 1985; 78: 438–448
  • Page C P. Platelets as inflammatory cells. Immunopharmacol 1989; 17: 51–59
  • Simpson R M, Prancan A, Izzi J M, Fiedel B A. Generation of thromboxane A2 and aorta-contracting activity from platelets stimulated with modified C-reactive protein. Immunology 1982; 47: 193–202
  • Bout D, Joseph M, Pontet M, Vorng H, Deslee D, Capron A. Rat resistance to schistomasiasis: Platelet-mediated cytotoxicity induced by C-reactive protein. Science 1986; 231: 153–156
  • Damonneville M, Monte D, Auriault C. The neuropeptide substance P stimulates the effector functions of platelets. Clin Exp Immunol 1990; 81: 346–351
  • Henson P M, Ginsberg M H. Immunological reactions of platelets. Platelets in biology and pathology 2, J L Gordon. Elsevier, Amsterdam 1981; 265–308
  • Rohrbach M S, Wheatley C L, Slifman N R, Gleich G J. Activation of platelets by eosinophil granule proteins. J Exp Med 1990; 172: 1271–1274
  • Pancre V, Joseph M, Capron A. Recombinant human interferon induced increased IgE receptor expression on human platelets. Eur J Immunol 1988; 18: 829–832
  • Damonneville M, Wietzerbin J, Pancre V. Recombinant tumor necrosis factors mediate platelet cytotoxicity to Schistosoma mansoni larvae. J Immunol 1988; 140: 3962–3965
  • Tsicopoulos A, Lasalle P, Joseph M, Tonnel T, Dessaint J P, Capron A. Effect of disodium cromogycate on inflammatory cells bearing the Fc epsilon receptor Type II (FcRH). Int J Immunopharmacol 1988; 10: 227–236
  • Thorel T, Joseph M, Tsicopoulos A, Tonnel A B, Capron A. Inhibition by nedocromil sodium of IgE mediated activation of human mononuclear phagocytes and platelets in allergy. Int Arch Allergy Appl Immunol 1988; 85: 232–237
  • Lewis A J, Dervinis A, Chang J. The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. Agents Actions 1984; 15: 636–642
  • Page C P. The role of platelet activating factor in asthma. J Allergy Clin Immunol 1988; 81: 144–152
  • Gresele P. The platelet in asthma. The platelet in health and disease, C P. Page. Blackwell Scientific Press, Oxford 1991; 132–157
  • Lellouch-Tubiana A, Lefort J, Simon M-T, Pfister A, Vargaftig B B. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Am Rev Respir Dis 1988; 137: 948–954
  • Coyle A J, Spina D, Page C P. PAF-induced bronchial hyperresponsiveness in the rabbit: contribution of platelets and airway smooth muscle. Br J Pharmacol 1990; 101: 31–38
  • Arnoux B, Joseph M, Simoes M H. Antigenic release of PAF-acether and beta-glucuronidase from alveolar macrophages of asthmatics. Bull Eur de Physiopathol Respir 1987; 23: 119–124
  • Lee T, Lenihan D J, Malone B, Roddy L L, Wasserman S I. Increased biosynthesis of platelet activating factor in activated human eosinophils. J Biol Chem 1984; 259: 5526–5530
  • Metzger W J, Sjoerdsma K, Richerson H B. Platelets in bronchoalveolar lavage from asthmatic patients and allergic rabbits with allergen-induced late phase responses. Agents Actions 1987; 21: 151–159
  • Beasley R, Roche W R, Roberts A, Holgate S T. Cellular events in the bronchi of asthmatics. Am Rev Respir Dis 1989; 139: 806–817
  • Benveniste J, Roubin R, Chignard M, Jouvin-Marche E. Release of platelet activating factor (PAF-acether) and 2-lyso-PAF-acether from three cell types. Agents Actions 1982; 12: 711–713
  • Jouvin-Marche E, Ninio E, Beurain G, Tence M, Niaudet P, Benveniste J. Biosynthesis of Paf-acether (platelet activating factor). Vii. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. J Immunol 1984; 133: 892–898
  • Chignard M, Le Couedic J P, Tence M. The role of platelet-activating factor in platelet aggregation. Nature 1979; 279: 799–800
  • Chignard M, Le Couedic J P, Delautier D, Benveniste J. Formation of PAF-acether and of another aggregatory phospholipid by human platelets. Fed Proc 1983; 42: 659
  • Touqui L, Hatmi M, Vargaftig B B. Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. Biochem J 1985; 229: 811–816
  • Camussi G, Bussolino F, Tetta Piacibello W, Aglietta M. Biosynthesis and release of platelet-activating factor from human monocytes. Int Arch Allergy Appl Immunol 1983; 70: 245–251
  • Camussi G, Aglietta M, Malavasi F. The release of platelet-activating factor from human endothelial cells in culture. J Immunol 1983; 131: 2397–2403
  • Fitzgerald M F, Moncada S, Parente L. The anaphylactic release of platelet activating factor from perfused guinea pig lung. Br J Pharmacol 1986; 88: 149–153
  • Heuer H O. Current status of PAF antagonists. Clin Exp Allergy 1992; 22: 980–983
  • Chung K F, Dent G, McCusker M, Guinot P H, Page C P, Barnes P J. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses in atopic subjects. Lancet 1987; 1: 248–250
  • Roberts N M, Page C P, Chung K F, Barnes P J. Effect of a PAF antagonist, BN 52063, on antigen-induced, acute, and late-onset cutaneous responses in atopic subjects. J Allergy Clin Immunol 1988; 82: 236–241
  • Roberts N M, McCusker M, Chung K F, Barnes P J. Effect of a PAF antagonist, BN 52063, on PAF-induced bronchoconstriction in normal subjects. Br J Clin Pharmacol 1988; 26: 65–72
  • Adamus W S, Heuer H O, Meade C J, Schilling J C. Inhibitory effects of the new PAF acether antagonist WEB 2086 on pharmacologic changes induced by PAF inhalation in human beings. Clin Pharmacol Ther 1990; 47: 456–462
  • O'Connor B J, Ridge S M, Chen-Wordseil Y M, Uden S, Barnes P J, Chung K F. Complete inhibition of airway and neutrophil responses to inhaled platelet activating factor (PAF) by an oral PAF antagonist UK-74,505. Am Rev Respir Dis 1991; 143: A156
  • Guinot P, Brambilla C, Duchier J, Braquet P, Bonvoison B. Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergen in asthmatic patients. A preliminary study. Prostaglandins 1987; 34: 723–731
  • Hsieh K. H. Effects of a PAF antagonist, BN 52021, on the PAF-, methacholine-, and allergen-induced bronchoconstriction in asthmatic children. Chest 1991; 99: 877–882
  • Kuitert L M, Hui K P, Uthayarkumar S. Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. Am Rev Respir Dis 1993; 147: 82–86
  • Freitag A, Watson R M, Matsos G, Eastwood C, O'Byrne P M. The effect of treatment with an oral platelet activating factor antagonist (WEB 2086) on allergen-induced asthmatic responses in human subjects. Am Rev Respir Dis 1991; 143: A157
  • Bel E H, De Smet M, Rossing T H, Timmers M C, Dijkman J H, Sterk P J. The effect of a specific oral PAF-antagonist, MK-287, on antigen-induced early and late asthmatic reactions in man. Am Rev Respir Dis 1991; 143: A811
  • Bratton D, Henson P M. Cellular origins of PAF. Platelet activating factor and human disease, P J Barnes, C P Page, P M Henson. Blackwell Scientific Publications, Oxford 1989; 23–57
  • Stewart A G, Phillips W A. Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages. Br J Pharmacol 1989; 98: 141–148
  • Lellouch-Tubiana A, Lefort J, Pirotzky E, Vargaftig B B, Pfister A. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet activating factor (PAF-acether) to guinea-pigs. Br J Exp Pathol 1985; 66: 345–355
  • McManus L M, Morley C A, Levine S P, Pinckard R N. Platelet activating factor (PAF) induced release of platelet factor 4 (PF4) in vitro during IgE anaphylaxis in the rabbit. J Immunol 1979; 123: 2835–2841
  • Vaage J, Hauge A. Small airway constriction and closure after induced intravascular platelet aggregation. Acta Physiol Scand 1977; 100: 221–230
  • Vargaftig B B, Lefort J, Chignard M, Benveniste J. Platelet activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. Eur J Pharmacol 1980; 65: 185–192
  • Vargaftig B B, Lefort J. Differential effects of prostacyclin and prostaglandin E1 on bronchoconstriction and thrombocytopaenia during collagen and arachidonate infusions and anaphylactic shock in the guinea pig. Prostaglandins 1979; 18: 519–528
  • Pinckard R N, Halonen M, Palmer J D, Butler C, Shaw J O, Henson P M. Intravascular aggregation and pulmonary sequestration of platelets during IgE-induced systemic anaphylaxis in the rabbit. Abrogation of lethal anaphylactic shock by platelet depletion. J Immunol 1977; 119: 2185–2193
  • Halonen M, Palmer J D, Lohman C, McManus L M, Pinckard R N. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. Am Rev Respir Dis 1981; 124: 416–421
  • Schellenberg R R, Walker B, Snyder F. Platelet-dependent contraction of human bronchus by platelet activating factor. J Allergy Clin Immunol 1983; 71: 145
  • Pretolani M, Page C P, Lefort J, Lagente V, Vargaftig B B. Pharmacological modulation of the respiratory and haematological changes accompanying active anaphylaxis in the guinea-pig. Eur J Pharmacol 1985; 125: 403–409
  • Page C P, Paul W, Morley J. Platelets and bronchospasm. Int Arch Allergy Appl Immunol 1984; 74: 347–351
  • Butler K D, Smith J R. Mechanisms of Forssman-induced bronchospasm and their inhibition. Br J Pharmacol 1981; 73: 25–32
  • Arnoux B, Denjean A, Page C P, Nolibe D, Morley J, Benveniste J. Accumulation of platelets and eosinophils in baboon lung after Paf-acether challenge. Am Rev Respir Dis 1988; 137: 855–860
  • Page C P, Tomiak R H H, Sanjar S, Morley J. Suppression of Paf-acether responses: an anti inflammatory effect of anti-asthma drugs. Agents Actions 1985; 16: 33–35
  • Morley J, Sanjar S, Page C P. The platelet in asthma. Lancet 1984; ii: 1142–1144
  • Chignard M, Wal F, Lefort J, Vargaftig B B. Inhibition by sulphinpyrazone of the platelet-dependent bronchoconstriction due to platelet activating factor (Paf-acether) in the guinea pig. Eur J Pharmacol 1982; 78: 71–79
  • Vargaftig B B, Lefort J, Wal F, Chignard M, Medeiros M. Non-steroidal antiinflammatory drugs if combined with antihistamine and antiserotonin agents interfere with the bronchial and platelet effects of'platelet activating factor' (PAF-acether). Eur J Pharmacol 1982; 82: 121–130
  • Chung K F, Aizawa H, Leikauf G D, Ueki I F, Evans T W, Nadel J A. Airway hyperresponsiveness induced by platelet activating factor: role of thromboxane generation. J Pharmacol Exp Ther 1986; 236: 580–548
  • Cockcroft D W, Killian D N, Mellon J J A, Hargreave F E. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy 1977; 7: 235–243
  • Coyle A J, Page C P, Atkinson L, Flanagan R, Metzger W J. The requirement for platelets in allergen-induced late asthmatic airway obstruction. Am Rev Respir Dis 1990; 142: 587–593
  • Barnes P J, Chung K F, Page C P. Inflammatory mediators and asthma. Pharmacol Rev 1988; 40: 49–84
  • Mazzoni L, Morley J, Page C P, Sanjar S. Induction of airway hyperreactivity by platelet activating factor in the guinea-pig. J Physiol 1985; 365: 107P
  • Robertson D N, Page C P. Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. Br J Pharmacol 1987; 92: 105–111
  • Smith D, Sanjar S, Morley J. Platelet activation and PAF-induced airway hyperreactivity in the anaesthetised guinea-pig. Br J Pharmacol 1989; 96: 74P
  • Sanjar S, Smith D, Kristersson A. Incubation of platelets with PAF produces a factor which causes airway hyperreactivity in guinea-pigs. Br J Pharmacol 1989; 96: 75P
  • Morley J, Chapman I D, Sanjar S, Schaeublin E. Actions of ketotifen on PAF-induced airway hyperreactivity in the anesthetised guinea-pig. Br J Pharmacol 1989; 96: 76P
  • Fisher R H, Henriksen R A, Wirfel-Svet K L, Atkinson L B, Metzger W J. Bronchial challenge with platelet-derived histamine releasing factor (PD-HRF) supernatant induces prolonged changes in dynamic compliance (Cdyn) and hyperreactivity in the allergic asthmatic rabbit model. J Allergy Clin Immunol 1990; 85: 261
  • Elouaer-Blanc L, Zafrani E S, Farcet J P, Saint-Marc Girardin M F, Mathieu D, Dhumeaux D. Hepatic vein obstruction in idiopathic hypereosinophilic syndrome. Arch Int Med 1985; 145: 751–753
  • Coyle A J, Page C P, Atkinson L, Sjoerdsma K, Touvay C, Metzger W J. Modification of allergen-induced airway obstruction and airway hyperresponsiveness in an allergic rabbit model by the selective platelet-activating factor antagonist, BN 52021. J Allergy Clin Immunol 1989; 84: 960–967
  • Coyle A J, Urwin S C, Page C P, Touvay C, Villain B, Braquet P. The effect of the selective PAF antagonist BN 52021 on PAF and antigen-induced bronchial hyperreactivity and eosinophil accumulation. Eur J Pharmacol 1988; 148: 51–58
  • Metzger W J, Henriksen R A, Zaleski T, Donnelly A. Evidence for platelet release and thrombin generation in early and late asthmatic responses. Clin Res 1983; 31: 164A
  • Sasaki T, Shimura S, Ikeda K, Sasaki H, Takishima T. Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. Am J Physiol 1989; 257: L373–378
  • Storck H, Hoigne R, Koller F. Thrombocytes in allergic reactions. Int Arch Allergy 1955; 6: 372–384
  • Knauer K A, Lichtenstein L M, Adkinson N F, Jnr, Fish J E. Platelet activation during antigen-induced airway reactions in asthmatic subjects. N Engl J Med 1981; 304: 1404–1406
  • Gresele P, Todisco T, Merante F, Nenci G G. Platelet activation and allergic asthma. N Engl J Med 1982; 306: 549
  • Traietti P, Marmaggi S, Dardes N, Moscatelli B, Bologna E, Vulterini S. Circulating platelet activation in respiratory diseases: Differences between arterial and venous blood in cold and asthmatic patients. Respiration 1984; 46: 62–63
  • Wasserman S I, Ginsberg M H. Release of platelet factor 4 into the blood after cold challenge of patients with cold urticaria. J Allergy Clin Immunol 1984; 74: 275–279
  • Johnson C E, Belfield P W, Davis S, Cooke N J, Spencer A, Davies J A. Platelet activation during excercise-induced asthma. Effect of prophylaxis with salbutamol. Thorax 1986; 42: 290–294
  • Szczeklik A, Milner P C, Birch J, Watkins J, Martin J F. Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Thromb Haemost 1986; 56: 283–287
  • Taytard A, Guenard H, Vuillemin L. Platelet kinetics in stable atopic asthmatic patients. Am Rev Respir Dis 1986; 134: 983–985
  • Martin J F, Slater D N, Trowbridge E A. Platelet production in the lungs. PAF, platelets and asthma, agents and actions supplements, M Schmitz-Schumann, G Menz, C P Page. Birkhauser Verlag, Basel 1987; 21: 37–57
  • Taytard A, Vuillemin L, Guenarg H, Rio P, Vergeret J, Ducassou D. Platelet kinetics in stable asthma patients: effect of ketotifen. Am Rev Respir Dis 1987; 135: 388A
  • Yamamoto H, Nagata M, Tabe K. The evidence of platelet activation in bronchial asthma. J Allergy Clin Immunol 1993; 91: 79–87
  • Rao A K, Walsh P N. Aquired qualitative platelet disorders. Clin Haematol 1983; 12: 201–238
  • Henson P M, Pinckard R N. Basophil-derived platelet-activating factor (PAF) as an in vivo mediator of acute allergic reactions: demonstration of specific desensitization of platelets to PAF during IgE-induced anaphylaxis in the rabbit. J Immunol 1977; 119: 2179–2184
  • Fishel C W, Zwemer R J. Aggregation of platelets from B. pertussis-injected mice and atopically sensitive human individuals. Fed Proc 1970; 29: 640
  • Solinger A, Bernstein I L, Glueck H I. The effect of epinephrine on platelet aggregation in normal and atopic subjects. J Allergy Clin Immunol 1973; 51: 29–34
  • Thompson J M, Hanson H, Bilani M, Turner-Warwick M, Morley J. Platelets, platelet activating factor and asthma. Am Rev Respir Dis 1984; 129: A3
  • D'Souza L, Glueck H I. Measurement of nucleotide pools in platelets using high pressure liquid chromatography. Thromb Haemost 1977; 38: 990–1001
  • Harker L A, Malpass T W, Branson H E, Hessel E A, Slichter S J. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: aquired transient platelet dysfunction associated with selective alpha granule release. Blood 1980; 56: 824–834
  • Pareti F I, Capitanio A, Mannucci L, Ponticelli C, Mannucci P M. Aquired dysfunction due to the circulation of ‘exhausted’ platelets. Am J Med 1980; 69: 235–240
  • Malmgren R, Grubbstrom J, Olsson P, Theorell H, Tornling G, Unge G. Defective serotonin (5-HT) transport mechanism in platelets from patients with endogenous and allergic asthma. Allergy 1982; 37: 29–39
  • Bakulin M P, Joffe E J. Content of biologically active substances, histamine and serotonin in patients with bronchial asthma. Terapevticheskii Arkhiv 1979; 51: 45–49
  • Block L H, Imhof E, Emmons L R, Roth M, Perruchoud A P. PAF-dependent phosphatidylinositol turnover in platelets: Differences between asthmatics and normal individuals. Respiration 1990; 57: 373–378
  • Toga H, Ohya N, Kitagawa S. Clinical studies on plasma platelet factor 4 in patients with bronchial asthma. Jap J Allergy 1984; 33: 474–479
  • Gresele P, Grasselli S, Todisco T, Merante F, Nenci G G. Platelets and asthma. Lancet 1985; 1: 347
  • Morrison J F J, Pearson S B, Dean H G, Craig I R, Bramley P N. Platelet activation in nocturnal asthma. Thorax 1991; 46: 197–200
  • Gresele P, Dottorini M, Selli M L. Altered platelet function associated with the bronchial hyperresponsiveness accompanying nocturnal asthma. J Allergy Clin Immunol 1993; 91: 894–902
  • Averill F J, Hubbard W C, Proud D, Gleich G J, Liu M C. Platelet activation in the lung after antigen challenge in a model of allergic asthma. Am Rev Respir Dis 1992; 145: 571–576
  • Lupinetti M D, Sheller J R, Catella F, Fitzgerald G A. Thromboxane biosynthesis in allergen-induced bronchospasm: evidence for platelet activation during exercise induced asthma. Am Rev Respir Dis 1989; 140: 932–935
  • Greer I A, Winter J H, Gaffney D. Platelets in asthma [letter]. Lancet 1984; ii: 1479
  • Durham S R, Dawes J, Kay A B. Platelets in asthma. Lancet 1985; 36
  • Shephard E G, Malan L, Macfarlane C M, Mouton W, Joubert J R. Lung function and plasma levels of thromboxane B2, 6-ketoprostaglandin Flalpha and B-thromboglobulin in antigen-induced asthma before and after indomethacin pretreatment. Br J Clin Pharmacol 1985; 19: 459–470
  • Hemmendinger S, Pauli G, Tenabene A. Platelet function: Aggregation by PAF or sequestration in lung is not modified during immediate or late allergen-induced bronchospasm in man. J Allergy Clin Immunol 1989; 83: 990–996
  • McDonald J R, Tan E M, Stevenson D D, Vaughan J H. Platelet aggregation in asthmatic and normal subjects. J Clin Invest 1974; 54: 200–208
  • Ind P W, Peters A M, Malik F, Lavender J P, Dollery C T. Pulmonary platelet kinetics in asthma. Thorax 1985; 40: 412–417
  • Slater D, Martin J, Trowbridge A. The platelet in asthma. Lancet 1985; i: 110–110
  • Harker L A. Platelet survival time: its measurement and use. Prog Hemost Thromb 1978; 4: 321–347
  • Audera C, Rocklin R, Vaillancourt R, Jakubowski J A, Deykin D. Altered arachidonic acid metabolism and platelet size in atopic subjects. Clin Immunol Immunopathol 1988; 46: 352–359
  • Jeffery P K, Wardlaw A J, Nelson F C, Collins J V, Kay A B. Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989; 140: 1745–1753
  • Joseph M. The involvement of platelets in the allergic response. The platelet in health and disease, C P Page. Blackwell Scientific Press, Oxford 1991; 120–131
  • Thorel T, Ameisen J C, Joseph M. Preventing effect of nedocromil sodium on the abnormal response to aspirin of platelets from aspirin-sensitive asthmatics. Am Rev Respir Dis 1987; 135: A398
  • Marquette C H, Joseph M, Tonnel A B. The abnormal in vitro response to aspirin of platelets from aspirin-sensitive asthmatics is inhibited after inhalation of nedocromil sodium but not of sodium cromoglycate. Br J Clin Pharmacol 1990; 29: 525–532

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