Intralesional immunotherapy with tuberculin purified protein derivative (PPD) in recalcitrant wart: A randomized, placebo-controlled, double-blind clinical trial including an extra group of candidates for cryotherapy

References

• Nofal A, Nofal E. Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine. J Eur Acad Dermatol Venereol. 2010;24:1166–70
   PubMed Web of Science ®Google Scholar
• Clifton MM, Johnson SM, Roberson PK, et al. Immunotherapy for recalcitrant warts in children using intralesional mumps or Candida antigens. Pediatr Dermatol. 2003;20:268–71
   PubMed Web of Science ®Google Scholar
• Bacelieri R, Johnson SM. Cutaneous warts: an evidence-based approach to therapy. Am Fam Physician. 2005;72:647–52
   PubMed Web of Science ®Google Scholar
• Gibbs S, Harvey I, Sterling JC, Stark R. Local treatments for cutaneous warts. The Cochrane Database Syst Rev. 2003;(3):CD001781. doi: 10.1002/14651858.CD001781
   Google Scholar
• Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts. Br J Dermatol. 2001;144:4–11
   PubMed Web of Science ®Google Scholar
• Lipke MM. An armamentarium of wart treatments. Clin Med Res. 2006;4:273–93
   PubMedGoogle Scholar
• Dasher DA, Burkhart CN, Morrell DS. Immunotherapy for childhood warts. Pediatr Ann. 2009;38:373–9
   PubMed Web of Science ®Google Scholar
• Horn TD, Johnson SM, Helm RM, Roberson PK. Intralesional immunotherapy of warts with mumps, Candida, and Trichophyton skin test antigens: a single-blinded, randomized, and controlled trial. Arch Dermatol. 2005;141:589–94
   PubMed Web of Science ®Google Scholar
• Harada S. Clinical application of fungus extracts and its culture filtrate in the treatment of skin diseases; (3) Candida vaccine in the treatment of warts (author's transl). Nihon Hifuka Gakkai Zasshi. 1979;89:397–402
   PubMedGoogle Scholar
• Johnson SM, Horn TD. Intralesional immunotherapy for warts using a combination of skin test antigens: a safe and effective therapy. J Drugs Dermatol. 2004;3:263–5
   PubMedGoogle Scholar
• King M, Johnson SM, Horn TD. Intralesional immunotherapy for genital warts. Arch Dermatol. 2005;141:1606–7
   PubMed Web of Science ®Google Scholar
• Gupta S, Malhotra AK, Verma KK, Sharma VK. Intralesional immunotherapy with killed Mycobacterium w vaccine for the treatment of ano-genital warts: an open label pilot study. J Eur Acad Dermatol Venereol. 2008;22:1089–93
   PubMed Web of Science ®Google Scholar
• Maronn M, Salm C, Lyon V, Galbraith S. One-year experience with candida antigen immunotherapy for warts and molluscum. Pediatr Dermatol. 2008;25:189–92
   PubMed Web of Science ®Google Scholar
• Fayed ST, Amer M, Ammar E, Salam MA. Local BCG injection administered to patients with flat condyloma of the cervix. Int J Gynaecol Obstet. 2009;107:253–4
   PubMed Web of Science ®Google Scholar
• Kim KH, Horn TD, Pharis J, et al. Phase 1 clinical trial of intralesional injection of Candida antigen for the treatment of warts. Arch Dermatol. 2010;146:1431–3
   PubMedGoogle Scholar
• Signore RJ. Candida albicans intralesional injection immunotherapy of warts. Cutis. 2002;70:185–92
   PubMed Web of Science ®Google Scholar
• Johnson SM, Roberson PK, Horn TD. Intralesional injection of mumps or Candida skin test antigens: a novel immunotherapy for warts. Arch Dermatol. 2001;137:451–5
   PubMed Web of Science ®Google Scholar
• Goihman-Yahr M, Goldblum OM. Immunotherapy and warts: a point of view. Clin Dermatol. 2008;26:223–5
   PubMed Web of Science ®Google Scholar
• Mulhem E, Pinelis S. Treatment of nongenital cutaneous warts. Am Fam Physician. 2011;84:288–93
   PubMed Web of Science ®Google Scholar
• Sharquie KE, Al-Rawi JR, Al-Nuaimy AA, Radhy SH. Bacille Calmette-Guerin immunotherapy of viral warts. Saudi Med J. 2008;29:589–93
   PubMed Web of Science ®Google Scholar
• Meena JK, Malhotra AK, Mathur DK, Mathur DC. Intralesional immunotherapy with Mycobacterium w vaccine in patients with multiple cutaneous warts: uncontrolled open study. JAMA Dermatol. 2013;149:237–9
   PubMed Web of Science ®Google Scholar
• Eassa BI, Abou-Bakr AA, El-Khalawany MA. Intradermal injection of PPD as a novel approach of immunotherapy in anogenital warts in pregnant women. Dermatol Ther. 2011;24:137–43
   PubMed Web of Science ®Google Scholar
• Kus S, Ergun T, Gun D, Akin O. Intralesional tuberculin for treatment of refractory warts. J Eur Acad Dermatol Venereol. 2005;19:515–6
   PubMed Web of Science ®Google Scholar
• Munoz-Santos C, Pigem R, Alsina M. New treatments for human papillomavirus infection. Actas Dermosifiliogr. 2013;104:883–9
   PubMedGoogle Scholar
• Nofal A, Salah E, Nofal E, Yosef A. Intralesional antigen immunotherapy for the treatment of warts: current concepts and future prospects. Am J Clin Dermatol. 2013;14:253–60
   PubMed Web of Science ®Google Scholar
• Chandrashekar L. Intralesional immunotherapy for the management of warts. Indian J Dermatol Venereol Leprol. 2011;77:261–3
   PubMed Web of Science ®Google Scholar
• Gibbs S, Harvey I, Sterling J, Stark R. Local treatments for cutaneous warts: systematic review. BMJ. 2002;325:461
   PubMed Web of Science ®Google Scholar
• Abd-Elazeim FM, Mohammed GF, Fathy A, Mohamed RW. Evaluation of IL-12 serum level in patients with recalcitrant multiple common warts, treated by intralesional tuberculin antigen. J Dermatolog Treat. 2014;25:264–7
   PubMed Web of Science ®Google Scholar
• Choi JW, Cho S, Lee JH. Does immunotherapy of viral warts provide beneficial effects when it is combined with conventional therapy? Ann Dermatol. 2011;23:282–7
   PubMed Web of Science ®Google Scholar
• Scott M, Nakagawa M, Moscicki AB. Cell-mediated immune response to human papillomavirus infection. Clin Diagn Lab Immunol. 2001;8:209–20
   PubMedGoogle Scholar
• Froeschle JE, Ruben FL, Bloh AM. Immediate hypersensitivity reactions after use of tuberculin skin testing. Clin Infect Dis. 2002;34:E12–13
   PubMed Web of Science ®Google Scholar
• Na CH, Choi H, Song SH, Kim MS, et al. Two-year experience of using the measles, mumps and rubella vaccine as intralesional immunotherapy for warts. Clin Exp Dermatol. 2014;39:583–9
   PubMed Web of Science ®Google Scholar
• Lahti A, Hannuksela M. Topical immunotherapy with tuberculin jelly for common warts. Arch Dermatol Res. 1982;273:153–4
   PubMed Web of Science ®Google Scholar
• Wananukul S, Chatproedprai S, Kittiratsacha P. Intralesional immunotherapy using tuberculin PPD in the treatment of palmoplantar and periungual warts. Asian Biomedicine. 2009;3:739–43
   Web of Science ®Google Scholar
• Lichon V, Khachemoune A. Plantar warts: a focus on treatment modalities. Dermatol Nurs. 2007;19:372–5
   PubMedGoogle Scholar
• Goncalves JC. 5-Fluorouracil in the treatment of common warts of the hands. A double-blind study. Br J Dermatol. 1975;92:89–91
   PubMed Web of Science ®Google Scholar
• Bunney MH, Nolan MW, Williams DA. An assessment of methods of treating viral warts by comparative treatment trials based on a standard design. Br J Dermatol. 1976;94:667–79
   PubMed Web of Science ®Google Scholar
• Bourke JF, Berth-Jones J, Hutchinson PE. Cryotherapy of common viral warts at intervals of 1, 2 and 3 weeks. Br J Dermatol. 1995;132:433–6
   PubMed Web of Science ®Google Scholar
• Scheinfeld N, Lehman DS. An evidence-based review of medical and surgical treatments of genital warts. Dermatol Online J. 2006;12(3):5
   PubMedGoogle Scholar
• Bruggink SC, Gussekloo J, Berger MY, et al. Cryotherapy with liquid nitrogen versus topical salicylic acid application for cutaneous warts in primary care: randomized controlled trial. CMAJ. 2010;182:1624–30
   PubMed Web of Science ®Google Scholar
• Metawea B, El-Nashar AR, Kamel I, et al. Application of viable bacille Calmette-Guerin topically as a potential therapeutic modality in condylomata acuminata: a placebo-controlled study. Urology. 2005;65:247–50
   PubMed Web of Science ®Google Scholar
• Tomson N, Sterling J, Ahmed I, et al. Human papillomavirus typing of warts and response to cryotherapy. J Eur Acad Dermatol Venereol. 2011;25:1108–11
   PubMed Web of Science ®Google Scholar