V-79 Chinese Hamster cells irradiated with antiprotons, a study of peripheral damage due to medium and long range components of the annihilation radiation

References

• Alsbeih G, Malone S, Lochrin C, et al 2000. Correlation between normal tissue complications and in vitro radiosensitivity of skin fibroblasts derived from radiotherapy patients treated for variety of tumors. International Journal of Radiation Oncology, Biology, and Physics 46:143–152.
   PubMed Web of Science ®Google Scholar
• Bassler N, Holzscheiter MH, Knudsen H, the AD4/ACE Collaboration. (2005) Cancer therapy with antiprotons. In: Grzonka D, Czyzykiewicz R, Oelert W, Roek T, Winter P, editors. Low Energy Antiproton Physics - LEAP '05. AIP Conference Proceedings, CP796: American Institute of Physics, pp. 423–430.
   Google Scholar
• Bernard BW, Kleihues P. 2003. In: World Cancer Report. Lyon: International Agency for Research on Cancer Press, 351 pp.
   Google Scholar
• Bishay K, Ory K, Olivier MF, Lebeau J, Levalois C, Chevillard C. 2001. DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation. Carcinogenesis 22:1179–1183.
   PubMed Web of Science ®Google Scholar
• Collins AR, Oscoz AA, Brunborg G, Gaivão I, Giovanelli L, Kruszewski M, Smith CC, Stetina R. 2008. The comet assay: topical issues. Mutagenesis 23:143–151.
   PubMed Web of Science ®Google Scholar
• Goodhead DT. 1994. Initial events in the cellular effects of ionizing radiation: Clustered damage in DNA. International Journal of Radiation Biology 65:7–17.
   PubMed Web of Science ®Google Scholar
• Gray L, Kalogeropoulos TE. 1984. Possible biomedical applications of antiproton beams: Focused radiation transfer. Radiation Research 97:246–252.
   PubMedGoogle Scholar
• Gulston M, Fulford J, Jenner T, de Lara C, O'Neill P. 2002. Clustered DNA damage induced by radiation in human fibroblasts (HF19), hamster (V79-4) cells and plasmid DNA is revealed as Fpg and Nth sensitive sites. Nucleic Acids Research 30:3464–3472.
   PubMed Web of Science ®Google Scholar
• Hartmann A, Agurell E, Beevers C, Brendler-Schwaab S, Burlinson B, Clay P, Collins A, Smith A, Speit G, Thybaud V, Tice RR. 2003. Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 18:45–51.
   PubMed Web of Science ®Google Scholar
• Holzscheiter MH, Bassler N, Agazaryan N, Beyer G, Blackmore E, DeMarco JJ, Doser M, Durand RE, Hartley O, Iwamoto KS, Knudsen HV, Landua R, Maggiore C, McBride WC, Møller SP, Petersen J, Skarsgard LD, Smathers JB, Solberg TD, Uggerhøj UI, Vranjes S, Withers HR, Wong W, Wouters BG. 2006. The biological effectiveness of antiproton irradiation. Radiotherapy and Oncology 81:233–242.
   PubMed Web of Science ®Google Scholar
• Little JB. 2000. Radiation carcinogenesis. Carcinogenesis 21:397–404.
   PubMed Web of Science ®Google Scholar
• Lovell DP, Omori T. 2008. Mutagenesis 23:171–182.
   PubMed Web of Science ®Google Scholar
• McKelvey-Martin VJ, Green MH, Schmezer P, Pool-Zobel BL, De Meo MP, Collins A. 1993. The single cell gel electrophoresis assay (comet assay): A European review. Mutation Research 288:47–63.
   PubMed Web of Science ®Google Scholar
• Mothersill C, Seymour CB, Joiner MC. 2002. Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiation Research 157:526–532.
   PubMed Web of Science ®Google Scholar
• Olive PL. 1998. The role of DNA single and double strand breaks in cell killing by ionising radiation. Radiation Research 150:S42–S51.
   PubMed Web of Science ®Google Scholar
• Olive PL, J. Banáth JP. 2006. The comet assay: A method to measure DNA damage in individual cells. Nature Protocols 1:23–29.
   PubMed Web of Science ®Google Scholar
• Olive PL, Banath JP, Durand RE. 1990. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the ‘Comet’ assay. Radiation Research 122:86–94.
   PubMed Web of Science ®Google Scholar
• Östling O, Johanson KJ. 1984. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochemical and Biophysical Research Communications 123:291–298.
   PubMed Web of Science ®Google Scholar
• Plappert U, Raddartz K, Roth S, Fliedner TM. 1995. DNA damage detection in man after radiation exposure: The comet assay, its potential applications for human biomonitoring. Stem Cells 13:215–222.
   PubMedGoogle Scholar
• Potter AJ, Gollahon KA, Palanca BJA, Harbert MJ, Choi YM, Moskovitz AH, Potter JD, Rabinovitch PS. 2002. Flow cytometric analysis of the cell cycle phase specificity of DNA damage induced by radiation, hydrogen peroxide and doxorubicin. Carcinogenesis 23:389–401.
   PubMedGoogle Scholar
• Pouget JP, Ravanat L, Douki T, Richard MJ, Cadet J. 1999. Formation of modified DNA bases in cells exposed either to gamma radiation or to high-LET particles. International Journal of Radiation Biology 75:51–58.
   PubMed Web of Science ®Google Scholar
• Raju MR. 1980. Heavy particle radiotherapy. New York: Academic Press.
   Google Scholar
• Schettino G, Folkard M, Prise KM, Vojnovic B, Bowey AG, Michael BD. 2001. Low-dose hypersensitivity in Chinese Hamster V79 cells targeted with counted protons using a charged-particle microbeam. Radiation Research 156:526–534.
   PubMed Web of Science ®Google Scholar
• Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantification of low levels of DNA damage in individual cells. Experimental Cell Research 175:184–191.
   PubMed Web of Science ®Google Scholar
• Sullivan HA. 1985. A measurement of the local energy deposition by antiprotons coming to rest in tissue-like material. Physics in Medicine and Biology 30:1297–1303.
   PubMedGoogle Scholar
• Tueni EA. 1989. Human tumor clonogenic assay: What is new? European Journal of Cancer & Clinical Oncology 25:1031–1033.
   PubMedGoogle Scholar
• Waters, LS. 2002. MCNPX User's Manual, Version 2.3.0. Los Alamos Unclassified Research Document LA-UR-02-2607.
   Google Scholar
• Wouters BG, Lam GK, Oelfke U, Gardey K, Durand RE, Skarsgard LD. 1996. Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay. Radiation Research 146:159–170.
   PubMed Web of Science ®Google Scholar