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Ionizing Radiation Induces ER Stress

ER stress induced by ionising radiation in IEC-6 cells

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Pages 429-435 | Received 07 Sep 2009, Accepted 29 Jan 2010, Published online: 15 May 2010

References

  • Akutsu Y, Matsubara H, Urashima T, Komatsu A, Sakata H, Nishimori T, Yoneyama Y, Hoshino I, Murakami K, Usui A, Kano M, Ochiai T. 2007. Combination of direct intratumoral administration of dendritic cells and irradiation induces strong systemic antitumor effect mediated by GRP94/gp96 against squamous cell carcinoma in mice. International Journal of Oncology 31:509–515.
  • Amundson SA, Bittner M, Fornace AJ Jr. 2003. Functional genomics as a window on radiation stress signaling. Oncogene 22:5828–5833.
  • Anscher MS, Vujaskovic Z. 2005. Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Seminars in Oncology 32:S86–91.
  • Boraks G, Tampelini FS, Pereira KF, Chopard RP. 2008. Effect of ionizing radiation on rat parotid gland. Brazilian Dental Journal 19:73–76.
  • Demasters G, Di X, Newsham I, Shiu R, Gewirtz DA. 2006. Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery. Molecular Cancer Therapeutics 5:2786–2797.
  • Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. 2009. Ischemia activates the ATF6 branch of the endoplasmic reticulum (ER) stress response. Journal of Biological Chemistry 284:29735–29745.
  • Feinendegen LE, Pollycove M, Neumann RD. 2007. Whole-body responses to low-level radiation exposure: new concepts in mammalian radiobiology. Experimental Hematology 35:37–46.
  • Greenberger JS, Epperly M. 2009. Bone marrow-derived stem cells and radiation response. Seminars in Radiation Oncology 19:133–139.
  • Guo R, Ma H, Gao F, Zhong L, Ren J. 2009. Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. Journal of Molecular and Cellular Cardiology 47:228–237.
  • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Molecular Cell 6:1099–1108.
  • Hussein MR, Abu-Dief EE, Kamel E, Abou El-Ghait AT, Abdulwahed SR, Ahmad MH. 2008. Melatonin and roentgen irradiation-induced acute radiation enteritis in Albino rats: an animal model. Cell Biology International 32:1353–1361.
  • Isohashi F, Endo H, Mukai M, Inoue T, Inoue M. 2008. Insulin-like growth factor stimulation increases radiosensitivity of a pancreatic cancer cell line through endoplasmic reticulum stress under hypoxic conditions. Cancer Science 99:2395–2401.
  • Kim I, Xu W, Reed JC. 2008. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nature reviews. Drug Discovery 7:1013–1030.
  • Kubota H, Suzuki T, Lu J, Takahashi S, Sugita K, Sekiya S, Suzuki N. 2005. Increased expression of GRP94 protein is associated with decreased sensitivity to X-rays in cervical cancer cell lines. International Journal of Radiation Biology 81:701–709.
  • Li S, Ye L, Yu X, Xu B, Li K, Zhu X, Liu H, Wu X, Kong L. 2009. Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation. Virology 391:257–264.
  • McCullough KD, Martindale JL, Klotz LO, Aw TY, Holbrook NJ. 2001. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Molecular and Cellular Biology 21:1249–1259.
  • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. 2000. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403:98–103.
  • Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F, Imaizumi K. 2006. Autophagy is activated for cell survival after endoplasmic reticulum stress. Molecular and Cellular Biology 26:9220–9231.
  • Rudner J, Lepple-Wienhues A, Budach W, Berschauer J, Friedrich B, Wesselborg S, Schulze-Osthoff K, Belka C. 2001. Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis. Journal of Cell Science 114:4161–4172.
  • Santos CX, Tanaka LY, Wosniak JJ, Laurindo FR. 2009. Mechanisms and implications of reactive oxygen species generation during the unfolded protein response: Roles of endoplasmic reticulum oxidoreductases, mitochondrial electron transport and NADPH oxidase. Antioxidants Redox Signaling 11:2409–2427.
  • Shimizu Y, Hendershot LM. 2009. Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species. Antioxidants Redox Signaling 11:2317–2331.
  • Watterson TL, Hamilton B, Martin R, Coulombe RA Jr. 2009. Urban particulate matter causes ER stress and the unfolded protein response in human lung cells. Toxicological Science 112:111–122.
  • Xie Z, Klionsky DJ. 2007. Autophagosome formation: core machinery and adaptations. Nature Cell Biology 9:1102–1109.
  • Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. 2003. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. Journal of Neurosurgery 98:378–384.
  • Yoshida H. 2007. ER stress and diseases. FEBS Journal 274:630–658.
  • Zhang B, Wang M, Yang Y, Wang Y, Pang X, Su Y, Wang J, Ai G, Zou Z. 2008. Erp29 is a radiation-responsive gene in IEC-6 cell. Journal of Radiation Research 49:587–596.

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