Solar radiation induced skin damage: Review of protective and preventive options

References

• Aburatani H, Hippo Y, Ishida T, Takashima R, Matsuba C, Kodama T, Takao M, Yasui A, Yamamoto K, Asano M. 1997. Cloning and characterization of mammalian 8-hydroxy-guanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Research 57:2151–2156.
   PubMed Web of Science ®Google Scholar
• Adhami VM, Syed DN, Khan N, Afaq F. 2008. Phytochemicals for prevention of solar ultraviolet radiation-induced damages. Photochemistry and Photobiology 84:489–500.
   PubMed Web of Science ®Google Scholar
• Afaq F, Mukhtar H. 2001. Effects of solar radiation on cutaneous detoxification pathways. Journal of Photochemistry and Photobiology B Biology 63:61–69.
   PubMed Web of Science ®Google Scholar
• Afaq F, Malik A, Syed D, Maes D, Matsui MS, Mukhtar H. 2005a. Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochemistry and Photobiology 81:38–45.
   PubMed Web of Science ®Google Scholar
• Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H. 2009. Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Experimental Dermatology 18:553–561.
   PubMed Web of Science ®Google Scholar
• Afaq F, Adhami VM, Mukhtar H. 2005b. Photochemoprevention of ultraviolet B signaling and photocarcinogenesis. Mutation Research 571:153–173.
   PubMed Web of Science ®Google Scholar
• Akerboom TP, Bilzer M, Sies H. 1982. The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver. Journal of Biological Chemistry 257:4248–4252.
   PubMed Web of Science ®Google Scholar
• Allanson M, Reeve VE. 2005. Ultraviolet A (320–400 nm) modulation of ultraviolet B (290–320 nm)-induced immune suppression is mediated by carbon monoxide. Journal of Investigative Dermatology 124:644–650.
   PubMed Web of Science ®Google Scholar
• Alonso-Lebrero JL, Domínguez-Jiménez C, Tejedor R, Brieva A, Pivel JP. 2003. Photoprotective properties of a hydrophilic extract of the fern Polypodium leucotomos on human skin cells. Journal of Photochemistry and Photobiology B Biology 70:31–37.
   PubMed Web of Science ®Google Scholar
• Aricioglu A, Bozkurt M, Balabanli B, Kilinç M, Nazaroglu NK, Türközkan N. 2001. Changes in zinc levels and superoxide dismutase activities in the skin of acute, ultraviolet-B-irradiated mice after treatment with Ginkgo biloba extract. Biological Trace Element Research 80:175–179.
   PubMed Web of Science ®Google Scholar
• Armeni T, Damiani E, Battino M, Greci L, Principato G. 2004. Lack of in vitro protection by a common sunscreen ingredient on UVA-induced cytotoxicity in keratinocytes. Toxicology 203:165–178.
   PubMed Web of Science ®Google Scholar
• Athar M, Back JH, Tang X, Kim KK, Kopelovich L, Bickers DR, Kim AL. 2007. Resveratrol: A review of preclinical studies for human cancer prevention. Toxicology and Applied Pharmacology 224:274–283.
   PubMed Web of Science ®Google Scholar
• Autier P, Boniol M, Doré JF. 2007. Sunscreen use and increased duration of intentional sun exposure: Still a burning issue. International Journal of Cancer 121:1–5.
   PubMed Web of Science ®Google Scholar
• Aziz MH, Afaq F, Ahmad N. 2005. Prevention of ultraviolet-B radiation damage by resveratrol in mouse skin is mediated via modulation in survivin. Photochemistry and Photobiology 81:25–31.
   PubMed Web of Science ®Google Scholar
• Balajee AS, Bohr VA. 2000. Genomic heterogeneity of nucleotide excision repair. Gene 250:15–30.
   PubMed Web of Science ®Google Scholar
• Baron ED, Kirkland BE, Domingo DS. 2008. Advances in photoprotection. Dermatology Nursing 20:265–272.
   PubMedGoogle Scholar
• Bartek J, Lukas J. 2001. Mammalian G1- and S-phase checkpoints in response to DNA damage. Current Opinion in Cell Biology 13:738–747.
   PubMed Web of Science ®Google Scholar
• Basu-Modak S, Gordon MJ, Dobson LH, Spencer JP, Rice-Evans C, Tyrrell RM. 2003. Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts. Free Radical Biology and Medicine 35:910–921.
   PubMed Web of Science ®Google Scholar
• Basu-Modak S, Luscher P, Tyrrell RM. 1996. Lipid metabolite involvement in the activation of the human heme oxygenase-1 gene. Free Radical Biology and Medicine 20:887–897.
   PubMed Web of Science ®Google Scholar
• Baumann L. 2007. Skin ageing and its treatment. Journal of Pathology 211:241–251.
   PubMed Web of Science ®Google Scholar
• Beyer TA, Auf dem Keller U, Braun S, Schäfer M, Werner S. 2007. Roles and mechanisms of action of the Nrf2 transcription factor in skin morphogenesis, wound repair and skin cancer. Cell Death and Differentiation 14:1250–1254.
   PubMed Web of Science ®Google Scholar
• Bito T, Ueda M, Nagano T, Fujii S, Ichihashi M. 1995. Reduction of ultraviolet-induced skin cancer in mice by topical application of DNA excision repair enzymes. Photodermatology, Photoimmunology and Photomedicine 11:9–13.
   PubMed Web of Science ®Google Scholar
• Böhm F, Edge R, Lange L, Truscott TG. 1998. Enhanced protection of human cells against ultraviolet light by antioxidant combinations involving dietary carotenoids. Journal of Photochemistry and Photobiology B Biology 44:211–215.
   PubMed Web of Science ®Google Scholar
• Boiteux S, Radicella JP. 2000. The human OGG1 gene: Structure, functions, and its implication in the process of carcinogenesis. Archives of Biochemistry and Biophysics 377:1–8.
   PubMed Web of Science ®Google Scholar
• Brigelius-Flohé R. 2006. Glutathione peroxidases and redox-regulated transcription factors. Journal of Biological Chemistry 387:1329–1335.
   Google Scholar
• Brown DA. 2001. Skin pigmentation enhancers. Journal of Photochemistry and Photobiology B Biology 63:148–161.
   PubMed Web of Science ®Google Scholar
• Burke KE, Clive J, Combs GF Jr, Nakamura RM. 2003. Effects of topical L-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. Journal of the American Academy of Dermatology 49:458–472.
   PubMed Web of Science ®Google Scholar
• Byrne SN, Spinks N, Halliday GM. 2002. Ultraviolet a irradiation of C57BL/6 mice suppresses systemic contact hypersensitivity or enhances secondary immunity depending on dose. Journal of Investigative Dermatology 119:858–864.
   PubMed Web of Science ®Google Scholar
• Cao C, Wan Y. 2009. Parameters of protection against ultraviolet radiation-induced skin cell damage. Journal of Cellular Physiology 220:277–284.
   PubMed Web of Science ®Google Scholar
• Carell T, Burgdorf LT, Kundu LM, Cichon M. 2001. The mechanism of action of DNA photolyases. Current Opinion in Chemical Biology 5:491–498.
   PubMed Web of Science ®Google Scholar
• Carless MA, Lea RA, Curran JE, Appleyard B, Gaffney P, Green A, Griffiths LR. 2002. The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. Journal of Investigative Dermatology 119:1373–1378.
   PubMed Web of Science ®Google Scholar
• Casso D, Beach D. 1996. A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast Schizosaccharomyces pombe. Archives of Dermatology 123:615–619.
   Google Scholar
• Chen ML, Li J, Xiao WR, Sun L, Tang H, Wang L, Wu LY, Chen X, Xie HF. 2006. Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:635–639.
   PubMedGoogle Scholar
• Chiu A, Kimball AB. 2003. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. British Journal of Dermatology 149:681–691.
   PubMed Web of Science ®Google Scholar
• Cook N, Freeman S. 2001. Report of 19 cases of photoallergic contact dermatitis to sunscreens seen at the Skin and Cancer Foundation. Australasian Journal of Dermatology 42:257–259.
   PubMedGoogle Scholar
• Coroneo MT. 1993. Pterygium as an early indicator of ultraviolet insolation: A hypothesis. British Journal of Ophthalmology 77:734–739.
   PubMed Web of Science ®Google Scholar
• Costa MR, Chiganeas V, Galhardo RS, Calvarho H, Menck CF. 2003. The euraryotic nucleotide excision repair pathway. Biochimie 85:1083–1099.
   PubMed Web of Science ®Google Scholar
• Cotter MA, Thomas J, Cassidy P, Robinette K, Jenkins N, Florell SR, Leachman S, Samlowski WE, Grossman D. 2007. N-acetylcysteine protects melanocytes against oxidative stress/damage and delays onset of ultraviolet-induced melanoma in mice. Clinical Cancer Research 13:5952–5958.
   PubMed Web of Science ®Google Scholar
• D'Agostiny F, Balansky RM, Camoirano A, De Flora S. 2005. Modulation of light-induced skin tumors by N-acetylcysteine and/or ascorbic acid in hairless mice. Carcinogenesis 26:657–664.
   PubMed Web of Science ®Google Scholar
• Dahle J, Brunborg G, Svendsrud DH, Stokke T, Kvam E. 2008. Overexpression of human OGG1 in mammalian cells decreases ultraviolet A induced mutagenesis. Cancer Letters 267:18–25.
   PubMed Web of Science ®Google Scholar
• Dany AL, Tissier A. 2001. A functional OGG1 homologue from Arabidopsis thaliana. Molecular Genetics and Genomics 265:293–301.
   PubMed Web of Science ®Google Scholar
• Darr D, Combs S, Dunston S, Manning T, Pinnell S. 1992. Topical vitamin C protects porcine skin from ultraviolet radiation-induced damage. British Journal of Dermatology 127:247–253.
   PubMed Web of Science ®Google Scholar
• Darr D, Dunston S, Faust H, Pinnell S. 1996. Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants. Acta Dermato-Venereologica 76:264–268.
   PubMed Web of Science ®Google Scholar
• Darvin M, Zastrow L, Sterry W, Lademann J. 2006. Effect of supplemented and topically applied antioxidant substances on human tissue. Skin Pharmacology and Physiology 19:238–247.
   PubMed Web of Science ®Google Scholar
• Davies KJ. 2000. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life 50:279–289.
   PubMed Web of Science ®Google Scholar
• de Boer J, Hoeijmakers JH. 2000. Nucleotide excision repair and human syndromes. Carcinogenesis 21:453–460.
   PubMed Web of Science ®Google Scholar
• de Winter S, Vink AA, Roza L, Pavel S. 2001. Solar-simulated skin adaptation and its effect on subsequent UV-induced epidermal DNA damage. Journal of Investigative Dermatology 117:678–682.
   PubMed Web of Science ®Google Scholar
• Declercq L, Sente I, Hellemans L, Corst1ens H, Maes D. 2004. Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface. International Journal of Cosmetic Science 26:255–263.
   PubMedGoogle Scholar
• Deep G, Agarwal R. 2007. Chemopreventive efficacy of silymarin in skin and prostate cancer. Integrative Cancer Therapies 6:130–145.
   PubMed Web of Science ®Google Scholar
• Deliconstantinos G, Villitou V, Stavrides JC. 1997. Inhibition of ultraviolet B-induced skin erythema by N-nitro-L-arginine and N-monomethyl-L-arginine. Journal of Dermatological Science 15:23–35.
   PubMed Web of Science ®Google Scholar
• D'Errico M, Teson M, Calcagnile A, Proietti De Santis L, Nikaido O, Botta E, Zambruno G, Stefanini M, Dogliotti E. 2003. Apoptosis and efficient repair of DNA damage protect human keratinocytes against UVB. Cell Death and Differentiation 10:754–756.
   PubMed Web of Science ®Google Scholar
• Didier C, Kerblat I, Drouet C, Favier A, Béani JC, Richard MJ. 2001a. Induction of thioredoxin by ultraviolet-A radiation prevents oxidative-mediated cell death in human skin fibroblasts. Free Radical Biology and Medicine 31:585–598.
   PubMed Web of Science ®Google Scholar
• Didier C, Pouget JP, Cadet J, Favier A, Béani JC, Richard MJ. 2001b. Modulation of exogenous and endogenous levels of thioredoxin in human skin fibroblasts prevents DNA damaging effect of ultraviolet A radiation. Free Radical Biology and Medicine 30:537–546.
   PubMed Web of Science ®Google Scholar
• Diffey B. 2001b. Sunscreen isn't enough. Journal of Photochemistry and Photobiology B Biology 64:105–108.
   PubMed Web of Science ®Google Scholar
• Dinkova-Kostova AT. 2008. Phytochemicals as protectors against ultraviolet radiation: Versatility of effects and mechanisms. Planta Medica 74:1548–1559.
   PubMed Web of Science ®Google Scholar
• El Sayed F, Ammoury A, Nakhle F, Dhaybi R, Marguery MC. 2006. Photoprotection in teenagers. Photodermatology, Photoimmunology and Photomedicine 22:18–21.
   PubMed Web of Science ®Google Scholar
• Eller MS, Ostrom K, Gilchrest BA. 1996. DNA damage enhances melanogenesis. Proceedings of the National Academy of Sciences of the USA 93:1087–1092.
   PubMed Web of Science ®Google Scholar
• Eller MS, Yaar M, Gilchrest BA. 1994. DNA damage and melanogenesis. Nature 372:413–414.
   PubMed Web of Science ®Google Scholar
• Eller MS, Maeda T, Magnoni C, Arwal D, Gilchrest BA. 1997. Enhancement of DNA repair in human skin cells by thymidine dinucleotides: Evidence for p53-mediated mammalian SOS response. Proceedings of the National Academy of Sciences of the USA 94:12627–12632.
   PubMed Web of Science ®Google Scholar
• Erden IM, Kahraman A, Köken T. 2001. Beneficial effects of quercetin on oxidative stress induced by ultraviolet A. Clinical and Experimental Dermatology 26:536–539.
   PubMed Web of Science ®Google Scholar
• Essen LO, Klar T. 2006. Light-driven DNA repair by photolyases. Cellular and Molecular Life Sciences 63:1266–1277.
   PubMed Web of Science ®Google Scholar
• Ettler K. 2004. Fotoprotekce kůže. Ochrana kůže před účinky ultrafialového záření. Praque: Triton.
   Google Scholar
• F'guyer S, Afaq F, Mukhtar H. 2003. Photochemoprevention of skin cancer by botanical agents. Photodermatology, Photoimmunology and Photomedicine 19:56–72.
   PubMed Web of Science ®Google Scholar
• Faurschou A, Wulf HC. 2007. The relation between sun protection factor and amount of sunscreen applied in vivo. Photobiology 156:716–719.
   Google Scholar
• Fitzpatrick TB, Breathnach AS. 1963. The epidermal melanin unit system. Dermatologische Wochenschrift 147:481–489.
   PubMedGoogle Scholar
• Fonnum F, Lock EA. 2004. The contributions of excitotoxicity, glutathione depletion and DNA repair in chemically induced injury to neurones: Exemplified with toxic effects on cerebellar ganule cells. Journal of Neurochemistry 88:513–531.
   PubMed Web of Science ®Google Scholar
• Frank S, Kämpfer H, Wetzler C, Pfeilschifter J. 2002. Nitric oxide drives skin repair: Novel functions of an established mediator. Kidney International 61:882–888.
   PubMed Web of Science ®Google Scholar
• Fuller B, Smith D, Howerton A, Kern D. 2006. Anti-inflammatory effects of CoQ10 and colorless carotenoids. Journal of Cosmetic Dermatology 5:30–38.
   PubMedGoogle Scholar
• Gallardo A, Teixidó J, Miralles R, Raga M, Guglietta A, Marquillas F, Sallarès J, Nonell S. 2010. Dose-dependent progressive sunscreens. A new strategy for photoprotection? Photochemical and Photobiological Sciences 9:530–534.
   PubMed Web of Science ®Google Scholar
• Gambichler T, Laperre J, Hoffmann K. 2006. The European standard for sun-protective clothing: EN 13758. Journal of the European Academy of Dermatology and Venereology 20:125–130.
   PubMed Web of Science ®Google Scholar
• Garmyn M, Ribaya-Mercado JD, Russel RM, Bhawan J, Gilchrest BA. 1995. Effect of beta-carotene supplementation on the human sunburn reaction. Experimental Dermatology 4:104–111.
   PubMedGoogle Scholar
• Gaspar LR, Campos PM. 2007. Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A, C and E. International Journal of Pharmaceutics 343:181–189.
   PubMed Web of Science ®Google Scholar
• Gerber B, Mathys P, Moser M, Bressoud D, Braun-Fahrländer C. 2002. Ultraviolet emission spectra of sunbeds. Photochemistry and Photobiology 76:664–668.
   PubMed Web of Science ®Google Scholar
• Gies P. 2007. Photoprotection by clothing. Photodermatology, Photoimmunology and Photomedicine 23:264–274.
   PubMed Web of Science ®Google Scholar
• Gonzalez S, Alonso-Lebrero JL, Del Rio R, Jaen P. 2007. Polypodium leucotomos extract: A nutraceutical with photoprotective properties. Drugs of Today (Barcelona) 43:475–485.
   PubMed Web of Science ®Google Scholar
• Goukassian DA, Eller MS, Yaar M, Gilchrest BA. 1999. Thymidine dinucleotide mimics the effect of solar simulated irradiation on p53 and p53-regulated proteins. Journal of Investigative Dermatology 112:25–31.
   PubMed Web of Science ®Google Scholar
• Greul AK, Grudmann JU, Heinrich F, Pfitzner I, Bernhardt J, Ambach A, Biesalski HK, Gollnick H. 2002. Photoprotection of UV-irradiated human skin: An antioxidative combination of vitamins E and C, carotenoids, selenium and proanthocyanidins. Skin Pharmacology and Applied Skin Physiology 15:307–315.
   PubMedGoogle Scholar
• Hadshiew IM, Eller MS, Gasparro FP, Gilchrest BA. 2001. Stimulation of melanogenesis by DNA nucleotides. Effects of size, sequence and 5′ phosphorilation. Journal of Dermatological Science 5:127–138.
   Google Scholar
• Hall AG. 1999. The role of glutathione in the regulation of apoptosis. European Journal of Clinical Investigation 29:238–245.
   PubMed Web of Science ®Google Scholar
• Halliday GM. 2005. Inflammation, gene mutation and photoimmunosuppression in response to UVR-induced oxidative damage contributes to photocarcinogenesis. Mutation Research 571:107–120.
   PubMed Web of Science ®Google Scholar
• Halliday GM, Rana S. 2008. Waveband and dose dependency of sunlight-induced immunomodulation and cellular changes. Photochemistry and Photobiology 84:35–46.
   PubMed Web of Science ®Google Scholar
• Hanada K, Sawamura D, Tamai K, Hashimoto I, Kobayashi S. 1997. Photoprotective effect of esterified glutathione against ultraviolet B-induced sunburn cell formation in the hairless mice. Journal of Investigative Dermatology 108:727–730.
   PubMed Web of Science ®Google Scholar
• Hayes JD, Strange RC. 2000. Glutathione-S-transferase polymorphisms and their biological consequence. Pharmacology 61:154–166.
   PubMed Web of Science ®Google Scholar
• Haywood R, Wardman P, Sanders R, Linge C. 2003. Sunscreens inadequately protect against ultraviolet-A- induced free radicals in skin: Implications for skin aging and melanoma? Journal of Investigative Dermatology 121:862–868.
   PubMed Web of Science ®Google Scholar
• Hellemans L, Corstjens H, Neven A, Declercq L, Maes D. 2003. Antioxidant enzyme activity in human stratum corneum shows seasonal variations with an age-dependent recovery. Journal of Investigative Dermatology 120:434–439.
   PubMed Web of Science ®Google Scholar
• Herzog B, Mongiat S, Quass K, Deshayes C. 2004. Prediction of sun protection factors and UVA parameters of sunscreens by using a calibrated step film model. Journal of Pharmaceutical Sciences 93:1780–1795.
   PubMed Web of Science ®Google Scholar
• Hirota A, Kawachi Y, Itoh K, Nakamura Y, Xu X, Banno T, Takahashi T, Yamamoto M, Otsuka F. 2005. Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: Protective role in UVA-induced apoptosis. Journal of Investigative Dermatology 124:825–832.
   PubMed Web of Science ®Google Scholar
• Hirota K, Murata M, Sachi Y, Nakamura H, Takeuchi J, Mori K, Yodoi J. 1999. Distinct roles of thioredoxin in the cytoplasm and in the nucleus. A two-step mechanism of redox regulation of transcription factor NF-kappaB. Journal of Biological Chemistry 274:27891–27897.
   PubMed Web of Science ®Google Scholar
• Hoffmann K, Laperre J, Avermaete A, Altmeyer P, Gambichler T. 2001. Defined UV protection by apparel textiles. Archives of Dermatology 137:1089–1094.
   PubMed Web of Science ®Google Scholar
• Ibrahim SF, Brown MD. 2008. Tanning and cutaneous malignancy. Dermatologic Surgery 34:460–474.
   PubMed Web of Science ®Google Scholar
• Inui M, Ooe M, Fujii K, Matsunaka H, Yoshida M, Ichihashi M. 2008. Mechanisms of inhibitory effects of CoQ10 on UVB-induced wrinkle formation in vitro and in vivo. Biofactors 32:237–243.
   PubMed Web of Science ®Google Scholar
• Jaakola L, Määttä-Riihinen K, Kärenlampi S, Hohtola A. 2004. Activation of flavonoid biosynthesis by solar radiation in bilberry (Vaccinium myrtillus L.) leaves. Planta 218:721–728.
   PubMed Web of Science ®Google Scholar
• Javeri A, Huang XX, Bernerd F, Mason RS, Halliday GM. 2008. Human 8-oxoguanine-DNA glycosylase 1 protein and gene are expressed more abundantly in the superficial than basal layer of human epidermis. DNA Repair (Amst) 7:1542–1550.
   PubMedGoogle Scholar
• Jung K, Seifert M, Herrling T. 2008a. The fatal effects of self-tanning agents during UV radiation. SÖFW-Journal 3:12–17.
   Google Scholar
• Jung K, Seifert M, Herrling T, Fuchs J. 2008b. UV generated free radicals (FR) in the skin: Their prevention by sunscreens and their induction by self-tanning agents. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 69:1423–1428.
   PubMed Web of Science ®Google Scholar
• Junqueira LC, Carneiro J, Kelley RO. 1992. Basic histology. Norwalk: Prentice Hall International Inc. pp 339–351.
   Google Scholar
• Kaidbey KH, Agin PP, Sayre RM, Kligman AM. 1979. Photoprotection by melanin. A comparison of black and Caucasian skin. Journal of the American Academy of Dermatology 1:249–260.
   PubMed Web of Science ®Google Scholar
• Kanitakis J. 2002. Anatomy, histology and immunohistochemistry of normal human skin. European Journal of Dermatology 12:390–399.
   PubMed Web of Science ®Google Scholar
• Kappes UP, Luo D, Potter M, Schulmeister K, Runger TM. 2006. Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cells. Journal of Investigative Dermatology 126:667–675.
   PubMed Web of Science ®Google Scholar
• Katiyar S, Elmets CA, Katiyar SK. 2007. Green tea and skin cancer: Photoimmunology, angiogenesis and DNA repair. Journal of Nutritional Biochemistry 18:287–296.
   PubMed Web of Science ®Google Scholar
• Katiyar SK. 2005. Silymarin and skin cancer prevention: Anti-inflammatory, antioxidant and immunomodulatory effects (Review). International Journal of Oncology 26:169–176.
   PubMed Web of Science ®Google Scholar
• Katiyar SK. 2007. UV-induced immune suppression and photocarcinogenesis: Chemoprevention by dietary botanical agents. Cancer Letters 255:1–11.
   PubMed Web of Science ®Google Scholar
• Katiyar SK. 2008. Grape seed proanthocyanidines and skin cancer prevention: Inhibition of oxidative stress and protection of immune system. Molecular Nutrition and Food Research 52:S71–76.
   PubMed Web of Science ®Google Scholar
• Katiyar SK, Afaq F, Perez A, Mukhtar H. 2001. Green tea polyphenol (-)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis 22:287–294.
   PubMed Web of Science ®Google Scholar
• Kawachi Y, Xu X, Taguchi S, Sakurai H, Nakamura Y, Ishii Y, Fujisawa Y, Furuta J, Takahashi T, Itoh K, Yamamoto M, Yamazaki F, Otsuka F. 2008. Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice. Journal of Investigative Dermatology 128:1773–1779.
   PubMed Web of Science ®Google Scholar
• Kerb R, Brockmöller J, Reum T, Roots I. 1997. Deficiency of glutathione S-transferases T1 and M1 as heritable factors of increased cutaneous UV sensitivity. Journal of Investigative Dermatology 108:229–232.
   PubMed Web of Science ®Google Scholar
• Kim DW, Hwang IK, Kim DW, Yoo KY, Won CK, Moon WK, Won MH. 2007. Coenzyme Q effects on manganese superoxide dismutase and glutathione peroxidase in the hairless mouse skin induced by ultraviolet B irradiation. Biofactors 30:139–147.
   PubMed Web of Science ®Google Scholar
• Kobayashi S, Takehana M, Tohyama C. 1996. Glutathione isopropyl ester reduces UVB-induced skin damage in hairless mice. Photochemistry and Photobiology 63:106–110.
   PubMed Web of Science ®Google Scholar
• Koháryová M, Kolárová M. 2008. Oxidative stress and thioredoxin system. General Physiology and Biophysics 27:71–84.
   PubMed Web of Science ®Google Scholar
• Kohen R, Gati I. 2000. Skin low molecular weight antioxidants and their role in aging and in oxidative stress. Toxikology 148:149–157.
   PubMed Web of Science ®Google Scholar
• Korkina LG, Pastore S, De Luca C, Kostyuk VA. 2008. Metabolism of plant polyphenols in the skin: Beneficial versus deleterious effects. Current Drug Metabolism 9:710–729.
   PubMed Web of Science ®Google Scholar
• Krol ES, Kramrp-Stickland KA, Lieber DC. 2000. Photoprotective actions of topically applied vitamin E. Drug Metabolism Reviews 32:413–420.
   PubMed Web of Science ®Google Scholar
• Kulms D, Schwarz T. 2002. Independent contribution of three different pathways to ultraviolet-B-induced apoptosis. Biochemical Pharmacology 64:837–841.
   PubMed Web of Science ®Google Scholar
• Kvam E, Noel A, Basu-Modak S, Tyrrell RM. 1999. Cyclooxygenase dependent release of heme from microsomal hemeproteins correlates with induction of heme oxygenase 1 transcription in human fibroblasts. Free Radical Biology and Medicine 26:511–517.
   PubMed Web of Science ®Google Scholar
• Lautenschlanger S, Wulf HC, Pittelkow MR. 2007. Photoprotection. The Lancet 370:528–537.
   PubMedGoogle Scholar
• Lautier D, Luscher P, Tyrrell RM. 1992. Endogenous glutathione levels modulate both constitutive and UVA radiation/hydrogen peroxide inducible expression of the human heme oxygenase gene. Carcinogenesis 13:227–232.
   PubMed Web of Science ®Google Scholar
• Lavker RM, Gerberick GF, Veres D, Irwin CJ, Kaidbey KH. 1995. Cumulative effects from repeated exposures to suberythemal doses of UVB and UVA in human skin. Journal of the American Academy of Dermatology 32:53–62.
   PubMed Web of Science ®Google Scholar
• Leccia MT, Yaar M, Allen N, Gleason M, Gilchrest BA. 2001. Solar simulated irradiation modulates gene expression and activity of antioxidants enzymes in cultured human dermal fibroblasts. Experimental Dermatology 10:272–279.
   PubMed Web of Science ®Google Scholar
• Leccia MT, Richard MJ, Beani JC, Faure H, Monjo AM, Cadet J, Amblard P, Favier A. 1993. Protective effect of selenium and zinc on UV-A damage in human skin fibroblasts. Photochemistry and Photobiology 58:548–553.
   PubMed Web of Science ®Google Scholar
• Lee JH, An HT, Chung JH, Kim KH, Eun HC, Cho KH. 2002. Acute effects of UVB radiation on the proliferation and differentiation of keratinocytes. Photodermatology, Photoimmunology and Photomedicine 18:253–261.
   PubMed Web of Science ®Google Scholar
• Lloyd RS. 2005. Investigations of pyrimidine dimer glycosylases – a paradigm for DNA base excision repair enzymology. Mutation Research 577:77–91.
   PubMed Web of Science ®Google Scholar
• Lopez-Torres M, Thiele JJ, Shindo Y, Han D, Packer L. 1998. Topical application of tocopherol modulates the antioxidant network and diminishes ultraviolet-induced oxidative damage in murine skin. British Journal of Dermatology 138:207–215.
   PubMed Web of Science ®Google Scholar
• Lucas CR, Ke MS, Matsui MS, Maes D, Cooper KD, Stevens SR, Baron ED. 2008. Immune protective effect of a moisturizer with DNA repair ingredients. Journal of Cosmetic Dermatology 7:132–135.
   PubMedGoogle Scholar
• Mahmoud BH, Hexsel CL, Hamzavi IH. 2008. Effects of visible light on the skin. Photochemistry and Photobiology 84:450–462.
   PubMed Web of Science ®Google Scholar
• Mahroos MA, Yaar M, Phillips TJ, Bhawan J, Gilchrest BA. 2002. Effect of sunscreen application on UV-induced thymine dimers. Archives of Dermatology 138:1480–1485.
   PubMedGoogle Scholar
• Maier T, Korting HC. 2005. Sunscreens – which and what for? Skin Pharmacology and Physiology 18:253–262.
   PubMed Web of Science ®Google Scholar
• Manzanas García A, López Carrioza MC, Vallejo Ocana C, Samper Ots P, Delgado Pérez JM, Carretero Accame E, Gómez-Serranillos P, de la Morena del Valle L. 2008. Superoxide dismutase (SOD) topical use in oncologic patients: Treatment of acute cutaneous toxicity secondary to radiotherapy. Clinical and Translational Oncology 10:163–167.
   PubMed Web of Science ®Google Scholar
• Marrot L, Jones C, Perez P, Meunier JR. 2007. The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis. Pigment Cell and Melanoma Research 21:79–88.
   Web of Science ®Google Scholar
• Marrot L, Belaidi J, Meunier J, Perez P, Agapakis-Causse C. 1999. The human melanocyte as a particular target for UVA radiation and an endpoint for photoprotection assessment. Photochemistry and Photobiology 69:686–693.
   PubMed Web of Science ®Google Scholar
• Masella R, Di Benedetto R, Vari R, Filesi C, Giovannini C. 2005. Novel mechanisms of natural antioxidant compounds in biological systems: Involvement of glutathione and glutathione-related enzymes. Journal of Nutritional Biochemistry 16:577–586.
   PubMed Web of Science ®Google Scholar
• Masnec IS, Voda K, Šitum M. 2007. UV radiation: What we know and do we protect ourselves adequates? Collegium Antropologicum 1:97–100.
   Google Scholar
• Matsumura Y, Ananthaswamy HN. 2004. Toxic effects of ultraviolet radiation on the skin. Toxicology and Applied Pharmacology 195:298–308.
   PubMed Web of Science ®Google Scholar
• McArdle F, Rhodes LE, Parslew RA, Close GL, Jack CI, Friedmann PS, Jackson MJ. 2004. Effects of oral vitamin E and beta-carotene supplementation on ultraviolet radiation-induced oxidative stress in human skin. American Journal of Clinical Nutrition 80:1270–1275.
   PubMed Web of Science ®Google Scholar
• Meewes C, Brenneisen P, Wenk J, Kuhr L, Ma W, Alikoski J, Poswig A, Krieg T, Scharffetter-Kochanek K. 2001. Adaptive antioxidant response protects dermal fibroblasts from UVA-induced phototoxicity. Free Radical Biology and Medicine 3:238–247.
   Google Scholar
• Meira LB, Cheo DL, Reis AM, Claij N, Burns DK, te Riele H, Friedberg EC. 2002. Mice defective in the mismatch repair gene Msh2 show increased predisposition to UVB radiation-induced skin cancer. DNA Repair (Amst) 1:929–934.
   PubMed Web of Science ®Google Scholar
• Melnikova VO, Ananthaswamy NH. 2005. Cellular and molecular events leading to the development of skin cancer. Mutation Research 571:91–106.
   PubMed Web of Science ®Google Scholar
• Mistry P, Herbert KE. 2003. Modulation of hOGG1 DNA repair enzyme in human cultured cells in response to pro-oxidant and antioxidant challenge. Free Radical Biology and Medicine 35:397–405.
   PubMed Web of Science ®Google Scholar
• Monteiro-Riviere NA. 2004. Anatomical factors affecting barrier function. In: Zhai H, Maibach HI, editors. Dermatotoxicology. Danvers, MA: CRC Press LLC. pp 43–70.
   Google Scholar
• Morley N, Curnow A, Salter L, Campbell S, Gould D. 2003. N-acetyl-L-cysteine prevents DNA damage induced by UVA, UVB and visible radiation in human fibroblasts. Journal of Photochemistry and Photobiology B Biology 72:55–60.
   PubMed Web of Science ®Google Scholar
• Mouret S, Baudouin C, Charveron M, Favier A, Cadet J, Douki T. 2006. Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation. Proceedings of the National Academy of Sciences of the USA 103:13765–13770.
   PubMed Web of Science ®Google Scholar
• Mouret S, Philippe C, Gracia-Chantegrel J, Banyasz A, Karpati S, Markovitsi D, Douki T. 2010. UVA-induced cyclobutane pyrimidine dimers in DNA: A direct photochemical mechanism? Organic and Biomolecular Chemistry 8:1706–1711.
   PubMed Web of Science ®Google Scholar
• Mullenders LH, Berneburg M. 2001. Photoimmunology and nucleotide excision repair: Impact of transcription coupled and global genome excision repair. Journal of Photochemistry and Photobiology B Biology 2/3:97–100.
   Google Scholar
• Murray JC, Burch JA, Streilein RD, Iannacchione MA, Hall RP, Pinnell RS. 2008. A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation. Journal of the American Academy of Dermatology 59:418–425.
   PubMed Web of Science ®Google Scholar
• Mustacich D, Powis G. 2000. Thioredoxin reductase. Biochemical Journal 346:1–8.
   PubMed Web of Science ®Google Scholar
• Naderi-Hachtroudi L, Peters T, Brenneisen P, Meewes C, Hommel C, Razi-Wolf Z, Schneider LA, Schuller J, Wlaschek M, Scharffetter-Kochanek K. 2002. Induction of manganese superoxide dismutase in human dermal fibroblasts: A UV-B-mediated paracrine mechanism with the release of epidermal interleukin 1 alpha, interleukin 1 beta, and tumor necrosis factor alpha. Archives of Dermatology 138:1473–1479.
   PubMedGoogle Scholar
• Nair S, Kekatpure VD, Judson BL, Rifkind AB, Granstein RD, Boyle JO, Subbaramaiah K, Guttenplan JB, Dannenberg AJ. 2009. UVR exposure sensitizes keratinocytes to DNA adduct formation. Cancer Prevention Research (Phila Pa) 2:895–902.
   PubMed Web of Science ®Google Scholar
• Nakamura Y, Yoshida C, Murakami A, Ohigashi H, Osawa T, Uchida K. 2004. Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Letters 572:245–250.
   PubMed Web of Science ®Google Scholar
• Nandakumar V, Singh T, Katiyar SK. 2008 Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Letters 269:378–387.
   PubMed Web of Science ®Google Scholar
• Nash JF. 2006. Human safety and efficacy of ultraviolet filters and sunscreen products. Dermatologic Clinics 24:35–51.
   PubMed Web of Science ®Google Scholar
• Nohynek GJ, Schaefer H. 2001. Benefit and risk of organic ultraviolet filters. Regulatory Toxicology and Pharmacology 33:285–291.
   PubMed Web of Science ®Google Scholar
• Nohynek GJ, Dufour EK, Roberts MS. 2008. Nanotechnology, cosmetics and the skin: Is there a health risk? Skin Pharmacology and Physiology 21:136–149.
   PubMed Web of Science ®Google Scholar
• Nolan BV, Taylor SL, Liguori A, Feldman SR.2009.Tanning as an addictive behavior: A literature review. Photodermatology, Photoimmunology and Photomedicine 25:12–19.
   PubMed Web of Science ®Google Scholar
• Obermuller-Jevic UC, Schlegel B, Flaccus A, Biesalski HK. 2001. The effect of beta-carotene on the expression of interleukin-6 and heme oxygenase-1 in UV-irradiated human skin fibroblasts in vitro. FEBS Letters 509:186–190.
   PubMed Web of Science ®Google Scholar
• Offord EA, Gautier JC, Avanti O, Scaletta C, Runge F, Krämer K, Applegate LA. 2002. Photoprotective potential of lycopene, beta-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts. Free Radical Biology and Medicine 32:1293–1303.
   PubMed Web of Science ®Google Scholar
• Okada K, Takahashi Y, Ohnishi K, Ishikawa O, Miyachi Y. 1994. Time-dependent effect of chronic UV irradiation on superoxide dismutase and catalase activity in hairless mice skin. Journal of Dermatological Science 8:183–186.
   PubMedGoogle Scholar
• Park HY, Mosmadaki M, Yaar M, Gilchrest BA. 2009. Cellular mechanisms regulating human melanogenesis. Cellular and Molecular Life Sciences 66:1493–1506.
   PubMed Web of Science ®Google Scholar
• Pearse AD, Gaskell SA, Marks R. 1987. Epidermal changes in human skin following irradiation with either UVB or UVA. Journal of Investigative Dermatology 88:83–87.
   PubMed Web of Science ®Google Scholar
• Pence BC, Naylor MF. 1990. Effects of single-dose ultraviolet radiation on skin superoxide dismutase, catalase, and xanthine oxidase in hairless mice. Journal of Investigative Dermatology 95:213–216.
   PubMed Web of Science ®Google Scholar
• Persson AE, Edström DW, Bäckvall H, Lundeberg J, Potén F, Ros AM, Williams C. 2002. The mutagenic effect of ultraviolet-A1 on human skin demonstrated by sequencing the p53 gene in single keratinocytes. Photodermatology, Photoimmunology and Photomedicine 18:287–293.
   PubMed Web of Science ®Google Scholar
• Petropoulos I, Friguet B. 2006. Maintenance of proteins and aging: The role of oxidized protein repair. Free Radical Research 40:1269–1276.
   PubMed Web of Science ®Google Scholar
• Phan TA, Halliday GM, Barnetson RC, Damian DL. 2006. Melanin differentially protects from the initiation and progression of threshold UV-induced erythema depending on UV waveband. Photodermatology, Photoimmunology and Photomedicine 22:174–180.
   PubMed Web of Science ®Google Scholar
• Pinnell SR. 2003. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. Journal of the American Academy of Dermatology 48:1–19.
   PubMed Web of Science ®Google Scholar
• Pitsikas P, Lee D, Rainbow AJ. 2007. Reduced host cell reactivation of oxidative DNA damage in human cells deficient in the mismatch repair gene hMSH2. Mutagenesis 22:235–243.
   PubMed Web of Science ®Google Scholar
• Podda M, Grundmann-Kollmann M. 2001. Low molecular weight antioxidants and their role in skin ageing. Clinical and Experimental Dermatology 26:578–582.
   PubMed Web of Science ®Google Scholar
• Poon TS, Barnetson RS, Halliday GM. 2005. Sunlight-induced immunosuppression in humans is initially because of UVB, then UVA, followed by interactive effects. Journal of Investigative Dermatology 125:840–846.
   PubMed Web of Science ®Google Scholar
• Poswig A, Wenk J, Brenneisen P, Wlaschek M, Hommel C, Quel G, Faisst K, Dissemond J, Briviba K, Krieg T, Scharffetter-Kochanek K. 1999. Adaptive antioxidant response of manganese-superoxide dismutase following repetitive UVA irradiaton. Journal of Investigative Dermatology 112:13–18.
   PubMed Web of Science ®Google Scholar
• Psotová J, Svobodová A, Kolářová H, Walterová D. 2006. Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes. Journal of Photochemistry and Photobiology B Biology 84:167–174.
   PubMed Web of Science ®Google Scholar
• Rafferty TS, Walker C, Hunter JA, Beckett GJ, McKenzie RC. 2002. Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds. British Journal of Dermatology 146:485–489.
   PubMed Web of Science ®Google Scholar
• Rahman I, MacNee W. 2000. Regulation of redox glutathione levels and gene transcription in lung inflammation: Therapeutic approaches. Free Radical Biology and Medicine 28:1405–1420.
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Mukhtar H, Ahmad N. 2008. Resveratrol imparts photoprotection of normal cells and enhances the efficacy of radiation therapy in cancer cells. Photochemistry and Photobiology 84:415–421.
   PubMed Web of Science ®Google Scholar
• Reedy MV, Faraco CD, Erickson CA. 1998. Specification and migration of melanoblasts at the vagal level and in hyperpigmented Silkie chickens. Developmental Dynamics 213:476–485.
   PubMed Web of Science ®Google Scholar
• Reeve VE, Tyrrell RM. 1999. Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse. Proceedings of the National Academy of Sciences of the USA 96:9317–9321.
   PubMed Web of Science ®Google Scholar
• Rezvani HR, Mazurier F, Cario-André M, Pain C, Ged C, Taïeb A, de Verneuil H. 2006a. Protective effect of catalase overexpression on UVB-induced apoptosis in normal human keratinocytes. Journal of Biological Chemistry 281:17999–18007.
   PubMed Web of Science ®Google Scholar
• Rezvani HR, Cario-André M, Pain C, Ged C, de Verneuil H, Taïeb A. 2006b. Protection of normal human reconstructed epidermis from UV by catalase overexpression. Cancer Gene Therapy 14:174–186.
   PubMed Web of Science ®Google Scholar
• Ridley AJ, Whiteside JR, McMillan TJ, Allinson SL. 2009. Cellular and sub-cellular responses to UVA in relation to carcinogenesis. International Journal of Radiation Biology 85:177–195.
   PubMed Web of Science ®Google Scholar
• Routaboul C, Denis A, Vinche A. 1999. Immediate pigment darkening: Description, kinetic and biological function. European Journal of Dermatology 9:95–99.
   PubMed Web of Science ®Google Scholar
• Saitoh T, Shinmura K, Yamaguchi S, Tani M, Seki S, Murakami H, Nojima Y, Yokota J. 2001. Enhancement of OGG1 protein AP lyase activity by increase of APEX protein. Mutation Research 486:31–40.
   PubMed Web of Science ®Google Scholar
• Sánchez-Campillo M, Gabaldon JA, Castillo J, Benavente-García O, Del Baño MJ, Alcaraz M, Vicente V, Alvarez N, Lozano JA. 2009. Rosmarinic acid, a photo-protective agent against UV and other ionizing radiations. Food and Chemical Toxicology 47:386–392.
   PubMed Web of Science ®Google Scholar
• Sasaki H, Akamatsu H, Horio T. 1997. Effects of a single exposure to UVB radiation on the activities and protein levels of copper-zinc and manganese superoxide dismutase in cultured human keratinocytes. Photochemistry and Photobiology 65:707–713.
   PubMed Web of Science ®Google Scholar
• Schäfer M, Werner S. 2008. Oxidative stress in normal and impaired wound repair. Pharmacological Research 58:165–171.
   PubMed Web of Science ®Google Scholar
• Schallreuter KU, Wood JM. 1986. The role of thioredoxin reductase in the reduction of free radicals at the surface of the epidermis. Biochemical and Biophysical Research Communications 136:630–637.
   PubMed Web of Science ®Google Scholar
• Schallreuter KU, Wood JM. 2001. Thioredoxin reductase – its role in epidermal redox status. Journal of Photochemistry and Photobiology B Biology 64:179–184.
   PubMed Web of Science ®Google Scholar
• Schallreuter KU, Hordinsky MK, Wood JM. 1987. Thioredoxin reductase. Role in free radical reduction in different hypopigmentation disorders. Archives of Dermatology 123:615–619.
   PubMedGoogle Scholar
• Schieke SM, Ruwiedel K, Gers-Barlag H, Grether-Beck S, Krutmann J. 2005. Molecular crosstalk of the ultraviolet A and ultraviolet B signaling responses at the level of mitogen-activated protein kinases. Journal of Investigative Dermatology 124:857–859.
   PubMed Web of Science ®Google Scholar
• Schieke SM, Schroeder P, Krutmann J. 2003. Cutaneous effects of infrared radiation: From clinical observations to molecular response mechanisms. Photodermatology, Photoimmunology and Photomedicine 19:228–234.
   PubMed Web of Science ®Google Scholar
• Schilling K, Bradford B, Castelli D, Dufour E, Nash JF, Pape W, Schulte S, Tooley I, van den Bosch J, Schellauf F. 2010. Human safety review of ‘nano’ titanium dioxide and zinc oxide. Photochemical and Photobiological Sciences 9:495–509.
   PubMed Web of Science ®Google Scholar
• Schroeder P, Haendeler J, Krutmann J. 2008. The role of near infrared radiation in photoaging of the skin. Experimental Gerontology 43:629–632.
   PubMed Web of Science ®Google Scholar
• Seifert M, Scherer SJ, Edelmann W, Böhm M, Meineke V, Löbrich M, Tilgen W, Reichrath J. 2008. The DNA- mismatch repair enzyme hMSH2 modulates UV-B-induced cell cycle arrest and apoptosis in melanoma cells. Journal of Investigative Dermatology 128:203–213.
   PubMed Web of Science ®Google Scholar
• Shaath NA. 2010. Ultraviolet filters. Photochemical and Photobiological Sciences 9:464–469.
   PubMed Web of Science ®Google Scholar
• Sharma SD, Meeran SM, Katiyar SK. 2007. Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-B signaling in vivo SKH-1 hairless mice. Molecular Cancer Therapeutics 6:995–1005.
   PubMed Web of Science ®Google Scholar
• Sheedy JE, Edlich RF. 2004. Ultraviolet eye radiation: The problem and solutions. Journal of Long-Term Effects of Medical Implants 14:67–71.
   PubMedGoogle Scholar
• Shen J, Bao S, Reeve VE. 1999. Modulation of IL-10, IL-12, and IFN-gamma in the epidermis of hairless mice by UVA (320–400 nm) and UVB (280–320 nm) radiation. Journal of Investigative Dermatology 113:1059–1064.
   PubMed Web of Science ®Google Scholar
• Shin-Darlak CY, Skinner AM, Turker MS. 2005. A role for Pms2 in the prevention of tandem CC→ TT substitutions induced by ultraviolet radiation and oxidative stress. DNA Repair (Amst) 4:51–57.
   PubMed Web of Science ®Google Scholar
• Shindo Y, Hashimoto T. 1997. Time course of changes in antioxidant enzymes in human skin fibroblasts after UVA irradiation. Journal of Dermatological Science 14:225–232.
   PubMed Web of Science ®Google Scholar
• Shindo Y, Witt E, Han D, Parker L. 1994a. Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis. Journal of Investigative Dermatology 102:470–475.
   PubMed Web of Science ®Google Scholar
• Shindo Y, Witt E, Han D, Epstein W, Packer L. 1994b. Enzymatic and non-enzymatic antioxidants in epidermis and dermis of human skin. Journal of Investigative Dermatology 102:122–124.
   PubMed Web of Science ®Google Scholar
• Shindo Y, Witt E, Hand D, Tzeng B, Aziz T, Nguyen L, Packer L. 1994c. Recovery of antioxidants and reduction in lipid hydroperoxides in murine epidermis and dermis after acute ultraviolet radiation exposure. Photodermatology, Photoimmunology and Photomedicine 10:183–191.
   PubMed Web of Science ®Google Scholar
• Sime S, Reeve VE. 2004. Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochemistry and Photobiology 79:193–198.
   PubMed Web of Science ®Google Scholar
• Sindhu RK, Wagner FE, Kikkawa Y. 2003. Induction of cytochrome p450 1A1 and 1B1 by photooxidized tryptophan in transformed human keratinocytes. Advances in Experimental Medicine and Biology 527:297–306.
   PubMed Web of Science ®Google Scholar
• Singh RP, Agarwal R. 2009. Cosmeceuticals and silibinin. Clinical Dermatology 27:479–484.
   PubMed Web of Science ®Google Scholar
• Singh RP, Agarwal R. 2005. Mechanisms and preclinical efficacy of silibinin in preventing skin cancer. European Journal of Cancer 41:1969–1979.
   PubMed Web of Science ®Google Scholar
• Song XZ, Xia JP, Bi ZG. 2004. Effects of (-)-epigallocatechin-3-gallate on expression of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 in fibroblasts irradiated with ultraviolet A. Chinese Medical Journal (Engl) 117:1838–1841.
   PubMed Web of Science ®Google Scholar
• Stahl W, Heinrich U, Aust O, Tronnier H, Sies H. 2006. Lycopene-rich products and dietary photoprotection. Photochemical and Photobiological Sciences 5:238–242.
   PubMed Web of Science ®Google Scholar
• Steenvoorden DP, Beijersbergen van Henegouwen GM. 1998a. Glutathione ethylester protects against local and systemic suppression of contact hypersensitivity induced by ultraviolet B radiation in mice. Radiation Research 150:292–297.
   PubMed Web of Science ®Google Scholar
• Steenvoorden DP, Beijersbergen van Henegouwen GM. 1998. Glutathione ethylester protects against local and systemic suppression of contact hypersensitivity induced by ultraviolet B radiation in mice. Radiation Research 150:292–297.
   PubMed Web of Science ®Google Scholar
• Steenvoorden DP, Hasselbaink DM, Beijersbergen van Henegouwen GM. 1998b. Protection against UV-induced reactive intermediates in human cells and mouse skin by glutathione precursors: A comparison of N-acetylcysteine and glutathione ethylester. Photochemistry and Photobiology 67:651–656.
   PubMed Web of Science ®Google Scholar
• Stege H, Roza L, Vink AA, Grewe M, Ruzicka T, Grether-Beck S, Krutmann J. 2000. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. PNAS 97:1790–1795.
   PubMed Web of Science ®Google Scholar
• Steinberg ML, Hubbard K, Utti C, Clas B, Hwang BJ, Hill HZ, Orlow I. 2009. Patterns of persistent DNA damage associated with sun exposure and the glutathione S-transferase M1 genotype in melanoma patients. Photochemistry and Photobiology 85:379–386.
   PubMed Web of Science ®Google Scholar
• Sturm RA. 1998. Human pigmentation genes and their response to solar UV radiation. Mutation Research 422:69–76.
   PubMed Web of Science ®Google Scholar
• Svobodová A, Zdařilová A, Mališková J, Mikulková H, Walterová D, Vostálová J. 2007. Attenuation of UVA-induced oxidative damage to human keratinocytes by silymarin. Journal of Dermatological Science 46:21–30.
   PubMed Web of Science ®Google Scholar
• Svobodová A. 2006. Effects of natural polyphenols on UV-induced damage to keratinocytes. PhD Thesis. Olomouc: Palacký University.
   Google Scholar
• Svobodová A, Walterová D, Vostálová J. 2006. Ultraviolet light induced alteration to the skin. Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia 150:25–38.
   PubMedGoogle Scholar
• Syed DN, Malik A, Hadi N, Sarfaraz S, Afaq F, Mukhtar H. 2006. Photochemopreventive effect of pomegranate fruit extract on UVA-mediated activation of cellular pathways in normal human epidermal keratinocytes. Photochemistry and Photobiology 82:398–405.
   PubMed Web of Science ®Google Scholar
• Takahashi H, Hashimoto Y, Aoki N, Kinouchy M, Ishida-Yamamoto A, Izuka H. 2000. Copper, zinc-superoxiddismutase protects from ultraviolet B-induced apoptosis of SV-40 transformed human kerationcytes: The protection is associated with the increased levels of antioxidant enzymes. Journal of Dermatological Science 23:12–21.
   PubMed Web of Science ®Google Scholar
• Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, Brash DE. 2004. Melanin acts as a potent UVB photosensitizer to cause an atypical mode of cell death in murine skin. Proceedings of the National Academy of Sciences of the USA 101:15076–15081.
   PubMed Web of Science ®Google Scholar
• Tanaka K, Sekiguchi M, Okada Y. 1975. Restoration of ultraviolet-induced unscheduled DNA synthesis of xeroderma pigmentosum cells by the concomitant treatment with bacteriophage T4 endonuclease V and HVJ (Sendai virus). Proceedings of the National Academy of Sciences of the USA 72:4071–4075.
   PubMed Web of Science ®Google Scholar
• Thiele JJ, Schroeter C, Hsieh SN, Podda M, Parker L. 2001. The antioxidant network of the stratum corneum. In: Thiele JJ, Elsner P, editors. Current problems in Dermatology, Vol. 29. Basel: Karger.
   Google Scholar
• Thiele JJ, Traber MG, Packer L. 1998. Depletion of stratum corneum vitamin E: An early and sensitive in vivo marker of UV-induced photooxidation. Journal of Investigative Dermatology 110:756–761.
   PubMed Web of Science ®Google Scholar
• Thody AJ, Higgins EM, Wakamatsu K, Ito S, Burchill SA, Marks JM. 1991. Pheomelanin as well as eumelanin is present in human epidermis. Journal of Investigative Dermatology 97:340–344.
   PubMed Web of Science ®Google Scholar
• Trevithick JR, Shum DT, Redae S, Mitton KP, Norley C, Karlik SJ, Groom AC, Schmidt EE. 1993. Reduction of sunburn damage to skin by topical application of vitamin E acetate following exposure to ultraviolet B radiation: Effect of delaying application or of reducing concentration of vitamin E acetate applied. Scanning Microscopy 7:1269–1281.
   PubMedGoogle Scholar
• Tsatmali M, Ancans J, Thody AJ. 2002. Melanocyte function and its control by melanocortin peptides. Journal of Histochemistry and Cytochemistry 50:125–133.
   PubMed Web of Science ®Google Scholar
• Tyrrell RM. 2004. Solar ultraviolet A radiation: An oxidizing skin carcinogen that activates heme oxygenase-1. Antioxidants and Redox Signaling 6:835–840.
   PubMed Web of Science ®Google Scholar
• Van der Broeke LT, Beijersbergen van Henegouwen GM. 1995. Topically applied N-acetylcysteine as a protector against UVB-induced systemic immunosuppression. Journal of Photochemistry and Photobiology B Biology 27:61–65.
   PubMed Web of Science ®Google Scholar
• Van der Kemp PA, Blais JC, Bazin M, Boiteux S, Santus R. 2002. Ultraviolet-B-induced inactivation of human OGG1, the repair enzyme for removal of 8-oxoguanine in DNA. Photochemistry and Photobiology 76:640–648.
   PubMed Web of Science ®Google Scholar
• Vayalil PK, Elmets CA, Katiyar SK. 2003. Treatment of green tea polyphenols in hydrophilic cream prevents UVB-induced oxidation of lipids and proteins, depletion of antioxidant enzymes and phosphorylation of MAPK proteins in SKH-1 hairless mouse skin. Carcinogenesis 24:927–936.
   PubMed Web of Science ®Google Scholar
• Verschooten LS, Claerhout S, Van Laethem A, Agostinis P, Garmyn M. 2006. New strategies of photoprotection. Photochemistry and Photobiology 82:1016–1023.
   PubMed Web of Science ®Google Scholar
• Vignot S, Faivre S, Aguirre D, Raymond E. 2005. mTOR-targeted therapy of cancer with rapamycin derivatives. Annals of Oncology 16:525–537.
   PubMed Web of Science ®Google Scholar
• Wang SQ, Stanfiel JW, Osterwalder U. 2008. In vitro assessment of UVA protection by popular sunscreens available in the United States. Journal of the American Academy of Dermatology 59:934–942.
   PubMed Web of Science ®Google Scholar
• Weller R. 2003. Nitric oxide: A key mediator in cutaneous physiology. Clinical and Experimental Dermatology 28:511–514.
   PubMed Web of Science ®Google Scholar
• Wenczl E, Pool S, Timmerman A, van der Schans G, Roza L, Schothorst A. 1997. Physiological doses of ultraviolet irradiation induce DNA strand breaks in cultured human melanocytes, as detected by means of an immunochemical assay. Photochemistry and Photobiology 66:826–830.
   PubMed Web of Science ®Google Scholar
• Werninghaus K, Meydani M, Bhawan J, Margolis R, Blumberg JB, Gilchrest BA. 1994. Evaluation of the photoprotective effect of oral vitamin E supplementation. Archives of Dermatology 130:1257–1261.
   PubMed Web of Science ®Google Scholar
• Whiteman DC, Parsons PG, Green AC. 1999. Determinants of melanocyte density in adult human skin. Archives of Dermatological Research 291:511–516.
   PubMed Web of Science ®Google Scholar
• Wilhelm D, Bender K, Knebel A, Angel P. 1997. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents. Molecular and Cellular Biology 17:4792–4800.
   PubMed Web of Science ®Google Scholar
• Winkel-Shirley B. 2002. Biosynthesis of flavonoids and effects of stress. Current Opinion in Plant Biology 5:218–223.
   PubMed Web of Science ®Google Scholar
• Witte MB, Barbul A. 2002. Role of nitric oxide in wound repair. American Journal of Surgery 183:406–412.
   PubMed Web of Science ®Google Scholar
• Wiswedel I, Keihoff G, Dörner L, Navaro A, Böckelmann R, Bonnekoh B, Gardemann A Gollnick H. 2007. UVB irradiation-induced impairment of keratinocytes and adaptive responses to oxidative stress. Free Radical Research 41:1017–1027.
   PubMed Web of Science ®Google Scholar
• Wolf P, Maier H, Müllegger RR, Chadwick CA, Hofmann-Wellenhof R, Soyer HP, Hofer A, Smolle J, Cerroni L, Yarosh D, Klein J, Bucana C, Dunner K, Potten CS, Hönigsmann H, Kerl H, Kripke ML. 2000. Topical treatment with liposomes containing T4 endonuclease V protects human skin in vivo from ultraviolet-induced upregulation of interleukin-10 and tumor necrosis factor-alpha. Journal of Investigative Dermatology 114:149–156.
   PubMed Web of Science ®Google Scholar
• Wondrak GT. 2007. Let the sun shine in: Mechanisms and potential for therapeutics in skin photodamage. Current Opinion in Investigational Drugs 8:390–400.
   PubMedGoogle Scholar
• Woollons A, Clingen PH, Price ML, Arlett CF, Green MH. 1997. Induction of mutagenic damage in human fibroblasts after exposure to artificial tanning lamps. British Journal of Dermatology 137:687–692.
   PubMed Web of Science ®Google Scholar
• Wulff BC, Schick JS, Thomas-Ahner JM, Kusewitt DF, Yarosh DB, Oberyszyn TM. 2008. Topical treatment with OGG1 enzyme affects UVB-induced skin carcinogenesis. Photochemistry and Photobiology 84:317–321.
   PubMed Web of Science ®Google Scholar
• Yaar M, Gilchrest BA. 2001. Ageing and photoageing of keratinocytes and melanocytes. Clinical and Experimental Dermatology 26:583–591.
   PubMed Web of Science ®Google Scholar
• Yaar M, Gilchrest BA. 2007. Photoaging: Mechanisms, prevention and therapy. British Journal of Dermatology 157:874–887.
   PubMed Web of Science ®Google Scholar
• Yamaguchi YK, Takahashi BZ, Zmudzka A, Kornhauser A, Miller SA, Tadokoro T, Berens W, Beer JZ, Hearing VJ. 2006. Human skin responses to UV radiation: Pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB Journal 20:1486–1488.
   PubMed Web of Science ®Google Scholar
• Yarosh DB, O'Connorl A, Alas L, Potten C, Wolf P. 1999. Photoprotection by topical DNA repair enzymes: Molecular correlates of clinical studies. Photochemistry and Photobiology 69:136–140.
   PubMed Web of Science ®Google Scholar
• Yarosh DB, Kibitel J, Green L, Spinowitz A. 1991. Enhanced unscheduled DNA synthesis in UV-irradiated human skin explants treated with T4N5 liposomes. Journal of Investigative Dermatology 97:147–150.
   PubMed Web of Science ®Google Scholar
• Yarosh DB, Klein J, O'Connor A, Hawk J, Rafal E, Wolf P. 2001. Effect of topically applied T4 endonuclease V in liposomes on skin cancer in xeroderma pigmentosum: A randomised study. The Lancet 357:926–929.
   PubMed Web of Science ®Google Scholar
• Yarosh DB, Tsimis J, Yee V. 1989. Enhacement of DNA repair of UV damage in mouse and human skin by liposomes containing a DNA repair enzyme. Journal of the Society of Cosmetic Chemists 41:85–92.
   Google Scholar
• Yarosh DB, Alas L, Yee V, Oheryszyn A, Kibitel J, Mitchell D, Rosenstein R, Spinowitz A, Citron M. 1992. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Research 52:4227–4231.
   PubMed Web of Science ®Google Scholar
• Young AR. 2006. Acute effects of UVR on human eyes and skin. Progress in Biophysics and Molecular Biology 92:80–85.
   PubMed Web of Science ®Google Scholar
• Zastrow L, Groth N, Klein F, Kockott D, Lademann J, Renneberg R, Ferrero L. 2009. The missing link – light-induced (280–1,600 nm) free radical formation in human skin. Skin Pharmacology and Physiology 22:31–44.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Barakat BM, Qin S, Ray A, Elp-Mahdy MA, Wani G, Arafa ES, Mir SN, Wang QE, Wani AA. 2008. The p38 mitogen-activated protein kinase augments nucleotide excision repair by mediating DDB2 degradation and chromatin relaxation. Journal of Biological Chemistry 283:32553–32561.
   PubMed Web of Science ®Google Scholar
• Zhevago NA, Samoilova KA, Calderhead RG. 2006. Polychromatic light similar to the terrestrial solar spectrum without its UV component stimulates DNA synthesis in human peripheral blood lymphocytes in vivo and in vitro. Photochemistry and Photobiology 82:1301–1308.
   PubMed Web of Science ®Google Scholar
• Zhevago NA, Samoilova KA, Obolenskaia KD, Sokolov DI. 2005. Changes in cytokine content in the peripheral blood of volunteers after their exposure to polychromatic visible and infrared light. Tsitologiia 47:450–463.
   PubMedGoogle Scholar
• Zhou BB, Elledge JS. 2000. The DNA damage response: Putting checkpoints in perspective. Nature 408:433–439.
   PubMed Web of Science ®Google Scholar
• Zhu M, Bowden GT. 2004. Molecular mechanism(s) for UV-B irradiation-induced glutathione depletion in cultured human keratinocytes. Photochemistry and Photobiology 80:191–196.
   PubMed Web of Science ®Google Scholar
• Zvyagin AV, Zhao X, Gierden A, Sanchez W, Ross JA Roberts MS 2008. Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo. Journal of Biomedical Optics 13:064031.
   PubMed Web of Science ®Google Scholar