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Research Article

Calculation of the biological effects of ion beams based on the microscopic spatial damage distribution pattern

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Pages 103-107 | Received 17 Dec 2010, Accepted 27 Jul 2011, Published online: 05 Oct 2011

References

  • Astrahan M. 2008. Some implications of linear-quadratic-linear radiation dose-response with regard to hypofractionation. Medical Physics 35:4161–4172.
  • Elsässer T, Scholz M. 2007. Cluster effects within the Local Effect Model. Radiation Research 167:319–329.
  • Elsässer T, Krämer M, Scholz M. 2008a. Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo. International Journal of Radiation Oncology*Biology*Physics 71:866–872.
  • Elsässer T, Cunrath R, Krämer M, Scholz M. 2008b. Impact of track structure calculations on biological treatment planning in ion radiotherapy. New Journal of Physics 10:075005
  • Elsässer T, Weyrather WK, Friedrich T, Durante M, Iancu G, Krämer M, Kragl G, Brons S, Winter M, Weber KJ, Scholz M. 2010. Quantification of the relative biological effectiveness for ion beam radiotherapy: Direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning. International Journal of Radiation Oncology*Biology*Physics 78:1177–1183.
  • Friedland W, Jacob P, Paretzke HG, Ottolenghi A, Ballarini F, Liotta M. 2006. Simulation of light ion induced DNA damage patterns. Radiation Protection Dosimetry 122:116–120.
  • Furusawa Y, Fukutsu K, Aoki M, Itsukaichi H, Eguchi-Kasai K, Ohara H, . 2000. Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne-ion beams. Radiation Research 154:485–496.
  • Johnston PJ, MacPhail SH, Banáth JP, Olive PL. 1998. Higher-order chromatin structure-dependent repair of DNA double-strand breaks: Factors affecting elution of DNA from nucleoids. Radiation Research 149:533–542.
  • Jones B. 2010. The apparent increase in the beta-parameter of the linear quadratic model with increased linear energy transfer during fast neutron irradiation. British Journal of Radiology 83:433–436.
  • Karger CP, Peschke P, Sanchez-Brandelik R, Scholz M, Debus J. 2006. Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: Experimental results and clinical implications. International Journal of Radiation Oncology*Biology*Physics 66:1488–1497.
  • Krämer M, Scholz M. 2006. Rapid calculation of biological effects in ion radiotherapy. Physics in Medicine and Biology 51:1959–1970.
  • Nikjoo H, O'Neill P, Wilson WE, Goodhead DT. 2001. Computational approach for determining the spectrum of DNA damage induced by ionizing radiation. Radiation Research 156:577–583.
  • Ostashevsky J. 1998. A polymer model for the structural organization of chromatin loops and minibands in interphase chromosomes. Molecular Biology of the Cell 9:3031–3040.
  • Ottolenghi A, Merzagora M, Tallone L, Durante M, Paretzke HG, Wilson WE. 1995. The quality of DNA double-strand breaks: A Monte Carlo simulation of the end-structure of strand breaks produced by protons and alpha particles. Radiation Environmental Biophysics 34:239–244.
  • Radulescu I, Elmroth K, Stenerlöw B. 2004. Chromatin organization contributes to non-randomly distributed double-strand breaks after exposure to high-LET radiation. Radiation Research 161(1):1–8.
  • Scholz M, Kellerer AM, Kraft-Weyrather W, Kraft G. 1997. Computation of cell survival in heavy ion beams for therapy. The model and its approximation. Radiation and Environmental Biophysics 36:59–66.
  • Solovjeva L, Svetlova M, Stein G, Chagin V, Rozanov Y, Zannis-Hadjopoulos M, Price G, Tomilin N. 1998. Conformation of replicated segments of chromosome fibres in human S-phase nucleus. Chromosome Research 6:595–602.
  • Ward JF. 1994. The complexity of DNA damage: Relevance to biological consequences. International Journal of Radiation Biology 66:427–432.
  • Yokota H, van den Engh G, Hearst JE, Sachs RK, Trask BJ. 1995. Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus. Journal of Cell Biology 130:1239–1249.

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