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3D-MODELLING OF RADON-INDUCED CELLULAR RADIOBIOLOGICAL EFFECTS

3D-modelling of radon-induced cellular radiobiological effects in bronchial airway bifurcations: Direct versus bystander effects

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Pages 477-492 | Received 15 Dec 2011, Accepted 08 Mar 2012, Published online: 13 Apr 2012

References

  • Balásházy I, Hofmann W. 1993. Particle deposition in airway bifurcations: I. Inspiratory flow. Journal of Aerosol Science 24:745–772.
  • Balásházy I, Hofmann W. 2000 Quantification of local deposition patterns of inhaled radon decay products in human bronchial airway bifurcations. Health Physics 78(2):147–158.
  • Balásházy I, Hofmann W, Heistracher T. 2003. Local particle deposition patterns may play a key role in the development of lung cancer. Journal of Applied Physiology 94:1719–1725.
  • Balásházy I, Farkas A, Madas B, Hofmann W. 2009. Non-linear relationship of cell hit and transformation probabilities in a low dose of inhaled radon progenies. Journal of Radiological Protection 29:147–162.
  • Belyakov OV, Malcolmson AM, Folkard M, Prise KM, Michael BD. 2001. Direct evidence for a bystander effect of ionizing radiation in primary human fibroblasts. British Journal of Cancer 84:674–679.
  • Brüske-Hohlfeld I, Rosario AS, Wolke G, Heinrich J, Kreuzer M, Kreienbrock L, Wichmann HE. 2006. Lung cancer risk among former uranium miners of the WISMUT Company in Germany. Health Physics 90:208–216.
  • Cassee FR., Freijer JI, Subramaniam R, Asgharian B, Miller FJ, Bree van L, Rombout PJA. 1999. RIVM, Research for man and environment, Report 650010018, December.
  • Churg A, Vedal S. 1996. Carinal and tubular airway particle concentrations in the large airways of non-smokers in the general population: Evidence for high particle concentration at airway carinas. Occupational and Environmental Medicine 53:553–558.
  • Cohen BS. 1996. Particle deposition in human and canine tracheobronchial casts: A determinant of radon dose to the critical cells of the respiratory tract. Health physics 70:695–705.
  • Fakir H, Hofmann W, Aubineau-Laniece I. 2006. Modelling the effect of non-uniform radon progeny activities on transformation frequencies in human bronchial airways. Radiation Protection Dosimetry 121:221–235.
  • Fakir H, Hofmann W, Tan WY, Sachs RK. 2009. Triggering-response model for radiation-induced bystander effects. Radiation Research 171:320–331.
  • Farkas Á, Hofmann W, Balásházy I, Szőke I. 2006. CFD as a tool in risk assessment of inhaled radon progenies. Radiation Protection Dosimetry 122:537–539.
  • Farkas Á, Balásházy I. 2008. Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Computers in Biology and Medicine 38:508–518.
  • Farkas Á, Hofmann W, Balásházy I, Szőke I, Madas BG, Moustafa M. 2011. Effect of site-specific bronchial radon progeny deposition on the spatial and temporal distributions of cellular responses. Radiation and Environmental Biophysics 50:281–297.
  • Gaillard S, Pusset D, de Toledo SM, Fromm M, Azzan EI. 2009. Propagation distance of the α-particle-induced bystander effect: the role of nuclear traversal and gap junction communication. Radiation Research 171:513–520.
  • George AC, Hinchliffe L. 1972. Measurements of uncombined radon daughters in uranium mines. Health Physics 23:791–803.
  • Hegedűs CJ, Balásházy I, Farkas Á. 2004. Detailed mathematical description of the geometry of airway bifurcations. Respiratory Physiology & Neurobiology 141:99–114.
  • Heidenreich WE, Paretzke HG. 2008. Promotion of initiated cells by radiation-induced cell inactivation. Radiation Research 170:613–617.
  • International Commission on Radiological Protection (ICRP). 1994. Human respiratory tract model for radiological protection. ICRP Publication 66, Annals of the ICRP, Vol. 24, Nos. 1–3. Oxford: Pergamon.
  • International Commission on Radiation Units (ICRU). 1993. Stopping powers and ranges for proton and alpha particles. ICRU Report 49. Bethesda: International Commission on Radiation Units and Measurements, Inc.
  • James AC, Birchall A, Akabani G. 2004. Comparative dosimetry of BEIR VI revisited. Radiation Protection Dosimetry 108:3–26.
  • Johnson NF. 1995. Radiobiology of lung target cells. Radiation Protection Dosimetry 60(4):327–330.
  • Kerekes A, Nagy A, Czitrovszky A, Oszetzky D. 2010a. Air flow measurements with a realistic transparent hollow airway model. In: Egmond and Zee, editors. Proceedings from the 18th International Conference on Advanced Laser Technologies, 9–16 September 2010, The Netherlands. pp 134–135.
  • Kerekes A, Nagy A, Czitrovszky A, Oszetzky D. 2010b. Airflow experiments with hollow bronchial airway model. Proceedings from the International Aerosol Conference. 29 August–3 September 2010, Helsinki, Finland. Available from: http://www.atm.helsinki.fi/IAC2010/abstracts/abstbook.html.
  • Kim CS, Fisher DM. 1999. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Science and Technology 31:198–220.
  • Kinsara AA, Loyalka SK, Tompson RV, Miller WH, Holub RF. 1995. Deposition patterns of molecular-phase radon progeny (po-218) in lung bifurcations. Health Physics 68:371–382.
  • Koblinger L, Hofmann W. 1988. Monte Carlo model for aerosol deposition in human lungs. Annals of Occupational Hygiene 32 (inhaled particles VI):65–70.
  • Koblinger L, Hofmann W. 1990. Monte Carlo modelling of aerosol deposition in human lungs, Part I: Simulation of particle transport in a stochastic lung structure. Journal of Aerosol Science 21:661–674.
  • Leonard BE. 2009. The range of the bystander effect signal in three-dimensional tissue and estimation of the range in human tissue at low radon levels. Radiation Research 171:374–378.
  • Lubin JH, Boice JD Jr, Edling C, Hornung RW, Howe G, Kunz E, Kusiak RA, Morrison HI, Radford EP, Samet JM, Tirmarche M, Woodward A, Yao SX. 1995. Radon-exposed underground miners and inverse dose-rate (protraction enhancement) effects. Health Physics 69: 494–500.
  • Madas BG, Balásházy I, Farkas Á. 2010. Role of bronchial mucus thickness in the biological effects of inhaled radon progenies. Proceedings from the International Aerosol Conference, 29 August–3 September 2010, Helsinki, Finland. P3Y3/3G0, Available from: http://www.atm.helsinki.fi/IAC2010/abstracts/abstbook.html.
  • Madas B, Balásházy I, Farkas Á, Szo ke I. 2011. Cellular burdens and biological effects on tissue level caused by inhaled radon progenies. Radiation Protection Dosimetry 143:253–257.
  • Madas BG, Balásházy I. 2011. Mutation induction by inhaled radon progeny modelled at the tissue level. Radiation and Environmental Biophysics 50:553–570.
  • Marsh JW, Bessa Y, Birchall A, Blanchardon E, Hofmann W, Nosske D, Tomasek L. 2008. Dosimetric models used in the Alpha-Risk project to quantify exposure of uranium miners to radon gas and its progeny. Radiation Protection Dosimetry 130:101–106.
  • Mercer RR, Russell ML, Crapo JD. 1991. Radon dosimetry based on the depth distribution of nuclei in human and rat lungs. Health Physics 61:117–130.
  • Mercer RR, Russell ML, Roggli VL, Crapo JD. 1994. Cell number and distribution in human and rat airways. American Journal of Respiratory Cell and Molecular Biology 10:613–624.
  • Mulloy KB, James DS, Mohs K, Kornfeld M. 2001. Lung cancer in a nonsmoking underground uranium miner. Environmental Health Perspectives 109:305–309.
  • National Research Council (NRC). 1999. Health effects of exposure to radon (BEIR VI). Washington, DC: National Academy Press.
  • Shuryak I, Sachs RK, Brenner DJ. 2007. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiation Research 168:741–749.
  • Sturm R, Hofmann W. 2007. Stochastic modelling for the clearance of insoluble particles from the tracheobronchial tree of the human lung. Bulletin of Mathematical Biology 69:395–415.
  • Szőke I, Farkas Á, Balásházy I, Hofmann W. 2008. Modelling of cell deaths and cell transformations of inhaled radon in homes and mines based on a biophysical and microdosimetric model. International Journal of Radiation Biology 84:127–138.
  • Szőke I, Farkas Á, Balásházy I, Hofmann W. 2009. Stochastic aspects of primary cellular consequences of radon inhalation. Radiation Research 171:96–106.
  • Tomasek L, Rogel A, Tirmarche M, Mitton N, Laurier D. 2008. Lung cancer in French and Czech uranium miners: Radon-associated risk at low exposure rates and modifying effects of time since exposure and age at exposure. Radiation Research 169:125–137.
  • Tubiana M, Aurengo A, Averbeck D, Masse R. 2006. The debate on the use of linear no threshold for assessing the effects of low doses. Journal of Radiological Protection 26:317–324.
  • Walsh L, Tschense A, Schnelzer M, Dufey F, Grosche B, Kreuzer M. 2010. The influence of radon exposures on lung cancer mortality in German uranium miners, 1946–2003. Radiation Research 173:79–90.
  • Wu LJ, Randers-Pehrson G, Xu A, Waldren CA, Geard CR, Yu ZL, Hei TK. 1999. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proceedings of the National Academy of Sciences of the USA 96:4959–4964.

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