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TUMOUR MICROENVIRONMENT AND RADIATION RESPONSE

Tumour microenvironment and radiation response in sarcomas originating from tumourigenic human mesenchymal stem cells

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Pages 457-465 | Received 17 Jul 2011, Accepted 02 Apr 2012, Published online: 08 May 2012

References

  • Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. 2003. Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the USA 100:3983–3988.
  • Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN. 2006. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756–760.
  • Baumann M, Krause M, Hill R. 2008. Exploring the role of cancer stem cells in radioresistance. Nature Reviews Cancer 8:545–554.
  • Bonnet D, Dick JE. 1997. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Medicine 3:730–737.
  • Brizel DM, Scully SP, Harrelson JM, Layfield LJ, Bean JM, Prosnitz LR, Dewhirst MW. 1996. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Research 56:941–943.
  • Burns JS, Abdallah BM, Guldberg P, Rygaard J, Schroder HD, Kassem M. 2005. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Cancer Research 65:3126–3135.
  • Burns JS, Abdallah BM, Shrøder HD, Kassem M. 2008. The histopathology of a human mesenchymal stem cell experimental tumor model: Support for an hMSC origin for Ewing's sarcoma? Histology and Histopathology 23:1229–1240.
  • Chan N, Pires IM, Bencokova Z, Coackley C, Luoto KR, Bhogal N, Lakshman M, Gottipati P, Oliver FJ, Helleday T, Hammond EM, Bristow RG. 2010. Contextual synthetic lethality of cancer cell kill based on the tumor microenvironment. Cancer Research 70: 8045–8054.
  • D'Andrea FP, Horsman MR, Kassem M, Overgaard J, Safwat A. 2011a. Tumourigenicity and radiation resistance of mesenchymal stem cells. Acta Oncologica online: 1–11 [Cited 2012 March 30]. Available from: http://informahealthcare.com/doi/full/10.3109/0284186X.2011.636752
  • D'Andrea FP, Safwat A, Kassem M, Gautier L, Overgaard J, Horsman MR. 2011b. Cancer stem cell overexpression of nicotinamide N-methyltransferase enhances cellular radiation resistance. Radiotherapy and Oncology 99:373–378.
  • Eramo A, Lotti F, Sette G, Pilozzi E, Biffoni M, Di Virgilio A, Conticello C, Ruco L, Peschle C, De Maria R. 2007. Identification and expansion of the tumorigenic lung cancer stem cell population. Cell Death & Differentiation 15:504–514.
  • Gibbs CP, Kukekov VG, Reith JD, Tchigrinova O, Suslov ON, Scott EW, Ghivizzani SC, Ignatova TN, Steindler DA. 2005. Stem-like cells in bone sarcomas: Implications for tumorigenesis. Neoplasia 7:967.
  • Gray LH, Conger AD, Ebert M, Hornsey S, Scott OCA. 1953. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. The British Journal of Radiology 26:638–648.
  • Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, Goodell MA, Brenner MK. 2004. A distinct ‘side population’ of cells with high drug efflux capacity in human tumor cells. Proceedings of the National Academy of Sciences of the USA 101:14228–14233.
  • Li Z, Bao S, Wu Q, Wang H, Eyler C, Sathornsumetee S, Shi Q, Cao Y, Lathia J, McLendon RE. 2009. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 15:501–513.
  • Nordsmark M, Alsner J, Keller J, Nielsen OS, Jensen OM, Horsman MR, Overgaard J. 2001. Hypoxia in human soft tissue sarcomas: Adverse impact on survival and no association with p53 mutations. British Journal of Cancer 84:1070–1075.
  • Nordsmark M, Overgaard M, Overgaard J. 1996. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiotherapy and oncology 41:31–39.
  • Offersen BV, Borre M, Overgaard J. 2003. Quantification of angiogenesis as a prognostic marker in human carcinomas: A critical evaluation of histopathological methods for estimation of vascular density. European Journal of Cancer 39:881–890.
  • Raleigh JA, Chou SC, Arteel GE, Horsman MR. 1999. Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiation Research 151:580–589.
  • Serakinci N, Guldberg P, Burns JS, Abdallah BM, Schrødder H, Jensen T, Kassem M. 2004. Adult human mesenchymal stem cell as a target for neoplastic transformation. Oncogene 23:5095–5098.
  • Simonsen JL, Rosada C, Serakinci N, Justesen J, Stenderup K, Rattan SI, Jensen TG, Kassem M. 2002. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nature Biotechnology 20: 592–596.
  • Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, Dirks PB. 2003. Identification of a cancer stem cell in human brain tumors. Cancer Research 63:5821–5828.
  • Torres MA, Ballo MT, Butler CE, Feig BW, Cormier JN, Lewis VO, Pollock RE, Pisters PW, Zagars GK. 2007. Management of locally recurrent soft-tissue sarcoma after prior surgery and radiation therapy. International Journal of Radiation Oncology*Biology*Physics 67:1124–1129.
  • Weidner N, Semple JP, Welch WR, Folkman J. 1991. Tumor angiogenesis and metastasis – correlation in invasive breast carcinoma. New England Journal of Medicine 324:1–8.
  • Yaromina A, Kroeber T, Meinzer A, Boeke S, Thames H, Baumann M, Zips D. 2011. Exploratory study of the prognostic value of microenvironmental parameters during fractionated irradiation in human squamous cell carcinoma xenografts. International Journal of Radiation Oncology*Biology*Physics 80:1205–1213.
  • Yaromina A, Thames H, Zhou X, Hering S, Eicheler W, Dörfler A, Leichtner T, Zips D, Baumann M. 2010. Radiobiological hypoxia, histological parameters of tumour microenvironment and local tumour control after fractionated irradiation. Radiotherapy and Oncology 96: 116–122.
  • Zips D, Le K, Yaromina A, Dörfler A, Eicheler W, Zhou X, Geyer P, Hilberg F, Baumann M. 2009. Triple angiokinase inhibition, tumour hypoxia and radiation response of FaDu human squamous cell carcinomas. Radiotherapy and oncology 92:405–410.

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