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Research Article

Proteasome inhibition protects human peripheral blood mononuclear cells from radiation-induced oxidative stress

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Pages 493-500 | Received 17 May 2012, Accepted 19 Feb 2013, Published online: 16 Apr 2013

References

  • Abbas S, Bhoumik A, Dahl R, Vasile S, Krajewski S, Cosford ND, Ronai ZA. 2007. Preclinical studies of celastrol and acetyl isogambogic acid in melanoma. Clinical Cancer Research: An official journal of the American Association for Cancer Research 13: 6769–6778.
  • Ahmed KM, Li JJ. 2008. NF-kappa B-mediated adaptive resistance to ionizing radiation. Free Radical Biology & Medicine 44:1–13.
  • Aiken CT, Kaake RM, Wang X, Huang L. 2011. Oxidative stress- mediated regulation of proteasome complexes. Molecular and Cellular Proteomics 10:R110.006924.
  • Chen J, Regan RF. 2005. Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury. Current Neurovascular Research 2:189–196.
  • Chow AM, Brown IR. 2007. Induction of heat shock proteins in differentiated human and rodent neurons by celastrol. Cell Stress & Chaperones 12:237–244.
  • Ciechanover A, Orian A, Schwartz AL. 2000. Ubiquitin-mediated proteolysis: biological regulation via destruction. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology 22:442–451.
  • Dai Y, DeSano JT, Meng Y, Ji Q, Ljungman M, Lawrence TS, Xu L. 2009. Celastrol potentiates radiotherapy by impairment of DNA damage processing in human prostate cancer. International Journal of Radiation Oncology, Biology, Physics 74:1217–1225.
  • Dai Y, Desano J, Tang W, Meng X, Meng Y, Burstein E, Lawrence TS, Xu L. 2010. Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB. PloS One 5:e14153.
  • de Sá JPM. 2007. Applied statistics: Using SPSS, STATISTICA, MATLAB and R. Berlin: Springer.
  • Ding Q, Reinacker K, Dimayuga E, Nukata V, Drake J, Butterfield DA, Dunn JC, Martin S, Bruce-Keller AJ, Keller JN. 2003. Role of proteasome in protein oxidation and neural viability following low-level oxidative stress. FEBS Letters 546:228–232.
  • Dreger H, Westphal K, Weller A, Baumann G, Stangl V, Meiners S, Stangl K. 2009. Nrf2-dependent upregulation of antioxidative enzymes: A novel pathway for proteasome inhibitor-mediated cardioprotection. Cardiovascular Research 83:354–361.
  • Dreger H, Westphal K, Wilck N, Baumann G, Stangl V, Stangl K, Meiners S. 2010. Protection of vascular cells from oxidative stress by proteasome inhibition depends on Nrf2. Cardiovascular Research 85:395–403.
  • Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL. 1995. Inhibition of proteasome activities and subunit-specific amino- terminal threonine modification by lactacystin. Science 268: 726–731.
  • Giguere CJ, Schnellmann RG. 2008. Limitations of SLLVY-AMC in calpain and proteasome measurements. Biochemical and Biophysical Research Communications 371:578–581.
  • Goldberg AL. 2003. Protein degradation and protection against misfolded or damaged proteins. Nature 426:895–899.
  • Hideshima T, Richardson P, Chauhan D, Palombella VJ, Elliott PJ, Adams J, Anderson KC. 2001. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Research 61:3071–3076.
  • Holley AK, Xu Y, St Clair DK, St Clair WH. 2010. RelB regulates manganese superoxide dismutase gene and resistance to ionizing radiation of prostate cancer cells. Annals of the New York Academy of Sciences 1201:129–136.
  • Holley AK, Bakthavatchalu V, Velez-Roman JM, St Clair DK. 2011. Manganese superoxide dismutase: Guardian of the powerhouse. International Journal of Molecular Sciences 12:7114–7162.
  • Ivanova KG, Stankova KG, Nikolov VN, Georgieva RT, Minkova KM, Gigova LG, Rupova IT, Boteva RN. 2010. The biliprotein C-phycocyanin modulates the early radiation response: a pilot study. Mutation Research 695:40–45.
  • Jackson G, Einsele H, Moreau P, Miguel JS. 2005. Bortezomib, a novel proteasome inhibitor, in the treatment of hematologic malignancies. Cancer Treatment Reviews 31:591–602.
  • Jesenberger V, Jentsch S. 2002. Deadly encounter: Ubiquitin meets apoptosis. Nature reviews. Molecular Cell Biology 3:112–121.
  • Kensler TW, Wakabayashi N, Biswal S. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology 47:89–116.
  • Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, Spitz DR, Deng CX, Gius D. 2010. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell 17:41–52.
  • Kraft DC, Deocaris CC, Wadhwa R, Rattan SI. 2006. Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts. Annals of the New York Academy of Sciences 1067:420–424.
  • Leach JK, Van Tuyle G, Lin PS, Schmidt-Ullrich R, Mikkelsen RB. 2001. Ionizing radiation-induced, mitochondria-dependent generation of reactive oxygen/nitrogen. Cancer Research 61:3894–3901.
  • Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ. 2008. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the USA 105:18525–18530.
  • Maseda D, Meister S, Neubert K, Herrmann M, Voll RE. 2008. Proteasome inhibition drastically but reversibly impairs murine lymphocyte development. Cell Death and Differentiation 15: 600–612.
  • McDonald JT, Kim K, Norris A, Vlashi E, Phillips TM, Lagadec C, Della Donna L, Ratikan J, Szelag H, Hlatky L, McBride WH. 2010. Ionizing radiation activates Nrf2 antioxidant response. Cancer Research 70:8886–8895.
  • Meiners S, Ludwig A, Stangl V, Stangl K. 2008. Proteasome inhibitors: Poisons and remedies. Medicinal Research Reviews 28:309–327.
  • Meiners S, Ludwig A, Lorenz M, Dreger H, Baumann G, Stangl V, Stangl K. 2006. Nontoxic proteasome inhibition activates a protective antioxidant defense response in endothelial cells. Free Radical Biology & Medicine 40:2232–2241.
  • Mera K, Kawahara K, Ttada K, Hashiguchi T, Maruyama I, Kanekura T. 2010. ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB. Biochemical and Biophysical Research Communications 397:350–354.
  • Naujokat C, Hoffmann S. 2002. Role and function of the 26S proteasome in proliferation and apoptosis. Laboratory Investigation; a Journal of Technical Methods and Pathology 82:965–980.
  • Nawrocki ST, Carew JS, Dunner K Jr, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, McConkey DJ. 2005. Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells. Cancer Research 65: 11510–11519.
  • Oberley LW. 2005. Mechanism of the tumor suppressive effect of MnSOD overexpression. Biomedicine & Pharmacotherapy 59: 143–148.
  • Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. 1994. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell 78: 773–785.
  • Reineckel T, Sitte N, Ullrich O, Kuckelkorn U, Davies KL, Grune T. 1998. Comparative resistance of the 20s and 26s proteasome to oxidative stress. Biochemical Journal 335:637–642.
  • Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL. 1994. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761–771.
  • Sasaki T, Kishi M, Saito M, Tanaka T, Higuchi N, Kominami E, Katunuma N, Murachi T. 1990. Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. Journal of Enzyme Inhibition 3:195–201.
  • Satou Y, Matsuoka M. 2004. Proteasome inhibitor, bortezomib (Vercade), potently inhibits the growth of adult T-cell leukemia cells. Japanese Journal of Clinical Medicine 62:1363–1367.
  • Stankova K, Ivanova K, Nikolov V, Minkova K, Gigova L, Georgieva R, Boteva R. 2011. The biliprotein C-phycocyanin modulates the DNA damage response in lymphocytes from nuclear power plant workers. In: Tsvetkov PV, editor. Nuclear power – operation, safety and environment. 51000 Rijeka, Croatia: InTech. pp. 327–340.
  • Trott A, West JD, Klaic L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. 2008. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Molecular Biology of the Cell 19: 1104–1112.
  • Wang S, Kaufman RJ. 2012. The impact of the unfolded protein response on human disease. Journal of Cell Biology 197:857–867.
  • Wang T, Hu Y-C, Dong S, Fan M, Tamae D, Ozeki M, Gao Q, Gius D, Li JJ. 2005. Co-activation of ERK, NF-κB, and GADD45β in response to ionizing radiation. The Journal of Biological Chemistry 280: 12593–12601.
  • Wang X, Luo H, Chen H, Duguid W, Wu J. 1998. Role of proteasomes in T cell activation and proliferation. Journal of Immunology 160: 788–801.
  • Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RI. 2004. Celastrols as inducers of the heat shock response and cytoprotection. The Journal of Biological Chemistry 279:56053–56060.
  • Yamamoto N, Sawada H, Izumi Y, Kume T, Katsuki H, Shimohama S, Akaike A. 2007. Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: Relevance to Parkinson disease. The Journal of Biological Chemistry 282:4364–4372.
  • Yang H, Chen D, Cui QC, Yuan X, Dou QP. 2006. Celastrol, a triterpene extracted from the Chinese ‘Thunder of God Vine’, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice. Cancer Research 66:4758–4765.
  • Yew EH, Cheung NS, Choy MS, Qi RZ, Lee AY, Peng ZF, Melendez AJ, Manikandan J, Koay ES, Chiu LL, Ng WL, Whiteman M, Kandiah J, Halliwell B. 2005. Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: A microarray analysis. Journal of Neurochemistry 94:943–956.
  • Zhou KM, Johnson AP, Rando TA. 2001. NF kappa B and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells. Free Radical Biology & Medicine 31:1405–1416.

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