Radioprotective combination of α-tocopherol and ascorbic acid promotes apoptosis that is evident by release of low-molecular weight DNA fragments into circulation

References

• Cheng C, Omura-Minamisawa M, Kang Y, Hara T, Koike I, Inoue T. 2009. Quantification of circulating cell-free DNA in the plasma of cancer patients during radiation therapy. Cancer Sci 100:303–309.
   PubMed Web of Science ®Google Scholar
• Choi JJ, Reich CF III, Pisetsky DS. 2004. Release of DNA from dead and dying lymphocyte and monocyte cell lines in vitro. Scand J Immunol 60:159–166.
   PubMed Web of Science ®Google Scholar
• Christmann M, Kaina B. 2013. Transcriptional regulation of human DNA repair genes following genotoxic stress: Trigger mechanisms, inducible responses and genotoxic adaptation. Nucleic Acids Res 41:8403–8420.
   PubMed Web of Science ®Google Scholar
• Clavería C, Giovinazzo G, Sierra R, Torres M. 2013. Myc-driven endogenous cell competition in the early mammalian embryo. Nature 500:39–44.
   PubMed Web of Science ®Google Scholar
• Decordier I, Dillen L, Cundari E, Kirsch-Volders M. 2002. Elimination of micronucleated cells by apoptosis after treatment with inhibitors of microtubules. Mutagenesis 17:337–344.
   PubMed Web of Science ®Google Scholar
• Ermakov AV, Konkova MS, Kostyuk SV, Izevskaya VL, Baranova A, Veiko NN. 2013. Oxidized extracellular DNA as a stress signal in human cells. Oxid Med Cell Longev 2013:e649747.
   PubMed Web of Science ®Google Scholar
• Garcia-Quevedo L, Blanco J, Sarrate Z, Vidal F. 2014. Apoptosis mediated by phosphatidylserine externalization in the elimination of aneuploid germ cells during human spermatogenesis. Andrology 2:892–898.
   PubMed Web of Science ®Google Scholar
• Gillies RJ, Verduzco D, Gatenby RA. 2012. Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer 12:487–493.
   PubMed Web of Science ®Google Scholar
• Green DR. 2005. Apoptotic pathways: Ten minutes to dead. Cell 121:671–674.
   PubMed Web of Science ®Google Scholar
• Hemmati AA, Nazari Z, Ranjbari N, Torfi A. 2008. Comparison of the preventive effect of vitamin C and E on hexavalent chromium induced pulmonary fibrosis in rat. Inflammopharmacology 16:195–197.
   PubMedGoogle Scholar
• Holdenrieder S, Stiber P. 2009. Clinical use of circulating nucleosomes. Crit Rev Clin Lab Sci 46:1–24.
   PubMed Web of Science ®Google Scholar
• Jiang B, Zong C, Zhao H, Ji Y, Tong J, Cao Y. 2013. Induction of adaptive response in mice exposed to 900 MHz radiofrequency fields: Application of micronucleus assay. Mutat Res 751:127–129.
   PubMed Web of Science ®Google Scholar
• Loganathan R, Selvaduray KR, Nesaretnam K, Radhakrishnan AK. 2013. Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity. Cell Prolif 46:203–213.
   PubMed Web of Science ®Google Scholar
• Mathieu J, Richard S, Ballester B, Chancerelle Y, Multon E. 1999. Apoptosis and gamma rays. Ann Pharm Fr 57:314–323.
   PubMedGoogle Scholar
• Mueller DL. 2010. Mechanisms maintaining peripheral tolerance. Nat Immunol 11:21–27.
   PubMed Web of Science ®Google Scholar
• Nogueira-Pedro A, Barbosa CM, Segreto HR, Lungato L, D’Almeida V, Moraes AA, Miranda A, Paredes-Gamero EJ, Ferreira AT. 2011. α-Tocopherol induces hematopoietic stem/progenitor cell expansion and ERK1/2-mediated differentiation. J Leukoc Biol 90:1111–1117.
   PubMed Web of Science ®Google Scholar
• Pisetsky DS, Fairhurst AM. The origin of extracellular DNA during the clearance of dead and dying cells. 2007. Autoimmunity 40:281–284.
   PubMed Web of Science ®Google Scholar
• Rothfuss A, Dennog C, Speit G. 1998. Adaptive protection against the induction of oxidative DNA damage after hyperbaric oxygen treatment. Carcinogenesis 19:1913–1917.
   PubMed Web of Science ®Google Scholar
• Rouaki F, Mazari A, Kanane A, Errahmani MB, Ammouche A. 2013. Cardiotoxicity induced by dietary oxidized sunflower oil in rats: pro-and antioxidant effects of α-tocopherol. Int J Vitam Nutr Res 83:367–376.
   PubMed Web of Science ®Google Scholar
• Schlade-Bartusiak K, Stembalska-Kozlowska A, Bernady M, Kudyba M, Sasiadek M. 2002. Analysis of adaptive response to bleomycin and mitomycin C. Mutat Res 513:75–81.
   PubMed Web of Science ®Google Scholar
• Shinozaki K, Hosokawa Y, Hazawa M, Kashiwakura I, Okumura K, Kaku T, Nakayama E. 2011. Ascorbic acid enhances radiation-induced apoptosis in an HL60 human leukemia cell line. J Radiat Res 52:229–237.
   PubMed Web of Science ®Google Scholar
• Singh PK, Wise SY, Ducey EJ, Brown DS, Singh VK. 2011. Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor. Cytokine 56:411–421.
   PubMed Web of Science ®Google Scholar
• Singh VK, Beattie LA, Seed TM. 2013a. Vitamin E: Tocopherols and tocotrienols as potential radiation countermeasures. J Radiat Res 54:973–988.
   PubMed Web of Science ®Google Scholar
• Singh VK, Singh PK, Wise SY, Posarac A, Fatanmi OO. 2013b. Radioprotective properties of tocopherol succinate against ionizing radiation in mice. J Radiat Res 54:210–220.
   PubMed Web of Science ®Google Scholar
• Tang FR, Loke WK. 2014. Molecular mechanisms of low dose ionizing radiation-induced hormesis, adaptive responses, radioresistance, bystander effects, and genomic instability. Int J Radiat Biol 21:1–15.
   Google Scholar
• Vasilyeva IN. 2001. Low-molecular-weight DNA as an index of the influence of ionizing radiation. Ann NY Acad Sci 945:221–228.
   PubMed Web of Science ®Google Scholar
• Vladimirov VG, Belokhvostov AS, Sherlina SS, Vasilyeva IN, Voskresensky AM. 1992. Extracellular DNA level in the blood of irradiated rats. Int J Radiat Biol 62:667–671.
   PubMed Web of Science ®Google Scholar
• Wambi CO, Sanzari JK, Sayers CM, Nuth M, Zhou Z, Davis J, Finnberg N, Lewis-Wambi JS, Ware JH, El-Deiry WS, Kennedy AR. 2009. Protective effects of dietary antioxidants on proton total-body irradiation-mediated hematopoietic cell and animal survival. Radiat Res 172:175–186.
   PubMed Web of Science ®Google Scholar
• Weiss JF, Landauer MR. 2003. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicology 189:1–20.
   PubMed Web of Science ®Google Scholar
• Yamamoto T, Kinoshita M, Shinomiya N, Hiroi S, Sugasawa H, Matsushita Y, Majima T, Saitoh D, Seki S. 2010. Pretreatment with ascorbic acid prevents lethal gastrointestinal syndrome in mice receiving a massive amount of radiation. J Radiat Res 51:145–156.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhang SB, Sun W, Yang S, Zhang M, Wang W, Liu C, Zhang K, Swarts S, Fenton BM, Keng P, Maguire D, Okunieff P, Zhang L. 2009. B1 sequence-based real-time quantitative PCR: A sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation. Int J Radiat Oncol Biol Phys 74:1592–1599.
   PubMed Web of Science ®Google Scholar