Dietary conjugated linoleic acid and long-chain n-3 fatty acids in mammary and prostate cancer protection: a review

References

• Alfaia CMM, Alves SP, Lopes AF, Fernandes MJE, Costa ASH, Fontes CMGA, . 2010. Effect of cooking methods on fatty acids, conjugated isomers of linoleic acid and nutritional quality of beef intramuscular fat. Meat Sci. 84:769–777.
   PubMed Web of Science ®Google Scholar
• Aro A, Männistö S, Salminen I, Ovaskainen ML, Kataja V, Uusitupa M. 2000. Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutr Cancer. 38:151–157.
   PubMed Web of Science ®Google Scholar
• Bagga D, Anders KH, Wang HJ, Glaspy JA. 2002. Long chain n-3-to-n-6 polyunsaturated fatty acid ratios in breast adipose tissue from women with and without breast cancer. Nutr Cancer. 42:180–185.
   PubMed Web of Science ®Google Scholar
• Banni S, Angioni E, Casu V, Melis MP, Carta G, Corongiu FP, . 1999. Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid. Carcinogenesis. 20:1019–1024.
   PubMed Web of Science ®Google Scholar
• Berquin IM, Edwards IJ, Chen YQ. 2008. Multi-targeted therapy of cancer by omega-3 fatty acids. Cancer Lett. 269:363–377.
   PubMed Web of Science ®Google Scholar
• Bourre JM. 2005. Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful?. J Nutr Health Aging. 9:232–242.
   PubMed Web of Science ®Google Scholar
• Brasky TM, Lampe JW, Potter JD, Patterson RD, White E. 2010. Specialty supplements and breast cancer risk in the vitamins and lifestyle (VITAL) Cohort. Cancer Epidemiol Biomarkers Prev.. 19:1696–1708.
   PubMed Web of Science ®Google Scholar
• Chajès V, Lavillonnière F, Ferrari P, Jourdan ML, Pinault M, Maillard V, . 2002. Conjugated linoleic acid content in breast adipose tissue is not associated with the relative risk of breast cancer in a population of French patients. Cancer Epidemiol Biomarkers Prev. 11:672–673.
   PubMed Web of Science ®Google Scholar
• Chambrier C, Bastard JP, Rieusset J, Chevillotte E, Bonnefont-Rousselot D, Therond P, . 2002. Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. Obes Res. 10:518–525.
   PubMedGoogle Scholar
• Chavarro JE, Stampfer MJ, Li H, Campos H, Kurth T, Ma J. 2007. A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 16:1364–1370.
   PubMed Web of Science ®Google Scholar
• Cho E, Spiegelman D, Hunter DJ, Chen WY, Stampfer MJ, Colditz GA, Willett WC. 2003. Premenopausal fat intake and risk of breast cancer. J Natl Cancer Inst. 95:1079–1085.
   PubMed Web of Science ®Google Scholar
• Cohen LA, Zhao Z, Pittman B, Scimeca J. 2003. Effect of soy protein isolate and conjugated linoleic acid on the growth of dunning R-3327-AT-I rat prostate tumors. Prostate. 54:169–180.
   PubMedGoogle Scholar
• Collett ED, Davidson LA, Fan YY, Lupton JR, Chapkin RS. 2001. n-6 and n-3 polyunsaturated fatty acids differentially modulate oncogenic Ras activation in colonocytes. Am J Physiol. 280:C1066–C1075.
   PubMed Web of Science ®Google Scholar
• Corl BA, Barbano DM, Bauman DE, Ip C. 2003. Cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. J Nutr. 133:2893–2900.
   PubMed Web of Science ®Google Scholar
• Crowe FL, Key TJ, Appleby PN, Travis RC, Overvad K, Jakobsen MU, Johnsen NF. 2008. Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr. 87:1405–1413.
   PubMed Web of Science ®Google Scholar
• Dai Q, Shu XO, Jin F, Gao YT, Ruan ZX, Zheng W. 2002. Consumption of animal foods, cooking methods, and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 11:801–808.
   PubMed Web of Science ®Google Scholar
• Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutr J.. 2010 http://www.nutritionj.com/content/9/1/10. Last accessed 2 February 2010.
   PubMedGoogle Scholar
• De la Torre A, Debiton E, Durand D, Chardigny JM, Berdeaux O, Loreau O, . 2005. Conjugated linoleic acid isomers and their conjugated derivatives inhibit growth of human cancer cell lines. Anticancer Res. 25:3943–3949.
   PubMed Web of Science ®Google Scholar
• De La Torre A, Gruffat D, Durand D, Micol D, Peyron A, Scislowski V, Bauchart D. 2006. Factors influencing proportion and composition of CLA in beef. Meat Sci. 73:258–268.
   PubMed Web of Science ®Google Scholar
• Dhiman TR, Nam SH, Ure AL. 2005. Factors affecting conjugated linoleic acid content in milk and meat. Crit Rev Food Sci Nutr. 45:463–482.
   PubMed Web of Science ®Google Scholar
• Doughman SD, Krupanidhi S, Sanjeevi CB. 2007. Omega-3 fatty acids for nutrition and medicine: considering microalgae oil as a vegetarian source of EPA and DHA. Curr Diabetes Rev. 3:198–203.
   PubMedGoogle Scholar
• Duncan RE, El-Sohemy A, Archer MC. 2005. Regulation of HMG-CoA reductase in MCF-7 cells by genistein, EPA, and DHA, alone and in combination with mevastatin. Cancer Lett. 224:221–228.
   PubMed Web of Science ®Google Scholar
• Edefonti V, Randi G, La Vecchia C, Ferraroni M, Decarli A. 2009. Dietary patterns and breast cancer: a review with focus on methodological issues. Nutr Rev. 67:297–314.
   PubMed Web of Science ®Google Scholar
• Engeset D, Alsaker E, Lund E, Welch A, Khaw KT, Clavel-Chapelon F, . 2006. Fish consumption and breast cancer risk. The European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer. 119:175–182.
   PubMed Web of Science ®Google Scholar
• Eynard AR, Lopez CB. Conjugated linoleic acid (CLA) versus satured fats/cholesterol: their proportion in fatty and lean meats may affect the risk of developing colon cancer. Lipids Health Dis.. 2003 http://www.Lipidworld.com/content/2/1/6. Last accessed 12 January 2010.
   PubMedGoogle Scholar
• FAO. 2010. Fisheries and aquaculture consumption of fish and fishery products. http://www.fao.org/fishery/statistics/global-consumption/en. Last accessed 10 March 2010.
   Google Scholar
• Fradet V, Cheng I, Casey G, Witte JS. 2009. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. Clin Cancer Res.. 15:2559–2566.
   PubMed Web of Science ®Google Scholar
• Gagliostro GA, Rodríguez A, Pellegrini P, Museo G, Gatti P, Garciarena D. Effect of pasteurization on cows milk fatty acid composition. Rev Arg Prod Anim. 2007a; 27 Suppl. 1: 355.
   Google Scholar
• Gagliostro GA, Rodríguez A, Pellegrini P, Museo G, Gatti P, Garciarena D. Effect of yogurt-making technology on the composition of fatty acids. Rev Arg Prod Anim. 2007b; 27 Suppl 1: 352.
   Google Scholar
• Gagliostro GA, Rodríguez A, Pellegrini P, Museo G, Gatti P, Garciarena D. Persistency of conjugated linoleic acid (CLA) in cows spreadable cheese. Rev Arg Prod Anim. 2007c; 27 Suppl. 1: 351.
   Google Scholar
• Gago-Dominguez M, Yuan JM, Sun CL, Lee HP, Yu MC. 2003. Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study. Br J Cancer. 89:1686–1692.
   PubMed Web of Science ®Google Scholar
• Goodstine SL, Zheng T, Holford TR, Ward BA, Carter D, Owens PH, Mayne ST. 2003. Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women. J Nutr. 133:1409–1414.
   PubMed Web of Science ®Google Scholar
• Grimm H, Mayer K, Mayser P, Eigenbrodt E. 2002. Regulatory potential of n-3 fatty acids in immunological and inflammatory processes. Br J Nutr. 87:S59–S67.
   PubMed Web of Science ®Google Scholar
• Hedelin M, Chang ET, Wiklund F, Bellocco R, Klint A, Adolfsson J, . 2007. Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. Int J Cancer. 120:398–405.
   PubMed Web of Science ®Google Scholar
• Hirose K, Takezaki T, Hamajima N, Miura S, Tajima K. 2003. Dietary factors protective against breast cancer in Japanese premenopausal and postmenopausal women. Int J Cancer. 107:276–282.
   PubMed Web of Science ®Google Scholar
• Holmes MD, Colditz GA, Hunter DJ, Hankinson SE, Rosner B, Speizer FE, Willett WC. 2003. Meat, fish and egg intake and risk of breast cancer. Int J Cancer. 104:221–227.
   PubMed Web of Science ®Google Scholar
• Howe PR, Downing JA, Grenyer BF, Grigonis-Deane EM, Bryden WL. 2002. Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. Lipids. 37:1067–1076.
   PubMed Web of Science ®Google Scholar
• Hu J, La Vecchia C, DesMeules M, Negri E, Mery L. 2008. Meat and fish consumption and cancer in Canada. Nutr Cancer. 60:313–324.
   PubMed Web of Science ®Google Scholar
• Hubbard NE, Lim D, Erickson KL. 2003. Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. Cancer Lett. 190:13–19.
   PubMed Web of Science ®Google Scholar
• Ip C, Singh M, Thompson HJ, Scimeca JA. 1994. Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res. 54:1212–1215.
   PubMed Web of Science ®Google Scholar
• Ip C, Banni S, Angioni E, Carta G, McGinley J, Thompson HJ, . 1999. Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats. J Nutr. 129:2135–2142.
   PubMed Web of Science ®Google Scholar
• Ip C, Ip MM, Loftus T, Shoemaker S, Shea-Eaton W. 2000. Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland. Cancer Epidemiol Biomarkers Prev. 9:689–696.
   PubMed Web of Science ®Google Scholar
• Ip C, Dong Y, Thompson HJ, Bauman DE, Ip MM. 2001. Control of rat mammary epithelium proliferation by conjugated linoleic acid. Nutr Cancer. 39:233–238.
   PubMed Web of Science ®Google Scholar
• Jeyarajah DR, Kielar M, Penfield J, Lu CY. 1999. Docosahexaenoic acid, a component of fish oil, inhibits nitric oxide production in vitro. J Surg Res. 83:147–150.
   PubMedGoogle Scholar
• Kelley NS, Hubbard NE, Erickson KL. 2007. Conjugated linoleic acid isomers and cancer. J Nutr. 137:2599–2607.
   PubMed Web of Science ®Google Scholar
• Kemp MQ, Jeffy BD, Romagnolo DF. 2003. Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells. J Nutr. 133:3670–3677.
   PubMed Web of Science ®Google Scholar
• Kim JH, Hubbard NE, Ziboh V, Erickson KL. 2005. Attenuation of breast tumor cell growth by conjugated linoleic acid via inhibition of 5-lipoxygenase activating protein. Biochimica Biophys Acta. 1736:244–250.
   PubMedGoogle Scholar
• Kim J, Lim SY, Shin A, Sung MK, Ro J, Kang HS, . Fatty fish and fish omega-3 fatty acid intakes decrease the breast cancer risk: a case-control study. BMC Cancer.. 2009 http://www.biomedcentral.com/1471-2407/9/216. Last accessed 10 March 2010.
   Google Scholar
• Kramer JKG, Parodi PW, Jensen RG, Mossoba MM, Yurawecz MP, Adlof RO. 1998. Rumenic acid: a proposed common name for the major conjugated linoleic acid isomer found in natural products. Lipids. 33:835.
   PubMed Web of Science ®Google Scholar
• Kristal AR, Cohen JH, Qu P, Stanford JL. 2002. Associations of energy, fat, calcium, and vitamin D with prostate cancer risk. Cancer Epidemiol Biomarkers Prev. 11:719–725.
   PubMed Web of Science ®Google Scholar
• Kuriki K, Hirose K, Wakai K, Matsuo K, Ito H, Suzuki T, . 2007. Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer. 121:377–385.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Bergkvist L, Wolk A. 2009. Conjugated linoleic acid intake and breast cancer risk in a prospective cohort of Swedish Women. Am J Clin Nutr. 90:556–560.
   PubMed Web of Science ®Google Scholar
• Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A. 2004. Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr. 79:935–945.
   PubMed Web of Science ®Google Scholar
• Latimori NJ, Kloster AM, García PT, Carduza FJ, Grigioni G, Pensel NA. 2008. Diet and genotype effects on the quality index of beef produced in the Argentine Pampeana region. Meat Sci. 79:463–469.
   PubMedGoogle Scholar
• Laurenti G. 2007. 1961–2005 fish and fishery products: world apparent consumption statistics based on food balance sheets. FAO Fisheries Circular. 821 9: 429.
   Google Scholar
• Lavillonniere F, Chajes V, Martin JC, Sebedio JL, Lhuillery C, Bougnoux P. 2003. Dietary purified cis-9,trans-11 conjugated linoleic acid isomer has anticarcinogenic properties in chemically induced mammary tumors in rats. Nutr Cancer. 45:190–194.
   PubMed Web of Science ®Google Scholar
• Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC, Giovannucci EL. 2004. Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. Am J Clin Nutr. 80:204–216.
   PubMed Web of Science ®Google Scholar
• Lock AL, Corl BA, Barbano DM, Bauman DE, Ip C. 2004. The anticarcinogenic effect of trans-11 18:1 is dependent on its conversion to cis-9,trans-11 CLA by delta9-desaturase in rats. J Nutr. 134:2698–2704.
   PubMed Web of Science ®Google Scholar
• Lucas M, Asselin G, Plourde M, Cunnane SC, Dewailly E, Dodin S. 2010. n-3 Fatty acid intake from marine food products among Quebecers: comparison to worldwide recommendations. Pub Health Nutr. 13:63–70.
   PubMedGoogle Scholar
• MacDonald HB. 2000. Conjugated linoleic acid and disease prevention: a review of current knowledge. J Am Coll Nutr. 19:111S–118S.
   PubMed Web of Science ®Google Scholar
• Maillard V, Bougnoux P, Ferrari P, Jourdan ML, Pinault M, Lavillonniere F, . 2002. n-3 and n-6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case-control study in Tours, France. Int J Cancer. 98:78–83.
   PubMed Web of Science ®Google Scholar
• Manna S, Chakraborty T, Damodaran S, Samanta K, Rana B, Chatterjee M. Protective role of fish oil (Maxepa) on early events of rat mammary carcinogenesis by modulation of DNA-protein crosslinks, cell proliferation and p53 expression. Cancer Cell Int.. 2007 http://www.cancerci.com/content/7/1/6. Last accessed 10 March 2010.
   PubMedGoogle Scholar
• Männistö S, Pietinen P, Virtanen MJ, Salminen I, Albanes D, Giovannucci E, Virtamo J. 2003. Fatty acids and risk of prostate cancer in a nested case-control study in male smokers. Cancer Epidemiol Biomarkers Prev. 12:1422–1428.
   PubMed Web of Science ®Google Scholar
• Martins S, Lopes PA, Alfaia CM, Ribeiro VS, Guerreiro TV, Fontes CM, . 2007. Contents of conjugated linoleic acid isomers in ruminant-derived foods and estimation of their contribution to daily intake in Portugal. Br J Nutr. 98:1206–1213.
   PubMed Web of Science ®Google Scholar
• McAfee AJ, McSorley EM, Cuskelly GJ, Moss BW, Wallace JMW, Bonham MP, Fearon AM. 2010. Red meat consumption: an overview of the risks and benefits. Meat Sci. 84:1–13.
   PubMed Web of Science ®Google Scholar
• McCann SE, Ip C, Ip MM, McGuire MK, Muti P, Edge SB, . 2004. Dietary intake of conjugated linoleic acids and risk of premenopausal and postmenopausal breast cancer, Western New York Exposures and Breast Cancer Study (WEB Study). Cancer Epidemiol Biomarkers Prev. 13:1480–1484.
   PubMed Web of Science ®Google Scholar
• Missmer SA, Smith-Warner SA, Spiegelman D, Yaun SS, Adami HO, Beeson WL, . 2002. Meat and dairy food consumption and breast cancer: a pooled analysis of cohort studies. Int J Epidemiol. 31:78–85.
   PubMed Web of Science ®Google Scholar
• Murata M, Kaji H, Iida K, Okimura Y, Chihara K. 2001. Dual action of eicosapentaenoic acid in hepatoma cells: up-regulation of metabolic action of insulin and inhibition of cell proliferation. J Biol Chem. 276:31422–31428.
   PubMedGoogle Scholar
• Navarro A, Muñoz SE, Lantieri MJ, Diaz MP, Cristaldo PE, de Fabro SP, Eynard AR. 2004. Meat cooking habits and risk of colorectal cancer in Córdoba. Argentina. Nutrition. 20:873–877.
   Google Scholar
• Nkondjock A, Shatenstein B, Ghadirian P. 2003. A case-control study of breast cancer and dietary intake of individual fatty acids and antioxidants in Montreal, Canada. Breast. 12:128–135.
   PubMedGoogle Scholar
• Novak TE, Babcock TA, Jho DH, Helton WS, Espat NJ. 2003. NF-kappa B inhibition by omega-3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Physiol. 284:L84–L89.
   PubMed Web of Science ®Google Scholar
• Ochoa JJ, Farquharson AJ, Grant I, Moffat LE, Heys SD, Wahle KW. 2004. Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: different molecular mechanisms for cis-9,trans-11 and trans-10,cis-12 isomers. Carcinogenesis. 25:1185–1191.
   PubMed Web of Science ®Google Scholar
• Pala V, Krogh V, Muti P, Chajes V, Riboli E, Micheli A, . 2001. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J Natl Cancer Inst. 93:1088–1095.
   PubMed Web of Science ®Google Scholar
• Palmquist DL, Lock AL, Shingfield KJ, Bauman DE. 2005. Biosynthesis of conjugated linoleic acid in ruminants and humans. Adv Food Nutr Res. 50:179–217.
   PubMedGoogle Scholar
• Palombo JD, Ganguly A, Bistrian BR, Menard MP. 2002. The antiproliferative effects of biologically active isomers of conjugated linoleic acid on human colorectal and prostatic cancer cells. Cancer Lett. 177:163–172.
   PubMed Web of Science ®Google Scholar
• Park SY, Murphy SP, Wilkens LR, Henderson BE, Kolonel LN. 2007. Fat and meat intake and prostate cancer risk: the multiethnic cohort study. Int J Cancer. 121:1339–1345.
   PubMed Web of Science ®Google Scholar
• Realini CE, Duckett SK, Brito GW, Dalla Rizza M, De Mattos D. 2004. Effect of pasture vs. concentrate feeding with or without antioxidants on carcass characteristics, fatty acid composition, and quality of Uruguayan beef. Meat Sci. 66:567–577.
   PubMed Web of Science ®Google Scholar
• Ritzenthaler KL, McGuire MK, Falen R, Shultz TD, Dasgupta N, McGuire MA. 2001. Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology. J Nutr. 131:1548–1554.
   PubMed Web of Science ®Google Scholar
• Robinson LE, Clandinin MT, Field CJ. 2001. R3230AC rat mammary tumor and dietary long-chain (n-3) fatty acids change immune cell composition and function during mitogen activation. J Nutr. 131:2021–2027.
   PubMed Web of Science ®Google Scholar
• Saadatian-Elahi M, Toniolo P, Ferrari P, Goudable J, Akhmedkhanov A, Zeleniuch-Jacquotte A, Riboli E. 2002. Serum fatty acids and risk of breast cancer in a nested case-control study of the New York University Women's Health Study. Cancer Epidemiol Biomarkers Prev. 11:1353–1360.
   PubMed Web of Science ®Google Scholar
• Sarriés MV, Murray BE, Moloney AP, Troy D, Beriain MJ. 2009. The effect of cooking on the fatty acid composition of longissimus muscle from beef heifers fed rations designed to increase the concentration of conjugated linoleic acid in tissue. Meat Sci. 81:307–312.
   PubMed Web of Science ®Google Scholar
• Schmid A, Collomb M, Sieber R, Bee G. 2006. Conjugated linoleic acid in meat and meat products: a review. Meat Sci. 73:29–41.
   PubMed Web of Science ®Google Scholar
• Serini S, Piccioni E, Merendino N, Calviello G. 2009. Dietary polyunsaturated fatty acids as inducers of apoptosis: implications for cancer. Apoptosis. 14:135–152.
   PubMed Web of Science ®Google Scholar
• Shannon J, Cook LS, Stanford JL. 2003. Dietary intake and risk of postmenopausal breast cancer (United States). Cancer Causes Control. 14:19–27.
   PubMed Web of Science ®Google Scholar
• Shannon J, King IB, Moshofsky R, Lampe JW, Gao DL, Ray RM, Thomas DB. 2007. Erythrocyte fatty acids and breast cancer risk: a case-control study in Shanghai, China. Am J Clin Nutr. 85:1090–1097.
   PubMed Web of Science ®Google Scholar
• Shannon J, O'Malley J, Mori M, Garzotto M, Palma AJ, King IB. 2010. Erythrocyte fatty acids and prostate cancer risk: a comparison of methods. Prostaglandins Leukot Essent Fatty Acids.. 83:161–169.
   PubMed Web of Science ®Google Scholar
• Song HJ, Sneddon AA, Heys SD, Wahle KW. 2006. Induction of apoptosis and inhibition of NF-kappaB activation in human prostate cancer cells by the cis-9,trans-11 but not the trans-10, cis-12 isomer of conjugated linoleic acid. Prostate. 66:839–846.
   PubMed Web of Science ®Google Scholar
• Sonoda T, Nagata Y, Mori M, Miyanaga N, Takashima N, Okumura K, . 2004. A case-control study of diet and prostate cancer in Japan: possible protective effect of traditional Japanese diet. Cancer Sci. 95:238–242.
   PubMed Web of Science ®Google Scholar
• Spencer L, Mann C, Metcalfe M, Webb M, Pollard C, Spencer D, . 2009. The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential. Eur J Cancer. 45:2077–2086.
   PubMed Web of Science ®Google Scholar
• Stripp C, Overvad K, Christensen J, Thomsen BL, Olsen A, Møller S, Tjønneland A. 2003. Fish intake is positively associated with breast cancer incidence rate. J Nutr. 133:3664–3669.
   PubMed Web of Science ®Google Scholar
• Tanmahasamut P, Liu JB, Hendry LB, Sidell N. 2004. Conjugated linoleic acid blocks estrogen signaling in human breast cancer cells. J Nutr. 134:674–680.
   PubMed Web of Science ®Google Scholar
• Terry P, Rohan TE, Wolk A, Maehle-Schmidt M, Magnusson C. 2002. Fish consumption and breast cancer risk. Nutr Cancer. 44:1–6.
   PubMed Web of Science ®Google Scholar
• Thiébaut AC, Chajès V, Gerber M, Boutron-Ruault MC, Joulin V, Lenoir G, . 2009. Dietary intakes of omega-6 and omega-3 polyunsaturated fatty acids and the risk of breast cancer. Int J Cancer. 124:924–931.
   PubMed Web of Science ®Google Scholar
• Voorrips LE, Brants HA, Kardinaal AF, Hiddink GJ, van den Brandt PA, Goldbohm RA. 2002. Intake of conjugated linoleic acid, fat, and other fatty acids in relation to postmenopausal breast cancer: the Netherlands cohort study on diet and cancer. Am J Clin Nutr. 76:873–882.
   PubMed Web of Science ®Google Scholar
• Wakai K, Tamakoshi K, Date C, Fukui M, Suzuki S, Lin Y, . 2005. Dietary intakes of fat and fatty acids and risk of breast cancer: a prospective study in Japan. Cancer Sci. 96:590–599.
   PubMed Web of Science ®Google Scholar
• Wallström P, Bjartell A, Gullberg B, Olsson H, Wirfält E. 2007. A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden). Cancer Causes Control. 18:1107–1121.
   PubMed Web of Science ®Google Scholar
• Wang Y, Li S. 2008. Worldwide trends in dairy production and consumption and calcium intake: is promoting consumption of dairy products a sustainable solution for inadequate calcium intake?. Food Nutr Bull. 29:172–185.
   PubMed Web of Science ®Google Scholar
• Welch AA, Lund E, Amiano P, Dorronsoro M, Brustad M, Kumle M, . 2002. Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Pub Health Nutr. 5 6B: 1273–1285.
   PubMed Web of Science ®Google Scholar
• Whelan J, Rust C. 2006. Innovative dietary sources of n-3 fatty acids. Annu Rev Nutr. 26:75–103.
   PubMed Web of Science ®Google Scholar
• Whigham LD, Watras AC, Schoeller DA. 2007. Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans. Am J Clin Nutr. 85:1203–1211.
   PubMed Web of Science ®Google Scholar
• Williams CM, Burdge G. 2006. Long-chain n-3 PUFA: Plant v. marine sources. Proc Nutr Soc. 65:42–50.
   PubMed Web of Science ®Google Scholar
• Wirfält E, Vessby B, Mattisson I, Gullberg B, Olsson H, Berglund G. 2004. No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmö Diet Cancer cohort (Sweden). Eur J Clin Nutr. 58:761–770.
   PubMed Web of Science ®Google Scholar
• Witt PM, Christensen JH, Schmidt EB, Dethlefsen C, Tjønneland A, Overvad K, Ewertz M. 2009. Marine n-3 polyunsaturated fatty acids in adipose tissue and breast cancer risk: a case-cohort study from Denmark. Cancer Causes Control. 20:1715–1721.
   PubMedGoogle Scholar
• World Cancer Research Fund/American Institute for Cancer Research. 1997. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: AICR pp. 1–19, 54–56, 317, 373, 401–403.
   Google Scholar
• World Cancer Research Fund/American Institute for Cancer Research. 2007. Food, nutrition, physical activity, and the prevention of cancer: A global perspective. Washington DC: AICR.
   Google Scholar
• Yang H, Holcroft J, Glickman BW, de Boer JG. 2003. Conjugated linoleic acid inhibits mutagenesis by 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in the prostate of Big Blue rats. Mutagenesis. 18:195–200.
   PubMedGoogle Scholar
• Yang P, Chan D, Felix E, Cartwright C, Menter DG, Madden T, . 2004. Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells. J Lipid Res. 45:1030–1039.
   PubMed Web of Science ®Google Scholar
• Yuri T, Danbara N, Tsujita-Kyutoku M, Fukunaga K, Takada H, Inoue Y, . 2003. Dietary docosahexaenoic acid suppresses N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats more effectively than eicosapentaenoic acid. Nutr Cancer. 45:211–217.
   PubMed Web of Science ®Google Scholar