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Cellular and animal indispensable amino acid limitation responses and health promotion. Can the two be linked? A critical review

Pages 300-311 | Published online: 01 Nov 2012

References

  • Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. 2004. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. J Biol Chem. 279:36553–36561.
  • Averous J, Bruhat A, Mordier S, Fafournoux P. 2003. Recent advances in the understanding of amino acid regulation of gene expression. J Nutr. 133 Suppl. 1: 2040S–2045S.
  • Avruch J, Long X, Ortiz-Vega S, Rapley J, Papageorgiou A, Dai N. 2009. Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab. 296:592–602.
  • Buerger C, DeVries B, Stambolic V. 2006. Localization of Rheb to the endomembrane is critical for its signaling function. Biochem Biophys Res Commun. 344:869–880.
  • Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. 2009. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. J Biol Chem. 284:32742–32749.
  • Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. 2010. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. J Nutr. 140:2020–2027.
  • Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson M. 2010. Cellular stress responses, the hormesis paradigm and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal. 13:1763–1811.
  • Choo AY, Blenis J. 2009. Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle. 8:567–572.
  • Chotenchuang N, Azzout-Marniche D, Bos C, Chaumontent C, Gausserès N, Steiler T,, . 2009. mTOR, AMPK, and GCN2 coordinate the adaptation of hepatic energy metabolic pathways in response to protein intake in the rat. Am J Physiol Endocrinol Metab. 297:1313–1323.
  • Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. 2009. eIF2α kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver. Physiol Genomics. 38:328–341.
  • De Marte ML, Enesco HE. 1986. Influence of low tryptophan diet on survival and organ growth in mice. Mech Ageing Dev. 36:161–171.
  • Deval C, Chaveroux C, Maurin AC, Cherasse Y, Parry L, Carraro V, . 2009. Amino acid limitation regulates the expression of genes involved in several specific biological processes through GCN2-dependent and GCN2-independent pathways. FEBS J. 276:707–718.
  • Draznin B. 2006. Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin. Diabetes. 55:2392–2397.
  • Gabauer F, Hentze M. 2004. Molecular mechanisms of translational control. Mol Cell Biol. 5:827–834.
  • Gingras AC, Raught B, Sonenberg N. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem. 68:913–963.
  • Goberdhan DC, Ogmundsdóttir MH, Kazi S, Reynolds B, Visvalingam SM, Wilson C, Boyd CA. 2009. Amino acid sensing and mTOR regulation: inside or out?. Biochem Soc Trans. 37:248–252.
  • Guo F, Cavener DR. 2007. The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. Cell Metab. 5:103–114.
  • Haghighat A, Mader S, Pause A, Sonenberg N. 1995. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14:5701–5709.
  • Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, . 2005. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science. 307:1776–1778.
  • Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. 2000. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 6:1099–1108.
  • Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, . 2003. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell. 11:619–633.
  • Hinnebusch AG. 2005. Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol. 59:407–450.
  • Hinnebusch AG. 2000. Mechanism and regulation of initiator methionyl-tRNA binding to ribosomes. In: Sonenberg N, Hershey JWB, Mathews MB. editors. Translational control of gene expression. Plainview, NY: Cold Springs Harbor Laboratory Press185–243.
  • Holcik M, Sonenberg N. 2005. Translational control in stress and apoptosis. Nat Rev Mol Cell Biol. 6:318–327.
  • Jousse C, Deval C, Maurin AC, Parry L, Cherasse Y, Chaveroux C, . 2007. TRB3 inhibits the transcriptional activation of stress-regulated genes by a negative feedback on the ATF4 pathway. J Biol Chem. 282:15851–15861.
  • Kaufman RJ. 2004. Regulation of mRNA translation by protein folding in the endoplasmic reticulum. Trends Biochem Sci. 29:152–158.
  • Kilberg MS, Pan YX, Chen H, Leung-Pineda V. 2005. Nutritional control of gene expression: how mammalian cells respond to amino acid limitation. Annu Rev Nutr. 25:59–85.
  • Kilberg MS, Shan J, Su N. 2009. ATF4-dependent transcription mediates signaling of amino acid limitation. Trends Endocrinol Metab. 20:436–443.
  • Kim E, Goraksha-Hicks P, Li L, Neufeld TP, Guan KL. 2008. Regulation of TORC1 by Rag GTPases in nutrient response. Nat Cell Biol. 10:935–945.
  • Kimball SR, Antonetti DA, Brawley RM, Jefferson LS. 1991. Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2α phosphatase activity. J Biol Chem. 266:1969–1976.
  • Kubica N, Jefferson LS, Kimball SR. 2006. Eukaryotic initiation factor 2B and its role in alterations in mRNA translation that occur under a number of pathophysiological and physiological conditions. Prog Nucleic Acid Res Mol Biol. 81:271–296.
  • Lee J-I, Dominy JEJr, Sikalidis AK, Hirschberger LL, Wang W, Stipanuk MH. 2008. HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiol Genomics. 33:218–229.
  • Lu PD, Jousse C, Harding HP, Ron D. Translation reinitiation at alternative open reading frames regulate gene expression in an integrated stress response. J Cell Biol. 2004a; 167:27–33.
  • Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, . Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. EMBO J. 2004b; 23:169–179.
  • Mader S, Lee H, Pause A, Sonenberg N. 1995. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol. 15:4990–4997.
  • Martin B, Golden E, Egan JM, Mattson MP, Maudsley S. 2007. Reduced energy intake: the secret to a long and healthy life?. IBS J Sci. 2:35–39.
  • Masoro EJ. 1997. Hormesis and the antiaging action of dietary restriction. Exp Gerontol. 33:61–66.
  • Masoro EJ. 2007. Role of hormesis in life extension by caloric restriction. Dose Response. 5:163–173.
  • McCarty MF, Baroso-Aranda J, Contreras F. 2008. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. Med Hypotheses. 72:125–128.
  • McCay CM, Crowell MF, Maynard LA. 1935. The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutr. 10:63–79.
  • McCay CM, Maynard LA, Sperling G, Leroy Barnes L. 1939. Retarded growth, life span, ultimate body size and age changes in the albino rat after feeding diets restricted in calories. J Nutr. 18:1–13.
  • Milward DJ, Jackson AA. 2003. Protein/energy ratios of current diets in developed and developing countries compared with a safe protein/energy ratio: implications for recommended protein and amino acid intakes. Public Health Nutr. 7:387–405.
  • Ooka H, Segall PE, Timiras PS. 1988. Histology and survival in age-delayed low-tryptophan-fed rats. Mech Ageing Dev. 43:79–98.
  • Padyana AK, Qiu H, Roll-Mecak A, Hinnebusch AG, Burley SK. 2005. Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2α protein kinase GCN2. J Biol Chem. 280:29289–29299.
  • Pan YX, Chen H, Thiaville MM, Kilberg MS. 2007. Activation of the ATF3 gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation. Biochem J. 401:299–307.
  • Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N. 1998. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J Biol Chem. 273:14002–14007.
  • Prévôt D, Darlix JL, Ohlmann T. 2003. Conducting the initiation of protein synthesis: the role of eIF4G. Biol Cell. 95:141–156.
  • Raffaghello L, Lee C, Safdie FM, Wei M, Madia F, Bianchi G, Longo VD. 2008. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. Proc Natl Acad Sci USA. 105:8215–8220.
  • Ranganathan AC, Ojha S, Kourtidis A, Conklin DS, Aguirre-Ghiso JA. 2008. Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. Cancer Res. 68:3260–3268.
  • Rattan SIS. 2008. Hormesis in aging. Ageing Res Rev. 7:63–78.
  • Richie JPJr, Komninou D, Leutzinger Y, Kleinman W, Orentreich N, Malloy V, . 2001. Regulation of antioxidant metabolism by translation initiation factor 2alpha. Cell Biol. 152:997–1006.
  • Roth GS, Ingram DK, Lane MA. 2001. Caloric restriction in primates and relevance to humans. Ann NY Acad Sci. 928:305–315.
  • Salminen A, Kaarniranta K. 2010. ER stress and hormetic regulation of the aging process. Ageing Res Rev. 9:211–217.
  • Sancak Y, Peterson TR, Shaul YD, Lindquist RA, Thoreen CC, Bar-Peled L, Sabatini DM. 2008. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science. 320:1496–1501.
  • Sanz A, Caro P, Ayala V, Portero-Otin M, Pamplona R, Barja G. 2006. Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins. FASEB J. 20:1064–1073.
  • Sarbassov DD, Sabatini DM. 2005. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J Biol Chem. 280:39505–39509.
  • Sato H, Nomura S, Maebara K, Sato K, Tamba M, Bannai S. 2004. Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation. Biochem Biophys Res Commun. 325:109–116.
  • Schmelze T, Hall MN. 2000. TOR, a central controller of cell growth. Cell. 103:253–262.
  • Shan J, Ord D, Ord T, Kilberg MS. 2009. Elevated ATF4 expression, in the absence of other signals, is sufficient for transcriptional induction via CCAAT enhancer-binding protein-activating transcription factor response elements. J Biol Chem. 284:21241–21248.
  • Sikalidis AK, Stipanuk MH. 2010. Growing rats respond to a sulphur amino acid-deficient diet by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 heterotrimeric complex and induction of the adaptive components of the integrated stress response. J Nutr. 140:1080–1085.
  • Sikalidis AK, Lee JI, Stipanuk MH. 2011. Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium. Amino Acids. 41:159–171.
  • Tan S, Somia N, Maher P, Schubert DJ. 2001. Regulation of antioxidant metabolism by translation initiation factor 2 alpha. Cell Biol. 152:997–1006.
  • Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF. 2005. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4e-binding protein d4E-BP. Genes Dev. 19:1840–1843.
  • Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS. 2008. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. J Biol Chem. 283:10848–10857.
  • Watatani Y, Ichikawa K, Nakanishi N, Fujimoto M, Takeda H, Kimura N, . 2008. Stress-induced translation of ATF5 mRNA is regulated by the 5′-untranslated region. J Biol Chem. 283:2543–2553.
  • Wek RC, Jackson BM, Hinnebusch AG. 1989. Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability. Proc Natl Acad Sci USA. 86:4579–4583.
  • Wek SA, Zhu S, Wek RC. 1995. The histidyl-tRNA synthetase-related sequence in the eIF-2α a protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids. Mol Cell Biol. 15:4497–4506.
  • Wek RC, Jiang HY, Anthony TG. 2006. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans. 34:7–11.
  • Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, . 2011. Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways. Diabetes. 60:746–756.
  • Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, . 2008. ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metab. 7:269–276.
  • Ye J, Kumanova M, Hart LS, Sloane K, Zhang H, De Panis DN, . 2010. The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation. EMBO J. 29:2082–2096.
  • Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, . 2002. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol. 22:6681–6688.
  • Zimmerman JA. 2004. Tissue glutathione and cysteine levels in methionine-restricted rats. Nutrition. 20:800–805.
  • Zimmerman JA, Malloy V, Krajcik R, Orentreich N. 2003. Nutritional control of aging. Exp Gerontol. 38:47–52.

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