299
Views
26
CrossRef citations to date
0
Altmetric
Research Article

Effects of naringenin and its phase II metabolites on in vitro human macrophage gene expression

, , , , , , , & show all
Pages 843-849 | Received 21 Mar 2013, Accepted 07 May 2013, Published online: 12 Jun 2013

References

  • Bouhlel MA, Derudas B, Rigamonti E, Dièvart R, Brozek J, Haulon S, Zawadzki C, et al. 2007. PPAR gamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab 6:137–143
  • Bredsdorff L, Nielson ILF, Rasmussen SE, Cornett C, Barron D, Bouisset F, Offord E, Williamson G. 2010. Absorption, conjugation and excretion of the flavanones, naringenin and hesperetin from a-rhamnosidase – treated orange juice in human subjects. Br J Nutr 103:1602–1609
  • Chanet A, Milenkovic D, Claude S, Maier JA, Khan MK, Rakotomanomana N, Shinkaruk S, et al. Flavanone metabolites decrease monocyte adhesion to TNF-α-activated endothelial cells by modulating expression of atherosclerosis-related genes. Br J Nutr. 2013. [Epub ahead of print]. DOI: http://dx.doi.org/10.1017/S0007114512005454
  • Chao CL, Weng CS, Chang NC, Lin JS, Kao ST, Ho FM. 2010. Naringenin more effectively inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in macrophages than in microglia. Nutr Res 30:858–864
  • Dall'Asta M, Derlindati E, Ardigò D, Zavaroni I, Brighenti F, Del Rio D. 2012. Macrophage polarization: the answer to the diet/inflammation conundrum? Nutr Metab Cardiovasc Dis 22:387–392
  • Del Rio D, Rodriguez-Mateos A, Spencer JPE, Tognolini M, Borges G, Crozier A. 2013. Dietary (Poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818--1892
  • Derlindati E, Dall'Asta M, Ardigò D, Brighenti F, Zavaroni I, Crozier A, Del Rio D. 2012. Quercetin-3-O-glucuronide affects the gene expression profile of M1 and M2a human macrophages exhibiting anti-inflammatory effects. Food Funct 3:1144–1152
  • Dhaun N, Goddard J, Kohan DE, Pollock DM, Schiffrin EL, Webb DJ. 2008. Role of endothelin-1 in clinical hypertension: 20 years on. Hypertension 52:452–459
  • Erlund I, Meririnne E, Alfthan G, Aro A. 2001. Plasma kinetics and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. J Nutr 131:235–241
  • Fukai T, Ushio-Fukai M. 2011. Superoxide dismutases: role in redox signaling, vascular function, and diseases. Antioxid Redox Signal 15:1583–1606
  • Hämäläinen M, Nieminen R, Asmawi MZ, Vuorela P, Vapaatalo H, Moilanen E. 2011. Effects of flavonoids on prostaglandin E2 production and on COX-2 and mPGES-1 expressions in activated macrophages. Planta Med 77:1504–1511
  • Hämäläinen M, Nieminen R, Vuorela P, Heinonen M, Moilanen E. 2007. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-kappa B activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-kappa B activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators Inflamm 2007:45673
  • Huang JV, Greyson CR, Schwartz GG. 2012. PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty. J Lipid Res. 53:1738–1754
  • Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K, Shibata N, Kobayashi M, et al. 2008. Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 283:9424–9434
  • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. 2004. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677–686
  • Mendall MA, Patel P, Asante M, Ballam L, Morris J, Strachan DP, Camm AJ, Northfield TC. 1997. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart 78:273–277
  • Mullen W, Archeveque MA, Edwards CA, Matsumoto H, Crozier A. 2008. Bioavailability and metabolism of orange juice flavanones in humans: impact of a full-fat yogurt. J Agric Food Chem 56:11157–11164
  • Pérez-Jiménez J, Neveu V, Vos F, Scalbert A. 2010. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. Eur J Clin Nutr 64:S112–S120
  • Pravenec M, Churchill PC, Churchill MC, Viklicky O, Kazdova L, Aitman TJ, Petretto E, et al. 2008. Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension. Nat Genet 40:952–954
  • Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R. 2001. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68:921–931
  • Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL. 2012. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med 56:102–111
  • Rouanet JM, Décordé K, Del Rio D, Auger C, Borges Cristol JP, Lean MEJ, Crozier A. 2010. Berry juices, teas, antioxidants and the prevention of atherosclerosis in hamsters. Food Chem 118:266–271
  • Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW. 2000. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285:194–204
  • Shehzad A, Ha T, Subhan F, Lee YS. 2011. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr 50:151–161
  • Soromou LW, Zhang Z, Li R, Chen N, Guo W, Huo M, Guan S, et al. 2012. Regulation of inflammatory cytokines in lipopolysaccharide-stimulated RAW 264.7 murine macrophage by 7-O-methyl-naringenin. Molecules 17:3574–3585
  • Takeshige K, Yamazaki S, Eto A, Kataoka K, Muta T. 2002. Mechanism of macrophage activation by LPS. Masui 51:50–62
  • Tsai SH, Lin-Shiau SY, Lin JK. 1999. Suppression of nitric oxide synthase and the down-regulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol 126:673–680
  • Vafeiadou K, Vauzour D, Lee HY, Rodriguez-Mateos A, Williams RJ, Spencer JP. 2009. The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury. Arch Biochem Biophys 484:100–109
  • Varin A, Gordon S. 2009. Alternative activation of macrophages: immune function and cellular biology. Immunobiology 214:630–641

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.