Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions

References

• Adhami VM, Khan N, Mukhtar H. 2009. Cancer chemoprevention by pomegranate: laboratory and clinical evidence. Nutr Cancer 61:811–815
   PubMed Web of Science ®Google Scholar
• Aviram M, Volkova N, Coleman R, Dreher M, Kesava RM, Ferreira D, Rosenblat M. 2008. Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E0) mice and in vitro in cultured macrophages and lipoproteins. J Agric Food Chem 56:1148–1157
   PubMed Web of Science ®Google Scholar
• Betanzos-Cabrera G, Guerrero-Solano JA, Martínez-Pérez MM, Calderón-Ramos ZG, Belefant-Miller H, Cancino-Diaz JC. 2011. Pomegranate juice increases levels of paraoxanase1 (PON1) expression and enzymatic activity in streptozotocin-induced diabetic mice fed with a high-fat diet. Food Res Int 44:1381–1385
   Web of Science ®Google Scholar
• Boath AS, Grussu D, Stewart D, McDougall GJ. 2012a. Berry polyphenols inhibit digestive enzymes: a source of potential health benefits? Food Digest 3:1–7
   Google Scholar
• Boeing H, Bechthold A, Bub A, Ellinger S, Haller D, Kroke A, Leschik-Bonnet E, et al. 2012. Critical review: vegetables and fruit in the prevention of chronic diseases. Eur J Nutr 51:637–663
   PubMed Web of Science ®Google Scholar
• Cerdá B, Llorach R, Cerón JJ, Espín JC, Tomás-Barberán FA. 2003. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr 42:18–28
   PubMed Web of Science ®Google Scholar
• Del Rio D, Rodriguez-Mateos A, Spencer JPE, Tognolini M, Borges G, Crozier A. 2013. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818–1892
   PubMed Web of Science ®Google Scholar
• Di Silvestro RA, Di Silvestro DJ, Di Silvestro DJ. 2009. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res 23:1123–1127
   PubMed Web of Science ®Google Scholar
• Dolara P, Luceri C, De Filippo C, Femia AP, Giovannelli L, Caderni G, Cecchini C, et al. 2005. Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. Mutat Res 591:237–246
   PubMed Web of Science ®Google Scholar
• Fischer UA, Carle R, Kammerer DR. 2011. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD–ESI/MSn. Food Chem 127:807–821
   PubMed Web of Science ®Google Scholar
• Fuhrman B, Volkova N, Aviram M. 2010. Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients. Nutrition 26:359–366
   PubMed Web of Science ®Google Scholar
• González-Barrio R, Borges G, Mullen W, Crozier A. 2010. Bioavailability of anthocyanins and ellagitannins following consumption of raspberries by healthy humans and subjects with an ileostomy. J Agric Food Chem 58:3933–3939
   PubMed Web of Science ®Google Scholar
• Halliwell B, Zhao K, Whiteman M. 2000. The gastrointestinal tract: a major site for antioxidant action? Free Radic Res 33:819–830
   PubMed Web of Science ®Google Scholar
• Kaur M, Singh RP, Gu M, Agarwal R, Agarwal C. 2006. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res 12:6194–6201
   PubMed Web of Science ®Google Scholar
• Koh L W, Wong LL, Loo YY, Kasapis S, Huang D. 2010. Evaluation of different teas against starch digestibility by mammalian glycosidases. J Agric Food Chem 58:148–154
   PubMed Web of Science ®Google Scholar
• Krentz AJ, Bailey CJ. 2005. Oral antidiabetic agents. Current role in type 2 diabetes mellitus. Drugs 65:385–411
   PubMed Web of Science ®Google Scholar
• Kunst A, Draeger B, Ziegenhorn J. 1984. Methods of enzymatic analysis, 3rd ed., Vol. 6. Academic Press. p163–172
   Google Scholar
• Kwon YI, Apostolidis E, Shetty K. 2008. Inhibitory potential of wine and tea against α-amylase and α-glucosidase for management of hyperglycemia linked to type 2 diabetes. J Food Biochem 32:15–31
   Web of Science ®Google Scholar
• Larrosa M, García-Conesa MT, Espín JC, Tomás-Barberán FA. 2010. Ellagitannins, ellagic acid and vascular health. Mol Aspects Med 31:513–539
   PubMed Web of Science ®Google Scholar
• Li Y, Wen S, Kota BP, Peng G, Li GQ, Yamahara J, Ruofogalis BD. 2005. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 99:239–244
   PubMed Web of Science ®Google Scholar
• Liu Y, Zhang D, Wu Y, Wang D, Wei Y, Wu J, Ji B. 2014. Stability and absorption of anthocyanins from blueberries subjected to a simulated digestion process. Int J Food Sci Nutr 65:440–448
   PubMed Web of Science ®Google Scholar
• Matsui T, Ebuchi S, Kobayashi M, Fukui K, Sugita K, Terahara N, Matsumoto K. 2002. Anti-hyperglycemic effect of diacylated anthocyanin derived from Ipomoea batatas cultivar Ayamurasaki can be achieved through the α-glucosidase inhibitory action. J Agric Food Chem 50:7244–7248
   PubMed Web of Science ®Google Scholar
• McDougall GJ, Stewart D. 2005. The inhibitory effects of berry polyphenols on digestive enzymes. Biofactors 23:189–195
   PubMed Web of Science ®Google Scholar
• McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, Stewart D. 2005. Different polyphenolic components of soft fruits inhibit α-amylase and α-glucosidase. J Agric Food Chem 53:2760–2766
   PubMed Web of Science ®Google Scholar
• Medjakovic S, Jungbauer A. 2013. Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct 4:19–34
   PubMed Web of Science ®Google Scholar
• Nathanson D, Nyström T. 2009. Hypoglycemic pharmacological treatment of type 2 diabetes: targeting the endothelium. Mol Cell Endocrinol 297:112–126
   PubMed Web of Science ®Google Scholar
• Oki T, Matsui T, Osajima Y. 1999. Inhibitory effect of alpha-glucosidase inhibitor varies according to its origin. J Agric Food Chem 47:550–553
   PubMed Web of Science ®Google Scholar
• Okuda T, Yoshida T, Ashida M, Yazaki K. 1983. Tannins of Casuarina and Stachyurus species. Part 1. Structures of pedunculagin, casuarictin, strictinin, casuarinin, casuariin and stachyurin. J Chem Soc, Perkin Trans 1:1765–1772
   Google Scholar
• Park SH, Kim JL, Lee ES, Han SY, Gong JH, Kang MK, Kang YH. 2011. Dietary ellagic acid attenuates oxidized LDL uptake and stimulates cholesterol efflux in murine macrophages. J Nutr 141:1931–1937
   PubMed Web of Science ®Google Scholar
• Rock W, Rosenblat M, Miller-Lotan R, Levy AP, Elias M, Aviram M. 2008. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. J Agric Food Chem 56:8704–8713
   PubMed Web of Science ®Google Scholar
• Rosenblat M, Hayek T, Aviram M. 2006. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 187:363–371
   PubMed Web of Science ®Google Scholar
• Shiner M, Fuhrman B, Aviram M. 2007. Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation. Atherosclerosis 195:313–321
   PubMed Web of Science ®Google Scholar
• Singleton VL, Orthofer R, Lamuela-Raventos RM. 1999. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin–Ciocalteu reagent. Methods Enzymol 99:152–178
   Google Scholar
• Tadera K, Minami Y, Takamatsu K, Matsuoka T. 2006. Inhibition of alpha-glucosidase and alpha amylase by flavonoids. J Nutr Sci Vitaminol 52:149–153
   PubMed Web of Science ®Google Scholar
• Tagliazucchi D, Verzelloni E, Conte A. 2012. The first tract of alimentary canal as an extractor. Release of phytochemicals from solid food matrices during simulated digestion. J Food Biochem 36:555–568
   Google Scholar
• Tang W, Li S, Liu Y, Huang MT, Ho CT. 2013. Anti-diabetic activity of chemically profiled green tea and black tea extracts in a type 2 diabetes mice model via different mechanisms. J Funct Foods 5:1784–1793
   Web of Science ®Google Scholar
• Tomás-Barberán FA, García-Villalba R, González-Sarrías A, Selma MV, Espín JC. 2014. Ellagic acid metabolism by human gut microbiota: consistent observation of three urolithin phenotypes in intervention trials, independent of food source, age, and health status. J Agric Food Chem 62:6535–6538
   PubMed Web of Science ®Google Scholar
• Toshima A, Matsui T, Noguchi M, Qiu J, Tamaya K, Miyata Y. 2010. Identification of α-glucosidase inhibitors from a new fermented tea obtained by tea-rolling processing of loquat (Eriobotrya japonica) and green tea leaves. J Sci Food Agric 90:1545–1550
   PubMed Web of Science ®Google Scholar
• Usta C, Ozdemir S, Schiariti M, Puddu PE. 2013. The pharmacological use of ellagic acid-rich pomegranate fruit. Int J Food Sci Nutr 64:907–913
   PubMed Web of Science ®Google Scholar
• Verzelloni E, Tagliazucchi D, Conte A. 2007. Relationship between the antioxidant properties and the phenolic and flavonoid content in traditional balsamic vinegar. Food Chem 105:564–571
   Web of Science ®Google Scholar
• Verzelloni E, Pellacani C, Tagliazucchi D, Tagliaferri S, Calani L, Costa LG, Brighenti F, et al. 2011. Antiglycative and neuroprotective activity of colon-derived polyphenol catabolites. Mol Nutr Food Res 55:35–43
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhang H, Liang H, Yuan Q. 2013. Purification, antioxidant activity and protein-precipitating capacity of punicalin from pomegranate husk. Food Chem 138:437–443
   PubMed Web of Science ®Google Scholar