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Comprehensive Review

Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease

Pages 43-49 | Received 17 Feb 2014, Accepted 12 Aug 2014, Published online: 16 Oct 2014

References

  • Alshatwi AA. 2010. Breast cancer risk, dietary intake and methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms. Food Chem Toxicol 48:1881–1885
  • Batschauer AP, Cruz NG, Oliveira VC, Coelho FF, Santos IR, Alves MT, Fernandes AP, et al. 2011. HFE, MTHFR, and FGFR4 genes polymorphisms and breast cancer in Brazilian women. Mol Cell Biochem 357:247–253
  • Beetstra S, Suthers G, Dhillon V, Salisbury C, Turner J, Altree M, McKinnon R, Fenech M. 2008. Methionine dependence phenotype in the de novo pathway in BRCA1 and BRCA2 mutation carriers with and without breast cancer. Cancer Epidemiol Biomarkers Prev 17:2565–2571
  • Bravatà V, Cammarata FP, Forte GI and Minafra L. 2013a. “Omics” of HER2 Positive Breast Cancer. OMICS 17:119–129
  • Bravatà V, Stefano A, Cammarata FP, Minafra L, Russo G, Nicolosi S, Pulizzi S, et al. 2013b. Genotyping analysis and 18FDG uptake in breast cancer patients: a preliminary research. J Exp Clin Cancer Res 32:23
  • Carvalho Barbosa Rde C, Menezes DC, Freire TF, Sales DC, Alencar VH, Rabenhorst SH. 2012. Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent. Mol Biol Rep 39:4899–4907
  • Celtikci B, Lawrance AK, Wu Q, Rozen R. 2009. Methotrexateinduced apoptosis is enhanced by altered expression of methylenetetrahydrofolate reductase. Anticancer Drugs 20:787–793
  • Choi SW, Mason JB. 2000. Folate and carcinogenesis: an integrated scheme. J Nutr 130:129–132
  • Dhillon V, Thomas P, Fenech M. 2009. Effect of common polymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort. Mutat Res 665:1–6
  • Duthie SJ, Narayanan S, Sharp L, Little J, Basten G, Powers H. 2004. Folate, DNA stability and colo-rectal neoplasia. Proc Nutr Soc 63:571–578
  • Ericson U, Borgquist S, Ivarsson MI, Sonestedt E, Gullberg B, Carlson J, Olsson H, et al. 2010. Plasma folate concentrations are positively associated with risk of estrogen receptor beta negative breast cancer in a Swedish nested case control study. J Nutr 140:1661–1668
  • Ericson U, Sonestedt E, Gullberg B, Olsson H, Wirfält E. 2007. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort. Am J Clin Nutr 86:434–443
  • Ericson U, Sonestedt E, Ivarsson MI, Gullberg B, Carlson J, Olsson H, Wirfält E. 2009a. Folate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort. Cancer Epidemiol Biomarkers Prev 18:1101–1110
  • Ericson UC, Ivarsson MI, Sonestedt E, Gullberg B, Carlson J, Olsson H, Wirfält E. 2009b. Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele. Am J Clin Nutr 90:1380–1389
  • Eroglu A, Karabıyık A, Akar N. 2012. The association of protease activated receptor 1 gene -506 I/D polymorphism with disease-free survival in breast cancer patients. Ann Surg Oncol 19:1365–1369
  • Eussen SJ1, Vollset SE, Igland J, Meyer K, Fredriksen A, Ueland PM, Jenab M, et al. 2010. Plasma folate, related genetic variants, and colorectal cancer risk in EPIC. Cancer Epidemiol Biomarkers Prev 19:1328–1340
  • Feigelson HS, Jonas CR, Robertson AS, McCullough ML, Thun MJ, Calle EE. 2003. Alcohol, folate, methionine, and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II Nutrition Cohort. Cancer Epidemiol Biomarkers Prev 12:161–164
  • Ferroni P, Palmirotta R, Martini F, Riondino S, Savonarola A, Spila A, Ciatti F, et al. 2009. Determinants of homocysteine levels in colorectal and breast cancer patients. Anticancer Res 29:4131–4138
  • Goldstein DB. 2009. Common genetic variation and human traits. N Engl J Med 360:1696–1698
  • Guéant-Rodriguez RM, Guéant JL, Debard R, Thirion S, Hong LX, Bronowicki JP, Namour F, et al. 2006. Prevalence of methylenetetrahydrofolate reductase 677T and 1298C alleles and folate status: a comparative study in Mexican, West African, and European populations. Am J Clin Nutr 83:701–707
  • Guerreiro CS, Carmona B, Gonçalves S, Carolino E, Fidalgo P, Brito M, Leitão CN, Cravo M. 2008. Risk of colorectal cancer associated with the C677T polymorphism in 5,10-methylenetetrahydrofolate reductase in Portuguese patients depends on the intake of methyl-donor nutrients. Am J Clin Nutr 88:1413–1418
  • Guillem VM, Collado M, Terol MJ, Calasanz MJ, Esteve J, Gonzalez M, Sanzo C, et al. 2007. Role of MTHFR (677, 1298) haplotype in the risk of developing secondary leukemia after treatment of breast cancer and hematological malignancies. Leukemia 21:1413–1422
  • Hekim N, Ergen A, Yaylim I, Yilmaz H, Zeybek U, Oztürk O, Isbir T. 2007. No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer. Cell Biochem Funct 25:115–117
  • Hosseini M, Houshmand M, Ebrahimi A. 2011. MTHFR polymorphisms and breast cancer risk. Arch Med Sci 7:134–137
  • Huang MY, Wang YH, Chen FM, Lee SC, Fang WY, Cheng TL, Hou MF, et al. 2007. Multiple genetic polymorphisms of GSTP1 313AG, MDR1 3435CC, and MTHFR 677CC highly correlated with early relapse of breast cancer patients in Taiwan. Ann Surg Oncol 15:872–880
  • Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, et al. 2007. A genome-wide association study identifi es alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39:870–874
  • Izmirli M. 2013. A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk. Mol Biol Rep 40:625–637
  • Jackson MD, Tulloch-Reid MK, McFarlane-Anderson N, Watson A, Seers V, Bennett FI, Egleston B, Ragin C. 2013. Complex interaction between serum folate levels and genetic polymorphisms in folate pathway genes: biomarkers of prostate cancer aggressiveness. Genes Nutr 8:199–207
  • Jakubowska A, Gronwald J, Menkiszak J, Górski B, Huzarski T, Byrski T, Edler L, et al. 2007. Methylenetetrahydrofolate reductase polymorphisms modify BRCA1-associated breast and ovarian cancer risks. Breast Cancer Res Treat 104:299–308
  • Kamangar F, Dores GM, Anderson WF. 2006. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24:2137–2150
  • Kennedy DA, Stern SJ, Matok I, Moretti ME, Sarkar M, Adams-Webber T, Koren G. 2012. Folate Intake, MTHFR polymorphisms, and the risk of colorectal cancer: a systematic review and meta-analysis. J Cancer Epidemiol 2012:Article ID: 952508
  • Khoury MJ, Little J. 2000. Human genome epidemiologic reviews: the beginning of something HuGE. Am J Epidemiol 151:2–3
  • Kim YI. 2006. Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut 55:1387–1389
  • Kim YI. 2008. Folic acid supplementation and cancer risk: point. Cancer Epidemiol Biomarkers Prev 17:2220–2225
  • Kim YI. 2005. Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility. J Nutr 135:2703–2709
  • Knechtel G, Hofmann G, Gerger A, Renner W, Langsenlehner T, Szkandera J, Wolf G, et al. 2010. Analysis of common germline polymorphisms as prognostic factors in patients with lymph node-positive breast cancer. J Cancer Res Clin Oncol 136:1813–1819
  • Kotsopoulos J, Zhang WW, Zhang S, McCready D, Trudeau M, Zhang P, Sun P, Narod SA. 2008. Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer. Breast Cancer Res Treat 208 112:585–593
  • Lajous M, Lazcano-Ponce E, Hernandez-Avila M, Willett W, Romieu I. 2006a. Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev 15:443–448
  • Lajous M, Romieu I, Sabia S, Boutron-Ruault MC, Clavel-Chapelon F. 2006b. Folate, vitamin B(12) and postmenopausal breast cancer in a prospective study of French women. Cancer Causes Control 17:1209–1213
  • Lewis SJ, Harbord RM, Harris R, Smith GD. 2006. Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. J Natl Cancer Inst 98:1607–1622
  • Ma E, Iwasaki M, Kobayashi M, Kasuga Y, Yokoyama S, Onuma H, Nishimura H, et al. 2009. Dietary intake of folate, vitamin B2, vitamin B6, vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a casecontrol study in Japan. Nutr Cancer 61:447–456
  • Martin YN, Olson JE, Ingle JN, Vierkant RA, Fredericksen ZS, Pankratz VS, Wu Y, et al. 2006. Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 15:2322–2324
  • Maruti SS, Ulrich CM, Jupe ER, White E. 2009a. MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study. Breast Cancer Res 11:R91
  • Maruti SS, Ulrich CM, White E. 2009b. Folate and one-carbon metabolism nutrients from supplements and diet in relation to breast cancer risk. Am J Clin Nutr 89:624–633
  • Minafra L, Bravatà V, Saporito M, Cammarata FP, Forte GI, Caldarella S, D Arienzo M, et al. 2014. Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. Arthritis Res Ther 9 16:R91
  • Minafra L, Norata R, Bravatà V, Viola M, Lupo C, Gelfi C, Messa C. 2012. Unmasking epithelial-mesenchymal transition in a breast cancer primary culture: a study report. BMC Res Notes 5:343
  • Misotti AM, Gnagnarella P. 2013. Vitamin supplement consumption and breast cancer risk: a review. Ecancer Medicalsci 23:365
  • Mohammad NS, Yedluri R, Addepalli P, Gottumukkala SR, Digumarti RR, Kutala VK. 2011. Aberrations in one-carbon metabolism induce oxidative DNA damage in sporadic breast cancer. Mol Cell Biochem 349:159–167
  • Negri E, La Vecchia C, Franceschi S. 2000. Re: dietary folate consumption and breast cancer risk. J Natl Cancer Inst 92:1270–1271
  • Offit K. 2009. Breast cancer single-nucleotide polymorphisms: statistical significance and clinical utility. J Natl Cancer Inst 101:973–975
  • Offit K. 2008. Genomic profi les for disease risk: predictive or premature? JAMA 299:1353–1355
  • Pepe C, Guidugli L, Sensi E, Aretini P, D'Andrea E, Montagna M, Manoukian S, et al. 2007. Methyl group metabolism gene polymorphisms as modifier of breast cancer risk in Italian BRCA1/2 carriers. Breast Cancer Res Treat 103:29–36
  • Perel’muter VM, Zav’ialova MV, Vtorushin SV, Slonimskaia EM, Kritskaia NG, Garbukov EIu, Litviakov NV, et al. 2008. Genetic and clinical and pathological characteristics of breast cancer in premenopausal and postmenopausal women. Adv Gerontol 21:643–653
  • Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, et al. 2000. Molecular portraits of human breast tumors. Nature 406:747–752
  • Prasad VV, Wilkhoo H. 2011. Association of the functional polymorphism C677T in the methylenetetrahydrofolate reductase gene with colorectal, thyroid, breast, ovarian and cervical cancers. Onkologie 34:422–426
  • Qiu LX, Zhang J, Li WH, Zhang QL, Yu H, Wang BY, Wang LP, et al. 2011. Lack of association between methlenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility. Mol Biol Rep 38:2295–2299
  • Rakha EA, El-Sayed ME, Reis-Filho JS, Ellis IO. 2008. Expression profiling technology: its contribution to our understanding of breast cancer. Histopathology 52:67–81
  • Robien K, Boynton A, Ulrich CM. 2005. Pharmacogenetics of folate-related drug targets in cancer treatment. Pharmacogenomics 6:673–689
  • Rohan TE, Jain MG, Howe GR, Miller AB. 2000. Dietary folate consumptionand breast cancer risk. J Natl Cancer Inst 92:266–269
  • Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Khuhaprema T, Yoshida T. 2010. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. Breast Cancer Res Treat 123:885–893
  • Shrubsole MJ, Jin F, Dai Q, Shu XO, Potter JD, Hebert JR, Gao YT, Zheng W. 2001. Dietary folate intake and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Res 61:7136–7141
  • Stevens VL, McCullough ML, Pavluck AL, Talbot JT, Feigelson HS, Thun MJ, Calle EE. 2007. Association of polymorphisms in one-carbon metabolism genes and postmenopausal breast cancer incidence. Cancer Epidemiol Biomarkers Prev 16:1140–1147
  • Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, Johnson KA, Johnson C, Buys SS, Hoover RN, Ziegler RG. 2006. Folate intake, alcohol use, and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Am J Clin Nutr 83:895–904
  • Suzuki T, Matsuo K, Hirose K, Hiraki A, Kawase T, Watanabe M, Yamashita T, et al. 2008. One-carbon metabolism-related gene polymorphisms and risk of breast cancer. Carcinogenesis 29:356–362
  • Tao MH, Shields PG, Nie J, Marian C, Ambrosone CB, McCann SE, Platek M, et al. 2009. DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR. Cancer Epidemiol Biomarkers Prev 18:998–1002
  • Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG, Hankinson SE, et al. 2009. A multistage genome-wide association study in breast cancer identifi es two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet 41:579–584
  • Ulrich CM, Potter JD. 2007. Folate and cancer—timing is everything. JAMA 297:2408–2409
  • Ulrich CM, Robien K, Sparks R. 2002. Pharmacogenetics and folate metabolism a promising direction. Pharmacogenomics 3:299–313
  • Vaĭner AS, Boiarskikh UA, Voronina EN, Selezneva IA, Sinkina TV, Lazarev AF, Petrova VD, Filipenko ML. 2010. Polymorphic variants of folate metabolizing genes (C677T andA1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia. Mol Biol 44:816–823
  • Wilcken B, Bamforth F, Li Z, Zhu H, Ritvanen A, Renlund M, Stoll C, et al. 2003. Geographical and ethnic variation of the 677C > T allele of 5,10 methylenetetrahydrofolate reductase (MTHFR): findings from over 7000 newborns from 16 areas world wide. J Med Genet 40:619–625
  • Wu X-Y, Ni J, Xu WJ, Zhou T, Wang X. 2012. Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Asian Pac J Cancer Prev 13:2199–2206
  • Xiao WL, Wu M, Shi B. 2006. Folic acid rivals methylenetetrahydrofolate reductase (MTHFR) genesilencing effect on MEPM cell proliferation and apoptosis. Mol Cell Biochem 292:145–154
  • Xu X, Gammon MD, Wetmur JG, Bradshaw PT, Teitelbaum SL, Neugut AI, Santella RM, Chen J. 2008. B-vitamin intake, one-carbon metabolism, and survival in a population-based study of women with breast cancer. Cancer Epidemiol Biomarkers Prev 17:2109–2116
  • Xu X, Gammon MD, Wetmur JG, Rao M, Gaudet MM, Teitelbaum SL, Britton JA, et al. 2007. A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users. Am J Clin Nutr 85:1098–1102
  • Yang D1, Baumgartner RN, Slattery ML, Wang C, Giuliano AR, Murtaugh MA, Risendal BC, et al. 2013. Dietary intake of folate, B-vitamins and methionine and breast cancer risk among Hispanic and non-Hispanic white women. PLoS One 8:e54495
  • Yu CP, Wu MH, Chou YC, Yang T, You SL, Chen CJ, Sun CA. 2007. Breast cancer risk associated with multigenotypic polymorphisms in folate metabolizing genes: a nested case-control study in Taiwan. Anticancer Res 27:1727–1732
  • Zhang S, Hunter DJ, Hankinson SE, Giovannucci EL, Rosner BA, Colditz GA, Speizer FE, Willett WC. 1999. A prospective study of folate intake and the risk of breast cancer. JAMA 281:1632–1637
  • Ziva Cerne J, Stegel V, Gersak K, Novakovic S. 2011. Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk. Mol Med Report 4:175–179

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