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Studies in Humans

Beetroot juice increase nitric oxide metabolites in both men and women regardless of body mass

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Pages 40-46 | Received 08 May 2015, Accepted 07 Nov 2015, Published online: 13 Dec 2015

References

  • Alvares TS, Conte CA, Paschoalin VM, Silva JT, Meirelles CM, Bhambhani YN, Gomes PS. 2012a. Acute L-arginine supplementation increases muscle blood volume but not strength performance. Appl Physiol Nutr Metab 37:115–126.
  • Alvares TS, Conte-Junior CA, Silva JT, Paschoalin VM. 2012b. Acute L-arginine supplementation does not increase nitric oxide production in healthy subjects. Nutr Metab (Lond) 9:54.
  • Baylis C, Vallance P. 1998. Measurement of nitrite and nitrate levels in plasma and urine – what does this measure tell us about the activity of the endogenous nitric oxide system? Curr Opin Nephrol Hypertens 7:59–62.
  • Doel JJ, Benjamin N, Hector MP, Rogers M, Allaker RP. 2005. Evaluation of bacterial nitrate reduction in the human oral cavity. Eur J Oral Sci 113:14–19.
  • Gilchrist M, Winyard PG, Aizawa K, Anning C, Shore A, Benjamin N. 2013. Effect of dietary nitrate on blood pressure, endothelial function, and insulin sensitivity in type 2 diabetes. Free Radic Biol Med 60:89–97.
  • Hord NG, Tang Y, Bryan NS. 2009. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr 90:1–10.
  • Ignarro LJ, Fukuto JM, Griscavage JM, Rogers NE, Byrns RE. 1993. Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine. Proc Natl Acad Sci USA 90:8103–8107.
  • Jones AM. 2014. Dietary nitrate supplementation and exercise performance. Sports Med 44:S35–S45.
  • Kapil V, Khambata RS, Robertson A, Caulfield MJ, Ahluwalia A. 2015. Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension 65:320–327.
  • Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, et al. 2010. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56:274–281.
  • Kelly J, Fulford J, Vanhatalo A, Blackwell JR, French O, Bailey SJ, Gilchrist M, et al. 2013. Effects of short-term dietary nitrate supplementation on blood pressure, O2 uptake kinetics, and muscle and cognitive function in older adults. Am J Physiol Regul Integr Comp Physiol 304:73–83.
  • Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, et al. 2009. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol 5:865–869.
  • Lundberg JO, Weitzberg E, Gladwin MT. 2008. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7:156–167.
  • Machha A, Schechter AN. 2011. Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits. Eur J Nutr 50:293–303.
  • McKnight GM, Duncan CW, Leifert C, Golden MH. 1999. Dietary nitrate in man: friend or foe? Br J Nutr 81:349–358.
  • Pannala AS, Mani AR, Spencer JP, Skinner V, Bruckdorfer KR, Moore KP, Rice-Evans CA. 2003. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 34:576–584.
  • Rosselli M, Imthurm B, Macas E, Keller PJ, Dubey RK. 1994. Circulating nitrite/nitrate levels increase with follicular development: indirect evidence for estradiol mediated NO release. Biochem Biophys Res Commun 202:1543–1552.
  • Suzuki H, Ikenaga H, Hishikawa K, Nakaki T, Kato R, Saruta T. 1992. Increases in NO2-/NO3- excretion in the urine as an indicator of the release of endothelium-derived relaxing factor during elevation of blood pressure. Clin Sci (Lond) 82:631–634.
  • Tsikas D. 2005. Methods of quantitative analysis of the nitric oxide metabolites nitrite and nitrate in human biological fluids. Free Radic Res 39:797–815.
  • Tsikas D. 2015. Circulating and excretory nitrite and nitrate: their value as measures of nitric oxide synthesis, bioavailability and activity is inherently limited. Nitric Oxide 45:1–3.
  • Van Velzen AG, Sips AJ, Schothorst RC, Lambers AC, Meulenbelt J. 2008. The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett 181:177–181.
  • Wagner DA, Schultz DS, Deen WM, Young VR, Tannenbaum SR. 1983. Metabolic fate of an oral dose of 15N-labeled nitrate in humans: effect of diet supplementation with ascorbic acid. Cancer Res 43:1921–1925.
  • Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, et al. 2008. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 51:784–790.
  • Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, et al. 1993. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73:1121–1127.
  • Wylie LJ, Kelly J, Bailey SJ, Blackwell JR, Skiba PF, Winyard PG, Jeukendrup AE, et al. 2013. Beetroot juice and exercise: pharmacodynamic and dose-response relationships. J Appl Physiol 115:325–336.

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