Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study

References

• Abenavoli L, Beaugrand M. 2012. Transient elastography in non-alcoholic fatty liver disease. Ann Hepatol. 11:172–178.
   PubMed Web of Science ®Google Scholar
• Askari F, Rashidkhani B, Hekmatdoost A. 2014. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res. 34:143–148.
   PubMed Web of Science ®Google Scholar
• Barre DE, Mizier-Barre KA, Griscti O, Hafez K. 2008. High dose flaxseed oil supplementation may affect fasting blood serum glucose management in human type 2 diabetics. J Oleo Sci. 57:269–273.
   PubMed Web of Science ®Google Scholar
• Brant LH, Cardozo LF, Velarde LG, Boaventura GT. 2012. Impact of flaxseed intake upon metabolic syndrome indicators in female Wistar rats. Acta Cir Bras. 27:537–543.
   PubMed Web of Science ®Google Scholar
• Cassani RS, Fassini PG, Silvah JH, Lima CM, Marchini JS. 2015. Impact of weight loss diet associated with flaxseed on inflammatory markers in men with cardiovascular risk factors: a clinical study. Nutr J. 14:5.
   PubMed Web of Science ®Google Scholar
• Caughey GE, Mantzioris E, Gibson RA, Cleland LG, James MJ. 1996. The effect on human tumor necrosis factor alpha and interleukin 1 beta production of diets enriched in n-3 fatty acids from vegetable oil or fish oil. Am J Clin Nutr. 63:116–122.
   PubMed Web of Science ®Google Scholar
• Conlon BA, Beasley JM, Aebersold K, Jhangiani SS, Wylie-Rosett J. 2013. Nutritional management of insulin resistance in nonalcoholic fatty liver disease (NAFLD). Nutrients. 5:4093–4114.
   PubMed Web of Science ®Google Scholar
• Dentin R, Benhamed F, Pégorier JP, Foufelle F, Viollet B, Vaulont S, Girard J, Postic C. 2005. Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. J Clin Invest. 115:2843–2854.
   PubMed Web of Science ®Google Scholar
• Eslamparast T, Eghtesad S, Poustchi H, Hekmatdoost A. 2015. Recent advances in dietary supplementation, in treating non-alcoholic fatty liver disease. World J Hepatol. 7:204–212.
   PubMedGoogle Scholar
• Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. 2014. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr. 99:535–542.
   PubMed Web of Science ®Google Scholar
• Faghihzadeh F, Adibi P, Hekmatdoost A. 2015. The effects of resveratrol supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled study. Br J Nutr. 114:796–803.
   PubMed Web of Science ®Google Scholar
• Faghihzadeh F, Adibi P, Rafiei R, Hekmatdoost A. 2014. Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease. Nutr Res. 34:837–843.
   PubMed Web of Science ®Google Scholar
• Farrell GC, Larter CZ. 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 43:S99–S112.
   PubMed Web of Science ®Google Scholar
• Fukumitsu S, Aida K, Shimizu H, Toyoda K. 2010. Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in moderately hypercholesterolemic men. Nutr Res. 30:441–446.
   PubMed Web of Science ®Google Scholar
• Ghaemi A, Taleban FA, Hekmatdoost A, Rafiei A, Hosseini V, Amiri Z, Homayounfar R, Fakheri H. 2013. How much weight loss is effective on nonalcoholic fatty liver disease? Hepat Mon. 13:e15227.
   PubMed Web of Science ®Google Scholar
• Ghaffarpour M, Houshiar-Rad A, Kianfar H. 1999. The manual for household measures, cooking yields factors and edible portion of foods. Tehran: Nashre Olume Keshavarzy. p. 1–40.
   Google Scholar
• Gillingham LG, Gustafson JA, Han SY, Jassal DS, Jones PJ. 2011. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr. 105:417–427.
   PubMed Web of Science ®Google Scholar
• Goyal A, Sharma V, Upadhyay N, Gill S, Sihag M. 2014 . Flax and flaxseed oil: an ancient medicine & modern functional food. J Food Sci Technol. 51:1633–1653.
   PubMed Web of Science ®Google Scholar
• Hutchins AM, Brown BD, Cunnane SC, Domitrovich SG, Adams ER, Bobowiec CE. 2013. Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutr Res. 33:367–375.
   PubMed Web of Science ®Google Scholar
• Jump DB. 2008. N-3 polyunsaturated fatty acid regulation of hepatic gene transcription. Curr Opin Lipidol. 19:242.
   PubMed Web of Science ®Google Scholar
• Kelishadi R, Rabiei K, Khosravi A, Famouri F, Sadeghi M, Rouhafza H, Shirani SH. 2001. Assessment of physical activity of adolescents in Isfahan. Shahrekord Univ Med Sci J. 3:55–66.
   Google Scholar
• Kelley DS, Vemuri M, Adkins Y, Gill SH, Fedor D, Mackey BE. 2009. Flaxseed oil prevents trans-10, cis-12-conjugated linoleic acid-induced insulin resistance in mice. Br J Nutr. 101:701–708.
   PubMed Web of Science ®Google Scholar
• Kristensen M, Savorani F, Christensen S, Engelsen SB, Bügel S, Toubro S, Tetens I, Astrup A. 2013. Flaxseed dietary fibers suppress postprandial lipemia and appetite sensation in young men. Nutr Metab Cardiovasc Dis. 23:136–143.
   PubMed Web of Science ®Google Scholar
• Larter CZ, Farrell GC. 2006. Insulin resistance, adiponectin, cytokines in NASH: which is the best target to treat? J Hepatol. 44:253–261.
   PubMed Web of Science ®Google Scholar
• Leyva DR, Zahradka P, Ramjiawan B, Guzman R, Aliani M, Pierce GN. 2011. The effect of dietary flaxseed on improving symptoms of cardiovascular disease in patients with peripheral artery disease: rationale and design of the FLAX-PAD randomized controlled. Trial Contemp Clin Trials. 32:724–730.
   PubMed Web of Science ®Google Scholar
• Ma Y, Griffith JA, Chasan-Taber L, Olendzki BC, Jackson E, Stanek EJ, Li W, Pagoto SL, Hafner AR, Ockene IS. 2006. Association between dietary fiber and serum C-reactive protein. Am J Clin Nutr. 83:760–766.
   PubMed Web of Science ®Google Scholar
• Machado AM, DE Paula H, Cardoso LD, Costa NM. 2015. Effects of brown and golden flaxseed on the lipid profile, glycemia, inflammatory biomarkers, blood pressure and body composition in overweight adolescents. Nutrition. 31:90–96.
   PubMed Web of Science ®Google Scholar
• Malekzadeh R, Poustchi H. 2011. Fibroscan for assessing liver fibrosis: an acceptable alternative for liver biopsy: fibroscan: an acceptable alternative for liver biopsy. Hepatitis Monthly. 11:157–158.
   PubMed Web of Science ®Google Scholar
• Mani UV, Mani I, Biswas M, Kumar SN. 2011. An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. J Diet Suppl. 8:257–265.
   PubMedGoogle Scholar
• Marx N, Duez H, Fruchart JC, Staels B. 2004. Peroxisome proliferator-activated receptors and atherogenesis regulators of gene expression in vascular cells. Circ Res. 94:1168–1178.
   PubMed Web of Science ®Google Scholar
• Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. 1985. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419.
   PubMed Web of Science ®Google Scholar
• National Institutes of Health, National Heart, Lung, and Blood Institute, NHLBI Obesity Education Initiative, North American Association for the Study of Obesity. 2000. The practical guide: identification, evaluation, and treatment of overweight and obesity in adults. Bethesda (MD): National Institutes of Health.
   Google Scholar
• Pan A, Yu D, Demark-Wahnefried W, Franco OH, Lin X. 2009. Meta-analysis of the effects of flaxseed interventions on blood lipids. Am J Clin Nutr. 90:288–297.
   PubMed Web of Science ®Google Scholar
• Paschos GK, Yiannakouris N, Rallidis LS, Davies I, Griffin BA, Panagiotakos DB, Skopouli FN, Votteas V, Zampelas A. 2005. Apolipoprotein E genotype in dyslipidemic patients and response of blood lipids and inflammatory markers to alpha-linolenic acid. Angiology. 56:49–60.
   PubMed Web of Science ®Google Scholar
• Patade A, Devareddy L, Lucas EA, Korlagunta K, Daggy BP, Arjmandi BH. 2008. Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Women's Health. 17:355–366.
   PubMed Web of Science ®Google Scholar
• Patenaude A, Rodriguez-Leyva D, Edel AL, Dibrov E, Dupasquier CM, Austria JA, Richard MN, Chahine MN, Malcolmson LJ, Pierce GN. 2009. Bioavailability of alpha-linolenic acid from flaxseed diets as a function of the age of the subject. Eur J Clin Nutr. 63:1123–1129.
   PubMed Web of Science ®Google Scholar
• Rhee Y, Brunt A. 2011. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutr J. 10:44.
   PubMed Web of Science ®Google Scholar
• Rinella ME. 2015. Nonalcoholic fatty liver disease: a systematic review. JAMA 313:2263–2273.
   PubMed Web of Science ®Google Scholar
• Tilg H, Hotamisligil GS. 2006. Nonalcoholic fatty liver disease: cytokine-adipokine interplay and regulation of insulin resistance. Gastroenterology. 131:934–945.
   PubMed Web of Science ®Google Scholar
• Torres DM, Williams CD, Harrison SA. 2012. Features, diagnosis, and treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 10:837–858.
   PubMed Web of Science ®Google Scholar
• Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, Torres-Gonzalez A, Gra-Oramas B, Gonzalez-Fabian L, Friedman SL, Diago M, Romero-Gomez M. 2015. Weight loss via lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 149:367–378.e5. quiz e14–15.
   Google Scholar
• World Health Organization. 2012. STEPwise approach to surveillance (STEPS). Geneva, Switzerland: World Health Organization.
   Google Scholar
• Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, et al. 1999. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell. 3:397–403.
   PubMed Web of Science ®Google Scholar
• Xu J, Gao H, Song L, Yang W, Chen C, Deng Q, Huang Q, Yang J, Huang F. 2013. Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Lipids Health Dis. 12:58.
   PubMed Web of Science ®Google Scholar
• Zong G, Demark-Wahnefried W, Wu H, Lin X. 2013. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. Eur J Nutr. 52:1547–1551.
   PubMed Web of Science ®Google Scholar