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Original Article

Cyclic GMP regulates M3AChR activity at plasma membranes from Airway smooth muscle

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Pages 403-417 | Received 11 Jun 2013, Accepted 23 Sep 2013, Published online: 01 Nov 2013

References

  • Alfonzo MJ, Guerra de González L, Villaroel SS, Francis J, Misle AJ, Napoleón V, et al. 1998a. Signal transduction pathways through mammalian guanylyl cyclases. New Adv Cardiovasc Physiol Pharmacol 1184:147–172.
  • Alfonzo MJ, Becemberg IL, Villaroel SS, Herrera VN, Misle AJ, Alfonzo RG. 1998b. Two opposite signal transducing mechanisms regulate a G-protein-coupled guanylyl cyclase. Arch Biochem Biophys 350:19–25.
  • Alfonzo MJ, Placeres-Uray F, Hassan-Soto W, Borges A, Gonzalez de Alfonzo R, Lippo de Becemberg I. 2012. Two guanylylcyclases regulated the muscarinic activation of Airway Smooth Muscle. In: Sugi H, editor. Current basic and pathological approaches to the function of muscle cells and tissues – from molecules to humans. Croatia. InTech. 113–132.
  • Alvarez-Curto E, Ward RJ, Pediani JD, Milligan G. 2010. Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRET. J Biol Chem 285:23318–23330.
  • Angers S, Salahpour A, Bouvier M. 2002. Dimerization: An emerging concept for G protein-coupled receptor ontogeny and function. Ann Rev Pharmacol Toxicol 42:409–435.
  • Bender AT, Beavo JA. 2006. Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use. Pharmacol Rev 58:488–520.
  • Bennett JP Jr, Yamamura HI. 1985. Neurotransmitter, hormone, or drug receptor binding methods. In: Yamamura HI, Enna SJ, Kuhar MJ, editors. Neurotransmitter receptor binding. New Jersey: Raven. pp 61–89.
  • Bensadoun A, Weinstein D. 1976. Assay of proteins in the presence of interfering materials. Anal Biochem 70:241–250.
  • Borges A, Villarroel SS, Winand NJ, Becemberg IL, Alfonzo MJ, Alfonzo RG. 2001. Molecular and biochemical characterization of a CNP-sensitive guanylyl cyclase in bovine tracheal smooth muscle. Am J Respir Cell Mol Biol 25:98–103.
  • Bruges G, Borges A, Villarroel SS, Becemberg IL, Francis G, Pláceres F, et al. 2007. Coupling of M3 acetylcholine receptor to Gq16 activates a natriuretic peptide receptor guanylyl cyclase. J Recept Signal Transduct Res 27:189–216.
  • Burgisser E, De Lean A, Lefkowitz RJ. 1982. Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide. Proc Natl Acad Sci USA 79:1732–1736.
  • Burns F, Rodger IW, Pyne NJ. 1992. The catalytic subunit of protein kinase A triggers activation of the type V cyclic GMP-specific phosphodiesterase from guinea-pig lung. Biochem J 283:487–491.
  • Butt E, Nolte C, Schulz S, Beltman J, Beavo JA, Jastorff B, et al. 1992. Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. Biochem Pharmacol 43:2591–2600.
  • Butt E, Eigenthaler M, Geneiser HG. 1994. (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. Eur J Pharmacol 269:265–268.
  • Caulfield MP, Birdsall NJ. 1998. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50:279–290.
  • Corbin JD, Francis SH. 1999. Cyclic GMP phosphodiesterase-5: Target of sildenafil. J Biol Chem 274:13729–13732.
  • DebBurman SK, Kunapuli P, Benovic JL, Hosey MM. 1995. Agonist-dependent phosphorylation of human muscarinic receptor in Spodoptera frugiperda insect cell membranes by G protein-coupled receptor kinases. Mol Pharmacol 47:224–233.
  • Draijer R, Vaandrager AB, Nolte C, de Jonge HR, Walter U, van Hinsbergh VW. 1995. Expression of cGMP-dependent protein kinase I and phosphorylation of its substrate, vasodilator-stimulated phosphoprotein, in human endothelial cells of different origin. Circ Res 77:897–905.
  • El-Husseini AE, Bladen C, Vincent SR. 1995. Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain. J Neurochem 64:2814–2817.
  • Eller M, Jarv J. 1988. Two-step isomerization of quinuclidinyl benzilate-muscarinic receptor complex. Neurochem Int 12:285–289.
  • Francis SH, Busch JL, Corbin JD. 2010. cGMP-dependent protein kinases and cGMP. Phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev 62:525–563.
  • Fields JZ, Roeske WR, Morkin E, Yamamura HI. 1978. Cardiac muscarinic cholinergic receptors. Biochemical identification and characterization. J Biol Chem 253:3251–3258.
  • González de Alfonzo R, Bécemberg IL, Alfonzo MJ. 1996. A Ca2+/CaM dependent protein kinase associated with Ca2+ transport in sarco(endo) plasmic vesicles from tracheal smooth muscle. Life Sci 58:18–24.
  • Guerra de González L, Misle A, Pacheco G, Napoleon de Herrera V, González de Alfonzo R, Lippo de Bécemberg I, et al. 1999. Effects of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and N omega (ω)-nitro-L-arginine methyl ester (NAME) on cyclic GMP levels during muscarinic activation of tracheal smooth muscle. Biochem Pharmacol 58:563–569.
  • Haddad EB, Landry Y, Gies JP. 1991. Muscarinic receptor subtypes in guinea pig airways. Am J Physiol 261:L327–L333.
  • Han Y, Moreira IS, Urizar E, Weinstein H, Javitch JA. 2009. Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation. Nat Chem Biol 5:688–695.
  • Henis YI, Sokolovsky M. 1983. Muscarinic antagonists induce different receptor conformations in rat adenohypophysis. Mol Pharmacol 24:357–365.
  • Hofmann F, Dostmann W, Keilbach A, Landgraf W, Ruth P. 1992. Structure and physiological role of cGMP-dependent protein kinase. Biochim Biophys Acta 1135:51–60.
  • Hosey MM. 1992. Diversity of structure, signaling and regulation within the family of muscarinic cholinergic receptors. FASEB J 6:845–852.
  • Hosey MM, Benovic JL, DebBurman SK, Richardson RM. 1995. Multiple mechanisms involving protein phosphorylation are linked to desensitization of muscarinic receptors. Life Sci 56:951–955.
  • Jakubik J, El-Fakahany EE, Tucek S. 2000. Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors. J Biol Chem 275:18836–18844.
  • Katsuki S, Murad F. 1977. Regulation of adenosine cyclic 3′,5′-monophosphate and guanosine cyclic 3′,5′-monophosphate levels and contractility in bovine tracheal smooth muscle. Mol Pharmacol 13:330–341.
  • Kistemaker LE, Oenema TA, Meurs H, Gosens R. 2012. Regulation of airway inflammation and remodeling by muscarinic receptors: Perspectives on anticholinergic therapy in asthma and COPD. Life Sci 91:1126–1133.
  • Kostenis E, Zeng FY, Wess J. 1999. Structure-function analysis of muscarinic receptors and their associated G proteins. Life Sci 64:355–362.
  • Krupnick JG, Benovic JL. 1998. The role of receptor kinases and arrestins in G-protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol 38:289–319.
  • Kulkarni SK, Patil CS. 2004. Phosphodiesterase 5 enzyme and its inhibitors: Update on pharmacological and therapeutical aspects. Methods Find Exp Clin Pharmacol 26:789–799.
  • Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680–685.
  • Leff P. 1995. The two-state model of receptor activation. Trends Pharmacol Sci 16:89–97.
  • Lohmann SM, Vaandrager AB, Smolenski A, Walter U, De Jonge HR. 1997. Distinct and specific functions of cGMP-dependent protein kinases. Trends Biochem Sci 22:307–312.
  • Lucchesi PA, Scheid CR, Romano FD, Kargacin ME, Mullikin-Kilpatrick D, Yamaguchi H, et al. 1990. Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. Am J Physiol 258:C730–C738.
  • Luo J, Busillo JM, Benovic JL. 2008. M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol Pharmacol 74:338–347.
  • Mak JC, Barnes PJ. 1990. Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. Am Rev Respir Dis 141:1559–1568.
  • Michel AD, Whiting RL. 1988. Methoctramine reveals heterogeneity of M2 muscarinic receptors in longitudinal ileal smooth muscle membranes. Eur J Pharmacol 145:305–311.
  • Michel AD, Stefanich E, Whiting RL. 1989. Direct labeling of rat M3-muscarinic receptors by [3H]-4DAMP. Eur J Pharmacol 166:459–466.
  • McMillin SM, Heusel M, Liu T, Costanzi S, Wess J. 2011. Structural basis of M3 muscarinic receptor dimer/oligomer formation. J Biol Chem 286:28584–28598.
  • Milligan G. 2007. G protein-coupled receptor dimerisation: Molecular basis and relevance to function. Biochim Biophys Acta 1768–1825–835.
  • Misle AJ, Lippo de Becemberg I, Gonzalez de Alfonzo R, Alfonzo MJ. 1994. Methoctramine binding sites sensitive to alkylation on muscarinic receptors from tracheal smooth muscle. Biochem Pharmacol 48:191–195.
  • Misle AJ, Lippo de Becemberg I, Gonzalez de Alfonzo R, Alfonzo MJ. 1995. Subcellular distribution and pharmacological characterization of muscarinic receptors in tracheal smooth muscle. Acta Cient Venez 46:166–173.
  • Murad F, Kimura H. 1974. Cyclic nucleotide levels in incubations of guinea pig trachea. Biochim Biophys Acta 343:275–286.
  • Palczewski K. 2010. Oligomeric forms of G-protein coupled receptors (GPCRs). Trends Biochem Sci 35:595–600.
  • Peterson GL, Schimerlik MI. 1984. Large scale preparation and characterization of membrane-bound and detergent-solubilized muscarinic acetylcholine receptor from pig atria. Prep Biochem 14:33–74.
  • Pfeifer A, Aszodi A, Seidler U, Ruth P, Hofmann F, Fassler R. 1996. Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274:2082–2086.
  • Reddy H, Watson N, Ford AP, Eglen RM. 1995. Characterization of the interaction between muscarinic M2 receptors and beta-adrenoceptor subtypes in guinea-pig isolated ileum. Br J Pharmacol 114:49–56.
  • Rovira X, Pin JP, Giraldo J. 2010. The asymmetric/symmetric activation of GPCR dimers as a possible mechanistic rationale for multiple signalling pathways. Trends Pharmacol Sci 31:15–21.
  • Schultz G, Hardman JG, Schultz K, Baird CE, Sutherland EW. 1973. The importance of calcium ions for the regulation of guanosine 3′:5′-cyclic monophosphate levels. Proc Natl Acad Sci USA 70:3889–3893.
  • Song GJ, Jones BW, Hinkle PM. 2007. Dimerization of the thyrotropin-releasing hormone receptor potentiates hormone-dependent receptor phosphorylation. Proc Natl Acad Sci USA 104:18303–18308.
  • Tränkle C, Kostenis E, Mohr K. 2001. Muscarinic allosteric modulation: M2/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity. Naunyn Schmiedebergs Arch Pharmacol 364:172–178.
  • Uray FP, de Alfonzo RG, de Becemberg IL, Alfonzo MJ. 2010. Muscarinic agonists acting through M2 acetylcholine receptors stimulate the migration of an NO-sensitive guanylyl cyclase to the plasma membrane of bovine tracheal smooth muscle. J Recept Signal Transduct Res 30:10–23.
  • Vaandrager AB, De Jonge HR. 1994. Effect of cyclic GMP on intestinal transport. Adv Pharmacol 26:253–283.
  • Vaandrager AB, Edixhoven M, Bot AG, Kroos MA, Jarchau T, Lohmann S, et al. 1997. Endogenous type II cGMP-dependent protein kinase exists as a dimer in membranes and can be functionally distinguished from the type I isoforms. J Biol Chem 272:11816–11823.
  • Wess J. 1996. Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol 10:69–99.
  • Wess J, Eglen RM, Gautam D. 2007. Muscarinic acetylcholine receptors: Mutant mice provide new insights for drug development. Nat Rev Drug Discov 6:721–733.
  • White JF, Grodnitzky J, Louis JM, Trinh LB, Shiloach J, Gutierrez J, et al. 2007. Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction. Proc Nat Acad Sci USA 104:12199–12204.
  • Willets JM, Chaliss RA, Kelly E, Nahorski SR. 2001. G protein-coupled receptor kinases 3 and 6 use different pathways to desensitize the endogenous M3 muscarinic acetylcholine receptor in human SH-SY5Y cells. Mol Pharmacol 60:321–330.
  • Zeng Y, Wess J. 1999. Identification and molecular characterization of m3 muscarinic receptor dimmers. J Biol Chem 274:19487–19497.

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