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Membrane Biochemistry Volume 10, 1993 - Issue 1
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Original Article

Synthesis of N-(4′-Pyridoxyl)Sphingosine and its Uptake and Metabolism by Isolated Cells

Zuomin Zhang Department of Biochemistry, Rollins Research, Emory University, Atlanta, GA, 30322
,
Elizabeth Smith Department of Biochemistry, Rollins Research, Emory University, Atlanta, GA, 30322
,
Scott M Surowiec Department of Biochemistry, Rollins Research, Emory University, Atlanta, GA, 30322
,
Alfred H. Merrill Department of Biochemistry, Rollins Research, Emory University, Atlanta, GA, 30322
&
Donald B. McCormick Department of Biochemistry, Rollins Research, Emory University, Atlanta, GA, 30322
Pages 53-59 | Received 17 Aug 1992, Accepted 09 Oct 1992, Published online: 09 Jul 2009

References

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  • Kazarinoff M. N., McCormick D. B. Rabbit liver pyridoxamine (pyridoxine)5′ -phosphate oxidase. Purification and properties. J. Biol. Chem. 1975; 250: 3436–3442
  • Kozik A., McCormick D. B. Mechanism of pyridoxine uptake by isolated rat liver cells. Arch. Biochem. Biophys. 1984; 229: 187–193
  • Merrill A. H., Jr. Cell regulation by sphingosine and more complex sphingolipids. J. Bioenerg. Biomembr. 1990; 23: 83–104
  • Merrill A. H., Jr., Nimkar S., Menaldino D., Hannun Y. A., Loomis C., Bell R. M., Tyagi S. R., Lambeth J. D., Stevens V. L., Hunter R., Liotta D. C. Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds. Biochemistry 1989; 28: 3138–3145
  • Merrill A. H., Jr., Wang E., Mullins R. E., Jamison W. C. L., Nimkar S., Liotta D. C. Quantitation of free sphingosine in liver by high-performance liquid chromatography. Anal. Biochem. 1988; 17: 373–381
  • McCormick D. B., Gregory M. E., Snell E. E. Pyridoxal phosphokinase. I. Assay, distribution, purification, and properties. J. Biol. Chem. 1961; 236: 2076–2084
  • McCormick D. B., Snell E. E. Pyridoxal phosphokinases. II. Effects of Inhibitors. J. Biol. Chem. 1961; 236: 2085–2088
  • Peterson E. A., Sober H. A. Preparation of crystalline phosphorylated derivatives of vitamin B6. J. Am. Chem. Soc. 1954; 76: 169–175
  • Reddy R. V. The measurement of critical micelle concentration of sphingosine using a fluorescent probe and light scattering. BA Thesis, Department of Chemistry, Emory University. 1992
  • Zhang Z., Gregory J. F., III, McCormick D. B. Pyridoxine-5′-β-D-glucoside competitively inhibits uptake of vitamin B6 into isolated rat liver cells. J. Nutr. 1993; 123: 85–89
  • Zhang Z., McCormick D. B. Uptake of N -(4′-pyridoxyl)-amines and release of amines by renal cells: a model for transporter-enhanced delivery of bioactive compounds. Proc. Natl. Acad. Sci. USA 1991; 88: 10407–10410
  • Zhang Z., McCormick D. B. Uptake and metabolism of N -(4′-pyridoxyl)amines by isolated rat liver cells. Arch. Biochem. Biophys. 1992; 294: 394–397

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