Antidepressant-like effects and possible mechanisms of amantadine on cognitive and synaptic deficits in a rat model of chronic stress

References

• Airaksinen E, Larsson M, Lundberg I, Forsell Y. (2004). Cognitive functions in depressive disorders: evidence from a population-based study. Psychol Med 34:83–91
   PubMed Web of Science ®Google Scholar
• Alfarez DN, Joels M, Krugers HJ. (2003). Chronic unpredictable stress impairs long-term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro. Eur J Neurosci 17:1928–34
   PubMed Web of Science ®Google Scholar
• An L, Yang Z, Zhang T. (2013a). Imbalanced synaptic plasticity induced spatial cognition impairment in male offspring rats treated with chronic prenatal ethanol exposure. Alcohol Clin Exp Res 37:763–70
   PubMed Web of Science ®Google Scholar
• An L, Yang Z, Zhang T. (2013b). Melamine induced spatial cognitive deficits associated with impairments of hippocampal long-term depression and cholinergic system in Wistar rats. Neurobiol Learn Mem 100:18–24
   PubMed Web of Science ®Google Scholar
• Baldessarini RJ, Lipinski JF, Chace KV. (1972). Effects of amantadine hydrochloride on catecholamine metabolism in the brain of the rat. Biochem Pharmacol 21:77–87
   PubMed Web of Science ®Google Scholar
• Bliss TV, Collingridge GL. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361:31–9
   PubMed Web of Science ®Google Scholar
• Casarotto PC, Andreatini R. (2007). Repeated paroxetine treatment reverses anhedonia induced in rats by chronic mild stress or dexamethasone. Eur Neuropsychopharmacol 17:735–42
   PubMed Web of Science ®Google Scholar
• Cera N, Bifolchetti S, Martinotti G, Gambi F, Sepede G, Onofrj M, Di Giannantonio M, Thomas A. (2014). Amantadine and cognitive flexibility: decision making in Parkinson’s patients with severe pathological gambling and other impulse control disorders. Neuropsychiatr Dis Treat 10:1093–101
   PubMed Web of Science ®Google Scholar
• Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, et al. (2013). The NMDA receptor as a target for cognitive enhancement. Neuropharmacology 64:13–26
   PubMed Web of Science ®Google Scholar
• Conrad CD. (2010). A critical review of chronic stress effects on spatial learning and memory. Prog Neuropsychopharmacol Biol Psychiatry 34:742–55
   PubMed Web of Science ®Google Scholar
• Cousins SL, Stephenson FA. (2012). Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. J Biol Chem 287:13465–76
   PubMed Web of Science ®Google Scholar
• Dixon CE, Kraus MF, Kline AE, Ma X, Yan HQ, Griffith RG, Wolfson BM, Marion DW. (1999). Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats. Restor Neurol Neurosci 14:285–94
   PubMed Web of Science ®Google Scholar
• Dong J, Min S, Wei K, Li P, Cao J, Li Y. (2010). Effects of electroconvulsive therapy and propofol on spatial memory and glutamatergic system in hippocampus of depressed rats. J ECT. 26:126–30
   PubMed Web of Science ®Google Scholar
• Ehrlich I, Klein M, Rumpel S, Malinow R. (2007). PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci USA 104:4176–81
   PubMed Web of Science ®Google Scholar
• Fox CJ, Russell KI, Wang YT, Christie BR. (2006). Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo. Hippocampus 16:907–15
   PubMed Web of Science ®Google Scholar
• Henningsen K, Andreasen JT, Bouzinova EV, Jayatissa MN, Jensen MS, Redrobe JP, Wiborg O. (2009). Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. Behav Brain Res 198:136–41
   PubMed Web of Science ®Google Scholar
• Hosenbocus S, Chahal R. (2013). Amantadine: a review of use in child and adolescent psychiatry. J Can Acad Child Adolesc Psychiatry 22:55–60
   PubMedGoogle Scholar
• Huber TJ, Dietrich DE, Emrich HM. (1999). Possible use of amantadine in depression. Pharmacopsychiatry 32:47–55
   PubMed Web of Science ®Google Scholar
• Kaefer V, Semedo JG, Kahl VFS, Von Borowsky RG, Gianesini J, Kist TBL, Pereira P, Picada JN. (2010). DNA damage in brain cells and behavioral deficits in mice after treatment with high doses of amantadine. J Appl Toxicol 30:745–53
   PubMed Web of Science ®Google Scholar
• Kim JJ, Diamond DM. (2002). The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci 3:453–62
   PubMed Web of Science ®Google Scholar
• Li B, Otsu Y, Murphy TH, Raymond LA. (2003). Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95. J Neurosci 23:11244–54
   PubMed Web of Science ®Google Scholar
• Lou JS, Li CY, Yang XC, Fang J, Yang YX, Guo JY. (2010). Protective effect of gan mai da zao decoction in unpredictable chronic mild stress-induced behavioral and biochemical alterations. Pharm Biol 48:1328–36
   PubMed Web of Science ®Google Scholar
• Marsden WN. (2013). Synaptic plasticity in depression: molecular, cellular and functional correlates. Prog Neuro Psychopharmacol Biol Psychiatry 43:168–84
   PubMed Web of Science ®Google Scholar
• McEwen BS, Magarinos AM. (2001). Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders. Hum Psychopharmacol 16:S7–19
   PubMed Web of Science ®Google Scholar
• Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T. (2000). Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci 20:1568–74
   PubMed Web of Science ®Google Scholar
• Moryl E, Danysz W, Quack G. (1993). Potential antidepressive properties of amantadine, memantine and bifemelane. Pharmacol Toxicol 72:394–7
   PubMedGoogle Scholar
• Neves G, Cooke SF, Bliss TV. (2008). Synaptic plasticity, memory and the hippocampus: a neural network approach to causality. Nat Rev Neurosci 9:65–75
   PubMed Web of Science ®Google Scholar
• Nishikawa N, Nagai M, Moritoyo T, Yabe H, Nomoto M. (2009). Plasma amantadine concentrations in patients with Parkinson’s disease. Parkinsonism Relat Disord 15:351–3
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Burlington, MA: Elsevier Academic Press; 2005
   Google Scholar
• Qi Y, Hu NW, Rowan MJ. (2013). Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced depotentiation in the rat hippocampus. Cereb Cortex 23:932–9
   PubMed Web of Science ®Google Scholar
• Quan M, Zheng C, Zhang N, Han D, Tian Y, Zhang T, Yang Z. (2011a). Impairments of behavior, information flow between thalamus and cortex, and prefrontal cortical synaptic plasticity in an animal model of depression. Brain Res Bull 85:109–16
   PubMed Web of Science ®Google Scholar
• Quan MN, Zhang N, Wang YY, Zhang T, Yang Z. (2011b). Possible antidepressant effects and mechanisms of memantine in behaviors and synaptic plasticity of a depression rat model. Neuroscience 182:88–97
   PubMed Web of Science ®Google Scholar
• Reagan-Shaw S, Nihal M, Ahmad N. (2008). Dose translation from animal to human studies revisited. FASEB J 22:659–61
   PubMed Web of Science ®Google Scholar
• Richter-Levin G, Canevari L, Bliss TV. (1995). Long-term potentiation and glutamate release in the dentate gyrus: links to spatial learning. Behav Brain Res 66:37–40
   PubMed Web of Science ®Google Scholar
• Richter-Levin G, Canevari L, Bliss TV. (1998). Spatial training and high-frequency stimulation engage a common pathway to enhance glutamate release in the hippocampus. Learn Mem 4:445–50
   PubMed Web of Science ®Google Scholar
• Rogoz Z, Skuza G, Daniel WA, Wojcikowski J, Dudek D, Wrobel A. (2007). Amantadine as an additive treatment in patients suffering from drug-resistant unipolar depression. Pharmacol Rep 59:778–84
   PubMed Web of Science ®Google Scholar
• Rogoz Z, Skuza G, Legutko B. (2008). Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats. Pharmacol Rep 60:817–26
   PubMed Web of Science ®Google Scholar
• Sapolsky RM. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archiv Gen Psychiatry 57:925–35
   PubMed Web of Science ®Google Scholar
• Stryjer R, Strous RD, Shaked G, Bar F, Feldman B, Kotler M, Polak L, et al. (2003). Amantadine as augmentation therapy in the management of treatment-resistant depression. Int Clin Psychopharmacol 18:93–6
   PubMed Web of Science ®Google Scholar
• Szakacs R, Janka Z, Kalman J. (2012). The “blue” side of glutamatergic neurotransmission: NMDA receptor antagonists as possible novel therapeutics for major depression. Neuropsychopharmacol Hung 14:29–40
   PubMedGoogle Scholar
• Vorhees CV, Williams MT. (2006). Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–58
   PubMed Web of Science ®Google Scholar
• Wang T, Huang XJ, Van KC, Went GT, Nguyen JT, Lyeth BG. (2014). Amantadine improves cognitive outcome and increases neuronal survival after fluid percussion traumatic brain injury in rats. J Neurotrauma 31:370–7
   PubMed Web of Science ®Google Scholar
• Willner P. (1997). Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation. Psychopharmacology 134:319–29
   PubMed Web of Science ®Google Scholar
• Willner P. (2005). Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52:90–110
   PubMed Web of Science ®Google Scholar
• Xu P, Xu J, Li Z, Yang Z. (2012). Expression of TRPC6 in renal cortex and hippocampus of mouse during postnatal development. PLoS One 7:e38503
   PubMedGoogle Scholar
• Zarate CA, Quiroz J, Payne J, Manji HK. (2002). Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders. Psychopharmacol Bull 36:35–83
   PubMedGoogle Scholar