References
- Hollister LE, Kosek JC: Sudden death during treatment with phenothiazine derivatives. JAMA 1965; 192:1035–1038
- Baselt RC, et al: Human tissue distribution of thioridazine during therapy and after poisoning. J Anal Toxicol 1978; 2:41–43
- Dinovo EC, et al: Distribution of thioridazine and its metabo-lites in human tissues and fluids obtained postmortem. Clin Chem 1978; 24:1828–1830
- Caplan YH, Ottinger WE, Crooks RC: Therapeutic and toxic drug concentrations in postmortem blood: a six year study in the state of Maryland. J Anal Toxicol 1983; 7:225–230
- Jortani SA, Valentour JC, Poklis A: Thioridazine enantiomersin human tissues. Forensic Sci Int 1994; 64:165–170
- Hilberg T. Rogde S, Morland J: Postmortem drug redistribu-tion-human cases related to results in experimental animals. J Forensic Sci 1999; 44:3–9
- Kelly HG, Fay JE, Laverty, SG: Thioridazine hydrochloride: its effect on the electrocardiogram and a report of two fatali-ties with ECG abnormalities. CMAJ 1963; 89:546
- Wendkos MH: Thioridazine and electrocardiographic abnor-malities. CMAJ 1963; 89:1296
- Madan BR, Pendse VK: Antiarrhythmic activity of thiorida-zine hydrochloride. Am J Cardiol. 1963; 11:78
- Ban TA, St. Jean A: The effect of phenothiazines on the electrocardiogram. CMAJ 1964; 91:537
- Graupner KI, Murphree ED: Electrocardiographic changes associated with the use of thioridazine. J Neuropsych. 1964; 5:344
- Ban TA: Electrocardiographic changes induced by phenothi-azine drugs. Am Heart J 1965; 70(4):575–576
- Huston JR, Bell GE: The effect of thioridazine hydrochloride and chlorpromazine on the ECG. JAMA 1966; 198:134
- Alexander S. Shader R, Grinspoon L: Electrocardiographic effects of thioridazine hydrochloride. Lahey Clin Found Bull. 1967; 16:207
- Fletcher GF, Kazamias TM, Wenger NK: Cardiotoxic effects of Mellaril: Conduction disturbances and supraventricular ar-rhythmias. Am Heart J 1969; 78:135–138
- Kalbian VV: Q-T prolongation associated with the use of thioridazine hydrochloride (Mellaril). W V Med .1 1971; 67:296–298
- Wendkos MH: The significance of electrocardiographic changes produced by thioridazine. J New Drugs 1964; 4:322
- Wendkos MG, Thornton CC: An electrocardiographic survey of thioridazine treated-patients. Behav Neuropsych. 1969; 1:18–22
- Moore RH, Rainey JM: Electrocardiographic changes follow-ing intravenous administration of thioridazine to Macaque monkeys. J Clin Psych. 1982; 43:41–43
- Axelsson R. Aspenstrom G: Electrocardiographic changes and serum concentrations in thioridazine-treated patients. J Clin Psych 1982; 43:332–335
- Habibzadeh MA: Cardiovascular effects of phenothiazines: a review. Arizona Med 1979; 36:518–520
- Brannan MD, Riggs JJ, Hageman WE, Pruss TP: A compari-son of the cardiovascular effects of haloperidol, thioridazine and chlorpromazine hydrochloride. Arch Int Pharmacodyn Ther. 1980; 244:48–57
- Hale PW, Poklis A: Cardiotoxicity of thioridazine and two stereoisomeric forms of thioridazine 5-sulfoxide in the isolated perfused rat heart. Toxicol App Pharmacol. 1986; 86:44–55
- Donalini B, Le Blaye I, Krupp P: Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thiorid-azine. Cardiology 1992; 81:340–341
- Fowler NO, et al: Electrocardiographic changes and cardiac arrhythmias is patients receiving psychotropic drugs. Am J Cardiol 1976; 37:223–230
- Yoon MS, et at: Effects of thioridazine (Mellaril) on ventricu-lar electrophysiologic properties. Am J Cardiology 1979; 43:1155–1158
- Nasrallah HA: Factors influencing phenothiazine-induced ECG changes. Am J Psychiatry 1978; 135:118–119
- Turnbull, J: Letter to the editor: hypotensive effect of pheno-thiazines. CMAJ 1966; 94:918
- Lipscomb, PA: Cardiovascular side-effects of phenothiazines and tricyclic antidepressants. Postgrad Med 1980; 67:189–196
- Schoenberger JA: Drug-induced orthostatic hypotension. Drug Safety 1991; 6:402–407
- Cowen TD, Meythaler, JM: Case report: hypotensive effects of thioridazine in an elderly patient with traumatic brain in-jury. Brain Injury 1994; 8:735–737
- Kumar BB: Letter to the editor: acute hypotension from thio-ridazine. JAMA 1975; 234:1321
- Desautels S, Filteau C, St.-Jean A: Ventricular tachycardia associated with administration of thioridazine hydrochloride: case report. CMAJ 1964; 90:1030
- Schoonmaker FS, Osteen RT, Greenfield JC: Thioridazine-induced ventricular tachycardia controlled with an artificial pacemaker. Ann Intern Med 1966; 65:1076–1078
- Peele R, von Loetzen I: Phenothiazine deaths: a critical re-view. Am J Psychiatry 1973; 130:306–309
- Giles TD, Modlin RK: Death associated with ventricular ar-rhythmia and thioridazine hydrochloride. JAMA 1968; 205: 98–100
- Goodson WH, Litkenhous EE: Sudden unexplained death in a psychiatric patient taking thioridazine. South Med J 1976; 69:311, 315). 320
- Chouinard G, Ghadirian AM, Jones BD: Death attributed to ventricular arrhythmia induced by thioridazine in combina-tion with a single Contac.0 capsule. CMAJ 1978; 119:729–731
- Thomas SHL, Cooper PN: Sudden death in a patient taking antipsychotic drugs. Postgrad Med J 1998; 74:445–446
- Rosenquist RJ, Brauer WW, Mork JN: Recurrent major ven-tricular arrhythmias associated with thioridazine therapy. Minn Med 1971; 54:877–880
- Tranum BL, Murphy ML: Case report: successful treatment of ventricular tachycardia associated with thioridazine. South Med J 1969; 62:357–358
- Kemper AJ, Dunlap R, Pietro DA: Thioridazine-induced tor-sades de pointes: successful therapy with isoproterenol. JAMA 1983; 249:2931–2934
- Kiriike N, et al: Iatrogenic torsades de pointes induced by thioridazine. Biol Psychiatry 1987; 22:99–103
- Wilens TE, Stern TA: Ventricular tachycardia associated with desipramine and thioridazine. Psychosomatics. 1990; 31: 100–103
- Denvir, MA, Sood A, Dow R, Brady AJ, Rankin AC: Thiorid-azine, diarrhoea and torsades de pointe. J Royal Soc Med 1998; 91:145–147
- Hale PW, Poklis A: Thioridazine-r-sulfoxide cardiotoxicity in the isolated, perfused rat heart. Toxicol Lett. 1984; 21:1–8
- Gottschalk LA, Dinovo E, Biener R, Nandi BR: Plasma con-centrations of thioridazine metabolites and ECG abnormalit-ies. J Pharm Sci 1978; 67:155–157
- Dinovo EC, et al: Thioridazine-r-sulfoxide and EKG abnor-malities. Proc West Pharmacol Soc 1978; 21:311–312
- Hale P, Poklis A: Letter to the editor: thioridazine cardiotoxic-ity. Clin Toxicol 1996; 34:127–128
- Craig TJ, Lin SP: Medication use and mortality. Comp Psych 1983; 24:183–192
- Mehtonen OP, Aranko K, Malkonen L, Vapaatalo H: A sur-vey of sudden death associated with use of antipsychotic or antidepressant drugs: 49 cases in Finland. Acta Psychiatr Scand 1991; 84:58–64
- Buckley NA, Whyte IM, Dawson AH: Cardiotoxicity more common in thioridazine overdose than with other neurolep-tics. Clin Toxicol 1995; 33:199–204
- Burggraf GW: Are psychotropic drugs at therapeutic levels a concern for cardiologists? Can J Cardiol 1997; 13:75–80
- Wendkos, MH: Letter to the editor: death attributed to ven-tricular arrhythmias. CMAJ 1979; 120:1058–1060