Techniques for the Microassay of Drugs in Biological Materials

References

• Analytical Reviews 1972/Fundamentals. Anal. Chem. April, 1972; 44((5))
   Google Scholar
• Analytical Reviews 1973/Applications. Anal. Chem. April, 1973; 45((5))
   Google Scholar
• Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. XXVIII/1
   Google Scholar
• Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. XXVIII/2
   Google Scholar
• Fundamentals of Drug Metabolism and Drug Disposition, B. N. LaDu, H. G. Mandel, E. L. Way. Williams & Wilkins, Baltimore 1971
   Google Scholar
• Titus E. O. Isolation procedures - liquid extraction and isolation techniques. Fundamentals of Drug Metabolism and Drug Disposition, B. N. LaDu, H. G. Mandel, E. L. Way. Williams & Wilkins, Baltimore 1971; 419
   Google Scholar
• Craig L. C., Craig D. Extraction and distribution. Technique of Organic Chemistry, 2nd ed., A. Weissberger. Interscience, New York 1956; Vol. 3: 172
   Google Scholar
• Titus E. O. Countercurrent distribution. Toxicology, Mechanisms and Analytical Methods, C. P. Stewart, A. Stolman. Academic Press, New York 1970; Vol. 1: 392
   Google Scholar
• Brodie B. B., Udenfriend S., Baer J. E. The estimation of basic organic compounds in biological material. I. General principles. J. Biol. Chem. 1947; 168: 299
   PubMed Web of Science ®Google Scholar
• Salzman N. P., Brodie B. B. Physiological disposition and fate of chlorpromazine and a method for its estimation in biological material. J. Pharmacol. Exp. Ther. 1956; 118: 46
   PubMedGoogle Scholar
• Dingell J. V., Sulser F., Gillette J. R. Species differences in the metabolism of imipramine and desmethylimipramine. J. Pharmacol. Exp. Ther. 1964; 143: 14
   PubMed Web of Science ®Google Scholar
• Curry S. H. Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma using gas liquid chromatography with an electron-capture detector. Anal. Chem. 1968; 40: 1251
   PubMed Web of Science ®Google Scholar
• Carless J. E., Woodhead H. R. Separation of alkaloids by paper chromatography. Nature 1951; 168: 203
   Google Scholar
• DeZeeuw R. A. Paper and thin-layer chromatographic techniques for separation and identification of barbiturates and related hypnotics. Progress in Chemical Toxicology, A. Stolman. Academic Press, New York 1969; Vol. 4: 123
   Google Scholar
• Roberts M. A note on the use of cellulose phosphate cation-exchange paper for the separation of catecholamines and some other biogenic amines. J. Pharm. Pharmacol. 1962; 14: 746
   Google Scholar
• Heftmann E. Chromatography. Reinhold, New York 1961
   Google Scholar
• Hirtz J. L. Analytical Metabolic Chemistry of Drugs. Marcel Dekker, New York 1971
   Google Scholar
• Kirkland J. J. Modern Practice of Liquid Chromatography. Interscience, New York 1971
   Google Scholar
• Byrne S. H. Detectors in liquid chromatography. Modern Practice of Liquid Chromatography, J. J. Kirkland. Interscience, New York 1971; 95
   Google Scholar
• Scott C. G., Bommer P. The liquid chromatography of some benzodiazepines. J. Chromatogr. Sci. 1970; 8: 446
   Web of Science ®Google Scholar
• Hinsvark O. N., Zazulak W., Cohen A. I. Liquid chromatography: its use in the biological characterization and study of metolazone - a new diuretic. J. Chromatogr. Sci. 1972; 10: 379
   PubMed Web of Science ®Google Scholar
• Henry R. A., Schmit J., Dieckman J. F. The analysis of steroids and derivatized steroids by high speed liquid chromatography. J. Chromatogr. Sci. 1971; 9: 513
   Web of Science ®Google Scholar
• Schmit J. Applications of high speed liquid chromatography using controlled surface porosity support. Modern Practice of Liquid Chromatography, J. J. Kirkland. Interscience, New York 1971; 375
   Google Scholar
• Crone H. D. Chromatography of some quaternary drugs on columns of Sephadex G-10. J. Chromatogr. 1971; 60: 185
   PubMed Web of Science ®Google Scholar
• Edwards R. W. H. Column chromatography. Chromatography, D. R. Browning. McGraw-Hill, New York 1969; 12
   Google Scholar
• Huber J. F. K. Liquid chromatography in columns. Comprehensive Analytical Chemistry, Physical Separation Methods, C. L. Wilson, P. W. Wilson, C. R. N. Strouts. Elsevier, New York 1968; Vol. 2B: 179
   Google Scholar
• Fujimoto J. M., Wang R. I. H. A method of identifying narcotic analgesics in human urine after therapeutic doses. Toxicol. Appl. Pharmacol. 1970; 16: 186
   PubMedGoogle Scholar
• Wilkinson G. R. Qualitative and quantitative applications of thin-layer, gas-liquid and column chromatography. Fundamentals of Drug Disposition and Drug Metabolism, B. N. LaDu, H. G. Mandel, E. L. Way. Williams & Wilkins, Baltimore 1972; 458
   Google Scholar
• Stahl E. Thin-layer Chromatography - A Laboratory Handbook, 2nd ed. Springer-Verlag, New York 1969
   Google Scholar
• Haer F. C. Introduction to Chromatography on Impregnated Glass Fiber. Ann Arbor Science, Ann Arbor 1968
   Google Scholar
• Warfield R. W. A New Procedure for Biomedical and Forensic Identification of Drugs. Ph.D. thesis, Indiana University, Bloomington 1973
   Google Scholar
• Szymanski H. A. Biomedical Applications of Gas Chromatography. Plenum Press, New York 1968; Vol. 2
   Google Scholar
• Gudzinowicz B. J. Gas Chromatographic Analysis of Drugs and Pesticides. Marcel Dekker, New York 1967
   Google Scholar
• Anders M. W., Mannering G. J. Application of gas chromatography to toxicology. Progr. Chem. Toxicol. 1967; 3: 121
   Google Scholar
• Hartmann C. H. Alkali flame detector for organic nitrogen compounds. J. Chromatogr. Sci. 1969; 7: 163
   Web of Science ®Google Scholar
• Burchfield H. P., Johnson H. P., Rhoades J. W., Wheeler R. J. Selective detection of phosphorous, sulfur, and halogen compounds in the gas chromatography of drugs and pesticides. J. Gas Chromatogr. 1965; 3: 28
   Web of Science ®Google Scholar
• Coulson D. M. Electrolytic conductivity detector in gas chromatography. Advances in Chromatography, J. C. Giddings, R. A. Keller. Marcel Dekker, New York 1966; Vol. 3
   Google Scholar
• Anders M. W. Gas chromatography. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 63, Part 2
   Google Scholar
• Hammar C. G., Holmstedt B., Ryhage R. Mass fragmentometry. Identification of chlorpromazine and its metabolites in human blood by a new method. Anal. Biochem. 1968; 25: 532
   PubMed Web of Science ®Google Scholar
• Kirk P. L. Chromatographic advances in chromatography. Advances in Chromatography, J. C. Giddings, R. A. Keller. Marcel Dekker, New York 1968; Vol. 5
   Google Scholar
• Gunne L. M. The urinary output of d-and l-aminetamine in man. Biochem. Pharmacol. 1967; 16: 863
   PubMed Web of Science ®Google Scholar
• Feibush B., Gil-Av E. Gas chromatography with optically active stationary phases. Resolution of primary amines. J. Gas Chromatogr. 1967; 5: 257
   Google Scholar
• Horning M. G. Gas phase analytical methods for the study of urinary acids. Biochemical Applications of Gas Chromatography, H. A. Szymanski. Plenum Press, New York 1968
   Google Scholar
• Way J. L., Masterson P. B., Beres J. A. The metabolism of 14C-Z-PAM in the isolated perfused rat liver. J. Pharmacol. Exp. Ther. 1963; 140: 117
   Google Scholar
• McMartin C. The separation and detection of metabolites of guanethidine. Biochem. Pharmacol. 1969; 18: 238
   PubMed Web of Science ®Google Scholar
• Schneider G., Schneider G. Zur papierelektrophoretischen Trannung des Psychophnimakons Tofranil und einiger seiner Metaboliten. J. Chromatogr. 1968; 37: 348
   Google Scholar
• Reisch J., Alfer H., Moellmana H. Bertrag zur Hochspannungselektrophorese einiger Phenylathylamino-Abkommlinge. Pharmazie 1968; 23: 245
   Google Scholar
• Potter W. Z. Acetaminophen-induced Hepatic Necrosis: Possible Biochemical Mechanisms. Ph.D. thesis, Indiana University, Bloomington 1973
   Google Scholar
• Oliverio V. T., Guarino A. M. Isotope dilution analysis. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 160, Part 2
   Google Scholar
• Titus E., Weiss H. The use of biologically prepared radioactive indicators in metabolic studies. Metabolism of pentobarbital. J. Biol. Chem. 1955; 214: 807
   Google Scholar
• Thomas R. C., Ikeda G. G. The metabolic fate of tolbutamide in man and in the rat. J. Med. Chem. 1966; 9: 507
   PubMed Web of Science ®Google Scholar
• Barker W. M., Hermondson M. A., Link K. P. The metabolism of 4-14 C-warfarin sodium by the rat. J. Pharmacol. Exp. Ther. 1970; 171: 307
   PubMed Web of Science ®Google Scholar
• Guarino A. M., Schanker L. S. Biliary excretion of probenecid and its glucuronide. J. Pharmacol. Exp. Ther. 1968; 164: 387
   PubMed Web of Science ®Google Scholar
• Febro S., Smith R. L., Williams R. T. The fate of 14 C-thalidomide in the pregnant rabbit. Biochem. J. 1967; 104: 565
   Google Scholar
• Parke D. V. Radioisotopes in the study of the metabolism of foreign compounds. Isotopes in Experimental Pharmacology, L. J. Roth. University of Chicago Press, Chicago 1965; 315
   Google Scholar
• Maickel R. P., Beaven M. A., Brodie B. B. Implications of uptake and storage of norepinephrine by sympathetic nerve endings. Life Sci. 1963; 2: 953
   Google Scholar
• Beaven M. A., Maickel R. P. Stereoselectivity of norepinephrine storage sites in heart. Biochem. Biophys. Res. Commun. 1964; 14: 509
   PubMed Web of Science ®Google Scholar
• Fuhner H. Nachweis und Bestimmung von Giften auf Pharmakologisches Wege. Handbook der Biologischen Arbeitsmethoden. Urban and Schwarzenberg, Berlin 1923; 421, Abt. IV, Teil 7
   Google Scholar
• Roberts M., Adam H. M. New methods for the quantitative estimation of free and conjugated histamine in body fluids. Br. J. Pharmacol. 1950; 5: 526
   Web of Science ®Google Scholar
• Sharman D. F., Vogt M. The noradrenaline content of the caudate nucleus of the rabbit. J. Neurochem. 1965; 12: 62
   Google Scholar
• Boura A., Mongar J. L., Schild H. O. Improved automatic apparatus for pharmacological assays on isolated preparations. Br. J. Pharmacol. 1954; 9: 24
   Google Scholar
• Saffran M., Schally A. V. In vitro bioassay of corticotropin: modification and statistical treatment. Endocrinology 1955; 56: 523
   PubMed Web of Science ®Google Scholar
• Szerb J. C. The estimation of acetylcholine, using leech muscle in a microbath. J. Physiol. (Lond.) 1961; 158: 8
   Google Scholar
• Keele C. A. Clinical and pathological aspects of kinins in man. Proc. R. Soc. Lond. [Biol.] 1969; 173: 361
   Google Scholar
• Smith G. M., Lawrence A. J., Colin-Jones D. G., Schild H. O. The assay of gastrin using the perfused rat stomach. Br. J. Pharmacol. 1970; 38: 206
   PubMed Web of Science ®Google Scholar
• Gaddum J. H., Lembeck F. The assay of substances from the adrenal medulla. Br. J. Pharmacol. 1949; 4: 401
   Google Scholar
• Bisset G. W., Clark B. J., Haldar J. Blood levels of oxytocin and vasopressin during suckling in the rabbit and the problem of their independent release. J. Physiol. (Lond.) 1970; 206: 711
   Google Scholar
• Vane J. R. A sensitive method for the assay of 5-hydroxytryptamine. Br. J. Pharmacol. 1957; 12: 344
   PubMed Web of Science ®Google Scholar
• Berson S. A., Yalow R. S. Quantitative aspects of reaction between insulin and insulin-reacting antibody. J. Clin. Invest. 1959; 38: 1996
   PubMed Web of Science ®Google Scholar
• Yalow R. S., Berson S. A. Immunoassay of endogenous plasma insulin in man. J. Clin. Invest. 1960; 39: 1157
   PubMed Web of Science ®Google Scholar
• Spector S. Radioimmunoassay. Annu. Rev. Pharmacol. 1973; 13: 359
   PubMedGoogle Scholar
• Landsteiner K. Specificity of Serological Reactions. Harvard University Press, Cambridge, Mass. 1946
   Google Scholar
• Goodfriend T. L., Levine L., Fassman G. D. Antibodies to bradykinin and angiotensin: a use of carbodiimides in immunology. Science 1964; 144: 1344
   PubMed Web of Science ®Google Scholar
• Tabachnick M., Sobotka H., Azoproteins H. A spectrophotometric study of the coupling of diazotized arsanilic acid with proteins. J. Biol. Chem. 1960; 235: 1051
   Google Scholar
• Butler V. P., Jr., Chen J. P. Digoxin specific antibodies. Proc. Natl. Acad. Sci. U.S.A. 1967; 57: 71
   PubMed Web of Science ®Google Scholar
• Spector S., Parker C. W. Radioimmunoassay for morphine. Science 1970; 168: 1347
   PubMed Web of Science ®Google Scholar
• Flynn E. J., Spector S. Determination of barbiturate derivatives by radioimmunoassay. J. Pharmacol. Exp. Ther. 1972; 181: 547
   PubMed Web of Science ®Google Scholar
• Smith T. W., Butler V. P., Haber E. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassays. New Engl. J. Med. 1969; 281: 1212
   PubMed Web of Science ®Google Scholar
• Farr R. S. A quantitative immunochemical measure of the primary interaction between I BSA and antibody. J. Infect. Dis. 1958; 103: 239
   PubMed Web of Science ®Google Scholar
• Catt K., Niall H. D., Tregar G. W. Solid phase radioimmunoassay. Nature 1967; 213: 285
   Google Scholar
• Karush F. Immunologic specificity and molecular structure. Advances in Immunology, W. H. Taliaferro, J. H. Humphrey. Academic Press, New York 1972; Vol. 2
   Google Scholar
• Axelrod J., Tomchick R. Enzymatic O-methylation of epinephrine and other catechols. J. Biol. Chem. 1958; 233: 702
   PubMed Web of Science ®Google Scholar
• Axelrod J. Enzymatic formation of psychotomimetic metabolites from normally occurring compounds. Science 1961; 134: 343
   Google Scholar
• Morgan M., Mandell A. J. Indolethylamine N-methyltransferase in the brain. Science 1969; 165: 492
   PubMed Web of Science ®Google Scholar
• Axelrod J., Daly J. Phenol-O-methyltransferase. Biochim. Biophys. Acta 1968; 159: 472
   PubMedGoogle Scholar
• Axelrod J. Purification and properties of phenylethanolamine-N-methyltransferase. J. Biol. Chem. 1962; 237: 1657
   PubMed Web of Science ®Google Scholar
• Gatenbeck S., Brunsberg U. A polyphenol-O-transmethylase isolated from Streptomyces rimosus. Acta Chem. Scand. 1964; 18: 2061
   Google Scholar
• Mann J. D., Mudd S. H. Alkaloids and plant metabolism. IV. The tyramine methylphorase of barley roots. J. Biol. Chem. 1963; 238: 381
   Google Scholar
• Giang P. A. Organophosphorous insecticides. Methods of Enzymatic Analysis, H. U. Bergmeyer. Academic Press, New York 1963
   Google Scholar
• Keller H. Di(p-chlorophenyl)trichloroethane (DDT). Methods of Enzymatic Analysis, H. U. Bergmeyer. Academic Press, New York 1963
   Google Scholar
• Maickel R. P., Bosin T. R. Absorption spectrometry. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 9, Part 2
   Google Scholar
• Josephson E. S., Udenfriend S., Brodie B. B. The estimation of basic organic compounds in biological material. VI. Estimation by ultraviolet spectrophotometry. J. Biol. Chem. 1947; 168: 341
   Google Scholar
• Scott A. I. Interpretation of the Ultraviolet Spectra of Natural Products. Macmillan, New York 1964
   Google Scholar
• Bush M. T. Extraction and identification of barbiturates. Microchem. J. 1961; 5: 73
   Web of Science ®Google Scholar
• Bush M. T., Mazel P., Chambers J. The metabolic fate of thiobarbiturates. Thiobarbital in man. J. Pharmacol. Exp. Ther. 1961; 134: 110
   Google Scholar
• Brodie B. B., Soberman R., Levy B. B. The estimation of antipyrine in biological materials. J. Biol. Chem. 1949; 179: 25
   PubMed Web of Science ®Google Scholar
• Cooper J. R., Brodie B. B. Enzymatic metabolism of hexobarbital (Evipal). J. Pharmacol. Exp. Ther. 1955; 114: 409
   PubMed Web of Science ®Google Scholar
• Salzman N. P., Brodie B. B. Physiological disposition and fate of chlorpromazine and a method for its determination in biological material. J. Pharmacol Exp. Ther. 1956; 118: 46
   PubMedGoogle Scholar
• Bratton A. C., Marshall E. K., Jr. A new coupling component for sulfanilamide determination. J. Biol. Chem. 1939; 128: 537
   Google Scholar
• Brodie B. B., Axelrod J. The estimation of acetanilide and its metabolic products, aniline, N-acetyl-p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues. J. Pharmacol. Exp. Ther. 1948; 94: 22
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Axelrod J. The fate of aminopyrine in man and methods for the estimation of aminopyrine and its metabolites in biological material. J. Pharmacol. Exp. Ther. 1950; 99: 171
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Udenfriend S., Taggart J. V. The estimation of basic organic compounds in biological material. IV. Estimation by coupling with diazonium salts. J. Biol. Chem. 1947; 168: 327
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Udenfriend S., Dill W. The estimation of basic organic compounds in biological material. V. Estimation by salt formation with methyl orange. J. Biol. Chem. 1947; 168: 335
   PubMed Web of Science ®Google Scholar
• Axelrod J. Studies on sympathomimetic amines. II. The biotransformation and physiological disposition of D-amphetamine, D-p-hydroxyamphetamine and D-methamphetamine. J. Pharmacol. Exp. Ther. 1954; 110: 315
   PubMed Web of Science ®Google Scholar
• Brodie B. B., Udenfriend S., Coburn A. F. Determination of salicylic acid in plasma. J. Pharmacol. Exp. Ther. 1944; 80: 114
   Google Scholar
• Maickel R. P. A rapid procedure for the determination of adrenal ascorbic acid. Application of the Sullivan and Clarke method to tissues. Anal. Biochem. 1960; 1: 498
   PubMed Web of Science ®Google Scholar
• Erley D. S., Blake B. H., Potts W. J. Small volume long path infrared cell for liquids. Appl. Spectrosc. 1960; 14: 108
   Google Scholar
• Applied Infrared Spectroscopy, D. N. Kendall. Reinhold, New York 1966
   Google Scholar
• Fales H. M. Isolation and identification procedures - spectral methods. Fundamentals of Drug Metabolism and Drug Disposition, B. N. La Du, H. G. Mandel, E. L. Way. Williams & Wilkins. 1971; 437
   Google Scholar
• Bowman R. L., Caulfield P. A., Udenfriend S. Spectrophotofluorometric assay in the visible and ultraviolet. Science 1955; 122: 32
   PubMedGoogle Scholar
• Ackerman H. S., Udenfriend S. Fluorometry. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 21, Part 2
   Google Scholar
• Udenfriend S. Fluorescence Assay in Biology and Medicine. Academic Press, New York 1969; Vol. II
   Google Scholar
• Williams R. T. Fluorescence of some aromatic compounds in aqueous solution. J. Roy. Inst. Chem. 1959; 83: 611
   Google Scholar
• Glazko A. J., Dill W. A., Fransway R. L. Determination of diphenhydramine blood levels using a new fluorescent dye-salt procedure generally applicable to basic organic compounds. Fed Proc. 1962; 21: 269
   Google Scholar
• Freeman M. V. The fluorometric measurement of the absorption, distribution, and excretion of single doses of 3-amino-10-methyl pteroylglutamic acid (amethopterin) in man. J. Pharmacol. Exp. Ther. 1958; 122: 154
   Google Scholar
• Kupferberg H., Burkhalter A., Way E. L. A sensitive fluorometric assay for morphine in plasma and brain. J. Pharmacol. Exp. Ther. 1964; 145: 247
   PubMed Web of Science ®Google Scholar
• Creaven P. J., Parke D. V., Williams R. T. A fluorometric study of the hydroxylation of biphenyl in vitro by liver preparations of various species. Biochem. J. 1965; 96: 879
   PubMed Web of Science ®Google Scholar
• Mahju M. A., Maickel R. P. Accumulation of phenothiazine tranquilizers in rat brain and plasma after repeated dosage. Biochem. Pharmacol. 1969; 18: 2701
   PubMedGoogle Scholar
• Shore P. A., Burkhalter A., Cohn V. H. A method for the fluorometric assay of histamine in tissue. J. Pharmacol. Exp. Ther. 1959; 127: 182
   PubMed Web of Science ®Google Scholar
• Cohn V. H., Lyle J. A fluorometric assay for glutathione. Anal. Biochem. 1966; 14: 434
   PubMed Web of Science ®Google Scholar
• Maickel R. P., Miller F. P. Fluorescent products formed by reaction of indole derivatives and o-phthalaldehyde. Anal. Chem. 1966; 38: 1937
   Google Scholar
• Udenfriend S., Stein S., Bohlen P., Dairman W., Leimgruber W., Weigele M. Fluorescamine, a reagent for assay of amino acids, peptides, proteins and primary amines in the picomole range. Science 1972; 178: 871
   PubMed Web of Science ®Google Scholar
• Maickel R. P., Snodgrass W. R., Kuntzman R. Radioactive techniques; the use of labeled drugs. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 42, Part 2
   Google Scholar
• Keston A. S., Udenfriend S., Cannon R. K. A method for the determination of organic compounds in the form of isotopic derivatives. I. Estimation of amino acids by the carrier techniques. J. Am. Chem. Soc. 1949; 71: 249
   Google Scholar
• Keston A. S., Udenfriend S., Levy M. Determination of organic compounds as isotope derivatives. II. Amino acids by paper chromatographic and indicator techniques. J. Am. Chem. Soc. 1950; 72: 748
   Google Scholar
• Hammer W., Brodie B. B. Application of isotope derivative technique to assay of secondary amines. Estimation of desipramine by acetylation with3 H-acetic anhydride. J. Pharmacol. Exp. Ther. 1967; 157: 503
   PubMedGoogle Scholar
• Kuntzman R., Tsai I., Burns J. J. Importance of tissue and plasma binding in determining the retention of norchlorcyclizine and norcyclizine in man, rat and dog. J. Pharmacol. Exp. Ther. 1967; 158: 332
   PubMed Web of Science ®Google Scholar
• Quinn G. P., Cohn M. M., Reid M. B., Greengard P., Weiner M. The effect of formulation on phenmetrazine plasma levels in man studied by a sensitive analytic method. Clin. Pharmacol. Ther. 1967; 8: 369
   Google Scholar
• Kuntzman R., Sernatinger E., Tsai I., Klutch A. New methodology for studies of drug metabolism. Importance of Fundamental Principles of Drug Evaluation, D. H. Tedeschi, R. E. Tedeschi. Raven Press, New York 1969; 87
   Google Scholar
• Harris S. R., Efron D., Gaudette L. Radioactive derivative formation for the simultaneous estimation of plasma imipramine and desipramine. Pharmacologist 1968; 10: 166
   Google Scholar
• Efron D. H., Harris S. R., Manian A. A., Gaudette L. E. Radioassay of chlorpromazine and its metabolites in plasma. Psychopharmacologia 1971; 19: 207
   Google Scholar
• Kuntzman R., Cox R. H., Jr., Maickel R. P. Radioactive techniques: radioactive isotope derivatives of nonlabeled drugs. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 29: 58, Part 2
   Google Scholar
• Kuntzman R. Applications of tracer techniques in drug metabolism studies. Fundamentals of Drug Disposition and Drug Metabolism, B. N. La Du, H. G. Mandel, E. L. Way. Williams & Wilkins, Baltimore 1972; 489
   Google Scholar
• Cram S. P., Juvet R. S., Jr. Gas chromatography. Anat. Chem. 1972; 44: 213R
   PubMed Web of Science ®Google Scholar
• Guarino A. M., Fales H. M. Gas chromatography - mass spectrometry. Handbook of Experimental Pharmacology, B. B. Brodie, J. R. Gillette. Springer-Verlag, New York 1971; Vol. 28: 178, Part 2
   Google Scholar
• Green D. E. Automated detection of abused drugs by direct mass fragmentometry. Proc. West. Pharmacol. Soc. 1972; 15: 63
   Google Scholar
• Gaffney T. E., Hammar C. -G., Holmstedt B., McMahon R. E. Ion specific detection of internal standards labeled with stable isotopes. Anal. Chem. 1971; 43: 307
   Web of Science ®Google Scholar
• Jenden D. E., Cho A. K. Applications of integrated gas chromatography/mass spectrometry in pharmacology and toxicology. Annu. Rev. Pharmacol. 1973; 13: 371
   Google Scholar
• Chignell C. F. Spectroscopic techniques for the study of drug interactions with biological systems. Advances in Drug Research, N. J. Harper, A. B. Simmonds. Academic Press, New York 1970; Vol. 5: 55
   Google Scholar
• Pietrzyk D. J. Organic polarography. Anal. Chem. 1972; 44: 457R
   Google Scholar
• Curry A. S., Walker G. W., Simpson G. S. Determination of ethanol in blood by gas chromatography. Analyst 1966; 91: 742, 91, 742 1966.
   PubMed Web of Science ®Google Scholar
• Noonan J. S., Murdick P. W., Ray R. S. A method of detecting amphetamine using gas chromatography of a halogenated derivative. J. Pharmacol. Exp. Ther. 1969; 168: 205
   PubMed Web of Science ®Google Scholar
• Curry S. H. Determination of nanogram quantities of chlorpromazine and some of its metabolites in plasma by using gas-liquid chromatography with an electron capture detector. Anal. Chem. 1968; 40: 1251
   PubMed Web of Science ®Google Scholar
• Pulver R. Uber Irgapyrin, ein neues Antirheumaticum und Analgeticum. Blutkonzentration und synergistische Wirkung bei Pyrazolderivaten. Schweiz. Med. Wochenschr. 1950; 80: 308
   Google Scholar
• Mayer S. E., Maickel R. P., Brodie B. B. Kinetics of penetration of drugs and other foreign compounds into cerebrospinal fluid and brain. J. Pharmacol. Exp. Ther. 1959; 137: 205
   Google Scholar
• Dingell J. V., Sulser F., Gillette J. R. Species differences in the metabolism of imipramine and desmethylimipramine (DMI). J. Pharmacol. Exp. Ther. 1964; 143: 14
   PubMed Web of Science ®Google Scholar
• Bosin T. R., Campaigne E., Maickel R. P. Biochemical pharmacology of the benzo[b] thiophene analogs of harmaline and harmine. Life Sci 1972; II(Part I)685
   Google Scholar
• Garrett E. R., Tsau J. Application of ion-pair methods to drug extraction from biological fluids. I. Quantitative determination of biguanides in urine. J. Pharm. Sci. 1972; 61: 1404
   Google Scholar
• DeLeenheer A., Heyndrickx A. Improved method for determining dibenzepine and its N-demethylated metabolites in human urine. J. Pharm. Sci. 1973; 62: 31
   Google Scholar
• Naito S. -I., Umetsu K. Biopharmaceutical studies on 2-(aminoethanesulfonylamino)pyridine and related compounds. I. Absorption, excretion, metabolism, and preliminary pharmacological investigation. J. Pharm. Sci. 1972; 61: 684
   Google Scholar
• Colton D. G., Tate R. L., Mehlman M. A., Mackerer C. R., Haettinger J. R. Spectrophotometric assay for diphenylthiohydantoin in biological materials. Anal. Biochem. 1973; 51: 247
   Google Scholar
• Burns J. J., Rose R. K., Chenkin T., Goldman A., Schulert A., Brodie B. B. The physiological disposition of phenylbutazone (Butazolidin) in man and a method for its estimation in biological material. J. Pharmacol. Exp. Ther. 1963; 109: 346
   Google Scholar
• Jahnchen E., Levy G. Determination of phenylbutazone in plasma. Clin. Chem. 1972; 18: 984
   Google Scholar
• Wallace J. E., Hamilton H. E., Payte J. T., Blum K. Sensitive spectrophotometric method for determining methadone in biological specimens. J. Pharm. Sci. 1972; 61: 1397
   PubMed Web of Science ®Google Scholar
• Monforte J., Bath R. J., Sunshine I. Fluorometric determination of primary and secondary amines in blood and urine after thin-layer chromatography. Clin. Chem. 1972; 18: 1329
   PubMed Web of Science ®Google Scholar
• Rieder J. A fluorometric method for determining nitrazepam and the sum of its main metabolites in plasma and urine. Arzneim. Forsch. 1973; 23: 207
   PubMedGoogle Scholar
• Testa B., Beckett A. H. Studies on the metabolism of diethylpropion. I. Analytical procedures. J. Chromatogr. 1972; 71: 39
   PubMed Web of Science ®Google Scholar
• Verebely K., Inturrisi C. E. The simultaneous determination of propoxyphene and norpropoxyphene in human biofluids using gas-liquid chromatography. J. Chromatogr. 1973; 75: 195
   PubMed Web of Science ®Google Scholar
• Kadar D., Kalow W. A method for measuring glutethimide (Doriden®) in human serum after intake of therapeutic doses. J. Chromatogr. 1972; 72: 21
   Google Scholar
• Prescott L. F., Redman D. R. Gas-liquid chromatographic estimation of tolbutamide and chlorpropamide in plasma. J. Pharm. Pharmacol. 1972; 24: 713
   PubMed Web of Science ®Google Scholar
• Williams A. J., Jones T. W. G., Cooper J. D. H. A rapid method for the determination of therapeutic barbiturate levels in serum using gas-liquid chromatography. Clin. Chim. Acta 1973; 43: 327
   Google Scholar
• Goudie J. H., Burnett D. A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector. Clin. Chim. Acta 1973; 43: 423
   Google Scholar
• Vree T. B., Muskens A., Th J. M., Van Rossum J. M. Excretion of amphetamines in human sweat. Arch. Int. Pharmacodyn. Ther. 1972; 199: 311
   Google Scholar
• Henderson G. L., Wilson B. K. Excretion of methadone and metabolites in human sweat. Res. Commun. Chem. Pathol. Pharmacol. 1973; 5: 1
   PubMedGoogle Scholar
• Wittwer J. D., Jr., Kluckhohn J. H. Liquid chromatographic analysis of LSD. J. Chromatogr. Sci 1973; 11: 1
   Google Scholar
• Cadin D., Cleeland R., Grunberg E. A sensitive, rapid radioimmunoassay for morphine and immunologically related substances in urine and serum. Clin. Chem. 1973; 19: 216
   Google Scholar
• Tigelaar R. E., Rapport R. L., II, Inman J. K., Kupferberg H. J. A radioimmunoassay for diphenylhydantoin. Clin. Chim. Acta 1973; 43: 231
   PubMed Web of Science ®Google Scholar