Intra- and Transepithelial Analytical Techniques

References

• Bernard C. Lecons sur les Phenomenes de la vie communs aux animaux et aux vegetaux. Bailliere, Paris 1878
   Google Scholar
• Ussing H. H. The Relation Between Active Transport and Bioelectric Phenomena. Lectures at the Instituto de Biofisica Universidade do Brasil. 1955
   Google Scholar
• Wearn J. T., Richards A. N. Observations on the composition of glomerular urine with particular reference to the problem of reabsorption in the renal tubules. Am. J. Physiol. 1924; 71: 209
   Google Scholar
• Burg M. B., Grantham J., Abramow M., Orloff J. Preparation and study of fragments of single rabbit nephrons. Am. J. Physiol. 1966; 210: 1293
   PubMed Web of Science ®Google Scholar
• Armstrong W. McD., Garcia-Diaz J. F., O'Doherty J., O'Regan M. G. Transrnucosal Na* electrochemical potential difference and solute accumulation in epithelial cells of the small intestine. Fed. Proc 1979; 38: 2722
   Google Scholar
• Blankemeyer J. T. Active transport of potassium by insect midgut. Fed. Proc. 1981; 40: 2412
   Google Scholar
• Boulpaep E. L. Cellular Mechanisms of Renal Tubular Ion Transport. Current Topics in Membranes and Transport, F. Bronner, A. Kleinzeller. Academic Press, New York 1980; Vol. 13
   Google Scholar
• Boulpaep E. L., Sackin H. Equivalent electrical circuit analysis and rheogenic pumps in epithelia. Fed. Proc. 1979; 38: 2010
   Google Scholar
• Bourguet J., Chevalier J., Parisi M., Ripoche P. Controle Hormonal des Transports Epitheliaux. 1NSERM, Paris 1979; 85
   Google Scholar
• Civan M. M. The sodium transport pool of epithelial tissues. Water Relations in Membrane Transport in Plants and Animals, A. M. Jungreis, T. K. Hodges, A. Kleinzeller, S. G. Schultz. Academic Press, New York 1977; 187
   Google Scholar
• Civan M. M. Potassium activities in epithelia. Fed. Proc 1980; 39: 2865
   Google Scholar
• DeSousa R. C. Mecanismes de transport de l'eau et du sodium par les cellules des epithelia d'amphibians et du tubule renal isole'. J. Physiol. Paris 1975; 71: 5A
   Google Scholar
• De Sousa R. C, Grosso A., Rossier B. C, Rossier M., Voute C. L. Epithelia as hormone and drug receptors. J. Membrane Biol., 1978, special issue
   Google Scholar
• DiBone D. R., Mills J. W. Distribution of Na* pump sites in transporting epithelia. Fed. Proc 1979; 38: 134
   Google Scholar
• Erlij D. Solute transport across isolated epithelia. Kidney Int. 1976; 9: 76
   PubMed Web of Science ®Google Scholar
• Essig A., Caplan S. R. The use of linear nonequilibrium thermodynamics in the study of renal physiology. Am. J. Physiol. 1979; 236: F211
   PubMed Web of Science ®Google Scholar
• Frizzell R. A., Duffey M. E. Chloride activities in epithelia. Fed. Proc 1980; 39: 2860
   PubMedGoogle Scholar
• Frizzell R. A., Field M., Schultz S. G. Sodium-coupled chloride transport in epithelial tissues. Am. J. Physiol. 1979; 236: F1
   PubMed Web of Science ®Google Scholar
• Fromter E. The Feldberg Lecture 1976 Solute transport across epithelia: what can we learn from micropuncture studies on kidney tubules?. J. Physiol. London 1979; 288: 1
   Google Scholar
• Giebisch G. Problems of epithelial potassium transport: special consideration of the nephron. Fed. Proc 1981; 40: 2395
   Google Scholar
• Giebisch G., Tosteson D. C, Ussing H. H. Membrane Transport in Biology. Springer-Verlag, Berlin 1978; Vol. 3
   Google Scholar
• Giebisch G., Tosteson D. C, Ussing H. H. Membrane Transport in Biology. Springer-Verlag, Berlin 1979; Vol. 4(A and B)
   Google Scholar
• Helman S. I. Electrochemical potentials in frog skin: inferences for electrical and mechanistic models. Fed. Proc 1979; 38: 2743
   PubMedGoogle Scholar
• Jergensen P. L. Sodium and potassium ion pump in kidney tubules. Physiol. Rev. 1980; 60: 864
   Google Scholar
• Lewis S. A., Wills N. K. Intracellular ion activities and their relationship to membrane properties of tight epithelia. Fed. Proc 1979; 38: 2739
   Google Scholar
• Lindemann B., Voute C. Structure and function of the epidermis. Frog Neurobiology, R. Llines, W. Precht. Springer-Verlag, Berlin 1976; 169
   Google Scholar
• Macknight A. D.C. Epithelial transport of potassium. Kidney Int. 1977; 11: 39
   Google Scholar
• Macknight A. D.C. Comparison of analytical techniques: chemical, isotopic, and microprobe analysis. Fed. Proc 1980; 39: 2881
   Google Scholar
• Macknight A. D., Cdibona D. R., Leaf A. Sodium transport across toad urinary bladder: a model'tight'epithelium. Physiol., Rev. 1980; 60: 615
   PubMed Web of Science ®Google Scholar
• Macknight A. D. C., Leader J. P. Epithelial Ion and Water Transport. Raven Press, New York 1981
   Google Scholar
• O'Neil R. G. Potassium secretion by the cortical collecting tubule. Fed. Proc 1981; 40: 2403
   Google Scholar
• Reuss L. Mechanisms of sodium and chloride transport by gallbladder epithelium. Fed. Proc 1979; 38: 2733
   Google Scholar
• Schultz S. G. Application of equivalent electrical circuit models to study of sodium transport across epithelial tissues. Fed. Proc 1979; 38: 2024
   PubMedGoogle Scholar
• Schultz S. G. Potassium transport by rabbit descending colon. in vitro. Fed. Proc 1981; 40: 2408
   Google Scholar
• Schultz S. G., Thompson S. M., Suzuki Y. Equivalent electrical circuit models and the study of Na transport across epithelia: nonsteady-state current-voltage relations. Fed. Proc 1981; 40: 2443
   Google Scholar
• Ussing H. H., Bindslev N., Lassen N. A., Sten-Knudsen D. Water Transport across Epithelia. Barriers, Gradients, and Mechanisms. Munksgaard, Copenhagen 1981
   Google Scholar
• Wright F. S. Potassium transport of successive segments of the mammalian nephron. Fed. Proc 1981; 40: 2398
   Google Scholar
• Fromter E., Diamond J. M. Route of passive ion permeation in epithelia. Nature New Biol. 1972; 235: 9
   PubMedGoogle Scholar
• Koefoed-Johnsen V., Ussing H. H. The contributions of diffusion and flow to the passage of D2O through living membranes. Acta Physiol., Scand. 1953; 28: 60
   PubMedGoogle Scholar
• Aronson P. S. Identifying secondary active solute transport in epithelia. Am. J. Physiol. 1981; 240: Fl
   Google Scholar
• Gunn R. B. Co- and counter-transport mechanisms in cell membranes. Ann. Rev. Physiol. 1980; 42: 249
   PubMed Web of Science ®Google Scholar
• Tosteson D. C. Cation countertransport and cotransport in human red cells. Fed. Proc 1981; 40: 1429
   PubMedGoogle Scholar
• Kedem O. Criteria of active transport. Proc Symp. Transport and Metabolism, A. Kleinzeller, A. Kotyk. Academic Press, New York 1961; 87
   Google Scholar
• Katchalsky A., Curran P. F. Nonequilibrium Thermodynamics in Biophysics. Harvard University Press, Cambridge, Mass 1965
   Google Scholar
• Kedem O., Katchalsky A. Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochim. Biophys. Acta 1958; 27: 229
   PubMed Web of Science ®Google Scholar
• Diamond J. M. Osmotic water flow in leaky epithelia. J. Membrane Biol. 1979; 51: 195
   PubMed Web of Science ®Google Scholar
• Hill A. Salt-water coupling in leaky epithelia. J. Membrane Biol. 1980; 56: 177
   Google Scholar
• Ussing H. H., Zerahn K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol. Scand. 1951; 23: 110
   PubMedGoogle Scholar
• Ussing H. H., Kruheffer P., Thaysen J. H., Thorn N. A. The Alkali Metal Ions in Biology. Springer-Verlag, Berlin 1960
   Google Scholar
• Tai Y-H., Tai C-Y. The conventional short-circuiting technique under short-circuits most epithelia. J. Membrane Biol. 1981; 59: 173
   PubMed Web of Science ®Google Scholar
• Ussing H. H. The distinction by means of tracers between active transport and diffusion. Acta Physiol. Scand. 1949; 19: 43
   Google Scholar
• Curran P. F., Schultz S. G. Transport across membranes: general principles. Handbook of Physiology. Section 6, C. F. Code, W. Heidel. American Physiological Society, Washington, DC 1968; Vol. 3: 1217
   Google Scholar
• Ussing H. H. Interpretation of tracer fluxes. Membrane Transport in Biology, G. Giebisch, D. C. Tosteson, H. H. Ussing. Springer-Verlag, New York 1978; Vol. I: 15
   Google Scholar
• Dobson J. G., Jr, Kidder G. W., III. Edge damage and effect in in vitro frog skin preparations. Am. J. Physiol. 1968; 214: 719
   PubMed Web of Science ®Google Scholar
• Helman S. I., Miller D. A. In vitro techniques for avoiding edge damage in studies of frog skin. Science 1971; 173: 146
   PubMed Web of Science ®Google Scholar
• Walser M. Role of edge damage in sodium permeability of toad bladder and a means of avoiding it. Am. J. Physiol. 1970; 219: 252
   Google Scholar
• Erlij D. Basic electrical properties of tight epithelia determined with a simple method. Pfl'ug. Arch. 1976; 364: 91
   Google Scholar
• Higgins J. T., Jr, Cesaro L., Gebler B., Frömter E. Electrical properties of amphibian urinary bladder epithelia. I. Inverse relationship between potential difference and resistance in tightly mounted preparations. Pflug. Arch. 1975; 358: 41
   Google Scholar
• Lewis S. A., Diamond J. M. Na+ transport by rabbit urinary bladder, a tight epithelium. J. Membrane Biol. 1976; 28: I
   Google Scholar
• Lang F., Greger R., Lechene C, Knox F. G. Micropuncture techniques. Methods in Pharmacology, M. Martinez-Maldanado. Plenum Press, New York 1978; Vol. 4B: 75
   Google Scholar
• Ullrich K. J., Frömter E., Baumann K. Micropuncture and microanalysis in kidney physiology. Laboratory Techniques in Membrane Biophysics, H. Passow, R. Slampfli. Springer-Verlag, Berlin 1969; 106
   Google Scholar
• Chonko A. M., Irish J. M., Welling D. J. Microperfusion of isolated tubules. Methods in Pharmacology, M. Martinez-Maldanado. Plenum Press, New York 1978; Vol. 4B: 221
   Google Scholar
• Schafer J. A., Andreoli T. E. Perfusion of isolated mammalian renal tubules. Membrane Transport in Biology, G. Giebisch, D. C Tosteson, H. H. Ussing. Springer-Verlag, Berlin 1979; Vol. 4B: 473
   Google Scholar
• Spring K. R. Insertion of an axial electrode into renal proximal tubule. Yale J. Biol. Med. 1972; 45: 426
   Google Scholar
• Spring K. R., Paganelli G. Sodium flux in Necturus proximal tubule under voltage clamp. J. Gen. Physiol. 1972; 60: 181
   Google Scholar
• Sauer F. Nonequilibrium thermodynamics of kidney tubule transport. Handbook of Physiology, Section 8, J. Orloff, R. W. Berliner. American Physiological Society, Washington, DC 1973; 399
   Google Scholar
• Ullrich K. J. Permeability characteristics of the mammalian nephron. Handbook of Physiology, Section 8, J. Orloff, R. W. Berliner. American Physiological Society, Washington, DC 1973; 377
   Google Scholar
• Boulpaep E., Giebisch G. Electrophysiological measurements on the renal tubule. Methods in Pharmacology, M. Martinez-Maldanado. Plenum Press, New York 1978; Vol. 4B: 165
   Google Scholar
• Giebisch G., Windhager E. E. Electrolyte transport across renal tubular membranes. Handbook of Physiology, Section 8, J. Orloff, R. W. Berliner. American Physiological Society, Washington, DC 1973; 315
   Google Scholar
• Wright E. M., Diamond J. M. Effects of pH and polyvalent cations on the selective permeability of gallbladder epithelium to monovalent ions. Biochim. Biophys. Acta 1968; 163: 57
   Google Scholar
• Jarrell J. A., Mills J. W., King J. G. A mass spectrometer to measure transepithelial unidirectional labelled water fluxes. Am. J. Physiol. 1981; 241: C86
   Google Scholar
• Sha'afi R. I. Permeability for water and other polar molecules. Membrane Transport, S. L. Bonting, J. J. H. de Pont. Elsevier/North-Holland Biomedical Press, Amsterdam 1981; 29
   Google Scholar
• Bentley P. J. The effects of neurohypophyseal extracts on water transfer across the wall of the isolated urinary bladder of the toad. Bufo marinus, J. Endocrincol 1958; 17: 201
   Google Scholar
• Diamond J. M. The reabsorptive function of the gallbladder. J. Physiol. London 1962; 161: 442
   Google Scholar
• Van Os C. H., Wiedner G., Wright E. M. Volume flows across gallbladder epithelium induced by small hydrostatic and osmotic gradients. J. Membrane Biol. 1979; 49: I
   Google Scholar
• Bourget J., Jard S. Un dispositif automatique de mesure et d'enregistrement du flux net d'eau a travers la peau et la vessie des amphibiens. Biochim. Biophys. Acta 1964; 88: 442
   Google Scholar
• Edelman I. S., Petersen M. J., Gulyassy P. F. Kinetic analysis of the antiduretic action of vasopressin and adenosine-3′,5′-monophosphate. J. Clin. Invest. 1964; 43: 2185
   PubMed Web of Science ®Google Scholar
• Ruphi M., de Sousa R. C, Farrod-Coune E., Posternak J. M. Optical method for measuring water flow with automatic recording. Experientia 1972; 28: 1391
   Google Scholar
• Reid E. W. Report on experiments upon “absorption without osmosis”. Br. Med. J. 1892; I: 323
   Google Scholar
• Grantham J. J., Irwin R. L., Qualizza P. B., Tucker D. R., Whittier F.C. Fluid secretion in isolated proximal straight renal tubules. Effects of human uremic serum. J. Clin. Invest. 1973; 52: 2441
   PubMedGoogle Scholar
• Grantham J. J., Qualizza P. B., Welling L. W. Influence of serum proteins on net fluid reabsorption of isolated proximal tubules. Kidney Int. 1972; 2: 66
   Google Scholar
• Pedley T. J., Fischbarg J. Unstirred layer effects on osmotic water flow across gallbladder epithelium. J. Membrane Biol. 1980; 54: 89
   PubMedGoogle Scholar
• Weinstein A. M., Stephenson J. L. Models of coupled salt and water transport across leaky epithelia, J. Membrane Biol. 1981; 60: 1
   Google Scholar
• Weinstein A. M., Stephenson J. L., Spring K. R. The coupled transport of water. Membrane Transport, S. L. Bonting, J. J. H. de Pont. Elsevier/North-Holland Biomedical Press, Amsterdam 1981; 311
   Google Scholar
• Dainty J. Water relations of plant cells. Adv. Bot. Res. 1963; 1: 279
   Google Scholar
• House C. R. Water Transport in Cells and Tissues. Physiological Society Monographs, No. 24, Arnold, London 1974
   Google Scholar
• Handler J. S., Orloff J. Antidiuretic hormone. Ann. Rev. Physiol. 1981; 43: 611
   PubMed Web of Science ®Google Scholar
• Andreoli T. E. Salt and water transport processes in the proximal straight tubule. Renal Function, G. Giebisch, E. F. Purcell. Josiah Macy Jr. Foundation, New York 1977; 186
   Google Scholar
• Thomas R. C. Ion-Sensitive Microelearodes. How to Make and Use Them. Academic Press, New York 1978
   Google Scholar
• Lassen U. V., Rasmussen B. E. Use of microelectrodes for measurement of membrane potential. Membrane Transport in Biology, G. Giebisch, D. C Tosteson, H. H. Ussing. Springer-Verlag, Berlin 1978; Vol. 1: 169
   Google Scholar
• Hironaka T., Morimoto S. The resting membrane potential of frog sartorius muscle. J. Physiol. 1979; 297: 1
   Google Scholar
• Adrian R. H. The effect of internal and external potassium concentration on the membrane potential of frog muscle. J. Physiol. London 1956; 133: 631
   Google Scholar
• Nastuk W. L., Hodgkin A. L. The electrical activity of single muscle fibres. J. Cell. Comp. Physiol 1950; 43: 39
   Google Scholar
• Armstrong W. McD., Garcia-Diaz J. F. Criteria for the use of micro-electrodes to measure membrane potentials in epithelial cells. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 43
   Google Scholar
• Brown K. T., Flaming D. G. New microelectrode techniques for intra-cellular work in small cells. Neuroscience 1977; 2: 813
   Google Scholar
• Thomas R. C., Cohen C. J. A liquid ion-exchanger alternative to KC1 for filling intracellular reference microelectrodes. Pflüg. Arch. 1981; 390: 96
   Google Scholar
• Ling G., Gerard R. W. The normal membrane potential of frog sartorius fibres. J. Cell. Comp. Physiol. 1949; 34: 383
   PubMedGoogle Scholar
• Fisher R. S., Erlij D., Helman S. I. Intracellular voltage of isolated epithelia of frog skin. Apical and basolateral cell punctures. J. Gen. Physiol. 1980; 76: 447
   Google Scholar
• Higgins J. T., Gebler B., Frbmter E. Electrical properties of amphibian urinary bladder. II. The cell potential profile in. Necturus maculosus, Pflug. Arch. 1977; 371: 87
   Google Scholar
• Narvarte J., Finn A. L. Microelectrode studies in toad urinary bladder epithelium. Effects of Na concentration changes in the mucosal solution on equivalent electromotive forces. J. Gen. Physiol. 1980; 75: 323
   Google Scholar
• Schultz S. G., Thompson S. M., Suzuki Y. On the mechanism of sodium entry across the apical membrane of rabbit colon. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 285
   Google Scholar
• Reuss L., Finn A. L. Passive electrical properties of toad urinary bladder epithelium. Intercellular electrical coupling and transepithelial cellular and shunt conductances. J. Gen. Physiol 1974; 64: 1
   PubMed Web of Science ®Google Scholar
• Nelson D. J., Ehrenfeld J., Lindemann B. Volume changes and potential artifacts of epithelial cells of frog skin following impalement with micro-electrodes filled with 3M KC1. J. Membrane Biol 1978; 91, special issue
   Google Scholar
• Zeuthen T. Intracellular gradients of electrical potential in the epithelial cells of the Necturus gallbladder. J. Membrane Biol 1977; 33: 281
   Google Scholar
• Helman S. I., Fisher R. S. Microelectrode studies of the active Na transport pathway of frog skin. J. Gen. Physiol 1977; 69: 571
   Google Scholar
• Helman S. I., Nagel W., Fisher R. S. Effects of ouabain on active transepithelial Na transport by frog skin: studies with microelectrodes. J. Gen. Physiol 1979; 74: 105
   Google Scholar
• Nagel W. The intracellular electrical potential profile of the frog skin epithelium. Pflüg. Arch. 1976; 365: 135
   PubMedGoogle Scholar
• DeLong J., Civan M. ML. Intracellular chemical activity of potassium in toad urinary bladder. Current Topics in Membranes and Transport, F. Bronner, A. Kleinzeller. Academic Press, New York 1980; Vol. 13: 93
   Google Scholar
• Reuss L., Finn A. L. Electrical properties of the cellular transepithelial pathway in Necturus gallbladder. I. Circuit analysis and steady-state effects of mucosal solution ionic substitutions. J. Membrane Biol 1975; 25: 115
   PubMedGoogle Scholar
• Suzuki K., Frbmter E. The potential and resistance profile of Necturus gallbladder cells. Pflüg. Arch. 1977; 371: 109
   Google Scholar
• Van Os C. H., Siegers J. F. G. The electrical potential profile of gall-bladder epithelium. J. Membrane Biol 1975; 24: 341
   PubMed Web of Science ®Google Scholar
• Nagel W., Durham J. H., Brodsky W. A. Electrical characteristics of apical and basal-lateral membranes in the turtle bladder epithelial cell layer. Biochim. Biophys. Acta 1981; 646: 77
   Google Scholar
• Rose R. C., Schultz S. G. Studies on the electrical potential profile across rabbit ileum. J. Gen. Physiol 1971; 57: 639
   PubMed Web of Science ®Google Scholar
• Schultz S. G., Frizzell R. A., Nellans H. N. Active sodium transport and the electrophysiology of rabbit colon. J. Membrane Biol 1977; 33: 351
   Google Scholar
• Boulpaep E. L. Electrophysiology of the kidney. Membrane Transport in Biology, G. Giebisch, D. C Tosteson, H.H. Ussing. Springer-Verlag, Berlin 1979; Vol. 4A: 97
   Google Scholar
• Leader J. P., Macknight A. D.C. Alternative methods for measurement of membrane potentials in epithelia. Fed. Proc 1982; 41: 54
   PubMedGoogle Scholar
• Lichtshtein D., Kaback H. R., Blume A. J. Use of a lipophilic cation for determination of membrane potential in neuroblastoma-glioma hybrid cell suspensions. Proc, Nail. Acad. Sci. U.S.A. 1979; 76: 650
   PubMed Web of Science ®Google Scholar
• Lichtshtein D, Dunlop K., Kaback H. R., Blume A. J. Mechanism of monensin-induced hyperpolarisation of neuroblastoma-glioma hybrid NG108-15. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 2580
   PubMed Web of Science ®Google Scholar
• Schuldiner S., Kaback H. R. Membrane potential and active transport in membrane vesicles from. Escherichia coli. Biochemistry 1975; 14: 5451
   PubMed Web of Science ®Google Scholar
• Waggoner A. G. Dye indicators of membrane potential. Ann. Rev. Biophys. Bioeng. 1979; 8: 47
   PubMedGoogle Scholar
• Hoffman J. F., Laris P. C. Determination of membrane potentials in human and Amphiuma red blood cells by means of a fluorescent probe. J. Physiol. London 1974; 239: 519
   Google Scholar
• Graves C. N., Sachs G., Rehm W. S. Use of a fluorescent cyanine dye for electrophysiological studies on the frog cornea. Am. J. Physiol. 1980; 238: C2I
   Google Scholar
• Cohen L. B., Salzberg B. M., Davila V., Ross W. N., Landowne D., Waggoner A. G., Wang C.-H. Change in axon fluoresence during activity: molecular probes of membrane potential. J. Membrane Biol. 1974; 19: 1
   PubMed Web of Science ®Google Scholar
• Cohen L. B., Salzberg B. M. Optical measurement of membrane potential. Rev. Physiol. Biochem. Pharmacol. 1978; 83: 36
   Google Scholar
• Fuji S., Hirota A., Kamino K. Optical signals from early embryonic chick heart stained with potential sensitive dyes: evidence for electrical activity. J. Physiol. London 1980; 304: 503
   Google Scholar
• Grinvald A., Salzberg B. M., Cohen L. B., Kamino K., Waggoner A. G., Wang C.-H., Ti D. Simultaneous recording from 14 neurons in the supra-oesophageal ganglion of the barnacle using a new potential-sensitive dye. Biophys. J. 1977; 17: 126a
   Google Scholar
• Salama G., Morad M. Merocyanine 540 as an optical probe of trans-membrane electrical activity in the heart. Science 1976; 191: 485
   PubMed Web of Science ®Google Scholar
• Robinson J. R. Some effects of glucose and calcium upon the metabolism of kidney slices from adult and newborn rats. Biochem. J. 1949; 45: 68
   PubMed Web of Science ®Google Scholar
• Robinson J. R. Osmoregulation in surviving slices from the kidneys of adult rats. Proc. R. Soc. Lond. B. 1950; 137: 378
   PubMed Web of Science ®Google Scholar
• Mudge G. H. Studies on potassium accumulation by rabbit kidney slices: effect of metabolic activity. Am. J. Physiol. 1951; 165: 113
   PubMed Web of Science ®Google Scholar
• Leaf A. On the mechanism of fluid exchange of tissues in vitro. Biochem. J. 1956; 62: 241
   PubMed Web of Science ®Google Scholar
• Burg M. B., Orloff J. Effect of strophanthidin on fluxes of potassium in rabbit kidney slice. Am. J. Physiol 1963; 205: 139
   Google Scholar
• Bojesen E., Leyssac P. P. The kidney cortex slice technique as a model for sodium transport in vivo. A qualitative evaluation. Acta Physiol. Scand. 1965; 65: 20
   Google Scholar
• Burg M. B., Orloff J. Effect of temperature and medium K on Na and K fluxes in separated renal tubules. Am. J. Physiol. 1966; 211: 1005
   Google Scholar
• Burg M. B., Orloff J. Oxygen consumption and active transport in separated renal tubules. Am. J. Physiol. 1962; 203: 327
   PubMed Web of Science ®Google Scholar
• Burg M. B., Grollman E. F., Orloff J. Sodium and potassium flux of separated renal tubules. Am. J. Physiol. 1964; 206: 483
   Google Scholar
• Frizzell R. A., Koch M. J., Schultz S. G. Ion transport by rabbit colon. 1. Active and passive components. J. Membrane Biol. 1976; 27: 297
   PubMed Web of Science ®Google Scholar
• Aceves J., Erlij D. Sodium transport across the isolated epithelium of the frog skin. J. Physiol. London 1971; 212: 195
   Google Scholar
• Parsons R. H., Hoshiko T. Separation of epithelium from frog skin and rapid washout of 22Na. J Gen. Physiol. 1971; 57: 254
   Google Scholar
• Rajerison R. M., Montegut M., Jard S., Morel F. The isolated frog skin preparation: permeability characteristics and responsiveness to oxytocin, cyclic AMP and theophylline. Pflüg, Arch. 1972; 332: 302
   Google Scholar
• Macknight A. D., Cdibona D. R., Leaf A., Civan M. M. Measurement of the composition of epithelial cells from the toad urinary bladder. J. Membrane Biol. 1971; 6: 108
   Google Scholar
• Shporer M., Civan M. M. The state of water and alkali cations within the intracellular fluids: the contribution of NMR spectroscopy. Current Topics in Membranes and Transport, F. Bronner, A. Kleinzeller. Academic Press, New York 1977; I
   Google Scholar
• Dworzack D. L., Grantham J. J. Preparation of renal papillary collecting duct cells for study. in vitro. Kidney Int. 1975; 191: 8
   Google Scholar
• Little J. R. Determination of water and electrolytes in tissue slices. Anal. Biochem. 1964; 7: 87
   Web of Science ®Google Scholar
• McLver D. J. L., Macknight A. D.C. Extracellular space in some isolated tissues. J. Physiol. London 1974; 239: 31
   Google Scholar
• Cotlove E., Trantham H. V., Bowman R. L. An instrument and method for automatic, rapid, accurate and sensitive titration of chloride in biological samples. J. Lab. Clin. Med. 1958; 51: 461
   PubMed Web of Science ®Google Scholar
• Macchia D. D., Polimeni P. I., Page E. Cellular CI content and concentrations of amphibian skeletal and heart muscle. Am. J. Physiol. 1978; 235: CI22
   Google Scholar
• Greger R., Lang F., Knox F. G., Lechene C. Analysis of tubule fluid. Methods in Pharmacology, M. Martinez-Maldanado. Plenum Press, New York 1978; Vol. 4B: 105
   Google Scholar
• Solomon A. K. Compartmental methods of kinetic analysis. Mineral Metabolism, C. L. Comer, F. Bronner. Academic Press, New York 1960; 119
   Google Scholar
• Finn A. L., Rockoff M. L. The kinetics of sodium transport in the toad bladder. I. Determination of the transport pool. J. Gen. Physiol. 1971; 57: 326
   Google Scholar
• Biagi B., Gonzalez E., Giebisch G. A kinetic model for ion fluxes in the isolated perfused tubule. Current Topics in Membranes and Transport, F. Bronner, A. Kleinzeller. Academic Press, New York 1980; Vol. 13: 229
   Google Scholar
• Robinson B. A., Macknight A. D.C. Relationships between serosal medium potassium concentration and sodium transport in toad urinary bladder. 111. Exchangeability of epithelial cellular potassium. J. Membrane Biol. 1976; 26: 269
   Google Scholar
• Zeuthen T., Wright E. M. Epithelial potassium transport: tracer and electrophysiological studies in choroid plexus. J. Membrane Biol. 1981; 60: 105
   PubMed Web of Science ®Google Scholar
• Nellans H. N., Schultz S. G. Relations among transepithelial sodium transport, potassium exchange and cell volume in rabbit ileum. J. Gen. Physiol. 1976; 68: 441
   Google Scholar
• Frizzell R. A., Jennings B. Potassium influx across basolateral membranes of rabbit colon: relation to sodium absorption. Fed. Proc 1977; 36: 360
   Google Scholar
• Civan M. M. Intracellular potassium in toad urinary bladder: the recycling hypothesis. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 107
   Google Scholar
• Biber T. U. L., Curran P. F. Direct measurement of the uptake of sodium at the outer surface of the frog skin. J. Gen. Physiol. 1970; 56: 83
   PubMed Web of Science ®Google Scholar
• Schultz S. G., Curran P. F., Chez R. A., Fuisz R. E. Alanine and sodium fluxes across mucosal border of rabbit ileum. J. Gen. Physiol. 1967; 50: 1241
   PubMed Web of Science ®Google Scholar
• Gupta B. L., Hall T. A., Moreton R. B. Electron probe x-ray microanalysis. Transport of Ions and Water in Animals, B. L. Gupta, R. B. Moreton, J. L. Oschman, B. J. Wall. Academic Press, New York 1978; 83
   Google Scholar
• Hutchinson T. E. Determination of subcellular elemental concentration through ultrahigh resolution electron microprobe analysis. Int. Rev. Cytoi 1979; 58: 115
   Google Scholar
• Lechene C. P. Electron probe microanalysis: its present, its future. Am. J. Physiol. 1977; 232: F39I
   Google Scholar
• Lechene C. P. Electron probe microanalysis of biological soft tissues: principle and technique. Fed. Proc 1980; 39: 2871
   Google Scholar
• Lechene C. P., Warner R. R. Microbeam Analysis in Biology. Academic Press, New York 1979
   Google Scholar
• Civan M. M., Hall T. A., Gupta B. L. Microprobe study of toad urinary bladder in absence of serosal K.+. J. Membrane Biol. 1980; 55: 187
   PubMedGoogle Scholar
• Gupta B. L., Hall T. A. Quantitative electron probe x-ray microanalysis of electrolyte elements within epithelial tissue compartments. Fed. Proc 1979; 38: 144
   PubMedGoogle Scholar
• Saubermann A. J., Echlin P., Peters P. D., Beeuwkes R. Application of scanning electron microscopy to x-ray analysis of frozen-hydrated sections. 1. Spectrum handling techniques. J. Cell Biol. 1981; 88: 257
   PubMed Web of Science ®Google Scholar
• Saubermann A. J., Beeuwkes R., Peters P. D. Application of scanning electron microscopy to x-ray analysis of frozen-hydrated sections. II. Analysis of standard solutions and artificial electrolyte gradients. J. Cell Biol. 1981; 88: 268
   PubMed Web of Science ®Google Scholar
• Hall T. A., Anderson H. C., Appleton T. The use of thin specimens for x-ray microanalysis in biology. J. Microsc, Oxford 1973; 99: 177
   Google Scholar
• Dörge A., Rick R., Gehring K., Thurau K. Preparation of freeze-dried cryosections for quantitative x-ray microanalysis of electrolytes in biological soft tissues. Pflüg. Arch. 1978; 373: 85
   PubMed Web of Science ®Google Scholar
• Rick R., Dörge A., Macknight A. D.C, Leaf A., Thurau K. Electron-microprobe analysis of the different epithelial cells of toad urinary bladder. J, Membrane Biol. 1978; 39: 257
   Google Scholar
• Bulger R. E., Beeuwkes R., Saubermann A. J. Application of scanning electron microscopy to x-ray analysis of frozen-hydrated section. III. Elemental content of cells in the rat renal papillary tip. J. Cell Biol 1981; 88: 274
   Google Scholar
• Bauer R., Rick R. A computer program for the analysis of energy dispersive x-ray spectra of thin sections of biological soft tissue. X-ray Spectrom. 1978; 7: 63
   Google Scholar
• Rick R., Dörge A., Arnim E. V., Thurau K. Electron microprobe analysis of frog skin epithelium: evidence for a syncytial Na transport compartment. J. Membrane Biol. 1978; 39: 313
   PubMed Web of Science ®Google Scholar
• Hall T. A. The microprobe assay of chemical elements. Physical Techniques in Biological Research, G. Oster. Academic Press, New York 1971; Vol. 1A: 17
   Google Scholar
• Dörge A., Rick R., Katz U., Thurau K. Intracellular electrolyte concentrations in toad skin epithelium during salinity and osmotic adaptation. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 127
   Google Scholar
• Rick R., Dorge A., Arnim E. V., Weigel M., Thurau K. Properties of the outer and inner barriers to transepithelial Na transport: an electron microprobe analysis. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 1: 17
   Google Scholar
• Rick R., Dörge A., Katz U., Bauer R., Thurau K. The osmotic behaviour of toad skin epithelium (Bufo viridis). An electron micro-probe analysis. Pflüg. Arch. 1980; 385: 1
   Google Scholar
• Beck F., Bauer R., Bauer U., Mason J., Dorge A., Rick R., Thurau K. Electron microprobe analysis of intracellular elements in the rat kidney. Kidney Int. 1980; 17: 756
   Google Scholar
• Mason J., Beck F., Dorge A., Rick R., Thurau K. Intracellular electrolyte composition following renal ischemia. Kidney Int. 1981; 20: 61
   PubMed Web of Science ®Google Scholar
• Thurau K, Beck F., Mason J., Dorge A., Rick R. Inside the cell - an electron microscope analysis of the renal tubular electrolyte concentrations. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 137
   Google Scholar
• Gupta B. L., Hall T. A., Naftalin R. J. Microprobe measurements of Na, K and Cl concentration profiles in epithelial cells and intercellular spaces in rabbit ileum. Nature (London) 1978; 272: 70
   PubMed Web of Science ®Google Scholar
• Gupta B. L., Hall T. A., Maddrell S. H. P., Moreton R. B. Distribution of ions in a fluid-transporting epithelium determined by electron-probe x-ray microanalysis. Nature (London) 1976; 264: 284
   PubMed Web of Science ®Google Scholar
• Gupta B. L., Berridge M. J., Hall T. A., Moreton R. B. Electron microprobe and ion-selective microelectrode studies of fluid secretion in the salivary glands of. Calliphora, J. Exp. Biol. 1978; 72: 261
   PubMedGoogle Scholar
• Gupta B. L., Wall B. J., Oschman J. L., Hall T. A. Direct microprobe evidence of local concentration gradients and recycling of electrolytes during fluid absorption in the rectal papillae of. Calliphora, J. Exp. Biol. 1980; 88: 21
   Google Scholar
• Civan M. M. Intracellular activities of sodium and potassium. Am. J. Physiol 1978; 234: F261
   Google Scholar
• Khuri R. N. Electrochemistry of the nephron. Membrane Transport in Biology, G. Giebisch, D. C Tosteson, H. H. Ussing. Springer-Verlag, Berlin 1979; Vol. 4A: 47
   Google Scholar
• Eisenman G. Glass Electrodes for Hydrogen and Other Cations. Marcel Dekker, New York 1967
   Google Scholar
• Carter N. W., Pucacco L. R. Measurement of pH by glass microelectrodes. Methods in Pharmacology, M. Martinez-Maldanado. Plenum Press, New York 1978; Vol. 4B: 195
   Google Scholar
• Armstrong W. McD. The use of ion-seleotive microelectrodes to measure intracellular ionic activities. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 85
   Google Scholar
• Guggi M., Oehme M., Pretsch E., Simon W. Neutraler ionophor fur flussigmembraneelek-troden mit hoher selektivitat fur Natrium-gegenuber Kalium-ionen. Helv. Chim. Acta 1976; 58: 2417
   Google Scholar
• Simon W., Morf W. E. Alkali cation specificity of carrier antibiotics and their behaviour in bulk membranes. Membranes, G. Eisenman. Marcel Dekker, New York 1973; Vol. 2: 329
   Google Scholar
• Armstrong W. McD., Garcia-Diaz J. F. Ion-selective microelectrodes: theory and technique. Fed. Proc 1980; 39: 2851
   PubMedGoogle Scholar
• Walker J. L., Jr. Ion-specific liquid ion exchanger microelectrodes. Anal. Chem. 1971; 43: 89A
   Web of Science ®Google Scholar
• Spring K. R., Kimura G. Chloride reabsorption by renal proximal tubules of. Necturus, J. Membrane Biol. 1978; 38: 233
   Google Scholar
• Zeuthen T. How to make and use double-barrelled ion-selective micro-electrodes. Current Topics in Membranes and Transport, F. Bronner, A. Kleinzeller. Academic Press, New York 1980; Vol. 13: 31
   Google Scholar
• Hinke J. A. M. The measurement of sodium and potassium activities in the squid axon by means of cation selective microelectrodes. J. Physiol. London 1961; 156: 314
   Google Scholar
• Frant M. S., Ross J. W., Jr. Potassium ion specific electrode with high selectivity for potassium over sodium. Science 1970; 167: 987
   PubMed Web of Science ®Google Scholar
• Reuss L., Weinman S. A., Grady T. P. Intracellular K+ activity and its relation to basolateral membrane ion transport in Necturus gallbladder epithelium. J. Gen. Physiol. 1980; 76: 33
   Google Scholar
• Nagel W., Pope M. B., Peterson K., Civan M. M. Electrophysiologic changes associated with potassium depletion of frog skin. J. Membrane Biol. 1980; 57: 235
   Google Scholar
• Nagel W., Garcia-Diaz J. F., Armstrong W. McD. Intracellular ionic activities in frog skin. J. Membrane Biol. 1981; 61: 127
   PubMed Web of Science ®Google Scholar
• DeLong J., Civan M. M. Dissociation of cellular K+ accumulation from net Na+ transport by toad urinary bladder. J. Membrane Biol. 1978; 42: 19
   Google Scholar
• Edelman A., Curci S., Samarzija I., Fromter E. Determination of intracellular K+ activity in rat kidney proximal tubular cells. Pflug. Arch. 1978; 378: 37
   Google Scholar
• Spring K. R., Kimura G. Intracellular ion activities in Neclurus proximal tubule. Fed. Proc 1979; 38: 2729
   Google Scholar
• Oberleithner H., Giebisch G. Mechanism of potassium transport across distal tubular epithelium of Amphiuma. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 97
   Google Scholar
• Palmer L. G., Civan M. M. Distribution of Na+, K+, and CI- between nucleus and cytoplasm in Chironomus salivary gland cells. J. Membrane Biol. 1977; 33: 41
   PubMed Web of Science ®Google Scholar
• Tjoherty J., Garcia-Diaz J. F., Armstrong W. McD. Sodium-selective liquid ion-exchanger microelectrodes for intracellular measurements. Science 1979; 203: 1349
   Google Scholar
• Lewis S. A., Wills N. K. Resistive artifacts in liquid-exchanger microelectrode estimates of Na+ activity in epithelial cells. Biophys. J. 1980; 31: 127
   PubMedGoogle Scholar
• Garcia-Diaz J. F., Armstrong W. McD. The steady-state relationship between sodium and chloride transmembrane electrochemical potential differences in Necturus gallbladder. J. Membrane Biol. 1980; 55: 213
   Google Scholar
• Wills N. K., Lewis S. A. Intracellular Na+ activity as a function of Na+ transport rate across a tight epithelium. Biophys. J. 1980; 30: 181
   Google Scholar
• Eaton D. C. Intracellular sodium ion activity and sodium transport in rabbit urinary bladder. J. Physiol. London 1981; 316: 527
   Google Scholar
• Saunders J. H., Brown H. M. Liquid and solid-state Cl-sensitive microelectrodes: characteristics and application to intracellular CI- activity in Balanus photoreceptors. J. Gen. Physiol. 1977; 70: 507
   PubMedGoogle Scholar
• Reuss L., Grady T. P. Effects of external sodium and cell membrane potential on intracellular chloride activity in gallbladder epithelium. J. Membrane Biol. 1979; 51: 15
   Google Scholar
• Odoherty J., Youmans S. J., Armstrong W. McD., Stark R. J. Calcium regulation during stimulus-secretion coupling: continuous measurement of intracellular calcium activities. Science 1980; 209: 510
   Google Scholar
• Boron W. F., Boulpaep E. L. Intracellular pH in isolated perfused proximal tubules of amphibian kidney. Fed. Proc 1980; 39: 713
   Google Scholar
• Leader J. P., Macknight A. D., O'Mason D. R., Armstrong W. McD. Cellular composition of Necturus gallbladder epithelial cells measured by chemical analysis and by ion-specific microelectrodes. Proc. Univ. Olago Med. Sch. 1981; 59: 82
   Google Scholar
• Leader J. P. The construction, calibration and use of liquid ion exchanger ion-selective double-barrelled microelectrodes for measurement of intracellular ion activities. Proc. Univ. Olago Med. Sch. 1981; 59: 80
   Google Scholar
• Claude P. Morphological factors influencing transepithelial permeability: a model for the resistance of the. Zonula occludens, J. Membrane Biol 1978; 39: 219
   PubMed Web of Science ®Google Scholar
• Claude P., Goodenough D. A. Fracture faces of Zonnulae occludentesfrom 'tight'and 'leaky' epithelia. J. Cell Biol. 1973; 58: 390
   PubMed Web of Science ®Google Scholar
• Bindslev N., Tormey J. McD., Pietras R. J., Wright E. M. Electrically and osmotically induced changes in permeability and structure of toad urinary bladder. Biochim. Biophys. Acta 1974; 332: 286
   Web of Science ®Google Scholar
• Civan M. M., DiBona D. R. Pathways for movement of ions and water across toad urinary bladder. II. Site and mode of action of vasopressin. J. Membrane Biol 1974; 19: 195
   Google Scholar
• Civan M. M., DiBona D. R. Pathways for movement of ions and water across toad urinary bladder, 111. Physiologic significance of the paracellular pathway. J. Membrane Biol 1978; 38: 359
   Google Scholar
• DiBona D. R., Civan M. M. Pathways for movement of ions and water across toad urinary bladder. I. Anatomic site of transepithelial shunt pathways. J. Membrane Biol 1973; 12: 101
   Google Scholar
• DiBona D. R. Direct visualization of epithelial morphology in the living amphibian urinary bladder. J. Membrane Biol, special issue 1978; 45
   Google Scholar
• Wade J. B., Karnovsky M. J. Fracture faces of osmotically disrupted. Zonnulae occludentes, J. Cell Biol 1974; 62: 344
   PubMed Web of Science ®Google Scholar
• DiBona D. R. Direct visualization of ADH-mediated transepithelial osmotic flow. INSERM 1979; 85: 195
   Google Scholar
• DiBona D. R., Civan M. M., Leaf A. The cellular specificity of vasopressin on toad urinary bladder. J. Membrane Biol 1969; 1: 79
   Google Scholar
• DiBona D. R., Civan M. M., Leaf A. The anatomic site of transepithelial permeability barriers of toad bladder. J. Cell Biol 1969; 40: 1
   Google Scholar
• Bobrycki V. A., Mills J. W., Macknight A. D.C., DiBona D. R. Structural responses to voltage-clamping in the toad urinary bladder. I. The principal role of granular cells in active transport of sodium. J. Membrane Biol 1981; 60: 21
   Google Scholar
• DiBona D. R., Sherman B., Bobrycki V. A., Mills J. W., Macknight A. D.C. Structural responses to voltage-clamping in the toad urinary bladder. 11. Granular cells and the natriferic action of vasopressin. J. Membrane Biol 1981; 60: 35
   Google Scholar
• Mills J. W., Ernst S. A. Localization of sodium pump sites in frog urinary bladder. Biochim. Biophys. Acta 1975; 375: 268
   Google Scholar
• Mills J. W., Ernst S. A., DiBona D. R. Localisation of Na'-pump sites in frogskin. J. Cell Biol. 1977; 73: 88
   PubMed Web of Science ®Google Scholar
• Chevalier J., Bourquet J., Hugon J. S. Membrane associated particles: distribution in frog urinary bladder epithelium at rest and after oxytocin treatment. Cell Tissue Res. 1974; 152: 129
   Google Scholar
• Kachadorian W. A., Levine S. D., Wade J. B., DiScala V. A., Hays R. M. Relationship of aggregated intramembranous particles to water permeability in vasopressin-treated toad urinary bladder. J. Clin. Invest. 1977; 59: 576
   Google Scholar
• Kachadorian W. A., Wade J. B., DiScala V. A. Vasopressin: induced structural change in toad bladder luminal membrane. Science 1975; 190: 67
   Google Scholar
• Wade J. B., Kachadorian W. A., DiScala V. A. Freeze-fracture electron microscopy: relationships of membrane structural features to transport physiology. Am. J. Physiol. 1977; 232: F77
   Google Scholar
• Welling L. W., Evan A. P., Welling D. J. Shape of cells and extra-cellular channels in rabbit cortical collecting ducts. Kidney Int. 1981; 20: 211
   PubMed Web of Science ®Google Scholar
• Welling D. J., Welling L. W. Cell shape as an indicator of volume reabsorption in proximal nephron. Fed. Proc 1979; 38: 121
   Google Scholar
• Spring K. R. Optical techniques for the evaluation of epithelial transport processes. Am. J. Physiol. 1979; 237: F167
   Google Scholar
• DiBona D. R., Schafer J. A., Berglindh T. A., Sachs G. The use of combined differential interference-contrast and fluorescence optics for the analysis of epithelial transport. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 1
   Google Scholar
• Spring K. R., Hope A. Size and shape of the lateral intercellular spaces in a living epithelium. Science 1978; 200: 54
   Google Scholar
• Spring K. R., Hope A. Fluid transport and the dimensions of cells and interspaces of living Necturus gallbladder. J. Gen. Physiol. 1979; 73: 287
   PubMed Web of Science ®Google Scholar
• Spring K. R., Persson B. E. Quantitative light microscopy and epithelial function. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 15
   Google Scholar
• Aronson P. S., Kinsella J. L. Use of ionophores to study Na+ transport pathways in renal microvillus membrane vesicles. Fed. Proc 1981; 40: 2213
   Google Scholar
• Hopfer U. Isolated membrane vesicles as tools for analysis of epithelial transport. Am. J. Physiol 1977; 233: E445
   Google Scholar
• Hopfer U. Transport in isolated plasma membranes. Am. J. Physiol 1978; 234: F89
   Google Scholar
• Hopfer U. Kinetic criteria for carrier-mediated transport mechanisms in membrane vesicles. Fed. Proc 1981; 40: 2480
   Google Scholar
• Kinne R., Schwartz J. L. Isolated membrane vesicles in the evaluation of the nature, localization and regulation of renal transport processes. Kidney Int. 1978; 14: 547
   Google Scholar
• Lever J. E. The use of membrane vesicles in transport studies. CRC Crit. Rev. Biochem. 1980; 7: 187
   PubMed Web of Science ®Google Scholar
• Murer H., Kinne R. The use of isolated membrane vesicles to study epithelial transport processes. J. Membrane Biol 1980; 55: 81
   PubMed Web of Science ®Google Scholar
• Sachs G., Jackson R. J., Rabon E.C. Use of plasma membrane vesicles. Am. J. Physiol. 1980; 238: G151
   Google Scholar
• Sachs G., Kinne R. Isolation and characterisation of biological membranes. Physiology of Membrane Disorders, T. E. Andreoli, J. F. Hoffman, D. D. Fanestil. Plenum Medical, New York 1978; 95
   Google Scholar
• Pretlow T. G., Weir E. E., Zettergren J. G. Problems connected with the separation of different kinds of cells. Int. Rev. Exp. Pathol 1975; 14: 91
   PubMedGoogle Scholar
• Hanning K. Separation of cells and particles by continuous free-flow electrophoresis. Techniques of Biochemical and Biophysical Morphology, D. Glick, R. M. Rosenbaum. Inter-science, New York 1972; Vol. 1: 191
   Google Scholar
• Kreisberg J. I., Sachs G., Pretlow T. G., McGuire R. A. Separation of proximal tubule cells from suspensions of rat kidney cells by free-flow electrophoresis. J. Cell Physiol 1977; 93: 169
   Google Scholar
• Hunger M. J., Commerford S. L. Pressure homogenization of mammalian tissues. Biochim. Biophys. Acta 1961; 47: 580
   Google Scholar
• Brunette B. M., Till J. E. A rapid method for the isolation of L-cell surface membranes using an aqueous two-phase polymer system. J. Membrane Biol 1971; 5: 215
   PubMed Web of Science ®Google Scholar
• Liang C. T., Saktor B. Preparation of renal cortex basal-lateral and brush border membranes. Localisation of adenylate cyclase and guanylate cyclase activities. Biochim. Biophys. Ada 1977; 466: 474
   PubMed Web of Science ®Google Scholar
• Saccomani G., Stewart H. B., Shaw D., Lewin M., Sachs G. Characterization of gastric mucosal membranes. IX. Fractionation and purification of K + -ATPase containing vesicles by zonal centrifugation and free-flow electrophoresis technique. Biochim. Biophys. Acta 1977; 465: 311
   PubMedGoogle Scholar
• Thines-Sempoun D., Amar-Costesec A., Beaufay H., Berthet J. The association of cholesterol 5′ nucleotidase and alkaline phosphodiesterase I with a distinct group of microsomal particles. J. Cell Biol. 1969; 43: 189
   Google Scholar
• Mircheff A. K., Wright E. M. Analytical isolation of plasma membranes of intestinal epithelial cells: identification of Na, K-ATPase rich membranes and the distribution of enzyme activities. J. Membrane Biol. 1976; 28: 309
   PubMed Web of Science ®Google Scholar
• Wallach D. H. F., Lin P. S. Critical evaluation of plasma membrane fractionation. Biochim. Biophys. Ada 1973; 300: 211
   PubMed Web of Science ®Google Scholar
• Aronson P. S., Saktor B. The Na+ gradient-dependent transport of D-glucose in renal brush border membranes. J. Biol. Chem. 1975; 250: 6032
   PubMed Web of Science ®Google Scholar
• Hopfer U., Nelson K., Perrotto J., Isselbacher K. J. Glucose transport in isolated brush border membranes from rat small intestine. J. Biol. Chem. 1973; 248: 25
   PubMed Web of Science ®Google Scholar
• Murer H., Hopfer U. Demonstration of electrogenic Na+-dependent D-glucose transport in intestinal brush border membranes. Proc. Nail. Acad. Sci. U.S.A. 1974; 71: 484
   PubMed Web of Science ®Google Scholar
• Murer H., Hopfer U., Kinne-Saffron E., Kinne R. Glucose transport in isolated brush border and lateral-basal plasma membrane vesicles from intestinal epithelial cells. Biochim. Biophys. Acta 1974; 345: 170
   Google Scholar
• Murer H., Hopfer U., Kinne R. Sodium/proton antiport in brush border membrane vesicles isolated from rat small intestine and kidney. Biochem. J. 1976; 154: 597
   PubMedGoogle Scholar
• Sachs G. H+ transport by a non-electrogenic gastric ATPase as a model for acid secretion. Rev. Physiol. Biochem. Pharmacol. 1977; 79: 133
   Google Scholar
• Shamoo A. E., Tivol W. F. Criteria for the reconstitution of ion transport systems. Current Topics in Membranes and Transport, F. Broner, A. Klenizeller. Academic Press, New York 1980; Vol. 14: 57
   Google Scholar
• Schultz S. G. Basic Principles of Membrane Transport. Cambridge University Press, Cambridge 1980
   Google Scholar
• Hodgkin A. L. The Conduction of the Nerve Impulse. Liverpool University Press, Liverpool 1964
   Google Scholar
• Cole K. S. Membranes, Ions and Impulses. University of California Press, Berkeley 1972
   Google Scholar
• Finkelstein A., Mauro A. Equivalent circuits as related to ionic systems. Biophys. J. 1963; 3: 215
   Google Scholar
• Lindemann B. The minimal information content of EaNa. INSERM 1979; 85: 241
   Google Scholar
• Schultz S. G., Frizzell R. A., Nellans H. N. An equivalent electrical circuit model for “sodium-transporting” epithelia in the steady-state. J. Theoret. Biol. 1977; 65: 215
   PubMedGoogle Scholar
• Boulpaep E. L. Electrophysiology of the kidney. Membrane Transport in Biology, G. Giebisch, D. C Tosteson, H. H. Ussing. Springer-Verlag, Berlin 1979; Vol. 4A: 97
   Google Scholar
• Fromter E., Gebler B. Electrical properties of amphibian urinary bladder epithelia. III. The cell membrane resistances and the effect of amiloride. Pflug, Arch. 1977; 371: 99
   Google Scholar
• Lewis S. A., Eaton D. C., Diamond J. M. The mechanism of Na+ transport by rabbit urinary bladder. J. Membrane Biol. 1976; 28: 41
   Google Scholar
• Lewis S. A., Eaton D. C., Clausen C, Diamond J. M. Nystatin as a probe for investigating the electrical properties of a tight epithelium. J Gen. Physiol. 1977; 70: 427
   PubMedGoogle Scholar
• Clausen C, Lewis S. A., Diamond J. M. Impedance analysis of a tight epithelium using a distributed resistance model. Biophys. J. 1979; 26: 291
   Google Scholar
• Fromter E., Suzuki K., Kottra G., Kampmann L. The paracellular shunt conductance of Necturus gallbladder epithelium: comparison of measurements made by cable analysis with measurements obtained by a new approach based on intracellular impedance analysis. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 73
   Google Scholar
• Hodgkin A. L., Horowicz P. The influence of potassium and chloride ions on the membrane potential of single muscle fibres. J. Physiol. London 1959; 148: 127
   Google Scholar
• Fuchs W., Hviid Larsen E., Lindemann B. Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin. J. Physiol. London 1977; 267: 137
   Google Scholar
• Palmer L. G., Edelman I. S., Lindemann B. Current-voltage analysis of apical sodium transport in toad urinary bladder: effects of inhibitors of transport and metabolism. J. Membrane Biol 1980; 57: 59
   PubMed Web of Science ®Google Scholar
• Wills N. K., Eaton D. C., Lewis S. A., Ifshin S. A. Current-voltage relationship of the baso-lateral membrane of a tight epithelium. Biochim. Biophys. Acta 1979; 555: 518
   Google Scholar
• Wills N. K. Antibiotics as tools for studying the electrical properties of tight epithelia. Fed. Proc 1981; 40: 2202
   Google Scholar
• Horowicz P., Schneider M. F., Begenisich T. Principles of electrical methods for studying membrane movements of ions. Physiology of Membrane Disorders, T. E. Andreoli, J. F. Hoffman, D. D. Fanestil. Plenum Medical, New York 1978; 185
   Google Scholar
• Verveen A. A., DeFelice L. F. Membrane noise. Progress in Biophysics and Molecular Biology, A. J. V. Butler, D. Noble. Pergamon Press, Oxford 1974; Vol. 28: 189
   Google Scholar
• Stevens C. F. Principles and applications of fluctuation analysis: a non-mathematical introduction. Fed. Proc 1975; 34: 1364
   PubMedGoogle Scholar
• Segal J. R. Electrical fluctuations associated with active transport. Biophys. J. 1972; 12: 1371
   PubMed Web of Science ®Google Scholar
• Van Driessche W., Borghgraef R. Noise generated during ion transport across frog skin. Arch. Int. Physiol. Biochim. 1975; 83: 140
   Google Scholar
• Hoshiko T. Power density spectra of frog skin potential, current and admittance functions during patch clamp. J. Membrane Biol., special issue 1978; 121
   Google Scholar
• Lindemann B. The beginning of fluctuation analysis of epithelial ion transport. J. Membrane Biol. 1980; 54: 1
   Google Scholar
• Gogelein H., Van Driessche W. Noise analysis of the K+ current through the apical membrane of Necturus gallbladder. J. Membrane Biol. 981; 60: 187
   Google Scholar
• Lindemann B., Van Driessche W. Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover. Science 1977; 195: 292
   PubMedGoogle Scholar
• Leaf A. Transepithelial transport and its hormonal control in toad bladder. Erg. Physiol. Biol. Chem. Exp. Pharmakol 1965; 56: 216
   Google Scholar
• Reinach P. S., Candia O. A., Alvarez L. J. Energetic requirements of active transepithelial Na and CI transport in the isolated bullfrog cornea. Exp. Eye Res. 1979; 29: 637
   Google Scholar
• Steinmetz P. R., Husted R. F., Mueller A., Beauwens R. Coupling between H+ transport and anaerobic glycolysis in turtle urinary bladder: effects of inhibitors of H+ ATPase. J. Membrane Biol. 1981; 59: 27
   Google Scholar
• Conway E. J. The biological performance of osmotic work. A redox pump. Science 1951; 113: 270
   PubMed Web of Science ®Google Scholar
• Mandel L. J., Balaban R. S. Stoichiometry and coupling of active transport to oxidative metabolism in epithelial tissues. Am. J. Physiol 1981; 240: F357
   PubMed Web of Science ®Google Scholar
• Weiner M. W., Maffly R. H. The provision of cellular metabolic energy for active ion transport. Physiology of Membrane Disorders, T. E. Andreoli, J. F. Hoffman, D. D. Fanestil. Plenum Medical, New York 1978; 287
   Google Scholar
• Lang M. A., Caplan S. R., Essig A. Thermodynamic analysis of active sodium transport and oxidative metabolism in toad urinary bladder. J. Membrane Biol 1977; 31: 19
   Google Scholar
• Nellans H. N., Finn A. L. Oxygen consumption and sodium transport in the toad urinary bladder. Am. J. Physiol 1974; 227: 670
   Google Scholar
• Viera F. L., Caplan S. R., Essig A. Energetics of sodium transport in frog skin. II. The effects of electrical potential on oxygen consumption. J. Gen. Physiol 1972; 59: 77
   Google Scholar
• Maffly R. H. A conductometric method for measuring micromolar quantities of carbon dioxide. Anal Biochem. 1968; 23: 252
   Google Scholar
• Al-Awqati Q., Beauwens R., Leaf A. Coupling of sodium transport to respiration in the toad bladder. J. Membrane Biol 1975; 22: 91
   Google Scholar
• Canessa M., Labarca P., Leaf A. Metabolic evidence that serosal sodium does not recycle through the active transepithelial transport pathway of toad bladder. J. Membrane Biol 1976; 30: 65
   Google Scholar
• Macknight A. D. C., McLaughlin C. W. Transepithelial sodium transport and CO2 production by the toad urinary bladder in the absence of serosal sodium. J. Physiol. London 1977; 269: 767
   Google Scholar
• Rosenthal S. J., King J. G., Essig A. Use of mass spectrometer to measure CO2 and O2 fluxes in voltage-clamped epithelia. Am. J. Physiol 1979; 236: F413
   Google Scholar
• Lau Y., Lang M. A., Essig A. Evaluation of the rate of basal oxygen consumption in the isolated frog skin and toad bladder. Biochim. Biophys. Acta 1979; 545: 215
   Google Scholar
• Coplon N. S., Steele R. E., Maffly R. H. Interrelationships of sodium transport and carbon dioxide production by the toad bladder: response to changes in musocal sodium concentration to vasopressin and to availability of metabolic substrate. J. Membrane Biol 1977; 34: 289
   Google Scholar
• McLaughlin C. W. Metabolic and transport effects of tissue culture medium on toad urinary bladder. Epithelial Ion and Water Transport, A. D. C. Macknight, J. P. Leader. Raven Press, New York 1981; 23
   Google Scholar
• Whittam R. Active cation transport as a pacemaker of respiration. Nature (London) 1961; 191: 603
   Google Scholar
• Chance B., Williams C. M. The respiratory chain and oxidative phosphorylation. Adv. Enz. Relat. Areas Mol Biol 1956; 17: 65
   PubMedGoogle Scholar
• Jöbsis F. F., Duffield J. C. Oxidative and glycolytic recovery metabolism in muscle. J. Gen. Physiol 1967; 50: 1009
   PubMed Web of Science ®Google Scholar
• Balaban R. S., Mandel L. J. Coupling of aerobic metabolism to active ion transport in the kidney. J. Physiol, London. 1980; 304: 331
   Google Scholar
• Balaban R. S., Dennis V. W., Mandel L. J. Microfluorometric monitoring of NAD redox state in isolated perfused renal tubules. Am. J. Physiol 1981; 240: F337
   Google Scholar
• Balaban R. S., Soltoff S. P., Slorey J. M., Mandel L. J. Improved renal cortical tubule suspension: spectrophotometric study of 02 delivery. Am. J. Physiol. 1980; 238: F50
   Google Scholar
• Chance B., Cohen P., Jobsis F. F., Schoener B. Localised fluorometry of oxidation-reduction states of intracellular pyridine nucleotide in brain and kidney cortex of the anaesthetised rat. Science 1962; 136: 325
   PubMed Web of Science ®Google Scholar
• Franke H., Barlow C. H., Chance B. Oxygen delivery in perfused rat kidney: NADH fluorescence and renal functional state. Am. J. Physiol. 1976; 231: 1082
   PubMedGoogle Scholar
• Van Rossum G. D. V. Relation of the oxidoreduction level of electron carriers to ion transport in slices of avian salt gland. Biochim. Biophys. Acta 1968; 153: 124
   Google Scholar
• Handler J. S., Perkins F. M., Johnson J. P. Studies of renal cell function using cell culture techniques. Am. J. Physiol. 1980; 238: Fl
   Google Scholar
• Wright E. M. Transepithelial transport in cell culture. Am. J. Physiol 1981; 240: C91
   Google Scholar
• Holley R. W., Amour R., Baldwin J. H., Brown K. D., Yeh Y.-C. Density dependent regulation of growth of BSC-1 cells in cell culture: control of growth by serum factors. Proc. Nail. Acad. Sci. U.S.A. 1977; 74: 5046
   PubMedGoogle Scholar
• Cereijido M., Robbins E. S., Dolan W. J., Rotunno C. A., Sabatini D. D. Polarised monolayers formed by epithelial cells on a permeable and translucent support. J. Cell Biol 1978; 77: 853
   PubMed Web of Science ®Google Scholar
• Handler J. S., Steele R. E., Sahib M., Wade J. B., Preston A. J., Lawson N., Johnson J. P. Toad urinary bladder epithelial cells in culture: maintenance of epithelial structure, sodium transport and response to hormones. Proc. Natl Acad. Sci. U.S.A. 1979; 76: 4151
   PubMedGoogle Scholar
• Misfeldt D. S., Hamamoto S. T., Pitelka D. R. Transepithelial transport in culture. Proc. Natl. Acad. Sci. U.S.A. 1976; 73: 1212
   PubMed Web of Science ®Google Scholar
• Taub M., Saier M. H. Amiloride-resistant Madin-Darby canine kidney (MDCK) cells exhibit decreased cation transport. Cell Physiol 1981; 106: 191
   Google Scholar
• Taub M., Chuman L., Saier M. H., Sato G. H. The growth of a kidney epithelial cell line (MDCK) in hormone-supplemented serum-free media. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 3338
   PubMedGoogle Scholar
• Lichtenstein N. S., Leaf A. Effect of amphotericin B on the permeability of the toad bladder. J. Clin. Invest. 1965; 44: 1328
   PubMed Web of Science ®Google Scholar
• Bissell D. M. Primary hepatocyte culture: substratum requirements and production of matrix components. Fed. Proc 1981; 40: 2469
   Google Scholar
• Emerman J. T., Pitelka D. R. Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro 1977; 13: 316
   PubMedGoogle Scholar
• Bisbee C. A., Machen T. E., Bern H. A. Mouse mammary epithelial cells on floating collagen gels: transepithelial ion transport and effects of prolactin. Proc. Natl. Acad. Sci. U.S.A. 1979; 76: 536
   Google Scholar
• Bisbee C. A. Prolactin effects on ion transport across cultured mouse mammary epithelium. Am. J. Physiol 1981; 240: C110
   Google Scholar
• Willis J. S., Ellory J. C., Becker J. H. Na-K pump and Na-K-ATPase; disparity of their temperature sensitivity. Am. J. Physiol 1978; 235: C159
   Google Scholar
• Mills J. W., Macknight A. D., O'Dayer J. M., Ausiello D. A. Localization of (3H) ouabain-sensitive Na+ pump site in cultured pig kidney cells. Am. J. Physiol 1979; 236: C157
   Web of Science ®Google Scholar
• Misfeldt D. S., Sanders M. J. Transepithelial transport in cell culture: D-glucose transport by a pig kidney cell line (LCC-PK. 1). J. Membrane Biol 1981; 59: 13
   PubMedGoogle Scholar
• Rabito C. A., Ausiello D. A. Na+-dependent sugar transport in a cultured epithelial cell line from pig kidney. J. Membrane Biol 1980; 54: 31
   PubMed Web of Science ®Google Scholar
• Mills J. W., Macknight A. D.C, Jarrell J. A., Dayer J. M., Ausiello D. A. Interaction of ouabain with a Na+ pump in intact epithelial cells. J. Cell Biol 1981; 88: 637
   Google Scholar
• Toback F. G. Induction of growth in kidney epithelial cells in culture by Na+. Proc. Natl. Acad. Sci. U.S.A. 1980; 77: 6654
   Google Scholar
• Cereijido M., Meza I., Martinez-Palomo A. Occluding junctions in cultured epithelial monolayers. Am. J. Physiol 1981; 240: C96
   Google Scholar
• Johnson J. P., Steele R. E., Perkins F. M., Wade J. B., Preston A. S., Green S. W., Handler J. S. Epithelial cultural organisation and hormone sensitivity of toad urinary bladder cells in culture. Am. J. Physiol 1981; 241: F129
   Google Scholar
• Goldring S. R., Dayer J. M., Ausiello D., Krane S. M. A cell strain cultured from porcine kidney increases cyclic AMP content upon exposure to calcitonin or vasopressin. Biochem. Biophys. Res. Commun. 1978; 83: 434
   PubMed Web of Science ®Google Scholar
• Rindler M. J., Taub M., Saier M. H., Jr. Uptake of 22Na by cultured dog kidney cells (M DCK). J. Biol. Chem. 1979; 254: 11431
   Google Scholar
• Simmons N. L. Ion transport in 'tight'epithelial monolayers of MDCK cells. J. Membrane Biol. 1981; 59: 105
   Google Scholar