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Research Article

Parathyroid Hormone-Related Protein

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Pages 299-343 | Published online: 27 Sep 2008

References

  • Martin T. J., Atkins D. Biochemical regulators of bone resorption and their significance in cancer. Essays Med Biochem 1979; 4: 49–82
  • Albright F. Case records of the Massachussetts General Hospital (Case 27401). N Engl J Med 1941; 225: 789–91
  • Moseley J. M., Kubota M., Diefenbach-Jagger H., et al. Parathyroid hormone-related protein purified from a human lung cancer cell line. Proc Natl Acad Set USA 1987; 84: 5048–52
  • Strewler G. J., Stern P. H., Jacobs J. W., et al. Parathyroid hormone-like protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest 1987; 80: 1803–07
  • Stewart A. F., Wu T., Goumas D., et al. N-terminal amino-acid sequence of two novel tumor-derived adenylate cyclase-stimulating proteins: identification of parathyroid hormone-like and unlike domains. Biochem Biophys Res Commun 1987; 146: 672–8
  • Suva L. J., Winslow G. A., Wettenhall REH, et al. A parathyroid hormone-related protein implicated in malignant hypercalcemia; cloning and expression. Science 1987; 237: 893–96
  • Martin T. J., Moseley J. M., Gillespie M. T. Parathyroid hormone-related protein: biochemistry and molecular biology. Crit Rev Biochem Mol Biol 1991; 26: 377–95
  • Martin T. J., Moseley J. M., Gillespie M. T. Regulation of the PTHrP gene and its protein products. Calcium regulating hormones and bone metabolism, D. V. Cohn, C. Gennari, AH Tasjian, Jr. Elsevier, Amsterdam 1992; 25–35
  • dePapp A. E., Stewart A. F. Parathyroid hormone-related protein a peptide of diverse physiological function. Trends Endocrinol Metab 1993; 4: 181–7
  • Zondek H., Petrow H., Siebert W. Die bedeutung der calciurn-bestimmering im blute fur die diagnose der niereninsuffizientz. Z. Klin Med 1924; 99: 129–32
  • Berson S. A., Yalow R. S. Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia and bronchogenic sarcoma. Science 1966; 154: 907–9
  • Knill-Jones R. P., Buckle R. M., Parsons V., et al. Hypercalcemia and increased parathyroid hormone activity in a primary hepatoma. Studies before and after hepatic transplantation. N Engl J Med 1970; 282: 704–8
  • Greenberg P. B., Martin T. J., Sutcliffe H. S. Synthesis and release of parathyroid hormone by a renal carcinoma in cell culture. Clin Sci Mol Med 1973; 45: 183–7
  • Roof B. S., Carpenter B., Fink D. J., et al. Some thoughts on the nature of ectopic parathyroid hormones. Am J Med 1971; 50: 686–91
  • Riggs B. L., Arnaud C. D., Reynolds J. C., et al. Immunological differentiation of primary hyperparathyroidism from hyperparathyroidism due to non-parathyroid cancer. J Clin Invest 1971; 50: 2079–83
  • Benson R. C., Rigg B. L., Pickard B. M., et al. Immunoreactive forms of circulating parathyroid hormone in primary and ectopic hyperparathyroidism. J Clin Invest 1974; 54: 175–81
  • Powell D., Singer F. R., Murray T. M., et al. Non-parathyroid humoral hypercalcemia in patients with neoplastic disease. N Engl J Med 1973; 289: 176–81
  • Atkins D., Ibbotson K. J., Hillier K., et al. Secretion of prostaglandins as bone-resorbing agents by renal conical carcinoma in culture. Br J Cancer 1977; 36: 601–7
  • Stewart A. F., Horst R., Deftos L. J., et al. Biochemical evaluation of patients with cancer-associated hypercalcemia. Evidence for humoral and non-humoral groups. N Engl J Med 1980; 303: 1377–81
  • Goltzman D., Stewart A. F., Broadus A. E. Malignancy-associated hypercalcemia evaluation with a cytochemical bioassay for parathyroid hormone. J Clin Endocrinol Metab 1981; 53: 899–905
  • Stewart A. F., Insogna K. L., Goltzman D., et al. Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proc Natl Acad Sci USA 1983; 80: 1454–58
  • Rodan S. B., Insogna K. L., Vignery AM-C. Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. J Clin Invest 1983; 72: 1511–15
  • Simpson E. L., Mundy G. R., d'Souza S. M., et al. Absence of parathyroid hormone messenger RNA in non-parathyroid tumors associated with hypercalcemia. N Engl J Med 3983; 309: 325–30
  • Gkonos P. J., Hayes T., Burtis W., et al. Squamous carcinoma model of humoral hypercalcemia of malignancy. Endocrinology 1984; 115: 2384–90
  • Abramson E. C., Kukla L. J., Shevrin D. H., et al. A model for malignancy-associated humoral hypercalcemia. Calcif Tiss Int 1984; 36: 563–7
  • Rosol T. J., Capen C. C., Weisbrode S. E., et al. Humoral hypercalcemia of malignancy in nude mouse model of a canine adenocarcinoma derived from apocrine glands of anal sac: biochemical, histomorphometric and ultrastructural studies. Lab Invest 1986; 54: 679–89
  • Ikeda K., Matsumoto T., Fukumoto S., et al. A hypercalcemic nude rat model that completely mimics human syndrome of humoral hypercalcemia of malignancy. Calcif Tiss Int 1988; 43: 97–102
  • Strewler G. J., Williams R. D., Nissenson R. A. Human renal carcinoma cells produce hypercalcemia in the nude mouse and a novel protein recognized by parathyroid hormone receptors. J Clin Invest 1983; 71: 769–74
  • Ellison M., Woodhouse D., Hillyard C. J., et al. Immunoreactive calcitonin production by human lung cancer cells in culture. Br J Cancer 1975; 32: 373–9
  • Mangin M., Ikeda K., Dreyer B. E., et al. Isolation and characterization of the human parathyroid hormone-related peptide gene. Proc Natl Acad Sci USA 1989; 86: 2408–12
  • Yasuda T., Banville D., Hendy G. N., et al. Characterization of the human parathyroid hormone-like peptide gene: functional and evolutionary aspects. J Biol Chem 1989; 264: 7720–5
  • Mangin M., Ikeda K., Broadus A. E. Structure of the mouse gene encoding parathyroid hormone-related protein. Gene 1990; 95: 195–202
  • Karaplis A. C., Yasuda T. Hendy G. N., et al. Gene-encoding parathyroid hormone-like peptide: nucleotide sequence of the rat gene and comparison with the human homologue. Endocrinology 1990; 4: 441–6
  • Yasuda T., Banville D., Rabbini S. A., et al. Rat parathyroid hormone-like peptide: comparison with the human homologue and expression in malignant and normal tissue. Mol Endocrinol 1989; 3: 518–25
  • Thiede M. A., Rutledge S. J. Nucleotide sequence of a parathyroid hormone-related peptide expressed by the 10 day chicken embryo. Nucleic Acids Res 1990; 18: 3062
  • Wu T., Soifer N. E., Burtis W. J., et al. Glycosylation of parathyroid hormone-related peptide secreted by human epidermal keratinocytes. J Clin Endocrinol Metab 1991; 73: 1002–7
  • Seidah N. G., Chretien M. Proprotein and prohormone convertases of the subtilisin family. Trends Endocrinol Metab 1992; 3: 133–40
  • Barr P. Mammalian subtilisin: the long-sought dibasic processing endoproteases. Cell 1991; 66: 1–3
  • Smith I. A., Funder J. W. Prepopiomelanocortin processing in the pituitary, central nervous system, and peripheral tissues. Endocrinol Rev 1988; 9: 159–79
  • Soifer N. E., Dee K. E., Insogna K. L., et al. Parathyroid hormone-related protein: evidence for secretion of a novel mid-region fragment by three different cell types. J Biol Chem 1992; 267: 18236–43
  • Rabbani S A, Mitchell J., Roy D. R., et al. Purification of peptides with parathyroid hormone-like bioactivity from human and rat malignancies associated with humoral hypercalcemia. Endocrinology 1986; 118: 1200–10
  • Brandt D. W., Burton D. W. Gazdar A. F., et al. All major lung cancer cell types produce parathyroid hormone-like hormone-like protein: heterogeneity assessed by high performance liquid chromatography. Endocrinology 1991; 129: 2466–70
  • Emly J. F., Ratcliffe W. A., Green L., et al. Immunocytochemical characterization of parathyroid hormone-related protein from tumor and non-tumoral cells. Biochim BiophysActa 1992; 1180: 58–64
  • Zajac J. D., Callaghan J., Eldridge C., et al. Production of parathyroid hormone-related protein by a rat parathyroid cell line. Mol Cell Endocrinol 1989; 67: 107–112
  • Hammonds R. G., McKay P., Winslow G. A., et al. Purification and characterization of recombinant human parathyroid hormone-related protein. J Biol Chem 1989; 264: 14806–11
  • Law FMK, Moate P. J., Leaver D. D., et al. Parathyroid hormone-related protein in milk and its correlation with bovine milk calcium. J Endocrinol 1991; 128: 21–6
  • Ratcliffe W. A., Green E., Emly J., et al. Identification and partial characterization of parathyroid hormone-related protein in human and bovine milk. J Endocrinol 1990; 127: 167–76
  • Danks J. A., Ebeling P. R., Hayman J. A., et al. Immunohistochemical localization of parathyroid hormone-related protein in parathyroid adenoma and hyperplasia. J Pathol 1990; 16: 27–33
  • Maclsaac R. J., Caple RW, Danks J. A., et al. Ontogeny of parathyroid hormone-related protein in the ovine parathyroid gland. Endocrinology 1991; 129: 757–62
  • Fenton A. J., Kemp R.G. Hammonds, et al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein: PTHrP 107–111. Endocrinology 1991; 129: 3424–26
  • Suva L. J., Mather K. A., Gillespie M. T., et al. Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP). Gene 1989; 77: 95–105
  • Moseley JM, Gillespie M. T. Parathyroid hormone-related protein. Cytokines and bone, M. Gowen. CRC Press, Boca Raton, FL 1992; 325–59, 331
  • Burtis W. J. Parathyroid hormone-related protein: structure, function and measurement. Clin Chem 1992; 38: 2171–83
  • Mangin M., Ikeda K., Dreyer B. E., et al. Identification of an up-stream promoter of the human parathyroid hormone-related peptide gene. Mol Endocrinol 1990; 4: 851–8
  • Comings D. E. Evidence for ancient tetraploidy and conservation of linkage groups in mammalian chromosomes. Nature 1972; 238: 455–7
  • Mannens M., Slater R. M., Heyting C., et al. Regional localization of RNA probes of the short arm of chromosome 11 using aniridia-Wilm's tumor associated deletions. Hum Genet 1987; 75: 180–7
  • Vakalopoulou E., Schaak J., Shenk T. A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs. Mol Cell Biol 1991; 11: 3355–64
  • Jones T. R., Cole M. D. Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences. Mol Cell Biol 1987; 7: 4513–21
  • Wilson T., Treisman R. Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3' AU-rich sequences. Nature 1988; 336: 396–9
  • Chen C-YA, Chen T-M, Shyu A-B. Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function. Mol Cell Biol 1994; 14: 416–26
  • Maker J. S. Identification of an AUUUA-specific messenger RNA binding protein. Science 1989; 246: 664–6
  • Zhang W., Wagner B. J., Ehrenman K., et al. Purification, characterization and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Mol Cell Biol 1993; 13: 7652–65
  • Bohjanen P. R., Petrryniak B., June C. H., et al. An inducible cytoplasmic factor (AU-B) binds selectively to AUUUA multimers in the 3' untranslated region of lymphokine mRNA. Mol Cell Biol 1991; 11: 3288–95
  • Gillespie M. T., Kiriyama T., Glatz J. A., et al. Human PTHrP gene transcription is stimulated by estrogen, EGF and TGF-β. Calcium regulating hormones and bone metabolism, D. V. Cohn, C. Gennari, AH Tasjian. Elsevier, JrAmsterdam 1992; 52–6
  • Lu C., Ikeda K., Deftos L. J., et al. Glucocorticoid regulation of parathyroid hormone-related peptide gene transcription in a human neuroendocrine cell line. Mol Endocrinol 1989; 3: 2034–40
  • Kiriyama T., Gillespie M. T., Glatz J. A., et al. Transforming growth factor stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator%. Mol Cell Endocrinol 1993; 92: 55–62
  • Ikeda K., Okazaki R., Inoue D., et al. Interleukin-2 increases production and secretion of parathyroid hormone-related peptide by human T cell leukemia virus type-1 infected T cells; possible role in hypercalcemia associated with adult T cell leukemia. Endocrinology 1993; 132: 2551–6
  • Allinson E. T., Drucker D. J. Parathyroid hormone-like peptide shares features with members of the early response gene family: rapid induction by serum, growth factors, and cycloheximide. Cancer Res 1992; 52: 3103–9
  • Freter R. R., Irminger J-C., Porter J. A., et al. A novel 7-nucleotide motif located in the 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene. Mol Cell Biol 1992; 12: 5288–300
  • Vasavada R. C., Wysolmerski J. J., Broadus A. E., et al. Identification and characterization of a GC-rich promoter of the human parathyroid hormone-related peptide gene. Mol Endocrinol 1993; 7: 273–82
  • Thiede M. A., Strewler R. A., Nissenson R. A. Human renal carcinoma expresses two messages encoding a parathyroid hormone like peptide: evidence for the alternate splicing of a single copy gene. Proc Natl Acad Sci USA 1988; 85: 4605–9
  • Campos R. V., Wang C., Drucker D. J. Regulation of parathyroid hormone-related peptide (PTHrP) gene transcription: cell- and tissue-specific promoter utilization mediated by multiple positive and negative m-acting DNA elements. Mot Endocrinol 1992; 6: 1642–52
  • Chilco P. J., Gerardi J. M., Kaczmarczyk S. J., et al. Calcitonin increases transcription of parathyroid hormone-related protein via cAMP. Mol Cell Endocrinol 1993; 94: 1–7
  • Suva L. J., Gillespie M. T., Wood W. I., et al. Multiple tissue-specific promoters and alternate splicing of the human parathyroid hormone-related protein gene. J Bone Miner Res. 1989; 4: A67, (Suppl. 1)
  • Holt E. H., Vasavada R., Broadus A. E., et al. Expression of the parathyroid hormone-related peptide gene in human renal cell carcinoma lines is associated with site-specific demethylation. J Biol Chem 1993; 268: 20639–45
  • Bamett T. R., Drake L., Pickle II W. Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed protein. Mol Cell Biol 1993; 13: 1273–82
  • Huang J-P, Tang C-JC, Kou G-H, et al. Genomic structure of the locus encoding protein 4.1. J Biol Chem 1993; 268: 3758–66
  • Concordet J-P, Salminen M., Demignon J., et al. An opportunistic promoter sharing regulatory sequences with either a muscle-specific or a ubiquitous promoter in the human aldolase A gene. Mol Cell Biol 1993; 13: 9–17
  • Southby J., O'Keeffe L. M., Martin T. J., et al. Regulators of parathyroid hormone-related protein expression influence promoter usage and mRNA splicing (submitted).
  • Hendy G. N., Sakaguchi A. Y., Lalley P. A., et al. Gene for parathyroid hormone like peptide is on mouse chromosome 6. Cytogenet Cell Genet 1990; 53: 80–2
  • Hendy G. N., Sakaguchi A. Y., Yasuda T., et al. Gene for parathyroid hormone-like peptide is on rat chromosome 2. Biochem Biophys Res Commun 1988; 157: 558–62
  • Haddad JG, Jr, Rutledge S. J., Thiede M. A. Structure and expression of the parathyroid hormone-related peptide gene in the chicken. J Bone Miner Res 1990; 5(Suppl 1)A732
  • Pirola C. J., Wang H-M, Kamyar A., et al. Angiotensin II regulates parathyroid hormone-related protein expression in cultured rat aortic smooth muscle cells through transcriptional and post-transcriptional mechanisms. J Biol Chem 1993; 268: 1987–94
  • Ikeda K., Okazaki R., Inoue D., et al. Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E, in HTLV-I-infected cells. J Biol Chem 1993; 268: 1174–9
  • Chan SDH, Strewler G. J., King K. L., et al. Expression of a parathyroid hormone-like protein and its receptor during differentiation of embryonal carcinoma cells. Mol Endocrinol 1990; 4: 638–^6.
  • Ikeda K., Lu C., Weir E. C., et al. Regulation of parathyroid hormone-related peptide gene expression by cycloheximide. J Biol Chem 1990; 265: 5398^4–02.
  • Rodan S. B., Wesolowski G., Ianacone J., et al. Production of parathyroid hormone-like peptide in a human osteosarcoma cell line: stimulation by phorbol esters and epidermal growth factor. Endocrinology 1988; 122: 1230–6
  • Heath J. K., Gillespie M. T., Fukumoto S., et al. Epidermal growth factor stimulation of parathyroid hormone-related protein gene expression involves transcriptional and post-transcriptional mechanisms. Biochem J 1995; 306: 159–167
  • Casey M. L., Mibe M., Erie A., et al. Transforming growth factor-f, stimulation of parathyroid hormone-related protein expression in human uterine cells in culture: mRNA levels and protein secretion. J Clin Endocrinol Metab 1992; 74: 950–2
  • Kremer R., Karaplis A. C., Henderson J., et al. Regulation of parathyroid hormone-like peptide in culture normal keratinocytes: effect of growth factors and 1,25-dihydroxyvitamin D3 on gene expression and secretion. J Biol Chem 1991; 87: 884–93
  • Ikeda K., Lu C., Weir E. C., et al. Transcriptional regulation of the parathyroid hormone-related peptide gene by glucocorticoids and vitamin D in a human C-cell line. J Biol Chem 1989; 285: 15743–6
  • Suva L. J., Gillespie M. T., Center R. J., et al. A sequence in the human PTHrP gene promoter responsive to estrogen. J Bone Miner Res 1991; 6(Suppl. 1)A450
  • Thiede M. A., Harm S. C., Hasson D. M., et al. In vivo regulation of parathyroid hormone-related peptide messenger ribonucleic acid in the rat uterus by 17β estradiol. Endocrinology 1991; 128: 2317–23
  • Paspaliaris V., Vargas S. J., Gillespie M. T., et al. Estrogen enhancement of parathyroid hormone-related protein production and myometrial responses in rat uterus. J Endocrinol 1992; 134: 415–25
  • Casey M. L., Mibe M., MacDonald P. C. Regulation of parathyroid hormone-related protein gene expression in human endometrial stromal cells in culture. J Clin Endocrinol Metab 1993; 77: 188–94
  • Thiede M. A. The raRNA encoding a parathyroid hormone-like peptide is produced in mammary tissue in response to elevations in serum prolactin. Mol Endocrinol 1989; 3: 1443–7
  • Streutker C., Drucker D. J. Rapid induction of parathyroid hormone-iike peptide gene expression by sodium butyrate in a rat islet cell line. Mol Endocrinol 1991; 5: 703–8
  • Watanabe T., Yamaguchi K., Takatsuki K., et al. Constitutive expression of parathyroid hormone-related protein gene in human T cell leukemia virus type 1 (HTLV-1) carriers and adult T cell leukemia patients that can be trans-activated by HTLV-1 tax gene. J Exp Med 1990; 172: 759–65
  • Okazaki R., Ikeda K., Inoue D., et al. Transcriptional activation of the human PTH-related peptide gene by serum-derived growth factors in HTLV-1-infected T-cells. Calcium regulating hormones and bone metabolism, D. V. Cohn, C. Gennari, A. H. Tasjian. Elsevier, JrAmsterdam 1992; 57–61
  • Ejima E., Rosenblatt J. D., Massari M., et al. Cell-type-specific transactivation of the parathyroid hormone-related protein gene promoter by the human T-cell leukemia virus type 1 (HTLV-I) tax and HTLV-II tax proteins. Blood 1993; 81: 1017–24
  • Thiede M. A., Daifotis A. G., Weir E. C., et al. Intrauterine occupancy controls expression of the parathyroid hormone-related peptide gene in preterm rat myometrium. Proc Natl Acad Sci USA 1990; 87: 6969–73
  • Dafoitis A. G., Weir E. C., Dreyer B. E., et al. Stretch-induced parathyroid hormone-related peptide gene expression in the rat uterus. J Biol Chem 1998; 267: 23455–8
  • Yamamoto S.C. Haun, Grasser W. A., et al. Parathyroid hormone-related protein in the rat urinary bladder: a smooth muscle relaxant produced locally in response to mechanical stretch. Proc Natl Acad Sci USA 1992; 89: 5326–33
  • Ikeda K., Weir E. C., Sakaguchi K., et al. Clonal rat cell line expresses a parathyroid hormone-related peptide but not parathyroid hormone itself. Biochem Biophys Res Commun 1989; 162: 1240–8
  • Hellman P., Ridefelt P., Juhlin C., et al. Parathyroid-like regulation of parathyroid-hormone-related protein release and cytoplasmic calcium in cytotrophoblast cells of human placenta. Arch Biochem Biophys 1992; 293: 174–80
  • Mori N., Ohsumi K., Murakami S., et al. Enhancing effect of interleukin-2 on production of parathyroid hormone-related protein by adult T-cell leukemia cells. Jpn J Cancer Res 1993; 84: 425–30
  • Glatz J. A., Heath J. K., Southby J., et al. Dexamethasone regulation of parathyroid hormone-related protein (PTHrP) expression in a squamous cancer cell line. Mol Cell Endocrinol 1994; 101: 295–306
  • Haq M., Kremer R., Goltzman D., et al. A vitamin D analogue (EB1089) inhibits parathyroid hormone-related peptide production and prevents development of malignancy-associated hypercalcemia in vivo. J Clin Invest 1993; 92: 2416–22
  • Liu B., Goltzman D., Rabbani S. A. Regulation of parathyroid hormone-related peptide production. in vitro by the rat hypercalcemic cell tumor H-500. Endocrinology 1993; 132: 1658–64
  • Mundy G. R., Ibbotson K. J., d'Souza S. M. Tumor products and the hypercalcemia of malignancy. J Clin Invest 1985; 76: 391–94
  • Mundy G. R., Martin T. J. The hypercalcemia of malignancy: pathogenesis and treatment. Metabolism 1982; 31: 1247–77
  • Mundy G. R., Ibbotson K. J., d'Souza S. M., et al. The hypercalcemia of cancer. N Engl J Med 1984; 310: 1718–27
  • Bertolini D. R., Medwin G. E., Bringham T. S., et al. Stimulation of bone resorption and inhibition of bone formation. in vitro by human tumor necrosis factors. Nature 1986; 319: 516–18
  • Ibbotson K. J., d'Souza S. M., Ng K. W., et al. Tumor derived growth factor increased bone resorption, in a tumor associated with humoral hypercalcemia of malignancy. Science 1983; 221: 1292–4
  • D'Souza S. M., Ibbotson K. J., Smith D. D. Co-purification of a transforming growth factor (TGF) with bone resorbing activity in the Walker rat carcinosarcoma: a mechanism for humoral hypercalcemia of malignancy (HHM). Calcif Tiss Int 1983; 35: A658
  • Gowen M., Wood D. W., Ihrie E. J., et al. An interleukin 1-like factor stimulates bone resorption. in vitro. Nature 1983; 306: 378–80
  • Heath J. K., Saklavatvala J., Meikle M. C., et al. Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tiss lnt 1985; 37: 95–7
  • Kukreja S. C., Rosol T. J., Winbiscus S. A., et al. Tumor resection and antibodies to parathyroid hormone-related protein cause similar changes on bone histomorphometry in hypercalcemia of cancer. Endocrinology 1990; 127: 305–10
  • Grill V., Ho P., Body J. J., et al. Parathyroid hormone-related protein: elevated levels both in humoral hypercalcemia of malignancy and in hypercalcemia complicating metastatic breast disease. J Clin Endocrinol.Metab 1992; 73: 110–5
  • Mundy G. R. Hypercalcemia of malignancy revisited. J Clin Invest 1988; 82: 1–6
  • Schmeltzer H. J., Hesch R. D., Mayer H. Parathyroid hormone and PTH mRNA in a human small cell lung cancer. Peptide hormones in lung cancer, K. Hevemann, G. Sorenson, C. Gropp. Springer Verlag, Berlin 1985; 85–93
  • Yoshimoto K., Yamasaki R., Sakai H., et al. Ectopic production of parathyroid hormone by small cell lung cancer in a patient with hypercalcemia. J Clin Endocrinol Metab 1989; 68: 976–81
  • Nussbaum S. R., Gaz R. D., Arnold A. Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. N Engl J Med 1990; 323: 1324–8
  • Martin T. J., Mundy G. R. Hypercalcaemia of malignancy. Clinical endocrinology of calcium metabolism, T. J. Martin, L. G. Raisz. Marcel Dekker, New York 1987; 171–199
  • Kukreja S. C., Shermerdiak W. P. Lad T. E., et al. Elevated nephrogenous cyclic AMP with normal serum parathyroid hormone levels in patients with lung cancer. J Clin Endocrinol Metab 1980; 51: 167–9
  • Rude R. K., Sharp CF, Jr, Fredericks R. S., et al. Urinary and nephrogenous adenosine 3'5'-monophosphate in the hypercalcemia of malignancy. J Clin Endocrinol Metab 1981; 52: 765–71
  • Ellis A. G., Adam W. R., Martin T. J., et al. Comparison of the effects of parathyroid hormone (PTH) and recombinant PTH-related protein on bicarbonate excretion by the isolated perfused rat kidney. J Endocrinol 1990; 126: 403–8
  • Fenton A. J., Kemp B. E., Kent G. N., et al. A carboxy-terminal fragment of parathyroid hormone-related protein inhibits bone resorption by osteoclasts. Endocrinology 1991; 129: 1762–8
  • Schilling T., Pecherstorfer M., Blind E., et al. Parathyroid hormone-related protein (PTHrP) does not regulate 1,25-dihydroxyvitamin D serum levels in hypercalcemia of malignancy. J Clin Endocrinol Metab 1993; 76: 801–8
  • Yamamoto I., Kitamura N., Aoki J., et al. Circulating 1,25-dihydroxyvitamin D concentrations in patients with renal cell carcinoma-associated hypercalcemia are rarely suppressed. J Clin Endocrinol Metab 1987; 64: 175–9
  • Walker A. T., Stewart A. F., Kom E. A., et al. Effect of parathyroid hormone-like peptides on 1,25-dihydroxyvitamin D-L-alpha hydroxylase activity in rodents. Am J Physiol 1990; 258: E297–303
  • Fraher L. J., Hodsman A. B., Jonas K., et al. A comparison of the in vivo biochemical responses to exogenous parathyroid hormone (1–34) [PTH 1–34] and PTH-related paptide (1–34) in man. J Clin Endocrinol Metab 1992; 75: 417–23
  • Rosol T. J., Capen C. C., Horst R. C. Infusion of human parathyroid hormone related protein (1–40) in nude mice: histomorphometric and biochemical investigation. J Bone Miner Res 1988; 3: 699–706
  • Fukumoto S., Matsumoto T., Yamoto H., et al. Suppression of serum l,25(OH)2D in humoral hypercalcemia of malignancy is caused by elaboration of a factor that inhibits renal 1,25 dihydroxyvitamin D production. Endocrinology 1989; 124: 2057–62
  • Horiuchi N., Caulfield M. P., Fisher J. E., et al. Similarity of synthetic peptide from human tumor to parathyroid hormone. in vivo and. in vitro. Science 1987; 238: 1566–8
  • Yates AJP, Gutierrez G. E., Smoleus P., et al. Effects of a synthetic peptide of a parathyroid hormone-related protein on calcium homeostasis, renal tubular calcium reabsorption and bone metabolism in vivo and in vitro in rodents. J Clin Invest. 1988; 81: 932–8
  • Stewart A. F., Mangin M., Wu T., et al. Synthetic human parathyroid hormone-like protein stimulates bone resorption and causes hypercalcemia in rats. J Clin Invest 1988; 81: 596–600
  • Thompson D. D., Seedor J. G., Fisher J., et al. Direct action of the human hypercalcemic factor on bone in thyroparathyroidectomised rats. Proc Natl Acad Sci USA 1988; 85: 5673–7
  • Sato K., Mimura H., Han D. C., et al. Production of bone resorbing activity and colony-stimulating activity in vivo and in Nitro by a human squamous carcinoma associated with hypercalcemia and leukocytosis. J Clin Invest. 1986; 78: 145–54
  • Nimberg R. B., Humphries D. E., Lloyd W. A., et al. Isolation of a bone resorptive factor from human cancer ascites fluid. Cancer Res. 1978; 38: 1983–9
  • Lorenzo J., Sousa S., Kemp B. E., et al. Comparison of parathyroid hormone-related peptide (1–34) of malignancy and bovine parathyroid (1–34) on bone resorption and the release of interleukin-1 -like activity in 4 to 5 day mice cal varia cultures. J Bone Miner Res 1988; 3(Suppl 1)A618
  • Sato K., Fuji Y., Kasano K., et al. Parathyroid hormone-related protein and interleukin la synergistically stimulate bone resorption. in vitro and increase serum calcium concentration in mice. in vivo. Endocrinology 1989; 124: 2172–8
  • Centrella M., Canalis E., McCarthy T. L., et al. Parathyroid hormone-related protein modulates the effect of transforming growth factor β on deoxyribonucleic acid and collagen synthesis in fetal bone cells. Endocrinology 1989; 125: 199–208
  • Guise T. A., Yoneda T. Yates A. J. et al. The combined effect of tumor-produced parathyroid hormone-related protein and transforming growth factor-alpha enhance hypercalcemia in vivo and bone resorption in vitro. J Clin Endocrinol Metab. 1993; 77: 40–5
  • Law F., Rizzoli R., Bonjour J-P. Transforming growth factor-beta modulates the parathyrroid hormone-related protein-induced responses in renal epithelial cells. Endocrinology 1993; 133: 145–51
  • Danks J. A., Ebeling P. R., Hayman J., et al. Parathyroid hormone-related protein of cancer: immunohistochemical localization in cancers and in normal skin. J Bone Miner Res 1989; 4: 273–7
  • Hayman J. A., Danks J. A., Ebeling P. R., et al. Expression of parathyroid hormone-related protein in normal skin and in tumors of skin and skin appendages. J Pathol 1989; 158: 293–6
  • Southby J., Kissin M. W., Danks J. A., et al. Immunohistochemical localization of parathyroid hormone-related protein in human breast cancer. Cancer Res 1990; 50: 7710–3366
  • Tsuchihasi T., Yamaguchi K., Miyake Y., et al. Parathyroid hormone-related protein in tumor tissues obtained from patients with humoral hypercalcemia of malignancy. J Natl Cancer Inst 1990; 82: 40–4
  • Asa S. L., Henderson J., Goltzman D., et al. Parathyroid hormone-like peptide in normal and neoplastic human endocrine tissues. J Clin Endocrinol Metab 1990; 71: 1112–8
  • Kitazawa S., Fukase M., Kitazawa R., et al. Immunohistologic evaluation of parathyroid hormone-related protein in human lung cancer and normal tissue with newly developed antibody. Cancer 1991; 67: 984–9
  • Kramer S., Reynolds F. H., Castillo M., et al. Immunological identification and distribution of parathyroid hormone-like protein polypeptides in normal and malignant tissues. Endocrinology 1991; 128: 1927–37
  • Ralston S. H., Danks J. A., Hayman J., et al. Parathyroid hormone-related protein of malignancy: immunochemical and biochemical studies in normocalcemic and hypercalcemic patients with cancer. J Clin Pathol 1991; 44: 472–6
  • Moseley J. M., Danks J. A., Grill V., et al. Immunocytochemical demonstration of PTHrP protein in neoplastic tissue of HTLV-1 positive human adult T cell leukemia/lymphoma: implications for the mechanisms of hypercalcemia. Br J Cancer 1991; 64: 745–8
  • di Iwamuram Sant', Agnese A., Wu G., et al. Immunohistochemical localization of parathyroid hormone-related protein in human prostate cancer. Cancer Res 1993; 53: 1724–6
  • Yamamura I. Y., Kitazawa S., Kitazawa R., et al. Parathyroid hormone-related protein in gastric cancers with heterotopic ossification. Cancer 1993; 72: 1849–52
  • Ito M., Enomoto H., Usa T., et al. Expression of parathyroid hormone-related peptide in human pituitary tumors. J Clin Pathol 1993; 46: 682–3
  • Mune T., Katakami H., Kato Y., et al. Production and secretion of parathyroid hormone-related protein in pheochromocytoma: participation of an α-adrenergic mechanism. J Clin Endocrinol Metab 1993; 76: 757–62
  • Ikeda K., Arndel A., Mangin M., et al. Expression of transcripts encoding a parathyroid hormone-related peptide in abnormal human parathyroid tissues. J Clin Endocrinol Metab 1989; 69: 1240–8
  • Ikeda K., Mangin M., Dreyer B. E., et al. Identification of transcripts encoding a parathyroid hormone-like peptide in messenger RNAs from a variety of human and animal tumors associated with humoral hypercalcemia of malignancy. J Clin Invest 1988; 81: 2010–4
  • Ikeda K., Weir E., Mangin M., et al. Expression of messenger ribonucleic acids encoding a parathyroid hormone-like peptide in normal human and animal tissues with abnormal expression in human parathyroid adenomas. Mol Endocrinol 1988; 2: 1230–6
  • Deftos L. J., Gazdar A. F., Ikeda K., et al. The parathyroid hormone-related protein associated with malignancy is secreted by neuroendocrine tumors. Mol Endocrinol 1989; 3: 503–8
  • Dnicker D. J., Asa S. L., Henderson J., et al. The parathyroid hormone-like peptide gene is expressed in the normal and neoplastic human endocrine pancreas. Mol Endocrinol 1990; 3: 1589–95
  • Heath D. A., Senior P. V., Varley J. M., et al. Parathyroid hormone-related protein in tumors associated with hypercalcemia. Lancet 1990; 1: 66–9
  • Burtis W. J., Brady T. G., Orloff J. J., et al. Immunochemical characterization of circulating parathyroid hormone-related protein in patients with humoral hypercalcemia of cancer. N Engl J Med 1990; 322: 1106–12
  • Burtis W. J., Dann P., Gaich G. A., et al. A high abundance of midregion parathyroid hormone-related protein: immunological and chromatographic characterization in plasma. J Endocrinol Metab 1994; 78: 317–22
  • Kao P. C., Glee G. G., Taylor R. L., et al. Parathyroid hormone-related peptide in plasma of patients with hypercalcemia and malignant lesions. Mayo Clin Proc 1990; 65: 1399–^07.
  • Budayr A. A., Nissenson R. A., Klein R. F., et al. Increased serum levels of a parathyroid hormonelike protein in malignancy-associated hypercalcemia. Ann Intern Med 1989; 111: 807–12
  • Henderson J. R., Shustik C., Kremer R., et al. Circulating concentrations of parathyroid hormone-like peptide in malignancy and hyperparathyroidism. J Bone Miner Res 1990; 5: 105–13
  • Ratcliffe W. A., Norbury S., Heath D. A., et al. Development and validation of an immunoradiometric assay for parathyroid hormone-related protein in unextracted plasma. Clin Chem 1991; 37: 678–85
  • Panadian M. R., Morgan C. H., Carlton E., et al. Modified immunoradiometric assay of parathyroid hormone-related protein: clinical application in the differential diagnosis of hypercalcemia. Clin Chem 1992; 38: 282–8
  • Fraser WD, Robinson J., Lawton R., et al. Clinical and laboratory studies of a new immunoradiometric assay of parathyroid hormone-related protein. Clin Chem 1993; 39: 414–9
  • Kashahari H., Tsuchiya M., Adachii R., et al. Development of a C-terminal-region specific radioimmunoassay of parathyroid hormone-related protein. Biomed Res 1992; 13: 155–61
  • Guise T. A., Chirgwin J. M., Favaroto G., et al. Chinese hamster ovarian cells transfected with human parathyroid hormone-related protein cDNA cause hypercalcemia in nude mice. Lab Invest 1992; 67: 477–85
  • Kukreja S. C., Schavin D. H., Wimbuscus S., et al. Antibodies to parathyroid hormone-related protein lower serum calcium in athymic mouse models of malignancy associated hypercalcemia due to human tumors. J Clin Invest 1988; 82: 1798–802
  • Sato K., Yamakawa Y., Schizume K., et al. Passive immunization with anti-parathyroid hormone-related protein monoclonal antibody markedly prolongs survival time of hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors. J Bone Miner Res 1993; 8: 849–60
  • Atillasoy E. J., Burtis W. J., Milstone L. M. Immunohistochemical localization of parathyroid hormone-related protein (PTHrP) in normal human skin. J Invest Dermatol 1991; 96: 277–80
  • Burtis W. J., Wu J., Bunch C. M., et al. Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem 1987; 262: 7151–6
  • Percival R. C., Yates AJP, Gray RES, et al. Mechanisms of malignant hypercalcemia in carcinoma of the breast. Br Med J 1985; 2: 766–79
  • Isales C., Carrangui M. L., Stewart A. F. Hypercalcemia in breast cancer: reassessment of the mechanism. Am J Med 1987; 82: 1143–7
  • Bundred N. J., Ratcliffe W. A., Walker R., et al. Parathyroid hormone-related protein and hypercalcemia in breast cancer. Br Med J 1991; 303: 1506–9
  • Bouiziar Z., Spyratos F., Deytieux S., et al. Polymerase chain reaction analysis of parathyroid hormone-related protein gene expression in breast cancer patients and occurrence of bone metastases. Cancer Res 1993; 53: 5076–8
  • Vargas S. J., Gillespie M. T., Powell G. J., et al. Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by. in situ hybridization. J Bone Miner Res. 1992; 7: 971–80
  • Powell G. J., Southby J. A., Danks R. G., et al. Localization of parathyroid hormone-related protein in breast cancer metastases: increased incidence in bone compared to other sites. Cancer Res. 1991; 51: 3091–3
  • McKenzie S., Gillespie M. T., Scurry J. P., et al. Parathyroid hormone-related protein and human papillomavirus in gynecological tumors. IntJ Cancer 1994; 56: 324–30
  • Bunn P. A., Schechter G. P., Jaffe E., et al. Clinical course of retrovirus associated adult T-cell lymphoma in the United States. N Engl J Med 1983; 309: 257–64
  • Dodd R. C., Winkler C. F., Williams M. E., et al. Calcitriol levels in hypercalcaemic patients with adult T-cell lymphoma. Arch Intern Med 1986; 146: 1971–2
  • Fukumoto S., Matsumoto T., Wanatabe T., et al. Secretion of parathyroid hormone-like activity from human T-cell lymphotropic virus type-1-infected lymphocytes. Cancer Res 1989; 49: 3849–52
  • Kinoshita K., Kamihira S., Ikeda S., et al. Clinical, hematologic and pathologic features of leukemia T-cell lymphoma. Cancer 1982; 50: 1554–62
  • Honda S., Yamaguchi K., Miyake Y., et al. Production of parathyroid hormone-related protein in adult T-cell leukemia cells. Jpn J Cancer Res 1988; 79: 1264–8
  • Kylie R. A. Multiple myeloma: review of 869 cases. Mayo Clin Proc 1975; 50: 29–40
  • Garret I. R., Durie BGM, Nedwin G. E., et al. Production of lymphotoxin, a bone resorbing cytokine, by cultures human myeloma cells. Mayo Clin Proc 1975; 50: 29–^0.
  • Grill V. Unpublished data.
  • Seymour J. F., Grill V., Martin T. J., et al. Hypercalcemia in the blastic phase of chronic myeloid leukemia associated with elevated parathyroid hormone-related protein. Leukemia 1993; 7: 1672–5
  • Wada S., Kitamura H., Matsuura Y., et al. Parathyroid hormone-related protein as a cause of hypercalcemia in B-cell type malignant lymphoma. Int Med. 1993; 31: 968–72
  • Rosol T. J., Nagode L. A., Couto G. C., et al. Parathyroid hormone(PTH)-related protein, PTH and 1,25-dihydroxyvitamin D on dogs with cancer associated hypercalcemia. Endocrinology 1992; 131: 1L57–64
  • Burtis W. J., Fodero J. P., Galeh G. et al. Preliminary Characterization of circulating amino and carboxy-terminal fragments of parathyroid hormone-related peptide in humoral hypercalcemia of malignancy. J Clin Endocrinol Metab 1992; 75: 110–4
  • Orloff J. J., Soifer N. E., Fedoro J. P., et al. Accumulation of carboxy-terminal fragments of parathyroid hormone-related protein in renal failure. Kidney Int. 1993; 43: 1371–6
  • Welling GN, Vander Wejser WJ, Zee R., et al. Production of sequential antigenic regions in proteins. FEBS Lett 1985; 215–9
  • Grill V. Identification of C-terminal fragments of PTHrP in urine. Unpublished data
  • Dodwell D. J., Abbas S. K., Morton A. R., et al. Parathyroid hormone-related protein (50–69) and response to pamidronate therapy for tumour induced hypercalcemia. Eur J Cancer. 1991; 27: 1629–33
  • Bucht E., Carlqvist M., Hedlund B., et al. Parathyroid hormone-related peptide in human milk measured by a mid-molecule radioimmunoassay. Metabolism. 1992; 41: 11–6
  • Immamura H., Sato K., Shizume K., et al. Urinary excretion of parathyroid hormone-related protein fragments in patients with humoral hypercalcemia of malignancy and hypercalcemic tumor-bearing nude mice. J Bone Miner Res 1991; 6: 77–84
  • Bowden S. J., Hughes S. V., Ratcliffe W. A. Molecular forms of parathyroid hormone-related protein in tumours and biological fluids. Clin Endocrinol 1993; 38: 287–94
  • Thorikay M., Kramer S., Reynolds F. H., et al. Synthesis of a gene encoding parathyroid hormone-like protein (1–141): purification and biological characterization of the expressed protein. Endocrinology 1989; 124: 111–7
  • Civitelli R., Martin T. J., Fausto A., et al. Parathyroid hormone-related peptide transiently increases cystotic calcium in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology 1989; 125: 204–1210
  • Gagnon L., Jouishomme H., Whitfield J. F., et al. Protein kinase C-activating domains of parathyroid hormone-related protein. J Bone Miner Res 1993; 8: 497–503
  • Kemp B. E., Moseley J. M., Rodda C. P., et al. Parathyroid hormone-related protein of malignancy; active synthetic fragments. Science 1987; 238: 1568–70
  • McKee R. L., Goldman M. E., Caulfield M. P., et al. The 7–34 fragment of human hypercalcemia factor is a partial agonist/antagonist for parathyroid stimulated cAMP production. Endocrinology 1988; 122: 3008–10
  • Abou-Sarma A., Uneno S., Jueppner H., et al. Non-homologous sequences of parathyroid hormone related protein bind to a common receptor on ROS 172.8 cells. Endocrinology 1989; 125: 2215–7
  • Barden J. A., Kemp B. E. NMR study of a 34-residue N-terminal fragment of the parathyroid hormone related protein secreted during humoral hypercalcemia of malignancy. EurJBiochem 1989; 184: 379–94
  • McFarlane D. R., Macfarlane E. F., Barden J. A., et al. PTIR spectroscopy study of PTHrP(l-34) involved in humoral hypercalcemia of malignancy. Biochim Biophys Acta. 1993; 1162: 1–8
  • Jueppner H., Abou-Samra A. B., Uneno S., et al. The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J Biol Chem 1988; 263: 8557–68
  • Jueppner H., Abou-Samra A. B., Freeman M., et al. A G-protein-linked receptor for parathyroid hormone and parathyroid hormone-related protein. Science 1991; 254: 1024–6
  • AbouSamra A-B, Juppner H., Force T., et al. Expression of a receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA 1992; 89: 2732–6
  • Raisz L. G., Simmons H. A., Vargar S. J., et al. Comparison of the effects of amino-terminal synthetic parathyroid hormone-related protein (PTHrP) of malignancy and parathyroid hormone on resorption of cultures fetal rat long bones. CalcifTiss Int 1990; 45: 233–8
  • Pilbeam C. C., Alander C. B., Simmons H. A., et al. Comparison of the effects of various lengths of synthetic human parathyroid hormone-related peptide (hPTHrP) of malignancy on bone resorption and formation in organ culture. Bone 1993; 14: 717–20
  • Evely R. S., Bonomo A., Schneider H-G, et al. Structural requirements for the action of parathyroid hormone-related protein (PTHrP) on bone resorption by isolated osteoclasts. J Bone Miner Res 1991; 6: 85–92
  • Hock J. M., Fonescu J., Gunness-Hey M., et al. Comparison of the anabolic effects of synthetic parathyroid hormone-related protein (PTHrP) 1–34 and PTH 1–34 on bone in rats. Endocrinology 1990; 125: 2022–7
  • Rizzoli R., Caverzasio J., Chapuy M. C., et al. Role of bone and kidney in parathyroid hormone-related peptide-induced hypercalcemia in rats. J Bone Miner Res 1989; 4: 759–65
  • Gumey H., Grill V., Martin T. J. Parathyroid hormone-related protein and response to pamidronate in tumour-induced hypercalcemia. Lancet 1993; 341: 1611–3
  • Inoue D., Matsumotot T., Ogata E., et al. 22-Oxacalcitriol, a noncalcemic analogue of calcitriol, suppresses both cell proliferation and parathyroid hormone-related peptide gene expression in human T cell lymphotrophic virus, type 1-infected cells. J Biol Chem 1993; 268: 16730–6
  • Zhou H., Leaver D. D., Moseley J. M., et al. Actions of parathyroid hormone-related protein on the rat kidney. in vivo. J Endocrinol 1989; 122: 227–35
  • Ebeling P. R., Adam W. R., Moseley J. M., et al. Actions of parathyroid hormone-related protein on the isolated rat kidney. J Endocrinol 1988; 12: 45–52
  • Pizurki L., Rizzoli R., Moseley J. M., et al. Effect of synthetic tumoral parathyroid hormone related peptide on cAMP production and sodium-dependent phosphate transport in cultured renal epithelial cells. Am J Physiol 1988; 255: 957–61
  • Saito K., Hirano K., Kubota M., et al. Effect of parathyroid hormone-related protein on sodium-dependent phosphate transport in renal brush border membrane vesicles in rats. Comparison with parathyroid hormone. Nephron 1993; 64: 600–4
  • Caverzasio J., Rizzoli R., Martin T. J., et al. Tumoral synthetic parathyroid hormone-related protein inhibit Na+/H+ antiporter activity in cultured renal epithelia. Pfluger's Arch 1988; 413: 96–8
  • Campos R. V., Asa S. L., Drucker D. J. Immunocytochemical localisation of parathyroid hormonelike peptide in the rat fetus. Cancer Res 1991; 51: 6351–7
  • Moseley J. M., Hayman J. A., Danks J. A., et al. Immunohistochemical detection of parathyroid hormone-related protein (PTHrP) in human fetal epithelia. J Clin Endocrinol Metab 1991; 73: 478–84
  • Bergmann P., Nijs-De Wolf N., Pepersack T., et al. Release of parathyroid hormone-like peptides by fetal rat long bones in culture. J Bone Miner Res, 5: 74–5
  • Nijs-De Wolf N., Pepersack T., Corvilain J. Adenylate cyclase stimulating activity immunologically similar to parathyroid hormone-related peptide can be extracted from fetal rat long bones. J Bone Miner Res 1991; 6: 921–8
  • Enomoto H., Yamashita S., Usa T., et al. Autocrine paracrine function of parathyroid hormone-related peptide in rat osteoblast-like cells. Biochem Biophys Res Commun 1993; 191: 261–9
  • Thiede M. A., Rodan G. A. Expression of a calcium-mobilizing parathyroid hormone-like peptide in lactating mammary tissue. Science 1988; 242: 278–80
  • Weir E. C., Brines M. L., Ikeda K., et al. Parathyroid hormone-related peptide gene is expressed in the mammalian central nervous system. Proc Natl Acad Sci USA 1990; 87: 108–12
  • Senior P. V., Death D. A., Beck F. Expression of parathyroid hormone-related protein mRNA in the rat before birth: demonstration by hybridization histochemistry. J Mol Endocrinol 1991; 6: 281–90
  • Karaplis A. C., Luz A., Glowacki J., et al. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes Dev 1994; 8: 277–89
  • Care A. D., Caple I. W., Pickard D. W. The roles of the parathyroid and thyroid glands on calcium homeostasis in the ovine fetus. The physiological development of the fetus and newborn, C. T. Jones, P. Nathaniels. Academic Press, New York 1985; 135–40
  • Abbas S. K., Caple I. W., Care A. D., et al. The role of the parathyroid glands in fetal calcium homeostasis in the sheep. J Physiol 1987; 386: 27
  • Loveridge N., Caple I. W., Rodda C. P., et al. Further evidence for parathyroid hormone-related protein in fetal parathyroid glands of sheep. Q J Exp Physiol 1988; 73: 781–4
  • Rodda C. P., Kubota M., Heath J. A., et al. Evidence for a novel parathyroid hormone-related protein in fetal lamb parathyroid glands and sheep placenta: comparisons with a similar protein implicated in humoral hypercalcemia of malignancy. J Endocrinol 1988; 117: 261–71
  • Care A. D., Abbas S. K., Pickard D. W., et al. Stimulation of ovine placental transport of calcium and magnesium by mid-molecule fragments of human parathyroid hormone-related protein. Exp Physiol 1991; 75: 605–8
  • Abbas S. K., Pickard D. W., Rodda C. P., et al. Stimulation of ovine placental calcium transport by purified natural and recombinant parathyroid hormone-related protein (PTHrP) preparations. Q J Exp Physiol 1989; 74: 549–52
  • Abbas S. K., Pickard D. W., Illingworth D., et al. Measurement of parathyroid hormone-related protein in extracts of fetal parathyroid glands and placental membranes. J Endocrinol 1990; 124: 319–25
  • Maclsaac R. J., Home RSC, Caple I. W., et al. Effects of thyroparathyroidectomy, parathyroid hormone and PTHrP on kidneys of ovine fetuses. Am J Physiol 1993; 264: E37–44
  • Khosla S., Johansen K. L., Ory S. J. Parathyroid hormone-related peptide in lactation and in umbilical cord blood. Mayo Clin Proc 1990; 65: 1408–14
  • Thiebaud D., Janisch S., Koelbl H., et al. Direct evidence of a parathyroid related protein gradient between the mother and newborn in humans. Bone Miner 1993; 23: 213–21
  • Budayr A. A., Halloran B. P., King J. C., et al. High levels of a parathyroid hormone-like protein in milk. Proc Natl Acad Sci USA 1989; 86: 7183–5
  • Thurston A. W., Cole J., Hillman L. S., et al. Purification and properties of parathyroid hormone-related peptide isolated from milk. Endocrinology 1990; 126: 1183–90
  • Ratcliffe W. A., Thompson G. E., Care A. D., et al. Production of parathyroid hormone-related protein by the mammary gland of the goat. J Endocrinol 1992; 133: 87–93
  • Bucht E., Carlqvist M., Hedlund B., et al. Parathyroid hormone-related peptide in human milk measured by a mid-molecule radioimmunoassay. Metabolism 1992; 41: 11–16
  • Melton M. E., Wimbiscusd'Anza J. J., et al. Parathyroid hormone-related protein and calcium homeostasis in lactating mice. Am J Physiol 1990; 259: E792–6
  • Grill V., Hillary J., Ho PMW, et al. Parathyroid hormone-related protein: a possible endocrine mechanism in lactation. Clin Endocrinol 1992; 37: 405–10
  • Yamamoto M., Duong L. T., Fisher J. R., et al. Suckling-mediated increases in urinary phosphate and 3'5' cyclic adenosine monophosphate excretion in lactating rats: possible systemic effects of parathyroid hormone-related protein. Endocrinology 1991; 129: 2614–22
  • Brommage R., Deluca H. F. Regulation of bone mineral loss during lactation. Am J Physiol 1985; 248: E182
  • Kent G. N., Price R. J., Gutteridge D. H., et al. Human lactation: forearm trabecular bone loss, increased bone turnover and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Miner Res 1990; 55: 361–9
  • Reid I. R., Wattie D. J., et al. Post-pregnancy osteoporosis associated with hypercalcemia. Clin Endocrinol 1992; 37: 298–303
  • Rouffet J., Durand D., Lefaivre J., et al. Parathyroid hormone-related peptide may increase mammary blood flow. J Bone Miner Res 1993; 8: 1519–24
  • van-Heerden J. A., Gharib H., Jackson I. T. Pseudohypoparathyroidism secondary to gigantic mammary hypertrophy. Arch Surg 1988; 123: 80–2
  • Marx S. J., Zusman R. M., Umiken W. O. Benign breast dysplasis causing hypercalcemia. J Clin Endocrinol Metab 1990; 45: 1049–52
  • Khosla S., van Heerden J. A., Gharib H., et al. Parathyroid hormone-related protein and hypercalcemia secondary to massive mammary hyperplasia. N Engl J Med 1990; 322: 1157
  • Seitz P. K., Cooper K. M., Ives K. L., et al. Parathyroid hormone-related peptide production and action in a myoepithelial cell line derived from normal human breast. Endocrinology 1993; 133: 1116–24
  • Lepre F., Grill V., Danks J. A., et al. Hypercalcemia in pregnancy and lactation due to parathyroid hormone-related protein production. Bone Miner 1990; 10: S317
  • Rakopoulos M., Vargas S. J., Gillespie M. T., et al. Production of parathyroid hormone-related protein by the rat mammary gland in pregnancy and lactation. Am J Physiol 1992; 263: E1077–85
  • Henning S. H., Michael D., Cheng C., et al. Calcium regulation of growth and differentiation of mouse epidermal cell in culture. Cell 1980; 19: 245–54
  • Fuchs E. Epidermal differentiation: the bare essentials. J Cell Biol 1990; 111: 2807–14
  • Milstone L., Fairley J., Insogna K. L., et al. PTH-like peptides increase intracellular calcium and differentiation in keratinocytes. Clin Res 1989; 37: 637–42
  • Civitelli R., Martin T. J., Fausto A., et al. Parathyroid hormone related peptide transiently increases cytosolic calcium in osteoblast-like cells: comparison with parathyroid hormone. Endocrinology 1990; 125: 1204–9
  • Henderson J. E., Kremer R., Rhim J. S., et al. Identification and functional characterization of adenylate cyclase-linked receptors for parathyroid hormone-like peptides on immortalized human keratinocyte. Endocrinology 1992; 130: 449–57
  • Wu T., Insogna K. L., Hough L. M., et al. Skin derived fibroblasts respond to human parathyroid hormone-like adenylate cyclase-stimulating proteins. J Clin Endocrinol Metab 1987; 65: 105–9
  • Ferrari S., Rizzoli R., Chaponnier C., et al. Parathyroid hormone-related protein increases cAMP production in mammary epithelial cells. Am J Physiol 1993; 264: E471–5
  • McCauley L. K., Rosol T. J., Merryman J. I., et al. Parathyroid hormone-related protein binding to human T-lymphotropic virus type 1-infected lymphocytes. Endocrinology 1992; 130: 300–6
  • Merendino T. J., Insogna K. L., Milstone L. M., et al. A parathyroid hormone-like protein from cultured human keratinocytes. Science 1986; 231: 388–90
  • Werkmeister J. R., Merryman J. I., et al. McCauley Parathyroid hormone-related protein production by normal keratinocytes in vitro. Exp Cell Res 1993; 208: 68–74
  • Lowik CWGM, Hoekman K., Offringa F., et al. Regulation of parathyroid hormone-related protein production in cultured normal and malignant keratinocytes. J Invest Dermatol 1992; 98: 198–203
  • Henderson J., Sebag M., Rhein J., et al. Dysregulation of parathyroid hormone-like peptide expression and secretion in a keratinocyte model of tumor progression. Cancer Res 1991; 51: 6521–8
  • Hosomi J., Hosoi J., Abe E., et al. Regulation of terminal differentiation of cultures mouse epidermal cells by 1,25-dihydroxyvitamin D3. Endocrinology 1993; 113: 1950–7
  • Kaiser S. M., Laneuville P., Bemier S. M., et al. Enhanced growth of a human keratinocyte cell line induced by antisense RNA for parathyroid hormone-related peptide. J Biol Chem 1992; 267: 13623–8
  • Li X., Drucker D. J. Growth factor-like properties of parathyroid hormone-related peptide in transfected rodent cell lines. Cancer Res 1993; 53: 2980–6
  • van-De Stolpe A., Karperien M., Lowik CWGM, et al. Parathyroid hormone-related peptide as an endogenous inducer of parietal endoderm differentiation. J Cell Biol 1993; 120: 235–43
  • Adachi N., Yamaguche K., Migake Y., et al. Parathyroid hormone-related protein is a possible autocrine growth inhibitor for lymphocytes. Biochem Biophys Res Commun 1990; 166: 1088–91
  • Hoekman K., Lowi CWGM, Ruit M., et al. Modulation of production of a parathyroid hormone-like protein in human squamous carcinoma cell lines by interaction with fibroblasts. Cancer Res 1990; 50: 3589–94
  • Collip J. B., Clark E. P. Further studies on parathyroid hormone. J Biol Chem 1925; 66: 485–507
  • Crass MF, III, Pang PKT. Parathyroid hormone: a coronary artery vasodilator. Science 1980; 207: 1087–9
  • Pang PKT, Young MCM, Shew R., et al. The vasorelaxant action of parathyroid hormone fragments on isolated rat tail artery. Blood Vessels 1985; 22: 57–61
  • Mok LLS, Cooper C. W., Thompson J. C. Relaxation of rat gastrointestinal smooth muscle by parathyroid hormone. J Bone Miner Res 1987; 2: 329–36
  • Nikols G. A., Nana A. D., Nikols M. A., et al. Hypotension and cardiac stimulation due to the parathyroid hormone-related protein, humoral hypercalcemia of malignancy factor. Endocrinology 1989; 125: 834–41
  • Winquist R. J., Baskin E. P., Vlasuk G. P. Synthetic tumor-derived human hypercalcemia factor exhibits parathyroid hormone-like vasorelaxation in renal arteries. Biochem Biophys Res Commun 1989; 49: 227–34
  • Crass M. F., Scapace P. J. Vasoactive properties of a parathyroid hormone-related protein in the rat aorta. Peptides 1993; 14: 179–83
  • Shew R. L., Yee J. A., Kliewer D. B., et al. Parathyroid hormone-related protein inhibits stimulated uterine contraction in vitro. J Bone Miner Res 1991; 6: 955–9
  • Mok LLS, Ajiwe E., Martin T. J., et al. Parathyroid hormone-related protein relaxes smooth muscle and shows cross-desensitization with parathyroid hormone. J Bone Miner Res 1989; 4: 433–9
  • Thiede M. A., Harm S. C., McKee R. L., et al. Expression of the parathyroid hormone-related protein gene in the avian oviduct: potential role as a local modulator of vascular smooth muscle tension and shell gland motility during the egg laying cycle. Endocrinology 1991; 129: 1958–66
  • Ferguson J. E., Gorman J. V., Burns D. E., et al. Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Proc Natl Acad Sci USA 1992; 89: 8384–8
  • Germain A. M., Attaroglou H., MacDonald P. C., et al. Parathyroid hormone-related protein mRNA in avascular human amnion. J Clin Endocrinol Metab, 76: 1173–5
  • Fenton A. J., Martin T. J., Nicholson G. C. Long-term culture of disaggregated rat osteoclasts: inhibition of bone resorption and reduction of osteoclast-like cell number by calcitonin and PTHrP[107–139]. Cell Physiol 1993; 155: 1–7
  • Sone T., Kohno H., Kikuchi H., et al. Human parathyroid hormone-related peptide (107–111) does not inhibit bone resorption in neonatal mouse calvariae. Endocrinology 1992; 131: 2742–6

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