1,147
Views
109
CrossRef citations to date
0
Altmetric
Review Article

Shape and steepness of toxicological dose–response relationships of continuous endpoints

&
Pages 270-297 | Received 21 Jun 2013, Accepted 06 Oct 2013, Published online: 19 Nov 2013

References

  • Appel MJ. (2001). Sub-acute (28-day) oral toxicity study with 1,4-dichlorobenzene in rats, TNO-report V3219, TNO Nutrition and Food research, Zeist, 2001
  • Crump KS. (1984). A new method for determining allowable daily intakes. Fundam Appl Toxicol, 4, 854–71
  • De Jong W, Van Och FMM, Den Hartog Jager CF, et al. (2002). Ranking of allergenic potency of rubber chemicals in a modified local lymph node assay. Toxicol Sci 2002, 66, 226–32
  • De Jong WH, Van Der Ven LTM, Sleijffers A, et al. (2013). Systemic and immunotoxicity of silver nanoparticles in an intravenous 28 days repeated dose toxicity study in rats. Biomaterials, 34, 8333--43
  • EFSA. (2009). European Food Safety Authority. Guidance of the scientific committee on use of the benchmark dose approach in risk assessment. EFSA J, 1150, 1–72
  • Elhajouji A, Van Hummelen P, Kirsch-Volders M. (1995). Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ Mol Mutagen, 26, 292–304
  • Faes C, Geys H, Aerts M, Molenberghs G. (2003). Use of fractional polynomials for dose–response modelling and quantitative risk assessment in developmental toxicity studies. Statistical Modelling, 3, 109–25
  • Genschow E, Spielmann H, Scholz G, et al. (2002). The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. Altern Lab Anim, 30, 151–76
  • Guha N, Roy A, Kopylev L, Fox J, et al. (2013). Nonparametric Bayesian methods for benchmark dose estimation. Risk Anal, 33, 1608--19
  • IPCS (2009). Environmental Health Criteria, 239, Principles for Modelling Dose–response for the Risk Assessment of Chemicals. Geneva: WHO Press
  • Moerbeek M, Piersma AH, Slob W. (2003). A comparison of three methods for calculating confidence intervals for the benchmark dose. Risk Anal, 24, 31–40
  • Peto R, Gray R, Brantom P, Grasso P. (1991a). Effects on 4080 rats of chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine: a detailed dose–response study. Cancer Res, 51, 6415–51
  • Peto R, Gray R, Brantom P, Grasso P. (1991b). Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodiemtylamine. Cancer Res, 51, 6452–69
  • Piersma AH, Verhoef A, te Biesebeek JD, et al. (2000). Developmental toxicity of butyl benzyl phtalate in the rat using a multiple dose study design. Reprod Toxicol, 14, 417–25
  • Piersma AH, Janer G, Wolterink G, et al. (2008). Quantitative extrapolation of in vitro whole embryo culture embryotoxicity data to developmental toxicity in vivo using the Benchmark Dose approach. Toxicol Sci, 101, 91–100
  • Shao K, Gift JS, Setzer RW. (2013). Is the assumption of normality or log-normality for continuous response data critical for benchmark dose estimation? Toxicol Appl Pharmacol 272, 767--79
  • Slob W. (2002). Dose–response modeling of continuous endpoints. Toxicol Sci, 66, 298–312
  • Slob W. (2007). What is a practical threshold? Toxicol Pathol, 35, 848–9
  • Stern BR, Solioz M, Krewski D, et al. (2007). Copper and human health: biochemistry, genetics and strategies for modeling dose–response relationships. J Toxicol Environ Health B, 10, 157–222
  • US EPA (2002). Revised Organophosphorus Pesticide Cumulative Risk Assessment. Office of the Pesticide Programs, U.S. Environmental Protection Agency, Washington D.C
  • US EPA (2011). Benchmark Dose Software (BMDS). National Center for Environmental Assessment, Research Triangle Park, NC. http://www.epa.gov/ncea/bmds
  • US EPA (2012). Benchmark Dose Technical Guidance. http://www.epa.gov/raf/publications/benchmarkdose.htm
  • Van Och FMM, Slob W, De Jong, WH, et al. (2000). A quantitative method for assessing the sensitizing potency of low molecular chemicals using a local lymph node assay: employment of a regression method that includes determination of the uncertainty margins. Toxicology, 146, 49–59
  • Wheeler MW, Bailer AJ. (2007). Properties of model-averaged BMDLs: a study of model averaging in dichotomous response risk estimation. Risk Anal, 27, 659–70
  • Wheeler MW, Bailer AJ. (2008). Model averaging software for dichotomous dose response risk estimation. J Statist Software, 26, 1–15
  • Wheeler MW, Bailer AJ. (2012). Monotonic Bayesian semiparametric benchmark dose analysis. Risk Anal, 32, 1207–18
  • Woutersen RA, Jonker D, Stevenson H, et al. (2001). The benchmark approach applied to a 28-day toxicity study with rhodorsil silane in rats: the impact of increasing the number of dose groups. Food Chem Toxicol, 39, 697–707

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.