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REVIEW ARTICLE

Diuron-induced rat urinary bladder carcinogenesis: Mode of action and human relevance evaluations using the International Programme on Chemical Safety framework

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Pages 393-406 | Received 10 Nov 2013, Accepted 18 Dec 2013, Published online: 11 Feb 2014

References

  • Abass K, Reponen P, Turpeinen M, Jalonen J, Pelkonen O. (2007). Characterization of diuron N-demethylation by mammalian hepatic microsomes and c-DNA expressed human cytochrome P450 enzymes. Drug Metab Disp, 35, 1634–41.
  • Andersen ME, Meek E, Boorman GA, Brusick DJ, Cohen SM, Dragan YP, et al. (2000). Lessons learned in applying the U.S. EPA's proposed cancer guidelines to specific compounds. Toxicol Sci, 53, 159–72.
  • Antonakopoulos GN, Turton J, Whitfield P, Newman J. (1991). Host-parasite interface of the urinary bladder-inhabiting nematode Trichosomoides crassicauda: changes induced in the urothelium of infected rats. Int J Parasitol, 21, 187–93.
  • Antony M, Shukla Y, Mehrota NK. (1989). Tumor activity of an herbicide diuron on mouse skin. Cancer Lett, 30, 125–8.
  • Arnold LL, Nyska A, Eldan M, Van Gemert M, Cohen SM. (2006). Dimethylarsinic acid: results of chronic toxicity/oncogenicity studies in F344 rats and B6C3F1 mice. Toxicology, 223, 82–100.
  • Australian Pesticides and Veterinary Medicine Authority (APVMA). (2005). The reconsideration of approvals of the active constituent diuron, registrations of products containing diuron and their associated labels. Tech Assess Rep 2. Australian Government.
  • Australian Pesticides and Veterinary Medicine Authority (APVMA). (2011). Review of the Mammalian Toxicology and Metabolism/Toxicokinetics of Diuron. Diuron Human Health Assessment. Australian Government.
  • Boobis AR, Cohen SM, Dellarco V, McGregor D, Meek ME, Vickers C, et al. (2006). IPCS framework for analyzing the relevance of a cancer mode of action for humans. Crit Rev Toxicol, 10, 781–92.
  • Boobis AR, Doe JE, Heinrich-Hirsch B, Meek ME, Munn S, Ruchirawat M, et al. (2008). IPCS framework for analyzing the relevance of a noncancer mode of action for humans. Crit Rev Toxicol, 38, 87–96.
  • Bouilly K, Bonnard M, Gagnaire B, Renault T, Lapègue S. (2007). Impact of diuron on aneuploidy and hemocyte parameters in Pacific oysters, Crassostrea gigas. Arch Environ Contam Toxicol, 52, 58–63.
  • Boven MV, Laruelle L, Daenens P. (1990). HPLC analysis of diuron and metabolites in blood and urine. J Anal Toxicol, 14, 231–4.
  • Burton DS, Maronpot RR, Howard FL. (1979). Frequency of hydronephrosis in Wistar rats. Lab Anim Sci, 29, 642–4.
  • Canna-Michaelidou S, Nicolaou AS. (1996). Evaluation of the genotoxicity potential (by Mutatox test) of ten pesticides found as water pollutants in cyprus. Sci Total Environ, 193, 27–35.
  • Cardoso APF, Ihlaseh SM, Da Rocha MS, Nascimento MG, De Camargo JLV, De Oliveira MLCS. (2013). Dose-response of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] on the urinary bladder of Wistar rats. Toxicology, 312C, 1–5.
  • Clayson DB, Fishbein L, Cohen SM. (1995). Effects of stones and other physical factors on the induction of rodent bladder cancer. Food Chem Toxicol, 33, 771–84.
  • Cohen SM. (1998). Urinary bladder carcinogenesis. Toxicol Pathol, 26, 121–7.
  • Cohen SM, Ellwein LB. (1990). Cell proliferation in carcinogenesis. Science, 249, 1007–11.
  • Cohen SM, Ellwein LB. (1991). Genetic errors, cell proliferation, and carcinogenesis. Cancer Res, 51, 6493–505.
  • Cohen SM, Ellwein LB. (1993). Use of cell proliferation data in modeling urinary bladder carcinogenesis. Environ Health Perspect, 5, 111–3.
  • Cohen SM, Lawson TA. (1995). Rodent bladder tumors do not always predict for humans. Cancer Lett, 93, 9–16.
  • Cohen SM, Fisher MJ, Sakata T, Cano M, Schoenig GP, Chappel CI, Garland EM. (1990). Comparative analysis of the proliferative response of the rat urinary bladder to sodium saccharin by light and scanning electron microscopy and autoradiography. Scanning Microsc, 4, 135–42.
  • Cohen SM, Purtilo DT, Ellwein LB. (1991). Pivotal role of increased cell proliferation in human carcinogenesis. Modern Pathol, 4, 371–82.
  • Cohen SM, Arnold LL, Uzvolgyi E, Cano M, St John M, Yamamoto S, et al. (2002). Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Chem Res Toxicol, 15, 1150–7.
  • Cohen SM, Arnold LL, Eldan M, Lewis AS, Beck BD. (2006). Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit Rev Toxicol, 36, 99–133.
  • Cohen SM, Ohnishi T, Clark NM, He J, Arnold LL. (2007). Investigations of rodent urinary bladder carcinogens: collection, processing, and evaluation of urine and bladders. Toxicol Pathol, 35, 337–47.
  • Cohen SM, Arnold LL, Beck BD, Lewis AS, Eldan M. (2013). Evaluation of the carcinogenicity of inorganic arsenic. Crit Rev Toxicol, 43, 711–52.
  • Da Rocha MS, Nascimento MG, Cardoso AP, Lima PL, Zelandi EA, De Camargo JL, De Oliveira ML. (2010). Cytotoxicity and regenerative proliferation as the mode of action for diuron-induced urothelial carcinogenesis in the rat. Toxicol Sci, 113, 37–44.
  • Da Rocha MS, Arnold LL, Pennington KL, Muirhead D, Dodmane PR, Anwar MM, et al. (2012a). Diuron-induced rat bladder epithelial cytotoxicity. Toxicol Sci, 130, 281–8.
  • Da Rocha MS, Dodmane PR, Arnold LL, Pennington KL, Anwar MM, Adams BR, et al. (2012b). Mode of action of pulegone on the urinary bladder of F344 rats. Toxicol Sci, 128, 1–8.
  • Da Rocha MS, Arnold LL, Pennington KL, Qiu F, Dodmane PR, De Camargo JLV, Cohen SM. (2013). Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology, 314, 238–46.
  • De Moura NA, Grassi TF, Rodrigues MA, Barbisan LF. (2010). Potential effects of the herbicide diuron on mammary and urinary bladder two-stage carcinogenesis in a female Swiss mouse model. Arch Toxicol, 84, 165–73.
  • European Union Risk Assessment Report (2006). 3,4-dichloroaniline (3,4-DCA). Volume 65. Office for Official Publications of the European Communities. Luxembourg, Germany.
  • Ferrucio B, Franchi CA, Boldrin NF, De Oliveira ML, De Camargo JL. (2010). Evaluation of diuron (3-[3,4-dichlorophenyl]-1,1-dimethyl urea) in a two-stage mouse skin carcinogenesis assay. Toxicol Pathol, 38, 756–64.
  • Giacomazzi S, Cochet N. (2004). Environmental impact of diuron transformation: a review. Chemosphere, 56, 1021–32.
  • Golden RJ, Holm SE, Robinson DE, Julkunen PH, Reese EA. (1997). Chloroform mode of action: implications for cancer risk assessment. Regul Toxicol Pharmacol, 26, 142–55.
  • Grassi TF, Rodrigues MA, De Camargo JL, Barbisan LF. (2011). Evaluation of carcinogenic potential of diuron in a rat mammary two-stage carcinogenesis model. Toxicol Pathol, 39, 486–95.
  • Greenfield RE, Ellwein LB, Cohen SM. (1984). A general probabilistic model of carcinogenesis: analysis of experimental urinary bladder cancer. Carcinogenesis, 5, 437–45.
  • Hailey JR, Walker NJ, Sells DM, Brix AE, Jokinen MP, Nyska A. (2005). Classification of proliferative hepatocellular lesions Harlan Sprague-Dawley rats chronically exposed to dioxin-like compounds. Toxicol Pathol, 33, 165–74.
  • Hard GC, Banton MI, Bretzlaff RS, Dekant W, Fowles JR, Mallett AK, et al. (2012). Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity. Toxicol Sci, 132, 268–75.
  • Hodge HC, Downs WL, Panner BS, Smith DW, Maynard EA. (1967). Oral toxicity and metabolism of diuron (N-(3,4-dichlorophenyl)-N’,N’-dimethylurea) in rats and dogs. Food Cosmet Toxicol, 5, 513–31.
  • Ihlaseh SM, Bailey KA, Hester SD, Jones C, Ren H, Cardoso AP, et al. (2011). Transcriptional profile of diuron-induced toxicity on the urinary bladder of male Wistar rats to inform mode of action. Toxicol Sci, 122, 330–8.
  • Iyer P. (2002). Evidence on the development and reproductive toxicity of diuron. Draft. Reproductive and cancer hazard assessment section. Office of Environmental Health Hazard Assessment, California Environmental Protection Agency.
  • Kalra SK, Chahal KS. (1979). Degradation of diuron [3-(3, 4-dichlorophenyl)-1,1-dimethylurea] in cows. Ecotox Environ Safe, 4, 362–8.
  • Kawamata H, Kameyama S, Nan L, Kawai K, Oyasu R. (1993). Effect of epidermal growth factor and transforming growth factor β1 on growth and invasive potentials of newly established rat bladder carcinoma cell lines. Int J Cancer, 55, 968–73.
  • Kinoshita FK, DuBois KP. (1970). Induction of hepatic microsomal enzymes by herban, diuron, and other substituted urea herbicides. Toxicol Appl Pharmacol, 17, 406–17.
  • Lina BA, Rutten AA, Woutersen RA. (1993). Effect of coffee drinking on cell proliferation in rat urinary bladder epithelium. Food Chem Toxicol, 31, 947–51.
  • Liu J. (2001). Handbook of pesticides toxicology. In: Phenyurea Herbicides. 2nd edition. Elsevier: Orlando, USA.
  • Majno G, Joris I. (1996). Cells, Tissues, and Disease: Principles of General Pathology. Oxford University Press: Cambridge, Massachusetts.
  • Malley LA. (2004). Diuron Technical: Subchronic Toxicity 90-Day feeding study in rats. DuPont Report Number13307. Unpublished Study.
  • Meek ME, Bucher JR, Cohen SM, Dellarco V, Hill RN, Lehman-McKeeman LD, et al. (2003). A framework for human relevance analysis of information on carcinogenic modes of action. Crit Rev Toxicol, 33, 591–653.
  • Mori S, Hosono M, Machino S, Nakai S, Makino S, Nakao H, et al. (1994). Induction of the renal pelvic and ureteral carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine in SD/cShi rats with spontaneous hydronephrosis. Toxicol Pathol, 22, 373–80.
  • Nascimento MG, De Oliveira ML, Lima AS, De Camargo JL. (2006). Effects of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] on the urinary bladder mucosa of male Wistar rats. Toxicology, 224, 66–73.
  • National Research Council Subcommittee on Arsenic in Drinking Water - NRC. (1999). Arsenic in Drinking Water. National Academy Press, Washington, DC.
  • National Toxicology Program (NTP). (2011). Toxicology and carcinogenesis studies of pulegone (CAS No. 89-82-7) in F344/N Rats and B6C3F1 mice (gavage studies). Nat Toxicol Program Tech Rep Ser, 563, 1–201.
  • Organization for Economic Co-operation and Development - OECD. (2002). Guidance notes for analysis and evaluation of chronic toxicity and carcinogenicity studies. OECD series on testing and assessment. No 35, OECD, Paris.
  • Organization for Economic Co-operation and Development - OECD. (2010). Guidance on the design and conduct of chronic toxicity and carcinogenicity studies, supporting TG 451, 452 and 453. OECD series on testing and assessment. No 116, OECD, Paris.
  • Robbins and Contran (1999). Pathologic bases of disease. In: The Lower Urinary Tract and Male Genital System. 7th edition. Elsevier: Philadelphia, USA.
  • Rosin MP, Saad el Din Zaki S, Ward AJ, Anwar WA. (1994). Involvement of inflammatory reactions and elevated cell proliferation in the development of bladder cancer in schistosomiasis patients. Mutat Res, 305, 283–92.
  • Seed J, Carney EW, Corley RA, Crofton KM, DeSesso JM, Foster PM, et al. (2005). Overview: using mode of action and life stage information to evaluate the human relevance of animal toxicity data. Crit Rev Toxicol, 35, 664–72.
  • Shiota S, Nagami-Oguihara R, Oguihara S, Kimura T, Imaida K, Fukushima S. (1994). Roles of bladder distension, urinary pH and urinary sodium ion concentration in cell proliferation of urinary bladder epithelium in rats ingesting sodium salts. Food Chem Toxicol, 32, 165–71.
  • Sonich-Mullin C, Fielder R, Wiltse J, Baetcke K, Dempsey J, Fenner-Crisp P, et al. (2001). IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul Toxicol Pharmacol, 34, 146–52.
  • United States Environmental Protection Agency (USEPA). (2003). Registration Eligibility Decision for Diuron. List A. Case 0046. Office of Prevention, Pesticides and Toxic Substances. USEPA, Washington, DC.
  • United States Environmental Protection Agency (USEPA). (2005). Guidelines for Carcinogen Risk Assessment (EPA/630/P-03/001 F) March, 2005.
  • United States Environmental Protection Agency (USEPA). (2012). 2012 Edition of the Drinking Water Standards and Health Advisories. USEPA, Washington, DC, p. 4.
  • Verheij ER, Van der Greef J, La Vos GF, van der Pol W, Niessen WM. (1989). Identification of diuron and four of its metabolites in human postmortem plasma and urine by LC/MS with a moving-belt interface. J Anal Toxicol, 13, 8–12.
  • Zhao B, Baston DS, Hammock B, Denison MS. (2006). Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. J Biochem Mol Toxicol, 20, 103–13.
  • Wei M, Wanibuchi H, Morimura K, Iwai S, Yoshida K, Endo G, et al. (2002). Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors. Carcinogenesis, 8, 1387–97.

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