Anchoring molecular mechanisms to the adverse outcome pathway for skin sensitization: Analysis of existing data

References

• Ade N, Leon F, Pallardy M, Peiffer JL, Kerdine-Romer S, Tissier MH, et al. (2009). HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol Sci, 107, 451–60.
   PubMed Web of Science ®Google Scholar
• Adler S, Basketter D, Creton S, Pelkonen O, van Benthem J, Zuang V, et al. (2011). Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol, 85, 367–485.
   PubMed Web of Science ®Google Scholar
• Aeby P, Ashikaga T, Bessou-Touya S, Schepky A, Gerberick F, Kern P, et al. (2010). Identifying and characterizing chemical skin sensitizers without animal testing: Colipa's research and method development program. Toxicol In Vitro, 24, 1465–73.
   PubMed Web of Science ®Google Scholar
• Albanesi C. (2010). Keratinocytes in allergic skin diseases. Curr Opin Allergy Clin Immunol, 10, 452–6.
   Google Scholar
• Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, et al. (2006). Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol In Vitro, 20, 767–73.
   PubMed Web of Science ®Google Scholar
• Basketter DA, Gerberick GF, Kimber I. (2007). The local lymph node assay: current position in the regulatory classification of skin sensitizing chemicals. Cutan Ocul Toxicol, 26, 293–301.
   PubMed Web of Science ®Google Scholar
• Basketter DA, Kimber I. (2010). Contact hypersensitivity. In: McQueen CA, Ed. Comparative Toxicology, Vol. 5. 2nd ed. Kidlington, UK: Elsevier.
   Google Scholar
• Bauch C, Kolle SN, Ramirez T, Eltze T, Fabian E, Mehling A, et al. (2012). Putting the parts together: combining in vitro methods to test for skin sensitizing potentials. Regul Toxicol Pharmacol, 63, 489–504.
   PubMed Web of Science ®Google Scholar
• Boehme KW, Compton T. (2004). Innate sensing of viruses by toll-like receptors. J Virol, 78, 7867–73.
   PubMed Web of Science ®Google Scholar
• Boorsma A, Foat BC, Vis D, Klis F, Bussemaker HJ. (2005). T-profiler: scoring the activity of predefined groups of genes using gene expression data. Nucleic Acids Res, 33, W592–5.
   Web of Science ®Google Scholar
• Bos JD, Teunissen MB, Kapsenberg ML. (1989). Immunology of contact dermatitis. Acta Derm Venereol Suppl (Stockh), 151, 84–7; discussion 106–10.
   PubMedGoogle Scholar
• Cavani A, De Luca A. (2010). Allergic contact dermatitis: novel mechanisms and therapeutic perspectives. Curr Drug Metab, 11, 228–33.
   PubMed Web of Science ®Google Scholar
• Cavani A, De Pita O, Girolomoni G. (2007). New aspects of the molecular basis of contact allergy. Curr Opin Allergy Clin Immunol, 7, 404–8.
   PubMed Web of Science ®Google Scholar
• Clark SC, Zirwas MJ. (2009). Management of occupational dermatitis. Dermatol Clin, 27, 365–83, vii–viii.
   PubMed Web of Science ®Google Scholar
• Clemmensen A, Andersen KE, Clemmensen O, Tan Q, Petersen TK, Kruse TA, Thomassen M. (2010). Genome-wide expression analysis of human in vivo irritated epidermis: differential profiles induced by sodium lauryl sulfate and nonanoic acid. J Invest Dermatol, 130, 2201–10.
   PubMed Web of Science ®Google Scholar
• Corsini E, Mitjans M, Galbiati V, Lucchi L, Galli CL, Marinovich M. (2009). Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens. Toxicol In Vitro, 23, 789–96.
   PubMed Web of Science ®Google Scholar
• Dancik Y, Miller MA, Jaworska J, Kasting GB. (2013). Design and performance of a spreadsheet-based model for estimating bioavailability of chemicals from dermal exposure. Adv Drug Deliv Rev, 65, 221–36.
   PubMed Web of Science ®Google Scholar
• Davis BK, Wen H, Ting JP. (2011). The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol, 29, 707–35.
   PubMed Web of Science ®Google Scholar
• de Jongh CM, Khrenova L, Verberk MM, Calkoen F, van Dijk FJ, Voss H, et al. (2008). Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study. Br J Dermatol, 159, 621–7.
   PubMed Web of Science ®Google Scholar
• dos Santos GG, Reinders J, Ouwehand K, Rustemeyer T, Scheper RJ, Gibbs S. (2009). Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol Appl Pharmacol, 236, 372–82.
   PubMed Web of Science ®Google Scholar
• EC-JRC. (2013). EURL ECVAM Recommendation on the Direct Peptide Reactivity Assay (DPRA) for Skin Sensitisation Testing.. November 2013 [Online]. Available at: http://ihcp.jrc.ec.europa.eu/our_labs/eurl-ecvam/eurl-ecvam-recommendations/files-dpra/EURL_ECVAM_Recommendation_DPRA_2013.pdf [Accessed on 5 June 2014].
   Google Scholar
• EC. (2008). EC Consolidated version of Cosmetics Directive 76/768/EEC. European Commission (EC) (Internet publication at http://www.ecb.jrc.it).
   Google Scholar
• El Ali Z, Gerbeix C, Hemon P, Esser PR, Martin SF, Pallardy M, Kerdine-Romer S. (2013). Allergic skin inflammation induced by chemical sensitizers is controlled by the transcription factor nrf2. Toxicol Sci, 134, 39–48.
   PubMed Web of Science ®Google Scholar
• Emter R, Ellis G, Natsch A. (2010). Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol Appl Pharmacol, 245, 281–90.
   PubMed Web of Science ®Google Scholar
• Enk AH, Katz SI. (1992a). Early events in the induction phase of contact sensitivity. J Invest Dermatol, 99, 39S–41S.
   PubMed Web of Science ®Google Scholar
• Enk AH, Katz SI. (1992b). Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci U S A, 89, 1398–402.
   PubMed Web of Science ®Google Scholar
• Enoch SJ, Ellison CM, Schultz TW, Cronin MT. (2011). A review of the electrophilic reaction chemistry involved in covalent protein binding relevant to toxicity. Crit Rev Toxicol, 41, 783–802.
   PubMed Web of Science ®Google Scholar
• Ermertcan AT, Ozturk F, Gunduz K. (2011). Toll-like receptors and skin. J Eur Acad Dermatol Venereol, 25, 997–1006.
   PubMed Web of Science ®Google Scholar
• Esser PR, Wolfle U, Durr C, von Loewenich FD, Schempp CM, Freudenberg MA, et al. (2012). Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation. PLoS One, 7, e41340.
   PubMed Web of Science ®Google Scholar
• EU. (2006). Regulation (EC) No. 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) no. 793/93 and Commission Regulation (EC) No. 1488/94 as well as Council Directive 76/769 EEC and Commission Directive 91/155/EEC, 93/67/EEC, 93/105EC and 2000/21/EC.
   Google Scholar
• Feldmeyer L, Werner S, French LE, Beer HD. (2010). Interleukin-1, inflammasomes and the skin. Eur J Cell Biol, 89, 638–44.
   PubMed Web of Science ®Google Scholar
• Freudenberg MA, Esser PR, Jakob T, Galanos C, Martin SF. (2009). Innate and adaptive immune responses in contact dermatitis: analogy with infections. G Ital Dermatol Venereol, 144, 173–85.
   PubMed Web of Science ®Google Scholar
• Gerberick GF, Ryan CA, Kern PS, Schlatter H, Dearman RJ, Kimber I, et al. (2005). Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis, 16, 157–202.
   PubMed Web of Science ®Google Scholar
• Gibbs S, Corsini E, Spiekstra SW, Galbiati V, Fuchs HW, Degeorge G, et al. (2013). An epidermal equivalent assay for identification and ranking potency of contact sensitizers. Toxicol Appl Pharmacol, 272, 529–541.
   PubMed Web of Science ®Google Scholar
• Gibbs S, Spiekstra S, Corsini E, McLeod J, Reinders J. (2012). Dendritic cell migration assay: a potential prediction model for identification of contact allergens. Toxicol In Vitro.
   Web of Science ®Google Scholar
• Hamilton T, de Gannes GC. (2011). Allergic contact dermatitis to preservatives and fragrances in cosmetics. Skin Therapy Lett, 16, 1–4.
   PubMedGoogle Scholar
• Hansen MB, Skov L, Menne T, Olsen J. (2005). Gene transcripts as potential diagnostic markers for allergic contact dermatitis. Contact Dermatitis, 53, 100–6.
   PubMed Web of Science ®Google Scholar
• Hartung T, Hoffmann S, Stephens M. (2013). Mechanistic validation. ALTEX, 30, 119–30.
   PubMedGoogle Scholar
• Hewitt NJ, Edwards RJ, Fritsche E, Goebel C, Aeby P, Scheel J, et al. (2013). Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations. Toxicol Sci, 133, 209–17.
   PubMed Web of Science ®Google Scholar
• Hirota M, Moro O. (2006). MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol In Vitro, 20, 736–42.
   PubMed Web of Science ®Google Scholar
• Jaworska J, Dancik Y, Kern P, Gerberick F, Natsch A. (2013). Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice. J Appl Toxicol.
   Web of Science ®Google Scholar
• Jaworska J, Harol A, Kern PS, Gerberick GF. (2011). Integrating non-animal test information into an adaptive testing strategy – skin sensitization proof of concept case. ALTEX, 28, 211–25.
   PubMedGoogle Scholar
• Johansson H, Lindstedt M, Albrekt AS, Borrebaeck CA. (2011). A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests. BMC Genomics, 12, 399.
   PubMed Web of Science ®Google Scholar
• Karlberg AT, Bergstrom MA, Borje A, Luthman K, Nilsson JL. (2008). Allergic contact dermatitis–formation, structural requirements, and reactivity of skin sensitizers. Chem Res Toxicol, 21, 53–69.
   PubMed Web of Science ®Google Scholar
• Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, Evelo CT, Pico AR. (2012). WikiPathways: building research communities on biological pathways. Nucleic Acids Res, 40, D1301–7.
   PubMed Web of Science ®Google Scholar
• Kimber I, Cumberbatch M. (1992). Dendritic cells and cutaneous immune responses to chemical allergens. Toxicol Appl Pharmacol, 117, 137–46.
   PubMed Web of Science ®Google Scholar
• Kimber I, Holliday MR, Dearman RJ. (1995). Cytokine regulation of chemical sensitization. Toxicol Lett, 82–83, 491–6.
   PubMed Web of Science ®Google Scholar
• Kimber I, Maxwell G, Gilmour N, Dearman RJ, Friedmann PS, Martin SF. (2011). Allergic contact dermatitis: a commentary on the relationship between T lymphocytes and skin sensitising potency. Toxicology.
   PubMed Web of Science ®Google Scholar
• Lalko JF, Dearman RJ, Gerberick GF, Troutman JA, Api AM, Kimber I. (2012). Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay. Toxicol In Vitro.
   PubMed Web of Science ®Google Scholar
• Li J, Johnson D, Calkins M, Wright L, Svendsen C, Johnson J. (2005). Stabilization of Nrf2 by tBHQ confers protection against oxidative stress-induced cell death in human neural stem cells. Toxicol Sci, 83, 313–28.
   PubMed Web of Science ®Google Scholar
• Martin SF, Esser PR, Schmucker S, Dietz L, Naisbitt DJ, Park BK, et al. (2010). T-cell recognition of chemicals, protein allergens and drugs: towards the development of in vitro assays. Cell Mol Life Sci, 67, 4171–84.
   PubMed Web of Science ®Google Scholar
• Martin SF, Esser PR, Weber FC, Jakob T, Freudenberg MA, Schmidt M, Goebeler M. (2011). Mechanisms of chemical-induced innate immunity in allergic contact dermatitis. Allergy, 21, 1398–9995.
   Google Scholar
• McKim JM, Jr., Keller DJ III, Gorski JR. (2010). A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol, 29, 171–92.
   PubMed Web of Science ®Google Scholar
• McNeilly AD, Woods JA, Ibbotson SH, Wolf CR, Smith G. (2012). Characterization of a human keratinocyte HaCaT cell line model to study the regulation of CYP2S1. Drug Metab Dispos, 40, 283–9.
   PubMed Web of Science ®Google Scholar
• Montelius J, Wahlkvist H, Boman A, Wahlberg JE. (1998). Murine local lymph node assay for predictive testing of allergenicity: two irritants caused significant proliferation. Acta Derm Venereol, 78, 433–7.
   PubMed Web of Science ®Google Scholar
• Mortz CG, Andersen KE. (2008). New aspects in allergic contact dermatitis. Curr Opin Allergy Clin Immunol, 8, 428–32.
   PubMed Web of Science ®Google Scholar
• Mortz CG, Lauritsen JM, Bindslev-Jensen C, Andersen KE. (2001). Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol, 144, 523–32.
   Google Scholar
• Nacak M, Erbagci Z, Aynacioglu AS. (2006). Human arylamine N-acetyltransferase 2 polymorphism and susceptibility to allergic contact dermatitis. Int J Dermatol, 45, 323–6.
   PubMed Web of Science ®Google Scholar
• Najim RA, Al-waizt M, Al-Razzuqi RA. (2005). Acetylator phenotype in Iraqi patients with allergic contact dermatitis. Ann Saudi Med, 25, 473–6.
   PubMed Web of Science ®Google Scholar
• Natsch A, Ryan CA, Foertsch L, Emter R, Jaworska J, Gerberick F, Kern P. (2013). A dataset on 145 chemicals tested in alternative assays for skin sensitization undergoing prevalidation. J Appl Toxicol.
   Web of Science ®Google Scholar
• Nielsen NH, Linneberg A, Menne T, Madsen F, Frolund L, Dirksen A, Jorgensen T. (2001). Allergic contact sensitization in an adult Danish population: two cross-sectional surveys eight years apart (the Copenhagen Allergy Study). Acta Derm Venereol, 81, 31–4.
   PubMed Web of Science ®Google Scholar
• Nosbaum A, Vocanson M, Rozieres A, Hennino A, Nicolas JF. (2009). Allergic and irritant contact dermatitis. Eur J Dermatol, 19, 325–32.
   PubMed Web of Science ®Google Scholar
• Novak N, Baurecht H, Schafer T, Rodriguez E, Wagenpfeil S, Klopp N, et al. (2008). Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. J Invest Dermatol, 128, 1430–5.
   PubMed Web of Science ®Google Scholar
• Nukada Y, Miyazawa M, Kazutoshi S, Sakaguchi H, Nishiyama N. (2013). Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals. Toxicol In Vitro, 27, 609–18.
   PubMed Web of Science ®Google Scholar
• OECD. (1992). OECD Guidelines for the Testing of Chemicals. Section 4 Health Effects. Test No. 406. Skin Sensitization.
   Google Scholar
• OECD. (2004). OECD Guidelines for the Testing of Chemicals. Section 4 Health Effects. Test No. 428. Skin Absorption: In Vitro Method.
   Google Scholar
• OECD. (2010a). OECD Guidelines for the Testing of Chemicals. Section 4: Health Effects. Test No. 429. Skin Sensitization: Local Lymph Node Assay.
   Google Scholar
• OECD. (2010b). OECD Guidelines for the Testing of Chemicals. Section 4: Health Effects. Test No. 442A Skin Sensitization: Local Lymph Node Assay: DA.
   Google Scholar
• OECD. (2010c). OECD Guidelines for the Testing of Chemicals. Section 4: Health Effects. Test No. 442B Skin Sensitization: Local Lymph Node Assay: BrdU-ELISA.
   Google Scholar
• OECD. (2012a). Organisation for Economic Co-operation and Development (OECD): The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 1: Scientific Evidence Series on Testing and Assessment No.168. ENV/JM/MONO(2012)10/PART1, http://www.search.oecd.org/officialdocuments/displaydocumentpdf/?cote = env/jm/mono(2012)10/part1&doclanguage = en.
   Google Scholar
• OECD. (2012b). Organisation for Economic Co-operation and Development (OECD): The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 2: Use of the AOP to Develop Chemical Categories and Integrated Assessment and Testing Approaches. ENV/JM/MONO(2012)10/PART2.
   Google Scholar
• Ouwehand K, Spiekstra SW, Reinders J, Scheper RJ, de Gruijl TD, Gibbs S. (2010). Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells. Toxicol In Vitro, 24, 578–85.
   PubMed Web of Science ®Google Scholar
• Patlewicz G, Dimitrov SD, Low LK, Kern PS, Dimitrova GD, Comber MI, et al. (2007). TIMES-SS–a promising tool for the assessment of skin sensitization hazard. A characterization with respect to the OECD validation principles for (Q)SARs and an external evaluation for predictivity.Regul Toxicol Pharmacol, 48, 225–39.
   PubMed Web of Science ®Google Scholar
• Pedersen MB, Skov L, Menne T, Johansen JD, Olsen J. (2007). Gene expression time course in the human skin during elicitation of allergic contact dermatitis. J Invest Dermatol, 127, 2585–95.
   PubMed Web of Science ®Google Scholar
• Saint-Mezard P, Rosieres A, Krasteva M, Berard F, Dubois B, Kaiserlian D, Nicolas JF. (2004). Allergic contact dermatitis. Eur J Dermatol, 14, 284–95.
   PubMed Web of Science ®Google Scholar
• Scheitza S, Bonifas J, Blomeke B. (2012). Variable NAT1 enzyme activity in long-term cultured human HaCaT keratinocytes. J Toxicol Environ Health A, 75, 471–7.
   PubMed Web of Science ®Google Scholar
• Schmidt M, Raghavan B, Muller V, Vogl T, Fejer G, Tchaptchet S, et al. (2010). Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel. Nat Immunol, 11, 814–9.
   PubMed Web of Science ®Google Scholar
• Schnuch A, Westphal G, Mossner R, Uter W, Reich K. (2011). Genetic factors in contact allergy–review and future goals. Contact Dermatitis, 64, 2–23.
   PubMed Web of Science ®Google Scholar
• Schnuch A, Westphal GA, Muller MM, Schulz TG, Geier J, Brasch J, et al. (1998). Genotype and phenotype of N-acetyltransferase 2 (NAT2) polymorphism in patients with contact allergy. Contact Dermatitis, 38, 209–11.
   PubMed Web of Science ®Google Scholar
• Schoeters E, Nuijten JM, Van Den Heuvel RL, Nelissen I, Witters H, Schoeters GE, et al. (2006). Gene expression signatures in CD34+2progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol Appl Pharmacol, 216, 131–49.
   PubMed Web of Science ®Google Scholar
• Stutz A, Golenbock DT, Latz E. (2009). Inflammasomes: too big to miss. J Clin Invest, 119, 3502–11.
   PubMed Web of Science ®Google Scholar
• Thyssen JP, Carlsen BC, Menne T. (2008). Nickel sensitization, hand eczema, and loss-of-function mutations in the filaggrin gene. Dermatitis, 19, 303–7.
   PubMed Web of Science ®Google Scholar
• Thyssen JP, Linneberg A, Menne T, Nielsen NH, Johansen JD. (2009). Contact allergy to allergens of the TRUE-test (panels 1 and 2) has decreased modestly in the general population. Br J Dermatol, 161, 1124–9.
   PubMed Web of Science ®Google Scholar
• Toebak MJ, Gibbs S, Bruynzeel DP, Scheper RJ, Rustemeyer T. (2009). Dendritic cells: biology of the skin. Contact Dermatitis, 60, 2–20.
   PubMed Web of Science ®Google Scholar
• Trompezinski S, Migdal C, Tailhardat M, Le Varlet B, Courtellemont P, Haftek M, Serres M. (2008). Characterization of early events involved in human dendritic cell maturation induced by sensitizers: cross talk between MAPK signalling pathways. Toxicol Appl Pharmacol, 230, 397–406.
   PubMed Web of Science ®Google Scholar
• van der Veen JW, Gremmer ER, Vermeulen JP, van Loveren H, Ezendam J. (2013a). Induction of skin sensitization is augmented in Nrf2-deficient mice. Arch Toxicol, 87, 763–6.
   PubMed Web of Science ®Google Scholar
• van der Veen JW, Pronk TE, van Loveren H, Ezendam J. (2013b). Applicability of a keratinocyte gene signature to predict skin sensitizing potential. Toxicol In Vitro, 27, 314–322.
   PubMed Web of Science ®Google Scholar
• van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C. (2008). Presenting and exploring biological pathways with PathVisio. BMC Bioinformatics, 9, 399.
   PubMed Web of Science ®Google Scholar
• van Loveren H, Cockshott A, Gebel T, Gundert-Remy U, de Jong WH, Matheson J, et al. (2008). Skin sensitization in chemical risk assessment: report of a WHO/IPCS international workshop focusing on dose-response assessment. Regul Toxicol Pharmacol, 50, 155–99.
   PubMed Web of Science ®Google Scholar
• Vandebriel RJ, Pennings JL, Baken KA, Pronk TE, Boorsma A, Gottschalk R, Van Loveren H. (2010). Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci, 117, 81–9.
   PubMed Web of Science ®Google Scholar
• Vandebriel RJ, van Loveren H. (2010). Non-animal sensitization testing: state-of-the-art. Crit Rev Toxicol, 40, 389–404.
   PubMed Web of Science ®Google Scholar
• Vocanson M, Achachi A, Mutez V, Cluzel-Tailhardat M, Varlet BL, Rozieres A, et al. (2014). Human T cell priming assay: depletion of peripheral blood lymphocytes in CD25(+) cells improves the in vitro detection of weak allergen-specific T cells. EXS, 104, 89–100.
   PubMedGoogle Scholar
• Vocanson M, Hennino A, Rozieres A, Poyet G, Nicolas JF. (2009). Effector and regulatory mechanisms in allergic contact dermatitis. Allergy, 64, 1699–714.
   PubMed Web of Science ®Google Scholar
• Wang J, Li MD. (2010). Common and unique biological pathways associated with smoking initiation/progression, nicotine dependence, and smoking cessation. Neuropsychopharmacology, 35, 702–19.
   PubMed Web of Science ®Google Scholar
• Wang X, Tomso DJ, Chorley BN, Cho HY, Cheung VG, Kleeberger SR, Bell DA. (2007). Identification of polymorphic antioxidant response elements in the human genome. Hum Mol Genet, 16, 1188–200.
   PubMed Web of Science ®Google Scholar
• Warshaw EM, Botto NC, Maibach HI, Fowler JF Jr, Rietschel RL, Zug KA, et al. (2009a). Positive patch-test reactions to propylene glycol: a retrospective cross-sectional analysis from the North American Contact Dermatitis Group, 1996 to 2006. Dermatitis, 20, 14–20.
   PubMed Web of Science ®Google Scholar
• Warshaw EM, Buchholz HJ, Belsito DV, Maibach HI, Fowler JF Jr, Rietschel RL, et al. (2009b). Allergic patch test reactions associated with cosmetics: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001–2004. J Am Acad Dermatol, 60, 23–38.
   PubMed Web of Science ®Google Scholar
• Watanabe H, Gaide O, Petrilli V, Martinon F, Contassot E, Roques S, et al. (2007). Activation of the IL-1beta-processing inflammasome is involved in contact hypersensitivity. J Invest Dermatol, 127, 1956–63.
   PubMed Web of Science ®Google Scholar
• Westphal GA, Schnuch A, Schulz TG, Reich K, Aberer W, Brasch J, et al. (2000). Homozygous gene deletions of the glutathione S-transferases M1 and T1 are associated with thimerosal sensitization. Int Arch Occup Environ Health, 73, 384–8.
   PubMed Web of Science ®Google Scholar
• Yamashita K, Shinoda S, Hagiwara S, Itagaki H. (2014). Development of LLNA:DAE: a new local lymph node assay that includes the elicitation phase, discriminates borderline-positive chemicals, and is useful for cross-sensitization testing. J Toxicol Sci, 39, 147–61.
   PubMed Web of Science ®Google Scholar
• Yazdi AS, Ghoreschi K, Rocken M. (2007). Inflammasome activation in delayed-type hypersensitivity reactions. J Invest Dermatol, 127, 1853–5.
   PubMed Web of Science ®Google Scholar
• Yoshikawa Y, Sasahara Y, Kitano Y, Kanazawa N, Shima H, Hashimoto-Tamaoki T. (2010). Upregulation of genes orchestrating keratinocyte differentiation, including the novel marker gene ID2, by contact sensitizers in human bulge-derived keratinocytes. J Biochem Mol Toxicol, 24, 10–20.
   PubMed Web of Science ®Google Scholar
• Zug KA, Warshaw EM, Fowler JF Jr, Maibach HI, Belsito DL, Pratt MD, et al. (2009). Patch-test results of the North American Contact Dermatitis Group 2005–2006. Dermatitis, 20, 149–60.
   PubMed Web of Science ®Google Scholar