Weight-of-evidence evaluation of short-term ozone exposure and cardiovascular effects

References

• Alarie Y. (1973). Sensory irritation by airborne chemicals. CRC Crit Rev Toxicol, 2, 299–363.
   PubMedGoogle Scholar
• Anderson HR, Armstrong B, Hajat S, Harrison R, Monk V, Poloniecki J, et al. (2010). Air pollution and activation of implantable cardioverter defibrillators in London. Epidemiology, 21, 405–13.
   PubMedGoogle Scholar
• Anderson GB, Bell ML. (2010). Does one size fit all? The suitability of standard ozone exposure metric conversion ratios and implications for epidemiology. J Expo Sci Environ, 20, 2–11.
   Google Scholar
• Arito H, Takahashi M, Iwasaki T, Uchiyama I. (1997). Age-related changes in ventilatory and heart rate responses to acute ozone exposure in the conscious rat. Ind Health, 35, 78–86.
   PubMed Web of Science ®Google Scholar
• Arito H, Uchiyama I, Yokoyama E. (1992). Acute effects of ozone on EEG activity, sleep-wakefulness and heart rate in rats. Ind Health, 30, 23–34.
   PubMed Web of Science ®Google Scholar
• Aro AL, Anttonen O, Kerola T, Junttila MJ, Tikkanen JT, Rissanen HA, et al. (2013). Prognostic significance of prolonged PR interval in the general population. Eur Heart J, 35, 123–9.
   Google Scholar
• Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Lanzani G, et al. (2007). Air pollution, smoking, and plasma homocysteine. Environ Health Perspect, 115, 176–81.
   PubMed Web of Science ®Google Scholar
• Baja ES, Schwartz JD, Wellenius GA, Coull BA, Zanobetti A, Vokonas PS, Suh HH. (2010). Traffic-related air pollution and QT interval: Modification by diabetes, obesity, and oxidative stress gene polymorphisms in the normative aging study. Environ Health Perspect, 118, 840–6.
   PubMed Web of Science ®Google Scholar
• Barath S, Langrish JP, Lundback M, Bosson JA, Goudie C, Newby DE, et al. (2013). Short-term exposure to ozone does not impair vascular function or affect heart rate variability in healthy young men. Toxicol Sci, 135, 292–9.
   PubMed Web of Science ®Google Scholar
• Bartell SM, Longhurst J, Tjoa T, Sioutas C, Delfino RJ. (2013). Particulate air pollution, ambulatory heart rate variability, and cardiac arrhythmia in retirement community residents with coronary artery disease. Environ Health Perspect, 121, 1135–41.
   PubMed Web of Science ®Google Scholar
• Bedada GB, Smith CJ, Tyrell PJ, Hirst AA, Agius R. (2012). Short-term effects of ambient particulates and gaseous pollutants on the incidence of transient ischaemic attack and minor stroke: A case-crossover study. Environ Health, 11, 77.
   Google Scholar
• Bell ML, Dominici F, Samet JM. (2005). A meta-analysis of time-series studies of ozone and mortality with comparison to the National Morbidity, Mortality, and Air Pollution Study. Epidemiology, 16, 436–45.
   PubMed Web of Science ®Google Scholar
• Bell ML, McDermott A, Zeger SL, Samet JM, Dominici F. (2004). Ozone and short-term mortality in 95 US urban communities. JAMA, 292, 2372–8.
   PubMed Web of Science ®Google Scholar
• Bhaskaran K, Hajat S, Armstrong B, Haines A, Herrett E, Wilkinson P, Smeeth L. (2011). The effects of hourly differences in air pollution on the risk of myocardial infarction: Case crossover analysis of the MINAP database. BMJ, 343, d5531.
   Google Scholar
• Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. (2012). Air pollution and markers of coagulation, inflammation, and endothelial function: Associations and epigene-environment interactions in an elderly cohort. Epidemiology, 23, 332–40.
   PubMed Web of Science ®Google Scholar
• Boffetta P, McLaughlin JK, La Vecchia C, Tarone RE, Lipworth L, Blot WJ. (2008). False-positive results in cancer epidemiology: A plea for epistemological modesty. J Natl Cancer Inst, 100, 988–95.
   PubMed Web of Science ®Google Scholar
• Brook RD, Urch B, Dvonch JT, Bard RL, Speck M, Keeler G, et al. (2009). Insights into the mechanisms and mediators of the effects of air pollution exposure on blood pressure and vascular function in healthy humans. Hypertension, 54, 659–67.
   PubMed Web of Science ®Google Scholar
• Brüske I, Hampel R, Baumgartner Z, Rückerl R, Greven S, Koenig W, et al. (2011). Ambient air pollution and lipoprotein-associated phospholipase A2 in survivors of myocardial infarction. Environ Health Perspect, 119, 921–6.
   PubMed Web of Science ®Google Scholar
• Buadong D, Jinsart W, Funatagawa I, Karita K, Yano E. (2009). Association between PM10 and O3 levels and hospital visits for cardiovascular diseases in Bangkok, Thailand. J Epidemiol, 19, 182–8.
   PubMed Web of Science ®Google Scholar
• Buckley RD, Hackney JD, Clark K, Posin C. (1975). Ozone and human blood. Arch Environ Contam, 30, 40–3.
   Google Scholar
• Cakmak S, Dales R, Leech J, Liu L. (2011). The influence of air pollution on cardiovascular and pulmonary function and exercise capacity: Canadian Health Measures Survey (CHMS). Environ Res, 111, 1309–12.
   PubMed Web of Science ®Google Scholar
• Carter WPL, Seinfeld JH. (2012). Winter ozone formation and VOC incremental reactivities in the Upper Green River Basin of Available at: http://www.cdc.gov/nccdphp/sgr/sgr.htm [Accessed on 21 May 2014].
   Google Scholar
• Chan CC, Chua Wyoming. Atmos Environ, 50, 255–66.
   Google Scholar
• Centers for Disease Control (CDC). (1999). Physical Activity and Health: A Report of the Surgeon General 1996. [Online]ng KJ, Chien LC, Chen WJ, Chang WT. (2006). Urban air pollution and emergency admissions for cerebrovascular diseases in Taipei, Taiwan. Eur Heart J, 27, 1238–44.
   Google Scholar
• Chan CC, Chuang KJ, Su TC, Lin LY. (2005). Association between nitrogen dioxide and heart rate variability in a susceptible population. Eur J Cardiovasc Prev Rehabil, 12, 580–6.
   PubMedGoogle Scholar
• Chen C, Arjomandi M, Balmes J, Tager I, Holland N. (2007). Effects of chronic and acute ozone exposure on lipid peroxidation and antioxidant capacity in healthy young adults. Environ Health Perspect, 115, 1732–7.
   PubMed Web of Science ®Google Scholar
• Chen SY, Su TC, Lin YL, Chan CC. (2012). Short-term effects of air pollution on pulse pressure among nonsmoking adults. Epidemiology, 23, 341–8.
   PubMed Web of Science ®Google Scholar
• Cheng MF, Tsai SS, Yang CY. (2009). Air pollution and hospital admissions for myocardial infarction in a tropical city: Kaohsiung, Taiwan. J Toxicol Environ Health A, 72, 1135–40.
   PubMed Web of Science ®Google Scholar
• Cheng Y, Kan H. (2012). Effect of the interaction between outdoor air pollution and extreme temperature on daily mortality in Shanghai, China. J Epidemiol, 22, 28–36.
   Google Scholar
• Chiu HF, Yang CY. (2009). Air pollution and emergency room visits for arrhythmias: Are there potentially sensitive groups? J Toxicol Environ Health A, 72, 817–23.
   PubMed Web of Science ®Google Scholar
• Choi JH, Xu QS, Park SY, Kim JH, Hwang SS, Lee KH, et al. (2007). Seasonal variation of effect of air pollution on blood pressure. J Epidemiol Community Health, 61, 314–18.
   PubMed Web of Science ®Google Scholar
• Chuang GC, Yang Z, Westbrook DG, Pompilius M, Ballinger CA, White CR, et al. (2009). Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis. Am J Physiol Lung Cell Mol Physiol, 297, L209–16.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Chan CC, Su TC, Lee CT, Tang CS. (2007a). The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults. Am J Respir Crit Care Med, 176, 370–6.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Chan CC, Su TC, Lin LY, Lee CT. (2007b). Associations between particulate sulfate and organic carbon exposures and heart rate variability in patients with or at risk for cardiovascular diseases. J Occup Environ Med, 49, 610–17.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Coull BA, Zanobetti A, Suh H, Schwartz J, Stone PH, et al. (2008). Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease. Circulation, 118, 1314–20.
   PubMed Web of Science ®Google Scholar
• Chuang KJ, Yan YH, Cheng TJ. (2010). Effect of air pollution on blood pressure, blood lipids, and blood sugar: A population-based approach. J Occup Environ Med, 52, 258–62.
   PubMed Web of Science ®Google Scholar
• Corea F, Silvestrelli G, Baccarelli A, Giua A, Previdi P, Siliprandi G, Murgia N. (2012). Airborne pollutants and lacunar stroke: A case cross-over analysis on stroke unit admissions. Neurol Int, 4, e11.
   Google Scholar
• de Almeida SP, Casimiro E, Calheiros J. (2011). Short-term association between exposure to ozone and mortality in Oporto, Portugal. Environ Res, 111, 406–10.
   PubMed Web of Science ®Google Scholar
• Delfino RJ, Tjoa T, Gillen DL, Staimer N, Polidori A, Arhami M, et al. (2010). Traffic-related air pollution and blood pressure in elderly subjects with coronary artery disease. Epidemiology, 21, 396–404.
   PubMed Web of Science ®Google Scholar
• Dennekamp M, Akram M, Abramson MJ, Tonkin A, Sim MR, Fridman M, Erbas B. (2010). Outdoor air pollution as a trigger for out-of-hospital cardiac arrests. Epidemiology, 21, 494–500.
   Google Scholar
• Devlin RB, Duncan KE, Jardim M, Schmitt MT, Rappold AG, Diaz-Sanchez D. (2012). Controlled exposure of healthy young volunteers to ozone causes cardiovascular effects. Circulation, 126, 104–11.
   PubMed Web of Science ®Google Scholar
• Dockery DW, Luttman-Gibson H, Rich DQ, Link MS, Mittleman MA, Gold DR, et al. (2005a). Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implanted cardioverter defibrillators. Environ Health Perspect, 113, 670–4.
   PubMed Web of Science ®Google Scholar
• Dockery DW, Luttmann-Gibson H, Rich DQ, Link MS, Schwartz JD, Gold DR, et al. (2005b). Particulate Air Pollution and Nonfatal Cardiac Events. Part II. Association of Air Pollution with Confirmed Arrhythmias Recorded by Implanted Defibrillators. Health Effects Institute Research Report 124 Part II. pp. 83–148.
   Google Scholar
• Dorato MA, Wolff RK. (1991). Inhalation exposure technology, dosimetry, and regulatory issues. Toxicol Pathol, 19, 373–83.
   PubMed Web of Science ®Google Scholar
• Droogmans S, Lauwers R, Cosyns B, Roosens B, Franken PR, Weytjens C, et al. (2008). Impact of anesthesia on valvular function in normal rats during echocardiography. Ultrasound Med Biol, 34, 1564–72.
   Google Scholar
• Ensor KB, Raun LH, Persse D. (2013). A case-crossover analysis of out-of-hospital cardiac arrest and air pollution. Circulation, 127, 1192–9.
   PubMed Web of Science ®Google Scholar
• Eskesen K, Olsen NT, Dimaano VL, Pinheiro A, Sogaard P, Fritz-Hansen T, et al. (2012). New approach to intracardiac hemodynamic measurements in small animals: Echo-guided percutaneous apical puncture. J Ultrasound Med, 31, 1233–8.
   Google Scholar
• Fakhri AA, Ilic LM, Wellenius GA, Urch B, Silverman F, Gold DR, Mittleman MA. (2009). Autonomic effects of controlled fine particulate exposure in young healthy adults: Effect modification by ozone. Environ Health Perspect, 117, 1287–92.
   PubMed Web of Science ®Google Scholar
• Farraj AK, Hazari MS, Winsett DW, Kulukulualani A, Carll AP, Haykal-Coates N, et al. (2012). Overt and latent cardiac effects of ozone inhalation in rats: Evidence for autonomic modulation and increased myocardial vulnerability. Environ Health Perspect, 120, 348–54.
   PubMed Web of Science ®Google Scholar
• Faustini A, Stafoggia M, Cappai G, Forastiere F. (2012). Short-term effects of air pollution in a cohort of patients with chronic obstructive pulmonary disease. Epidemiology, 23, 861–79.
   PubMed Web of Science ®Google Scholar
• Felber Dietrich D, Schindler C, Schwartz J, Barthelemy JC, Tschopp JM, Roche F, et al. (2006). Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors: Results of the SAPALDIA study. Europace, 8, 521–9.
   PubMed Web of Science ®Google Scholar
• Fink R, Erzen I, Medved S. (2012). Environmentally induced health impacts among elderly with cardio-vascular disease. HealthMed, 430, 193–201.
   Google Scholar
• Fischer PH, Marra M, Ameling CB, Janssen N, Cassee FR. (2011). Trends in relative risk estimates for the association between air pollution and mortality in The Netherlands 1992–2006. Environ Res, 111, 94–100.
   PubMed Web of Science ®Google Scholar
• Foster WM, Wills-Karp M, Tankersley CG, Chen X, Paquette NC. (1996). Bloodborne markers in humans during multiday exposure to ozone. J Appl Physiol, 81, 794–800.
   PubMedGoogle Scholar
• Franklin M, Schwartz J. (2008). “The impact of secondary particles on the association between ambient ozone and mortality.” Environ. Health Perspect, 116, 453–8.
   Google Scholar
• Garrett P, Casimiro E. (2011). Short-term effect of fine particulate matter (PM2.5) and ozone on daily mortality in Lisbon, Portugal. Environ Sci Pollut Res Int, 18, 1585–92.
   PubMed Web of Science ®Google Scholar
• Gilstrap LG, Wang TJ. (2012). Biomarkers and cardiovascular risk assessment for primary prevention: An update. Clin Chem, 58, 72–82.
   PubMed Web of Science ®Google Scholar
• Gold DR, Litonjua A, Schwartz J, Lovett E, Larson A, Nearing B, et al. (2000). Ambient pollution and heart rate variability. Circulation, 101, 1267–73.
   PubMed Web of Science ®Google Scholar
• Gold DR, Schwartz J, Litonjua A, Verrier R, Zanobetti A. (2003). Ambient pollution and reduced heart rate variability. In: Revised Analyses of Time-Series Studies of Air Pollution and Health. Health Effects Institute, Boston, MA. pp. 107–112.
   Google Scholar
• Goldberg MS, Giannetti N, Burnett RT, Mayo NE, Valois MF, Brophy JM. (2008). A panel study in congestive heart failure to estimate the short-term effects from personal factors and environmental conditions on oxygen saturation and pulse rate. Occup Environ Med, 65, 659–66.
   Google Scholar
• Gong H, Wong R, Sarma RJ, Linn WS, Sullivan ED, Shamoo DA, et al. (1998). Cardiovascular effects of ozone exposure in human volunteers. Am J Respir Crit Care Med, 158, 538–46.
   PubMed Web of Science ®Google Scholar
• Goodman JE, Dodge DG, Bailey LA. (2010). A framework for assessing causality and adverse effects in humans with a case study of sulfur dioxide. Regul Toxicol Pharmacol, 58, 308–22.
   PubMed Web of Science ®Google Scholar
• Goodman JE, Prueitt RL, Sax SN, Bailey LA, Rhomberg LR. (2013). Evaluation of the causal framework used for setting National Ambient Air Quality Standards. Crit Rev Toxicol, 43, 829–49.
   PubMed Web of Science ®Google Scholar
• Goodman M, Teta MJ, Hessel PA, Garabrant DH, Craven VA, Scrafford CG, Kelsh MA. (2004). Mesothelioma and lung cancer among motor vehicle mechanics: A meta-analysis. Ann Occup Hyg, 48, 309–26.
   PubMed Web of Science ®Google Scholar
• Gryparis A, Forsberg B, Katsouyanni K, Analitis A, Touloumi G, Schwartz J, et al. (2004). Acute effects of ozone on mortality from the Air Pollution and Health: A European Approach project. Am J Respir Crit Care Med, 170, 1080–7.
   PubMed Web of Science ®Google Scholar
• Halonen JI, Lanki T, Tiittanen P, Niemi JV, Loh M, Pekkanen J. (2010). Ozone and cause-specific cardiorespiratory morbidity and mortality. J Epidemiol Community Health, 64, 814–20.
   PubMed Web of Science ®Google Scholar
• Hampel R, Breitner S, Zareba W, Kraus U, Pitz M, Geruschkat U, et al. (2012). Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals. Occup Environ Med, 69, 428–36.
   PubMed Web of Science ®Google Scholar
• Hancock EW, Deal BJ, Mirvis SM, Okin P, Kligfield P, Gettes LS. (2009). AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram. Part V: Electrocardiogram changes associated with cardiac chamber hypertrophy; A scientific statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. J Am Coll Cardiol 53, 992–1002.
   PubMed Web of Science ®Google Scholar
• Hanna AF, Yeatts KB, Xiu A, Zhu Z, Smith RL, Davis NN, et al. (2011). Associations between ozone and morbidity using the Spatial Synoptic Classification system. Environ Health, 10, 49.
   Google Scholar
• Hatch GE, Slade R, Harris LP, McDonnell WF, Devlin RB, Koren HS, et al. (1994). Ozone dose and effect in humans and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med, 150, 676–83.
   PubMed Web of Science ®Google Scholar
• Hatch GE, McKee J, Brown J, McDonnell W, Seal E, Soukup J, et al. 2013. Biomarkers of dose and effect of inhaled ozone in resting versus exercising human subjects: Comparison with resting rats. Biomark Insights, 8, 53–67.
   PubMedGoogle Scholar
• Henrotin JB, Besancenot JP, Bejot Y, Giroud M. (2007). Short-term effects of ozone air pollution on ischaemic stroke occurrence: A case-crossover analysis from a 10-year population-based study in Dijon, France. Occup Environ Med, 64, 439–45.
   PubMed Web of Science ®Google Scholar
• Henrotin JB, Zeller M, Lorgis L, Cottin Y, Giroud M, Bejot Y. (2010). Evidence of the role of short-term exposure to ozone on ischaemic cerebral and cardiac events: The Dijon Vascular Project (DIVA). Heart, 96, 1990–6.
   PubMed Web of Science ®Google Scholar
• Higgins JPT, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al.; Cochrane Bias Methods Group, Cochrane Statistical Methods Group. (2011). The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ, 343, d5928.
   PubMed Web of Science ®Google Scholar
• Hill AB. 1965. The environment and disease: Association or causation? Proc R Soc Med, 58, 295–300.
   PubMed Web of Science ®Google Scholar
• Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, et al. (2012). Opposing effects of particle pollution, ozone, and ambient temperature on arterial blood pressure. Environ Health Perspect, 120, 241–6.
   PubMed Web of Science ®Google Scholar
• Holguin F, Tellez-Rojo MM, Hernandez M, Cortez M, Chow JC, Watson JG, et al. (2003). Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology, 14, 521–7.
   PubMed Web of Science ®Google Scholar
• Hooijmans CR, Leenaars M, Ritskes-Hoitinga M. (2010). A gold standard publication checklist to improve the quality of animal studies, to fully integrate the Three Rs, and to make systematic reviews more feasible. Altern Lab Anim, 38, 167–82.
   Web of Science ®Google Scholar
• Hsieh YL, Yang YH, Wu TN, Yang CY. (2010). Air pollution and hospital admissions for myocardial infarction in a subtropical city: Taipei, Taiwan. J Toxicol Environ Health A, 73, 757–65.
   PubMed Web of Science ®Google Scholar
• Huang W, Zhu T, Pan X, Hu M, Lu SE, Lin Y, et al. (2012). Air pollution and autonomic and vascular dysfunction in patients with cardiovascular disease: Interactions of systemic inflammation, overweight, and gender. Am J Epidemiol, 176, 117–26.
   PubMed Web of Science ®Google Scholar
• Hunova I, Maly M, Rezacova J, Branis M. (2013). Association between ambient ozone and health outcomes in Prague. Int Arch Occup Environ Health, 86, 89–97.
   PubMed Web of Science ®Google Scholar
• Institute of Medicine (IOM). (2008). Improving the Presumptive Disability Decision-Making Process for Veterans. Committee on Evaluation of the Presumptive Disability Decision-Making Process for Veterans, Board on Military and Veterans Health. Washington, DC: National Academies Press.
   Google Scholar
• Ioannidis JP, Tzoulaki I. (2012). Minimal and null predictive effects for the most popular blood biomarkers of cardiovascular disease. Circ Res, 110, 658–62.
   Google Scholar
• Jakobsen CJ, Torp P, Vester AE, Folkersen L, Thougaard A, Sloth E. (2010). Ketamine reduce left ventricular systolic and diastolic function in patients with ischaemic heart disease. Acta Anaesthesiol Scand, 54.
   Google Scholar
• Jia X, Song X, Shima M, Tamura K, Deng F, Guo X. (2011). Acute effect of ambient ozone on heart rate variability in healthy elderly subjects. J Expo Sci Environ Epidemiol, 21, 541–7.
   PubMed Web of Science ®Google Scholar
• Kan H, Chen B, Zhao N, London SJ, Song G, Chen G, et al. (2010). A time-series study of ambient air pollution and daily mortality in Shanghai, China. HEI Research Report, 154 Part 1, pp. 17–78.
   Google Scholar
• Kan H, London SJ, Chen G, Zhang Y, Song G, Zhao N, et al. (2008). Season, sex, age, and education as modifiers of the effects of outdoor air pollution on daily mortality in Shanghai, China: The Public Health and Air Pollution in Asia (PAPA) Study. Environ Health Perspect, 116, 1183–8.
   PubMed Web of Science ®Google Scholar
• Katsouyanni K, Samet JM, Anderson HR, Atkinson R, Le Tertre A, Medina S, et al. (2009). Air Pollution and Health: A European and North American Approach (APHENA). HEI Research Report 142. pp. 132, October 29.
   Google Scholar
• Khosravi A, Rao C, Naghavi M, Taylor R, Jafari N, Lopez AD. (2008). Impact of misclassification on measures of cardiovascular disease mortality in the Islamic Republic of Iran: A cross-sectional study. Bull World Health Org, 86, 688–96.
   Google Scholar
• Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. (2010). Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. PLoS Biol, 8, e1000412.
   PubMed Web of Science ®Google Scholar
• Klaassen CD. (2008). Casarett and Doull's Toxicology: The Basic Science of Poisons, 7th edition. New York: McGraw-Hill Companies, Inc.
   Google Scholar
• Klimisch HJ, Andreae M, Tillmann U. (1997). A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. Regul Toxicol Pharmacol, 25, 1–5.
   PubMed Web of Science ®Google Scholar
• Kodavanti UP, Thomas R, Ledbetter AD, Schladweiler MC, Shannahan JH, Wallenborn JG, et al. (2011). Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles. Environ Health Perspect, 119, 312–18.
   PubMed Web of Science ®Google Scholar
• Kusha M, Masse S, Farid T, Urch B, Silverman F, Brook RD, et al. (2012). Controlled exposure study of air pollution and T-wave alternans in volunteers without cardiovascular disease. Environ Health Perspect, 120, 1157–61.
   PubMedGoogle Scholar
• Lai LW. (2012). Effect of photochemical smog associated with synoptic weather patterns on cardiovascular and respiratory hospital admissions in metropolitan Taipei. Int J Environ Health Res, 22, 287–304.
   PubMed Web of Science ®Google Scholar
• Lavelle KS, Schnatter AR, Travis KZ, Swaen MMH, Pallapies D, Money C, et al. (2012). Framework for integrating human and animal data in chemical risk assessment. Regul Toxicol Pharmacol, 62, 302–12.
   PubMed Web of Science ®Google Scholar
• Lewington S, Bragg F, Clarke R. (2012). A review on metaanalysis of biomarkers: Promises and pitfalls. Clin Chem, 58, 1192–204.
   PubMed Web of Science ®Google Scholar
• Liang WM, Wei HY, Kuo HW. (2009). Association between daily mortality from respiratory and cardiovascular diseases and air pollution in Taiwan. Environ Res, 109, 51–8.
   Google Scholar
• Liao D, Duan Y, Whitsel E, Zheng Z, Heiss G, Chinchilli V, Lin H. (2004). Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: A population-based study. Am J Epidemiol, 159, 768–77.
   PubMed Web of Science ®Google Scholar
• Liao D, Heiss G, Chinchilli VM, Duan Y, Folsom AR, Lin HM, Salomaa V. (2005). Association of criteria pollutants with plasma hemostatic/inflammatory markers: A population-based study. J Expo Anal Environ Epidemiol, 15, 319–28.
   PubMedGoogle Scholar
• Lin CM, Liao CM. (2009). Temperature-dependent association between mortality rate and carbon monoxide level in a subtropical city: Kaohsiung, Taiwan. Int J Environ Health Res, 19, 163–74.
   PubMed Web of Science ®Google Scholar
• Lin H, An Q, Luo C, Pun VC, Chan CS, Tian L. (2013). Gaseous air pollution and acute myocardial infarction mortality in Hong Kong: A time-stratified case-crossover study. Atmos Environ, 76, 68–73.
   Google Scholar
• Linkov I, Welle P, Loney D, Tkachuk A, Canis L, Kim JB, Bridges T. (2011). Use of multicriteria decision analysis to support weight of evidence evaluation. Risk Anal, 31, 1211–25.
   PubMed Web of Science ®Google Scholar
• Linn WS, Szlachcic Y, Gong H, Kinney PL, Berhane KT. (2000). Air pollution and daily hospital admissions in metropolitan Los Angeles. Environ Health Perspect, 108, 427–34.
   PubMed Web of Science ®Google Scholar
• Lisabeth LD, Escobar JD, Dvonch JT, Sanchez BN, Majersik JJ, Brown DL, et al. (2008). Ambient air pollution and risk for ischemic stroke and transient ischemic attack. Ann Neurol, 64, 53–9.
   PubMed Web of Science ®Google Scholar
• Liu L, Leech JA, Urch RB, Silverman, FS. (1997). In vivo salicylate hydroxylation: A potential biomarker for assessing acute ozone exposure and effects in humans. Am J Respir Crit Care Med, 156, 1405–12.
   PubMed Web of Science ®Google Scholar
• Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al. (2010). Defining and setting national goals for cardiovascular health promotion and disease reduction: The American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation, 121, 586–613.
   PubMed Web of Science ®Google Scholar
• Lopez-Villarrubia E, Ballester F, Iniguez C, Peral N. (2010). Air pollution and mortality in the Canary Islands: A time-series analysis. Environ Health, 9, 8.
   PubMed Web of Science ®Google Scholar
• Macleod MR, Fisher M, O’Collins V, Sena ES, Dirnagl U, Bath PM, et al. (2009). Reprint: Good laboratory practice: Preventing introduction of bias at the bench. J Cereb Blood Flow Metab, 29, 221–3.
   Web of Science ®Google Scholar
• Massin MM, Derkenne B, von Bemuth H. (1999). Correlations between indices of heart rate variability in healthy children and children with congenital heart disease. Cardiology, 91, 109–13.
   PubMed Web of Science ®Google Scholar
• McDonnell WF. (1993). Utility of controlled human exposure studies for assessing the health effects of complex mixtures and indoor air pollutants. Environ Health Perspect, 101, 199–203.
   PubMed Web of Science ®Google Scholar
• Mechtouff L, Canoui-Poitrine F, Schott AM, Nighoghossian N, Trouillas P, Termoz A, et al. (2012). Lack of association between air pollutant exposure and short-term risk of ischaemic stroke in Lyon, France. Int J Stroke, 7, 669–74.
   Google Scholar
• Medinsky MA. (1996). Determinants of gas and vapor uptake in the respiratory tract. CIIT Activities, 16, 1–6.
   Google Scholar
• Metzger KB, Klein M, Flanders WD, Peel JL, Mulholland JA, Langberg JJ, Tolbert PE. (2007). Ambient air pollution and cardiac arrhythmias in patients with implantable defibrillators. Epidemiology, 18, 585–92.
   Google Scholar
• Miller FJ. (1995). Uptake and fate of ozone in the respiratory tract. Toxicol Lett, 82–83, 277–85.
   PubMed Web of Science ®Google Scholar
• Montgomery JE, Brown JR. (2013). Metabolic biomarkers for predicting cardiovascular disease. Vasc Health Risk Manag, 9, 37–45.
   PubMedGoogle Scholar
• Moshammer H, Hutter HP, Kundi M. (2013). Which metric of ambient ozone to predict daily mortality? Atmos Environ, 65, 171–6.
   Google Scholar
• Mustafic H, Jabre P, Caussin C, Murad MH, Escolano S, Tafflet M, et al. (2012). Main air pollutants and myocardial infarction: A systematic review and meta-analysis. JAMA, 307, 713–21.
   PubMed Web of Science ®Google Scholar
• Nascimento LF, Francisco JB, Patto MB, Antunes AM. (2012). Environmental pollutants and stroke-related hospital admissions. Cad Saude Publica, 28, 1319–24.
   Google Scholar
• National Library of Medicine (NLM). (2014). HazMap for ozone (CAS No. 10028–15-6). [Online] Available at: http://hazmap.nlm.nih.gov/category-details?id = 68&table = copytblagents [Accessed on 12 May 2014].
   Google Scholar
• National Research Council (NRC), Committee on Tropospheric Ozone Formation and Measurement. (1991). Rethinking the Ozone Problem in Urban and Regional Air Pollution. Washington, DC: National Academy Press, pp. 523.
   Google Scholar
• Ng CF, Ueda K, Nitta H, Takeuchi A. (2013). Seasonal variation in the acute effects of ozone on premature mortality among elderly Japanese. Environ Monit Assess, 185, 8767–76.
   Google Scholar
• Nichols JL, Owens EO, Dutton SJ, Luben TJ. (2013). Systematic review of the effects of black carbon on cardiovascular disease among individuals with pre-existing disease. Int J Public Health, 58, 707–24.
   PubMed Web of Science ®Google Scholar
• Nuvolone D, Balzi D, Pepe P, Chini M, Scala D, Giovannini F, et al. (2013). Ozone short-term exposure and acute coronary events: A multicities study in Tuscany (Italy). Environ Res 126, 17–23.
   PubMed Web of Science ®Google Scholar
• Oudin A, Stromberg U, Jakobsson K, Stroh E, Bjork J. (2010). Estimation of short-term effects of air pollution on stroke hospital admissions in southern Sweden. Neuroepidemiology, 34, 131–42.
   PubMed Web of Science ®Google Scholar
• Park SK, O’Neill MS, Stunder BJ, Vokonas PS, Sparrow D, Koutrakis P, Schwartz J. (2007). Source location of air pollution and cardiac autonomic function: Trajectory cluster analysis for exposure assessment. J Expo Sci Environ Epidemiol, 17, 488–97.
   PubMed Web of Science ®Google Scholar
• Park SK, O’Neill MS, Vokonas PS, Sparrow D, Schwartz J. (2005). Effects of air pollution on heart rate variability: The VA Normative Aging Study. Environ Health Perspect, 113, 304–9.
   PubMed Web of Science ®Google Scholar
• Park SK, O’Neill MS, Vokonas PS, Sparrow D, Wright RO, Coull B, et al. (2008). Air pollution and heart rate variability: Effect modification by chronic lead exposure. Epidemiology, 19, 111–20.
   PubMed Web of Science ®Google Scholar
• Pascal M, Wagner V, Chatignoux E, Falq G, Corso M, Blanchard M, et al. (2012). Ozone and short-term mortality in nine French cities: Influence of temperature and season. Atmos Environ, 62, 566–72.
   Google Scholar
• Pattenden S, Armstrong B, Milojevic A, Heal MR, Chalabi Z, Doherty R, et al. (2010). Ozone, heat and mortality: Acute effects in 15 British conurbations. Occup Environ Med, 67, 699–707.
   PubMed Web of Science ®Google Scholar
• Peel JL, Klein M, Flanders WD, Mulholland JA, Freed G, Tolbert PE. (2011). Ambient air pollution and apnea and bradycardia in high-risk infants on home monitors. Environ Health Perspect, 119, 1321–7.
   PubMed Web of Science ®Google Scholar
• Peel JL, Metzger KB, Klein M, Flanders WD, Mulholland JA, Tolbert PE. (2007). Ambient air pollution and cardiovascular emergency department visits in potentially sensitive groups. Am J Epidemiol, 165, 625–33.
   PubMed Web of Science ®Google Scholar
• Perepu RS, Dostal DE, Garcia C, Kennedy RH, Sethi R. (2012). Cardiac dysfunction subsequent to chronic ozone exposure in rats. Mol Cell Biochem, 360, 339–45.
   PubMed Web of Science ®Google Scholar
• Perepu RS, Garcia C, Dostal D, Sethi R. (2010). Enhanced death signaling in ozone-exposed ischemic-reperfused hearts. Mol Cell Biochem, 336, 55–64.
   PubMed Web of Science ®Google Scholar
• Peters A, Dockery DW, Muller JE, Mittleman MA. (2001). Increased particulate air pollution and the triggering of myocardial infarction. Circulation, 103, 2810–15.
   PubMed Web of Science ®Google Scholar
• Peters A, Liu E, Verrier RL, Schwartz J, Gold DR, Mittleman MA, et al. (2000). Air pollution and increased incidence of cardiac arrhythmia. Epidemiology, 11, 11–17.
   PubMed Web of Science ®Google Scholar
• Peters A, von Klot S, Heier M, Trentinaglia I, Cyrys J, Hormann A, et al. (2005). Particulate Air Pollution and Nonfatal Cardiac Events. Part I. Air Pollution, Personal Activities, and Onset of Myocardial Infarction in a Case–Crossover Study. Health Effects Institute Research Report 124 Part I. pp. 1–82.
   Google Scholar
• Poloniecki JD, Atkinson RW, de Leon AP, Anderson HR. (1997). Daily time series for cardiovascular hospital admissions and previous day's air pollution in London, UK. Occup Environ Med, 54, 535–40.
   PubMed Web of Science ®Google Scholar
• Poursafa P, Kelishadi R, Lahijanzadeh A, Modaresi M, Javanmard SH, Assari R, et al. (2011). The relationship of air pollution and surrogate markers of endothelial dysfunction in a population-based sample of children. BMC Public Health, 11, 115.
   PubMed Web of Science ®Google Scholar
• Prueitt RL, Lynch HN, Zu K, Sax SN, Venditti FJ, Goodman JE. (2014). Weight-of-evidence evaluation of long-term ozone exposure and cardiovascular effects. Crit Rev Toxicol, 44, 791–822.
   PubMed Web of Science ®Google Scholar
• Qian Z, He Q, Lin HM, Kong L, Liao D, Yang N, et al. (2007). Short-term effects of gaseous pollutants on cause-specific mortality in Wuhan, China. J Air Waste Manage Assoc, 57, 785–93.
   Web of Science ®Google Scholar
• Rainham DG, Smoyer-Tomic KE, Sheridan SC, Burnett RT. (2005). Synoptic weather patterns and modification of the association between air pollution and human mortality. Int J Environ Health Res, 15, 347–60.
   PubMed Web of Science ®Google Scholar
• Reed MJ, Robertson CE, Addison PS. (2005). Heart rate variability measurements and the prediction of ventricular arrhythmias. QJM, 98, 87–95.
   Google Scholar
• Ren C, Melly S, Schwartz J. (2010). Modifiers of short-term effects of ozone on mortality in eastern Massachusetts - A case-crossover analysis at individual level. Environ Health, 9, 3.
   Google Scholar
• Ren C, Williams GM, Mengersen K, Morawska L, Tong S. (2009). Temperature enhanced effects of ozone on cardiovascular mortality in 95 large US communities, 1987–2000: Assessment using the NMMAPS data. Arch Environ Occup Health, 64, 177–84.
   PubMed Web of Science ®Google Scholar
• Revich B, Shaposhnikov D. (2010). The effects of particulate and ozone pollution on mortality in Moscow, Russia. Air Qual Atmos Health, 3, 117–23.
   Google Scholar
• Revis NW, Major T, Dalbey WE. (1981). Cardiovascular effects of ozone and cadmium inhalation in the rat. EPA-600/9-81-001. In: Northrop Services, Inc., ed. Proceedings of the Research Planning Workshop on Health Effects of Oxidants, Raleigh, NC, January 28–30, 1980. US EPA, Research Triangle Park, NC, 171–179.
   Google Scholar
• Rhomberg LR, Chandalia JK, Long CM, Goodman JE. (2011). Measurement error in environmental epidemiology and the shape of exposure-response curves. Crit Rev Toxicol, 41, 651–71.
   PubMed Web of Science ®Google Scholar
• Rhomberg LR, Goodman JE, Bailey LA, Prueitt RL, Beck NB, Bevan C, et al. (2013). A survey of frameworks for best practices in weight-of-evidence analyses. Crit Rev Toxicol, 43, 753–84.
   PubMed Web of Science ®Google Scholar
• Rich DQ, Kim MH, Turner JR, Mittleman MA, Schwartz J, Catalano PJ, Dockery DW. (2006a). Association of ventricular arrhythmias detected by implantable cardioverter defibrillator and ambient air pollutants in the St Louis, Missouri metropolitan area. Occup Environ Med, 63, 591–6.
   PubMed Web of Science ®Google Scholar
• Rich DQ, Kipen HM, Huang W, Wang G, Wang Y, Zhu P, et al. (2012). Association between changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and thrombosis in healthy young adults. JAMA, 307, 2068–78.
   PubMed Web of Science ®Google Scholar
• Rich DQ, Kipen HM, Zhang J, Kamat L, Wilson AC, Kostis JB. (2010). Triggering of transmural infarctions, but not nontransmural infarctions, by ambient fine particles. Environ Health Perspect, 118, 1229–34.
   PubMed Web of Science ®Google Scholar
• Rich DQ, Mittleman MA, Link MS, Schwartz J, Luttman-Gibson H, Catalano PJ, et al. (2006b). Increased risk of paroxysmal atrial fibrillation episodes associated with acute increases in ambient air pollution. Environ Health Perspect, 114, 120–3.
   PubMed Web of Science ®Google Scholar
• Rich DQ, Schwartz J, Mittleman MA, Link M, Luttman-Gibson H, Catalano PJ, et al. (2005). Association of short-term ambient air pollution concentrations and ventricular arrhythmias. Am J Epidemiol, 161, 1123–32.
   PubMed Web of Science ®Google Scholar
• Rich KE, Petkau J, Vedal S, Brauer M. (2004). A case-crossover analysis of particulate air pollution and cardiac arrhythmia in patients with implantable cardioverter defibrillators. Inhal Toxicol, 16, 363–72.
   PubMed Web of Science ®Google Scholar
• Romieu I, Gouveia N, Cifuentes LA, de Leon AP, Junger W, Vera J, et al. (2012). Multicity Study of Air Pollution and Mortality in Latin America (The ESCALA Study). HEI Research Report 171. pp. 120. October.
   Google Scholar
• Rosenthal FS, Kuisma M, Lanki T, Hussein T, Boyd J, Halonen JI, Pekkanen J. (2013). Association of ozone and particulate air pollution with out-of-hospital cardiac arrest in Helsinki, Finland: Evidence for two different etiologies. J Expo Sci Environ Epidemiol, 23, 281–8.
   Google Scholar
• Rothman KJ, Greenland S. (1998). Modern Epidemiology (Second Edition). Philadelphia: Lippincott Williams & Wilkins.
   Google Scholar
• Rudez G, Janssen NA, Kilinc E, Leebeek FW, Gerlofs-Nijland ME, Spronk HM, et al. (2009). Effects of ambient air pollution on hemostasis and inflammation. Environ Health Perspect, 117, 995–1001.
   PubMed Web of Science ®Google Scholar
• Ruidavets J-B, Cassadou S, Cournot M, Bataille V, Meybeck M, Ferrieres J. (2005a). Increased resting heart rate with pollutants in a population based study. J Epidemiol Community Health, 59, 685–93.
   Google Scholar
• Ruidavets J-B, Cournot M, Cassadou S, Giroux M, Meybeck M, Ferrieres J. (2005b). Ozone air pollution is associated with acute myocardial infarction. Circulation, 111, 563–9.
   PubMed Web of Science ®Google Scholar
• Sacks JD, Ito K, Wilson WE, Neas LM. (2012). Impact of covariate models on the assessment of the air pollution-mortality association in a single- and multipollutant context. Am J Epidemiol, 176, 622–34.
   Google Scholar
• Samoli E, Zanobetti A, Schwartz J, Atkinson R, LeTertre A, Schnindler C, et al. (2009). The temporal pattern of mortality responses to ambient ozone in the APHEA project. J Epidemiol Community Health, 63, 960–6.
   PubMed Web of Science ®Google Scholar
• Sanderson JE, Yeung LY, Yeung DT, Kay RL, Tomlinson B, Critchley JA, et al. (1996). Impact of changes in respiratory frequency and posture on power spectral analysis of heart rate and systolic blood pressure variability in normal subjects and patients with heart failure. Clin Sci (Lond), 91, 35–43.
   PubMed Web of Science ®Google Scholar
• Sarnat SE, Suh HH, Coull BA, Schwartz J, Stone PH, Gold DR. (2006). Ambient particulate air pollution and cardiac arrhythmia in a panel of older adults in Steubenville, Ohio. Occup Environ Med, 63, 700–6.
   PubMed Web of Science ®Google Scholar
• Sarwar N, Thompson AJ, Di Angelantonio E. (2009). Markers of inflammation and risk of coronary heart disease. Dis Markers, 26, 217–25.
   PubMed Web of Science ®Google Scholar
• Schelegle ES, Adams WC. (1986). Reduced exercise time in competitive simulations consequent to low level ozone exposure. Med Sci Sports Exerc, 18, 408–14.
   PubMed Web of Science ®Google Scholar
• Schwartz J, Litonjua A, Suh H, Verrier M, Zanobetti A, Syring M, et al. (2005). Traffic related pollution and heart rate variability in a panel of elderly subjects. Thorax, 60, 455–61.
   PubMed Web of Science ®Google Scholar
• Sergio Chiarelli P, Amador Pereira LA, Nascimento Saldiva PH, Ferreira Filho C, Bueno Garcia ML, Ferreira Braga AL, Conceicao Martins L. (2011). The association between air pollution and blood pressure in traffic controllers in Santo André, São Paulo, Brazil. Environ Res, 111, 650–5.
   PubMed Web of Science ®Google Scholar
• Sethi R, Manchanda S, Perepu RS, Kumar A, Garcia C, Kennedy RH, et al. (2012). Differential expression of caveolin-1 and caveolin-3: Potential marker for cardiac toxicity subsequent to chronic ozone inhalation. Mol Cell Biochem, 369, 9–15.
   PubMed Web of Science ®Google Scholar
• Shah AS, Langrish JP, Nair H, McAllister DA, Hunter AL, Donaldson K, et al. (2013). Global association of air pollution and heart failure: A systematic review and meta-analysis. Lancet, 382, 1039–48.
   PubMed Web of Science ®Google Scholar
• Shang Y, Sun Z, Cao J, Wang X, Zhong L, Bi X, et al. (2013). Systematic review of Chinese studies of short-term exposure to air pollution and daily mortality. Environ Int, 54, 100–11.
   PubMed Web of Science ®Google Scholar
• Shields KN, Cavallari JM, Hunt MJ, Lazo M, Molina M, Molina L, Holguin F. (2013). Traffic-related air pollution exposures and changes in heart rate variability in Mexico City: A panel study. Environ Health, 12, 7.
   Google Scholar
• Silverman RA, Ito K, Freese J, Kaufman BJ, De Claro D, Braun J, Prezant DJ. (2010). Association of ambient fine particles with out-of-hospital cardiac arrests in New York City. Am J Epidemiol, 172, 917–23.
   PubMed Web of Science ®Google Scholar
• Sivagangabalan G, Spears D, Masse S, Urch B, Brook RD, Silverman F, et al. (2011). The effect of air pollution on spatial dispersion of myocardial repolarization in healthy human volunteers. J Am Coll Cardiol, 57, 198–206.
   PubMed Web of Science ®Google Scholar
• Smith RL, Xu B, Switzer P. (2009). Reassessing the relationship between ozone and short-term mortality in US urban communities. Inhal Toxicol, 21(Suppl 2), 37–61.
   Google Scholar
• Son JY, Lee JT, Kim H, Yi O, Bell ML. (2012). Susceptibility to air pollution effects on mortality in Seoul, Korea: A case-crossover analysis of individual-level effect modifiers. J Expo Sci Environ Epidemiol, 22, 227–34.
   Google Scholar
• Stafoggia M, Forastiere F, Faustini A, Biggeri A, Bisanti L, Cadum E, et al. (2010). Susceptibility factors to ozone-related mortality: A population-based case-crossover analysis. Am J Respir Crit Care Med, 182, 376–84.
   PubMed Web of Science ®Google Scholar
• Steinvil A, Kordova-Biezuner L, Shapira I, Berliner S, Rogowski O. (2008). Short-term exposure to air pollution and inflammation-sensitive biomarkers. Environ Res, 106, 51–61.
   PubMed Web of Science ®Google Scholar
• Stieb DM, Szyszkowicz M, Rowe BH, Leech JA. (2009). Air pollution and emergency department visits for cardiac and respiratory conditions: A multi-city time-series analysis. Environ Health, 8, 25.
   PubMed Web of Science ®Google Scholar
• Tank J, Biller H, Heusser K, Holz O, Diedrich A, Framke T, et al. (2011). Effect of acute ozone induced airway inflammation on human sympathetic nerve traffic: A randomized, placebo controlled, crossover study. PLoS ONE, 6, e18737.
   Google Scholar
• Tankersley CG, Peng RD, Begda D, Gabrielson K, Champion HC. (2010). Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice. Inhal Toxicol, 22, 695–707.
   PubMed Web of Science ®Google Scholar
• Tao Y, Huang W, Huang X, Zhong L, Lu SE, Li Y, et al. (2012). Estimated acute effects of ambient ozone and nitrogen dioxide on mortality in the Pearl River Delta of southern China. Environ Health Perspect, 120, 393–8.
   PubMed Web of Science ®Google Scholar
• Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. (1996). Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J, 17, 354–81.
   PubMed Web of Science ®Google Scholar
• Taubes G. (1995). Epidemiology faces its limits. Science, 269, 164–9.
   PubMed Web of Science ®Google Scholar
• Tepper JS, Weiss B, Wood RW. (1985). Alterations in behavior produced by inhaled ozone or ammonia. Fundam Appl Toxicol, 5(6 pt 1), 1110–18.
   Google Scholar
• Tepper JS, Wood RW. (1985). Behavioral evaluation of the irritating properties of ozone. Toxicol Appl Pharmacol, 78, 404–11.
   PubMed Web of Science ®Google Scholar
• Thompson AM, Zanobetti A, Silverman F, Schwartz J, Coull B, Urch B, et al. (2010). Baseline repeated measures from controlled human exposure studies: Associations between ambient air pollution exposure and the systemic inflammatory biomarkers IL-6 and fibrinogen. Environ Health Perspect, 118, 120–4.
   PubMed Web of Science ®Google Scholar
• Thomson E, Kumarathasan P, Vincent R. (2006). Pulmonary expression of preproET-1 and preproET-3 mRNAs is altered reciprocally in rats after inhalation of air pollutants. Exp Biol Med (Maywood), 231, 979–84.
   PubMed Web of Science ®Google Scholar
• Uberoi A, Stein R, Perez MV, Freeman J, Wheeler M, Dewey F, et al. (2011). Interpretation of the electrocardiogram of young athletes. Circulation, 124, 746–57.
   PubMed Web of Science ®Google Scholar
• Uchiyama I, Simomura Y, Yokoyama E. (1986). Effects of acute exposure to ozone on heart rate and blood pressure of the conscious rat. Environ Res, 41, 529–37.
   PubMed Web of Science ®Google Scholar
• Uchiyama I, Yokoyama E. (1989). Effects of short- and long-term exposure to ozone on heart rate and blood pressure of emphysematous rats. Environ Res, 48, 76–86.
   Google Scholar
• US EPA. (1998). Health Effects Test Guidelines: OPPTS 870.1000 - Acute Inhalation Toxicity. Office of Prevention, Pesticides and Toxic Substances, Washington, DC: EPA, 712-C-98-193. pp. 11, August.
   Google Scholar
• US EPA. (2006). Air Quality Criteria for Ozone and Related Photochemical Oxidants. Volume I. Office of Research and Development, National Center for Environmental Assessment (NCEA), Research Triangle Park, NC: EPA 600/R-05/004aF. pp. 821, February.
   Google Scholar
• US EPA. (2009). Integrated Science Assessment for Particulate Matter (Final). Office of Research and Development, National Center for Environmental Assessment(NCEA), Research Triangle Park, NC: EPA/600/R-08/139F. December.
   Google Scholar
• US EPA. (2013a). Integrated Science Assessment for Ozone and Related Photochemical Oxidants (Final). National Center for Environmental Assessment (NCEA), Research Triangle Park, NC: EPA/600/R–10/076F. pp. 1251, February.
   Google Scholar
• US EPA. (2013b). Process of Reviewing the National Ambient Air Quality Standards. [Online] Available at: http://www.epa.gov/ttn/naaqs/review.html [Accessed on 19 August 2013].
   Google Scholar
• US EPA. (2014). Health Risk and Exposure Assessment for Ozone (Second External Review Draft). [Online] Available at: http://www.epa.gov/ttn/naaqs/standards/ozone/s_o3_2008_rea.html [Accessed on 03 February 2014].
   Google Scholar
• US Public Health Service (USPHS), Office of the Surgeon General. (2014). The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. [Online] Available at: http://www.surgeongeneral.gov/library/reports/50-years-of-progress/[Accessed on 04 April 2014].
   Google Scholar
• van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O’Collins V, Macleod MR. (2010). Can animal models of disease reliably inform human studies? PLoS Med, 7, e1000245.
   PubMed Web of Science ®Google Scholar
• Vedal S, Rich K, Brauer M, White R, Petkau J. (2004). Air pollution and cardiac arrhythmias in patients with implantable cardioverter defibrillators. Inhal Toxicol, 16, 353–62.
   PubMed Web of Science ®Google Scholar
• Vesely DL, Giordano AT, Raska-Emery P, Montgomery MR. (1994). Ozone increases atrial natriuretic peptides in heart, lung and circulation of aged vs. adult animals. Gerontology, 40, 227–36.
   PubMed Web of Science ®Google Scholar
• Villeneuve PJ, Johnson JY, Pasichnyk D, Lowes J, Kirkland S, Rowe BH. (2012). Short-term effects of ambient air pollution on stroke: Who is most vulnerable? Sci Total Environ, 430, 193–201.
   Google Scholar
• Wang G, Jiang R, Zhao Z, Song W. (2013). Effects of ozone and fine particulate matter (PM(2.5)) on rat system inflammation and cardiac function. Toxicol Lett, 217, 23–33.
   PubMed Web of Science ®Google Scholar
• Wang L, Yang G, Jiemin M, Rao C, Wan X, Dubrovsky G, Lopez AD. (2007). Evaluation of the quality of cause of death statistics in rural China using verbal autopsies. J Epidemiol Community Health, 61, 519–26.
   PubMed Web of Science ®Google Scholar
• Watkinson WP, Campen MJ, Nolan JP, Costa DL. (2001). Cardiovascular and systemic responses to inhaled pollutants in rodents: Effects of ozone and particulate matter. Environ Health Perspect, 109(Suppl 4), 539–46.
   PubMed Web of Science ®Google Scholar
• Watkinson WP, Campen MJ, Wichers LB, Nolan JP, Costa DL. (2003). Cardiac and thermoregulatory responses to inhaled pollutants in healthy and compromised rodents: Modulation via interaction with environmental factors. Environ Res, 92, 35–47.
   PubMed Web of Science ®Google Scholar
• Wellenius GA, Burger MR, Coull BA, Schwartz J, Suh HH, Koutrakis P, et al. (2012). Ambient air pollution and the risk of acute ischemic stroke. Arch Intern Med, 172, 229–37.
   PubMed Web of Science ®Google Scholar
• Wellenius GA, Yeh GY, Coull BA, Suh HH, Phillips RS, Mittleman MA. (2007). Effects of ambient air pollution on functional status in patients with chronic congestive heart failure: A repeated-measures study. Environ Health, 6, 26.
   PubMed Web of Science ®Google Scholar
• Wheeler A, Zanobetti A, Gold DR, Schwartz J, Stone P, Suh HH. (2006). The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environ Health Perspect, 114, 560–6.
   PubMed Web of Science ®Google Scholar
• Wichmann J, Folke F, Torp-Pedersen C, Lippert F, Ketzel M, Ellermann T, Loft S. (2013). Out-of-hospital cardiac arrests and outdoor air pollution exposure in Copenhagen, Denmark. PLoS ONE, 8, e53684.
   PubMed Web of Science ®Google Scholar
• Wong CM. (2010). Public Health and Air Pollution in Asia (PAPA): A combined analysis of four studies of air pollution and mortality. HEI Research Report 154 Part 5. In: Public Health and Air Pollution in Asia (PAPA): Coordinated Studies of Short-Term Exposure to Air Pollution and Daily Mortality in Four Cities. Boston, MA: Health Effects Institute, pp. 377–431. November.
   Google Scholar
• Wu CF, Kuo IC, Su TC, Li YR, Lin LY, Chan CC, Hsu SC. (2010). Effects of personal exposure to particulate matter and ozone on arterial stiffness and heart rate variability in healthy adults. Am J Epidemiol, 171, 1299–309.
   PubMed Web of Science ®Google Scholar
• Xu X, Sun Y, Ha S, Talbott EP, Lissaker CT. (2013). Association between ozone exposure and onset of stroke in Allegheny County, Pennsylvania, USA 1994–2000. Neuroepidemiology, 41, 2–6
   PubMed Web of Science ®Google Scholar
• Yang C, Yang H, Guo S, Wang Z, Xu X, Duan X, Kan H. (2012). Alternative ozone metrics and daily mortality in Suzhou: The China Air Pollution and Health Effects Study (CAPES). Sci Total Environ, 426, 83–9.
   PubMed Web of Science ®Google Scholar
• Yokoyama E, Uchiyama I, Arito H. (1989). Extrapulmonary effects of low level ozone exposure. In: Schneider T, Lee SD, Wolters GJR, Grant LD, Eds. Atmospheric Ozone Research and its Policy Implications. Amsterdam, The Netherlands: Elsevier Science Publishers B.V., pp. 301–9.
   Google Scholar
• Zanobetti A, Canner MJ, Stone PH, Schwartz J, Sher D, Eagan-Bengston E, et al. (2004). Ambient pollution and blood pressure in cardiac rehabilitation patients. Circulation, 110, 2184–9.
   PubMed Web of Science ®Google Scholar
• Zanobetti A, Gold DR, Stone PH, Suh HH, Schwartz J, Coull BA, Speizer FE. (2010). Reduction in heart rate variability with traffic and air pollution in patients with coronary artery disease. Environ Health Perspect, 118, 324–30.
   PubMed Web of Science ®Google Scholar
• Zanobetti A, Schwartz J. (2006). Air pollution and emergency admissions in Boston, MA. J Epidemiol Community Health, 60, 890–5.
   PubMed Web of Science ®Google Scholar
• Zanobetti A, Schwartz J. (2008). Mortality displacement in the association of ozone with mortality: An analysis of 48 cities in the United States. Am J Respir Crit Care Med, 177, 184–9.
   Google Scholar
• Zhang Y, Huang W, London SJ, Song G, Chen G, Jiang L, et al. (2006). Ozone and daily mortality in Shanghai, China. Environ Health Perspect, 114, 1227–32.
   PubMed Web of Science ®Google Scholar
• Zhou X, Fragala MS, McElhaney JE, Kuchel GA. (2010). Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research. Curr Opin Clin Nutr Metab Care, 13, 541–7.
   PubMed Web of Science ®Google Scholar
• Zile MR, Brutsaert DL. (2002). New concepts in diastolic dysfunction and diastolic heart failure: Part I. Diagnosis, prognosis, and measurements of diastolic function. Circulation, 105, 1387–93.
   Google Scholar