Reassessment of MTBE cancer potency considering modes of action for MTBE and its metabolites

References

• Agresti A. (2002). Categorical Data Analysis. 2nd ed. New York, NY: John Wiley & Sons, pp. 181–2, 253.
   Google Scholar
• Albert R. (1994). Carcinogen risk assessment in the U.S. Environmental Protection Agency. Crit Rev Toxicol, 24, 75–85.
   PubMed Web of Science ®Google Scholar
• Aldridge WN. (1986). The biological basis and measurement of thresholds. Annu Rev Pharmacol Toxicol, 26, 39–58.
   PubMed Web of Science ®Google Scholar
• Altman SA, Randers L, Rao G. (1993). Comparison of trypan blue dye exclusion and fluorometric assays for mammalian cell viability determinations. Biotechnol Prog, 9, 671–4.
   PubMed Web of Science ®Google Scholar
• Amberg A, Rosner E, Dekant W. (1999). Biotransformation and kinetics of excretion of methyl tert-butyl ether in rats and humans. Toxicol Sci, 51, 1–8.
   PubMed Web of Science ®Google Scholar
• Amberg A, Rosner E, Dekant W. (2001). Toxicokinetics of methyl tert-butyl ether and its metabolites in humans after oral exposure. Toxicol Sci, 61, 62–777.
   PubMed Web of Science ®Google Scholar
• Andersen ME, Clewell HJ 3rd, Gargas ML, Smith FA, Reitz RH. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol Appl Pharmacol. 1987; 87(2):185–205.
   PubMed Web of Science ®Google Scholar
• Anderson ELand the Carcinogen Assessment Group of the U.S. Environmental Protection Agency. (1983). Quantitative approaches in use to assess cancer risk.Risk Anal, 3, 277–95.
   Google Scholar
• API. (2005). Hazard Narrative for Tertiary-Butyl Alcohol (TBA) CAS Number 75–65–0. Regulatory Analysis and Scientific Affairs Publication Number 4743, October 2005. American Petroleum Institute, Washington, DC. http://www.api.org/ehs/groundwater/upload/4743final.pdf
   Google Scholar
• ARCO. (1980). Methyl Tertiary Butyl Ether: Acute Toxicological Studies. Glenolden, PA: ARCO Chemical Company. As cited in: EU, 2002.
   Google Scholar
• Armitage P. (1955). Tests for linear trends in proportions and frequencies. Biometrics, 11, 375–86.
   Web of Science ®Google Scholar
• Armitage P, Doll R. (1954).The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer, 8, 1–12.
   PubMed Web of Science ®Google Scholar
• Armitage P, Doll R. (1957). A two-stage theory of carcinogenesis in relation to the age distribution of human cancer. Br J Cancer, 11, 161–9.
   PubMed Web of Science ®Google Scholar
• ATSDR. (1996). Toxicological Profile for Methyl Tert-Butyl Ether. Toxicological profile 91, August 1996. Atlanta, GA: Agency for Toxic Substances and Disease Registry (ATSDR). http://www.atsdr.cdc.gov/toxprofiles/tp91.pdf
   Google Scholar
• ATSDR. (1999). Toxicological Profile for Methyl Tert-Butyl Ether. Toxicological profile 111, August 1999. Atlanta, GA: Agency for Toxic Substances and Disease Registry (ATSDR).
   Google Scholar
• Baglivo J, Oliver D, Pagano M. (1988). Methods for the analysis of contingency tables with large and small cell counts. J Am Statist Assoc, 83, 1006–13.
   Web of Science ®Google Scholar
• Bailey GS, Reddy AP, Pereira CB, Harttig U, Baird W, Spitsbergen JM, et al. (2009). Non-linear cancer response at ultra-low dose: a 40,800-animal ED001 tumor and biomarker study. Chem Res Toxicol, 22, 1264–76.
   PubMed Web of Science ®Google Scholar
• Baker RC, Sorensen SM, Deitrich RA. (1982). The in vivo metabolism of tertiary butanol by adult rats. Alcohol Clin Exp Res, 6, 247–51.
   PubMed Web of Science ®Google Scholar
• Baker SG. (2014).Recognizing paradigm instability in theories of carcinogenesis. Br J Med Medical Res, 4, 1149–63.
   Google Scholar
• Baker SG. (2015).A cancer theory kerfuffle can lead to new lines of research. J Natl Cancer Inst, 107, dju405. doi: 10.1093/jnci/dju405.
   PubMed Web of Science ®Google Scholar
• Barker S, Weinfeld M, Murray D. (2005). DNA-protein crosslinks: their induction, repair, and biological consequences. Mutat Res, 589, 111–35.
   PubMed Web of Science ®Google Scholar
• Belpoggi F, Soffritti M, Maltoni C. (1995). Methyl tertiary butyl ether - a gasoline additive - causes testicular and lymphohaematopoietic cancers in rats. Toxicol Indus Health, 11, 119–49.
   PubMed Web of Science ®Google Scholar
• Belpoggi F, Soffritti M, Maltoni C. (1998).Pathological characterization of testicular tumors and lymphomasleukemias, and of their precursors observed in Sprague-Dawley rats exposed to methyl-tertiary-butyl-ether (MTBE). Eur J Oncol, 3, 201–6.
   Google Scholar
• Benson JM, Gigliotti AP, March TH, Barr EB, Tibbetts BM, Skipper BJ, et al. (2011). Chronic carcinogenicity study of gasoline vapor condensate (GVC) & GVC containing methyl tertiary butyl ether in F344 rats. J Toxicol Envir Health A, 74, 638–57.
   PubMed Web of Science ®Google Scholar
• Bermudez E, Willson G, Parkinson H, Dodd D. (2012). Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar rats for 13 weeks or one year via drinking water. J Appl Toxicol, 32, 687–706.
   PubMed Web of Science ®Google Scholar
• Bernauer U, Amberg A, Scheutzow D, Dekant W. (1998). Biotransformation of 12C- and 2-13C-labeled methyl tert-butyl ether, ethyl tert-butyl ether, and tert-butyl alcohol in rats: identification of metabolites in urine by 13C nuclear magnetic resonance and gas chromatography/mass spectrometry. Chem Res Toxicol, 11, 651–8.
   PubMed Web of Science ®Google Scholar
• BfR. (2006). Toxicological assessment of formaldehyde. Opinion of BfR No, 023/2006 of 30 March 2006. Bundesinstitut für Riskoberwertung (BfR) [Federal Institute for Risk Assessment].
   Google Scholar
• Bird MG, Burleigh-Flayer HD, Chun JS, Douglas JF, Kneiss JJ, Andrews LS. (1997). Oncogenicity studies of inhaled MTBE in CD-1 mice and F-344 rats. J Appl Toxicol, 17, S45–55.
   PubMed Web of Science ®Google Scholar
• Black KA, Eells JT, Noker PE, Hawtrey CA, Tephly TR. (1985).Role of hepatic tetrahydrofolate in the species difference in methanol toxicity. Proc Natl Acad Sci, 82, 3854–8. As cited in: U.S. EPA 2010.
   PubMed Web of Science ®Google Scholar
• Blair J. (2013). Bumblefoot: a comparison of clinical presentation and treatment of pododermatitis in rabbits, rodents, and birds. Vet Clin North Am Exot Anim Pract, 16, 715–35.
   PubMedGoogle Scholar
• Blancato JN, Evans MV, Power FW, Caldwell JC. (2007). Development and use of PBPK modeling and the impact of metabolism on variability in dose metrics for the risk assessment of methyl tertiary butyl ether (MTBE). J Environ Prot Sci, 1, 29–51.
   Google Scholar
• Blanck O, Fowles J, Schorsch F, Pallen C, Espinasse-Lormeau H, Schulte-Koerne E, et al. (2010). Tertiary butyl alcohol in drinking water induces phase I and II liver enzymes with consequent effects on thyroid hormone homeostasis in the B6C3F1 female mouse. J Appl Toxicol, 30, 125–32.
   PubMed Web of Science ®Google Scholar
• Bogdanffy MS, Keller DA. (1999). Metabolism of xenobiotics by the lung. In: Gardener DE, Crapo JD, McClellan RO, Eds. Toxicology of the Lung, 3rd ed. Philadelphia, PA: Taylor & Francis, pp. 85–124.
   Google Scholar
• Bogen KT. (1988). Pharmacokinetics for regulatory risk analysis: the case of trichloroethylene. Regul Toxicol Pharmacol, 8, 447 ‐ 466.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (1989). Cell proliferation kinetics and multistage cancer risk models. J Natl Cancer Inst, 81, 267–77.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (1995a). Improved prediction of carcinogenic from mutagenic potencies for chemicals positive in rodents and the Ames test. Molec Environ Mutagen, 25, 37–49.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (1995b).Methods to approximate joint uncertainty and variability in risk. Risk Anal, 15, 411–419.
   Web of Science ®Google Scholar
• Bogen KT. (2005). Risk analysis for environmental health triage. Risk Anal, 25, 1085–95.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2008). An adjustment factor for mode of action uncertainty with dual-mode carcinogens: the case of naphthalene-induced nasal tumors in rats. Risk Anal, 28, 1033–51.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2011).Generic hockey-stick model for estimating benchmark dose and potency: performance relative to BMDS and application to anthraquinone. Dose-Response, 9, 182–208.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2013a). Dermal uptake of 18 dilute aqueous chemicals: In vivo disappearance-method measures greatly exceed in vitro-based predictions. Risk Anal, 33, 1334–52.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2013b). Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia. Med Hypotheses, 80, 83–93.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2014a). Mechanistic models fit to ED001 data on > 40,000 trout exposed to dibenzo[a,l]pyrene indicate mutations do not drive increased tumor risk. Dose Response, 12, 386–403.
   PubMed Web of Science ®Google Scholar
• Bogen KT. (2014b). Unveiling variability and uncertainty for better science and decisions on cancer risks from environmental chemicals. Risk Anal, 34, 1795–806.
   PubMed Web of Science ®Google Scholar
• Bogen KT, Hall LC. (1989). Pharmacokinetics for regulatory risk analysis: the case of 1,1,1-trichloroethane (methyl chloroform). Regul Toxicol Pharmacol, 10, 26–50.
   PubMed Web of Science ®Google Scholar
• Bogen KT, Spear RC. (1987). Integrating uncertainty and inter-individual variability in environmental risk assessment. Risk Anal, 7, 427–36.
   PubMed Web of Science ®Google Scholar
• Bogen KT, Cullen AC, Frey HC, Price PS. (2009).Probabilistic exposure analysis for chemical risk characterization. Toxicol Sci, 109, 4–17.
   PubMed Web of Science ®Google Scholar
• Bolt HM, Foth H, Hengstler JG, Degen GH. (2004). Carcinogenicity categorization of chemicals-new aspects to be considered in a European perspective. Toxicol Lett, 151, 29–41.
   PubMed Web of Science ®Google Scholar
• Borghoff SJ, Lagarde WH. (1993). Assessment of binding of 2,4,4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans. Toxicol Appl Pharmacol, 119, 228–35.
   PubMed Web of Science ®Google Scholar
• Borghoff SJ, Short BG, Swenberg JA. (1990). Biochemical mechanisms and pathobiology of a alpha2u-globulin nephropathy. Ann Rev Pharmacol Toxicol, 30, 349–67.
   PubMed Web of Science ®Google Scholar
• Borghoff SJ, Murphy JE, Medinsky MA. (1996). Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats. Fundam Appl Toxicol, 30, 264–75.
   PubMedGoogle Scholar
• Borghoff SJ, Prescott JS, Janszen DB, Wong BA, Everitt JI. (2001). Alpha 2u-Globulin nephropathy, renal cell proliferation, and dosimetry of inhaled tert-butyl alcohol in male and female F-344 rats. Toxicol Sci, 61, 176–86.
   PubMed Web of Science ®Google Scholar
• Borghoff SJ, Parkinson H, Leavens TL. (2010). Physiologically based pharmacokinetic rat model for methyl tertiary-butyl ether). comparison of selected dose metrics following various MTBE exposure scenarios used for toxicity and carcinogenicity evaluation. Toxicol, 275, 79–91.
   PubMed Web of Science ®Google Scholar
• Brady JF, Xiao F, Ning SM, Yang CS. (1990). Metabolism of MTBE by rat hepatic microsomes. Arch Toxicol, 64, 157–60.
   PubMed Web of Science ®Google Scholar
• Breslow NE, Day NE. (1980). Statistical Methods in Cancer Research, Volume 1: The Analysis of Case-Control Studies. International Association for Cancer Research (IARC) Publication No, 32. IARC, Lyon, France, pp. 122–59.
   Google Scholar
• Brink A. (2007).The Biological Significance of Chemically-Induced DNA Adducts in Relation to Background DNA Damage. Doctoral Dissertation. der Bayerischen Julius-Maximilians-Universität Würzburg, Würzburg, Germany. http://opus.bibliothek.uni-wuerzburg.de/volltexte/2007/2385/pdf/Diss_Brink_S.pdf
   Google Scholar
• Brink A, Schulz B, Kobras K, Lutz WK, Stopper H. (2006). Time-dependent effects of sodium arsenite on DNA breakage and apoptosis observed in the comet assay. Mutat Res, 603, 121–8.
   PubMed Web of Science ®Google Scholar
• Bryce SM, Avlasevich SL, Bemis JC, Phonethepswath S, Dertinger SD. (2010).Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships. Mutat Res, 703, 191–9.
   PubMed Web of Science ®Google Scholar
• Buckley TJ, Prah JD, Ashley D, Zweidinger RA, Wallace LA. (1997). Body burden measurements and models to assess inhalation exposure to methyl tertiary butyl ether (MTBE). J Air Waste Manag Assoc, 47, 739–52.
   PubMedGoogle Scholar
• Burleigh-Flayer HD, Chun JS, Kintigh WJ. (1992). Methyl Tertiary Butyl Ether: Vapor Oncogenicity Study in CD-1 Mice and Fisher 344 Rats. BRRC Report, 91 N0013A. Union Carbide, Bushy Run Research Center, Export, PA.
   Google Scholar
• Burns KB, Melnick RL. (2012). MTBE: recent carcinogenicity studies. Int J Occup Environ Health, 18, 66–9.
   PubMed Web of Science ®Google Scholar
• Buttke TM, Sandstrom PA. (1994). Oxidative stress as a mediator of apoptosis. Immunol Today, 15, 7–10.
   PubMedGoogle Scholar
• Cairns J. (1981). The origin of human cancer. Nature, 289, 353–7.
   PubMed Web of Science ®Google Scholar
• Caldecott KW. (2008). Single-strand break repair and genetic disease. Nature Rev Genetics, 9, 619–31.
   PubMed Web of Science ®Google Scholar
• CalEPA OEHHA. (1999). Public Health Goal for Methyl Tertiary Butyl Ether (MTBE) in Drinking Water. California Environmental Protection Agency (CalEPA), Office of Environmental Health Hazard Assessment (OEHHA), Sacramento, CA. http://oehha.ca.gov/water/phg/pdf/mtbe_f.pdf
   Google Scholar
• CalEPA OEHHA. (2006). Vinclozolin- A Chemical Listed “As Causing Cancer” By The Authoritative Bodies Mechanism and Under Review by the Carcinogen Identification Committee. California Environmental Protection Agency (CalEPA), Office of Environmental Health Hazard Assessment (OEHHA), Sacramento, CA. http://www.oehha.ca.gov/prop65/CRNR_notices/pdf_zip/Vinclozolin090806.pdf
   Google Scholar
• Cantin AM, North SL, Hubbard RC, Crystal RG. (1987). Normal alveolar epithelial lining fluid contains high levels of glutathione. J App Physiol, 63, 152–7.
   PubMed Web of Science ®Google Scholar
• Casanova M, Heck HD. (1987). Further studies of the metabolic incorporation and covalent binding of inhaled [3 H]- and [14C]formaldehyde in Fischer-344 rats: effects of glutathione depletion. Toxicol Appl Pharmacol, 89, 105–21.
   PubMed Web of Science ®Google Scholar
• Casanova M, Heck HA. (1997). Lack of evidence for the involvement of formaldehyde in the hepatocarcinogenicity of methyl tertiary-butyl ether in CD-1 mice. Chem Biol Interact, 105, 131–43.
   PubMed Web of Science ®Google Scholar
• Casanova M, Heck HD, Everitt JI, Harrington Jr WW, Popp JA. (1988). Formaldehyde concentrations in the blood of Rhesus monkeys after inhalation exposure. Fd Chem Toxicol, 26, 715–6. As cited in NRC 2011.
   PubMed Web of Science ®Google Scholar
• Casanova M, Devo DF, Heck HD. (1989). Covalent binding of inhaled formaldehyde to DNA in the nasal mucus of Fischer 344 rats: analysis of formaldehyde and DNA by high performance liquid chromatography and provisional pharmacokinetic interpretation. Fundam Appl Toxicol, 12, 397–417.
   PubMedGoogle Scholar
• Casanova M, Morgan KT, Steinhagen WH, Everitt JI, Popp JA, Heck HD. (1991). Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam Appl Toxicol, 17, 409–28.
   PubMedGoogle Scholar
• Casanova M, Morgan KT, Gross EA, Moss OR, Heck HA. (1994). DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam Appl Toxicol, 23, 525–36. As cited in BfR 2006.
   PubMedGoogle Scholar
• Casanova-Schmitz M, Heck HD. (1983). Effects of formaldehyde exposure on the extractability of DNA from proteins in the rat nasal mucosa. Toxicol Appl Pharmacol, 70, 121–32.
   PubMed Web of Science ®Google Scholar
• Casanova-Schmitz M, Starr TB, Heck HD. (1984a). Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C]- and [3 H]formaldehyde. Toxicol Appl Pharmacol, 76, 26–44.
   PubMed Web of Science ®Google Scholar
• Casanova-Schmitz M, David RM, Heck HD. (1984b). Oxidation of formaldehyde and acetaldehyde by NAD+-dependent dehydroge-nases in rat nasal mucosal homogenates. Biochem Pharmacol, 33, 1137–42.
   PubMed Web of Science ®Google Scholar
• Casarett LJ, Doull J, Klaassen CD. (2008). Casarett and Doull's Toxicology: The Basic Science of Poisons. New York, NY: McGraw-Hill Companies, Inc, pp. 19–26, 116–19, 423–4.
   Google Scholar
• Chang LW, McMillan L, Wynne BR, Pereira MA, Colley RA, Ward JB, Legator MS. (1983a). The evaluation of six monitors from the exposure to formaldehyde in laboratory animals. Environ Mutagen, 5, 381–7. As cited in: WHO IPCS1997.
   Google Scholar
• Chang JCF, Gross EA, Swenberg JA, Barrow CS. (1983b). Nasal cavity deposition, histopathology, and cell proliferation after single or repeated formaldehyde exposures in B6C3F1 mice and F-344 rats. Toxicol Appl Pharmacol, 68, 161–76.
   PubMed Web of Science ®Google Scholar
• Charbonneau M, Strasser J Jr, Lock EA, Turner MJ Jr, Swenberg JA. (1989). Involvement of reversible binding to alpha 2 u-globulin in 1,4-dichlorobenzene-induced nephrotoxicity. Toxicol Appl Pharmacol, 99, 122–32.
   PubMed Web of Science ®Google Scholar
• Checkoway H, Boffetta P, Mundt DJ, Mundt KA. (2012). Critical review and synthesis of the epidemiologic evidence on formaldehyde exposure and risk of leukemia and other lymphohematopoietic malignancies. Cancer Causes Control, 23, 1747–66.
   PubMed Web of Science ®Google Scholar
• Chen CS, Hseu YC, Liang SH, Kuo JY, Chen SC. (2008). Assessment of genotoxicity of methyl-tert-butyl ether, benzene, toluene, ethylbenzene, and xylene to human lymphocytes using comet assay. J Hazard Mater, 153, 351–6.
   PubMed Web of Science ®Google Scholar
• Cherkasov VG, Vasilenko DA, Parakhin AA. (2010). Ultrastructual modifications in neurons of the rat frontal cortex induced by intoxication by tert-butyl methyl ether. Neurophysiol, 42, 471–81.
   Google Scholar
• Chun JS, Burleigh-Flayer HD, Kintigh WJ. (1992). Methyl Tertiary Butyl Ether: Vapor Inhalation Oncogenicity Study in Fischer 344 Rats. BRRC Report, 91 N0013B, November 13, 1992. Union Carbide, Bushy Run Research Center, Export, PA, 1463 pp.
   Google Scholar
• Cinelli S, Ciliutti P, Falezza A, Meli C, Caserta L, Marchetti S, et al. (1992).Absence of mutagenicity of methyl-tertiary-butyl ether. Toxicol Lett, 300, P36/P10. As cited in: EU 2002.
   Google Scholar
• Cirvello JD, Radovsky A, Heath JE, Farnell DR, Lindamood C. (1995). Toxicity and carcinogenicity of t-butyl alcohol in rats and mice following chronic exposure in drinking water. Toxicol Industr Health, 11, 151–65.
   PubMed Web of Science ®Google Scholar
• Clegg ED, Cook JC, Chapin RE, Foster PMD, Daston GP. (1997).Leydig cell hyperplasia and adenoma formation: mechanisms and relevance to humans. Reprod Toxicol, 11, 107–21.
   PubMed Web of Science ®Google Scholar
• Cochran WG. (1954). Some methods of strengthening the common χ2 tests. Biometrics, 10, 417–51.
   Web of Science ®Google Scholar
• Coggon D, Harris EC, Poole J, Palmer KT. (2003). Extended follow-up of a cohort of British chemical workers exposed to formaldehyde. J Natl Cancer Inst, 95, 1608–15.
   PubMed Web of Science ®Google Scholar
• Conaway CC, Whysner J, Verna LK, Williams GM. (1996). Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation. Pharmacol Ther, 71, 29–55. As cited in: U.S. EPA 2010.
   PubMed Web of Science ®Google Scholar
• Conolly RB, Kimbell JS, Janszen D, Schlosser PM, Kalisak D, Preston J, Miller F. (2003). Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol Sci, 75, 423–47.
   PubMedGoogle Scholar
• Cook JC, Klinefelter GR, Hardisty JF, Sharpe RM, Foster P. (1999). Rodent Leydig cell tumorigenesis: a review of the physiology, pathology, mechanisms, and relevance to humans. Crit Rev Toxicol, 29, 169–261.
   PubMed Web of Science ®Google Scholar
• Crebelli R, Conti G, Conti L, Carere A. (1989). A comparative study on ethanol and acetaldehyde as inducers of chromosome malsegregation in Aspergillus nidulans. Mutat Res, 215, 187–95. As cited in: WHO IPCS1997.
   PubMed Web of Science ®Google Scholar
• Crump KS, Hoel DG, Langley CH, Peto R. (1976). Fundamental carcinogenic processes and their implications for low dose risk assessment. Cancer Res, 36, 2973–9.
   PubMed Web of Science ®Google Scholar
• Cruzan G. (2009). Assessment of the cancer potential of methanol, a review article. Crit Rev Toxicol, 39, 347–63.
   PubMed Web of Science ®Google Scholar
• Cruzan G, Borghoff SJ, de Peyster A, Hard GC, McClain M, McGregor DB, Thomas MG. (2007). Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents. Regul Toxicol Pharmacol, 47, 156–65.
   PubMed Web of Science ®Google Scholar
• Dalmay T, Edwards DR. (2006). MicroRNAs and the hallmarks of cancer. Oncogene, 25, 6170–5.
   PubMed Web of Science ®Google Scholar
• Damian P, Raabe OG. (1996). Toxicokinetic modeling of dose-dependent formate elimination in rats: in vivo-in vitro correlations using the perfused rat liver. Toxicol Appl Pharmacol, 139, 22–32.
   PubMed Web of Science ®Google Scholar
• Dass PD, Bermes EW Jr, Holmes EW. (1992). Renal and hepatic output of glutathione in plasma and whole blood. Biochem Biophys Acta, 1156, 99–102.
   PubMed Web of Science ®Google Scholar
• Dekant W, Bernauer U, Rosner E, Amberg A. (2001).Biotransformation of MTBE, ETBE, and TAME after inhalation or ingestion in rats and humans. Res Rep Health Effects Inst, 102, 29–71.
   PubMedGoogle Scholar
• de Peyster A, MacLean KJ, Stephens BA, Ahern LD, Westover CM, Rozenshteyn D. (2003).Subchronic studies in Sprague-Dawley rats to investigate mechanisms of MTBE-induced Leydig cell cancer. Toxicol Sci, 72, 31–42.
   PubMed Web of Science ®Google Scholar
• de Peyster A, Rodriguez A, Shuto YR, Goldberg B, Gonzales F, Pu X, Klaunig JE. (2008). Effect of oral methyl-t-butyl ether (MTBE) on the male mouse reproductive tract and oxidative stress in liver. Reproduc Toxicol, 26, 246–53.
   PubMed Web of Science ®Google Scholar
• Deichmann WB, Henschler D, Holms-Tedt B, Keil G. (1986). What is there that is not a poison? A study of the Third Defense by Paracelsus. Arch Toxicol, 58, 207–13.
   PubMed Web of Science ®Google Scholar
• Demerec M, Bertaini G, Flint J. (1951). A survey of chemicals for mutagenic action on E. coli. Am Nat, 85, 9–36. As cited in: Nair and Andersen 1997.
   Google Scholar
• Dinse GE, Peddada SD, Harris SF, Elmore S. (2010). Comparison of NTP historical control tumor incidence rates in female Harlan Sprague Dawley and Fischer 344/N Rats. Toxicol Pathol, 38, 765–75.
   PubMed Web of Science ®Google Scholar
• Dodd D, Willson G, Parkinson H, Bermudez E. (2013).Two-year drinking water carcinogenicity study of methyl tertiary-butyl ether (MTBE) in Wistar rats. J Appl Toxicol, 33, 593–606.
   PubMed Web of Science ®Google Scholar
• Doi AM, Hill G, Seely J, Hailey JR, Kissling G, Bucher JR. (2007). Alpha 2 u-globulin nephropathy and renal tumors in national toxicology program studies. Toxicol Pathol, 35, 533–40.
   PubMed Web of Science ®Google Scholar
• Dong-mei L, Yi G, Chun-Tao Y, Yu-feng H, Xiao-dong H. (2009). Effects of subchronic methyl tert-butyl ether exposure on male Sprague-Dawley rats. Toxicol Indust Health, 25, 15–23.
   PubMed Web of Science ®Google Scholar
• Du HF, Xu LH, Wang HF, Liu YF, Tang XY, Liu KX, Peng SX. (2005). Formation of MTBE-DNA adducts in mice measured with accelerator mass spectrometry. Environ Toxicol, 20, 397–401.
   PubMed Web of Science ®Google Scholar
• Duan X, Plopper C, Brennan P, Buckpitt A. (1996). Rates of glutathione synthesis in lung subcompartments of mice and monkeys: possible role in species and site selective injury. J Pharmacol Exp Ther, 277, 1402–9.
   PubMed Web of Science ®Google Scholar
• Duesberg P, Rausch C, Rasnik D, Hehlmann R. (1998). Genetic instability of cancer cells is proportional to their degree of aneuploidy. Proc Natl Acad Sci USA, 95, 13692–7.
   PubMed Web of Science ®Google Scholar
• Eaton DL, Bammer TK. (1999). Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol Sci, 49, 156–64.
   PubMed Web of Science ®Google Scholar
• Eells JT, Makar AB, Noker PE, Tephly TR. (1981). Methanol poisoning and formate oxidation in nitrous oxide-treated rats. J Pharmacol Exp Ther, 217, 57–60.
   PubMed Web of Science ®Google Scholar
• Eells JT, Black KA, Tedford CE, Tephly TR. (1983).Methanol toxicity in the monkey: effects of nitrous oxide and methionine. J Pharmacol Exp Ther, 227, 349–53.
   PubMed Web of Science ®Google Scholar
• EFSA (2012). Minimum Criteria for the acceptance of in vivo alkaline Comet Assay Reports. European Food Safety Authority (EFSA), Scientific Report. EFSA, Parma, Italy. EFSA J, 10:2977. http://www.efsa.europa.eu/en/efsajournal/doc/2977.pdf
   Google Scholar
• EG&G Mason. (1981a). Salmonella/Mammalian-Microsome Preincubation Mutagenicity Assay. Test Article I.D. t-butyl alcohol - 99.9%. Submitted to the U.S. EPA under TSCA Section 8D by the ARCO Chemical Company. EG & G Mason Research Institute (EG&G Mason), ARCO Chemical Company, Worcester, MA. Microfiche No. OTS0572356. As cited in: NSF 2003.
   Google Scholar
• EG&G Mason. (1981b). Salmonella/Mammalian-Microsome Preincubation Mutagenicity Assay. Test article I.D. t-butyl alcohol - Arconol. Submitted to the U.S. EPA under TSCA Section, 8D by the ARCO Chemical Company. EG & G Mason Research Institute (EG&G Mason), ARCO Chemical Company, Worcester, MA. Microfiche No. OTS0572363. As cited in: NSF 2003.
   Google Scholar
• EG&G Mason. (1981c). Evaluation of Test Article T-Butyl Alcohol 99.9% (MRI #635) & Arconol (MRI # 636) for Mutagenic Potential Employing the L5178Y TK +/− Mutagenesis Assay. Submitted to the U.S. EPA under TSCA Section, 8D by the ARCO Chemical Company. EG&G Mason Research Institute (EG&G Mason), ARCO Chemical Company, Worcester, MA. Microfiche No. OTS0572365. As cited in: NSF 2003.
   Google Scholar
• EG&G Mason. (1981d). An In Vitro Evaluation of t-Butyl Alcohol 99.9% To Produce Sister Chromatid Exchanges In Chinese Hamster Ovary Cells. Submitted to the U.S. EPA under TSCA Section, 8D by the ARCO Chemical Company. EG & G Mason Research Institute (EG&G Mason), ARCO Chemical Company, Worcester, MA. Microfiche No. OTS0572357. As cited in: NSF 2003.
   Google Scholar
• Elhajouji A, Van Hummelen P, Kirsch-Volders M. (1995). Indications for a threshold of chemically-induced aneuploidy in vitro in human lymphocytes. Environ Molec Mutagen, 26, 292–304.
   PubMed Web of Science ®Google Scholar
• Elhajouji A, Lukamowicz M, Cammerer Z, Kirsch-Volders M. (2011). Potential thresholds for genotoxic effects by micronucleus scoring. Mutagenesis, 26, 199–204.
   PubMed Web of Science ®Google Scholar
• EU. (2002). EU Risk Assessment Report: Tert-Butyl Methyl Ether, Risk Assessment (CAS No. 1634–04-4, EINECS No.: 216–653-1). 3rd Priority List, Vol. 19, EUR 20417 EN, Final Report, 2002. European Union (EU), European Chemicals Bureau, Helsinki, Finland. http://www.efoa.eu/documents/document/20100715150023-mtbe_-_eu_risk_assessment_report_-_2002.pdf
   Google Scholar
• Fan VS, Savage RE Jr, Buckley TJ. (2007). Methods and measurements for estimating human dermal uptake of volatile organic compounds and for deriving dermal permeability coefficients. Toxicol Mechanisms Meth, 17, 295–304.
   PubMed Web of Science ®Google Scholar
• Fennell TR. (1994). Development of methods for measuring biological markers of formaldehyde exposure. Res Rep Health Eff Inst, 1–20, discussion 21–26. As cited in: U.S. EPA 2010.
   PubMedGoogle Scholar
• Festig MFW. (2010). Inbred strains should replace outbred stocks in toxicology, safety testing, and drug development. Toxicol Pathol, 38681–690.
   Google Scholar
• Foster MD. (2007). Induction of Leydig cell tumors by xenobiotics. In: Payne AH, Hardy MP, Eds. Contemporary Endocrinology: The Leydig Cell in Health and Disease. ISBN: 987-1-59745-453-7. Humana Press, Totowa, NJ, pp. 383–413.
   Google Scholar
• Gentry PR, Rodricks JV, Turnbull D, Bachand A, Van Landingham C, Shipp AM, et al. (2013). Formaldehyde exposure and leukemia: critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility. Crit Rev Toxicol, 43, 661–70.
   PubMed Web of Science ®Google Scholar
• German J, Bloom D, Passarge E. (1984).Bloom's syndrome XI. Progress report for 1983. Clin Genet, 25, 166–74.
   PubMed Web of Science ®Google Scholar
• Gillette JR. (1985). Biological variation: the unsolvable problem in quantitative extrapolation from laboratory animals and other surrogate systems to human populations. In: Hoel DG, Merrill RA, Perea FP, Eds. Banbury Report 19: Risk Quantitation and Regulatory Policy. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 199–209.
   Google Scholar
• Golden R. (2011). Identifying an indoor air exposure limit for formaldehyde considering both irritation and cancer hazards. Crit Rev Toxicol, 41, 672–721.
   PubMed Web of Science ®Google Scholar
• Gottschling, LM. Beaulieu, HJ. Melvin, WW. (1984). Monitoring of formic acid in urine of humans exposed to low levels of formaldehyde. Am Ind Hyg Assoc J, 45, 19–23. As cited in: U.S. EPA 2010.
   PubMed Web of Science ®Google Scholar
• Haddad JJ. (2004). Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int Immunopharmacol, 4, 475–93.
   PubMed Web of Science ®Google Scholar
• Hagan JP, Croce CM. (2007). MicroRNAs in carcinogenesis. Cytogenet Genome Res, 118, 252–9.
   PubMed Web of Science ®Google Scholar
• Hamir AN, Raju N, Hable C, Rupprecht CE. (1992). Retrospective study of testicular degeneration in raccoons with canine distemper infection. J Vet Diagnos Invest, 4, 159–63.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weingberg RA. (2000). The hallmarks of cancer. Cell, 100, 57–70.
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weingberg RA. (2011). Hallmarks of cancer: the next generation. Cell, 144, 646–74.
   PubMed Web of Science ®Google Scholar
• Hanzlik RP, Fowler SC, Eells JT. (2005). Absorption and elimination of formate following oral administration of calcium formate in female human subjects. J Am Soc Pharmacol Exper Therap, 33, 282–6.
   Google Scholar
• Hard GC, Alden CL, Bruner RHG, Frith CH, Lewis RM, Owen RA, et al. (1999). Non-proliferative lesions of the kidney and lower urinary track in the rat. In: Guides for Toxicologic Pathology, STP/ARP/AFIP, Washington, DC, pp. 1–9. Available at: https://www.toxpath.org/ssdnc/KidneyBladderNonprolifRat.pdf
   Google Scholar
• Hard GC, Bruner RH, Cohen SM, Pletcher JM, Regan KS. (2011). Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: a pathology working group review and re-evaluation. Regul Toxicol Pharmacol, 59, 430–6.
   PubMed Web of Science ®Google Scholar
• Hard GC, Betz LJ, Seely JC. (2012). Association of advanced chronic progressive nephropathy (CPN) with renal tubule tumors and precursor hyperplasia in control F344 rats from two-year carcinogenicity studies. Toxicol Pathol, 40, 473–81.
   PubMed Web of Science ®Google Scholar
• Hard GC, Banton MI, Bretzlaff RS, Dekant W, Fowles JR, Mallett AK, et al. (2013). Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity. Toxicol Sci, 132, 268–75.
   PubMed Web of Science ®Google Scholar
• Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. (2003). Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries. J Natl Cancer Inst, 95, 1615–23.
   PubMed Web of Science ®Google Scholar
• Hauptmann M, Lubin JH, Stewart PA, Hayes RB, Blair A. (2004).Mortality from solid cancers among workers in formaldehyde industries. Am J Epidemiol, 159, 1117–30.
   PubMed Web of Science ®Google Scholar
• Hauptmann M, Stewart PA, Lubin JH, Beane Freeman LE, Hornung RW, Herrick RF, et al. (2009). Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde. J Natl Cancer Inst, 101, 1696–708.
   PubMed Web of Science ®Google Scholar
• Heck H, Casanova M. (2004). The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity. Regul Toxicol Pharmacol, 40, 92–106.
   PubMed Web of Science ®Google Scholar
• Heck HD, Casanova-Schmitz M. (1984). The relevance of disposition studies to the toxicology of formaldehyde. CIIT Activities, 4, 1–5. As cited in: U.S. EPA 2010.
   Google Scholar
• Heck HD, White EL, Casanova-Schmitz M. (1982). Determination of formaldehyde in biological tissues by gas chromatography/mass spectrometry. Biomed Mass Spectrom, 9, 347–53.
   PubMedGoogle Scholar
• Heck HD, Chin TY, Schmitz MC. (1983). Distribution of [14C] formaldehyde in rats after inhalation exposure. In: Gibson J, Ed. Formaldehyde Toxicity. Hemisphere Publishing Corporation, Washington, DC, p. 26–37. As cited in: U.S. EPA 2010.
   Google Scholar
• Heck HD, Casanova-Schmitz M, Dodd PB, Schachter EN, Witek TJ, Tosun T. (1985). Formaldehyde (CH2O) concentrations in the blood of humans and Fischer-344 rats exposed to CH2O under controlled conditions. Am Ind Hyg Assoc J, 46, 1–3.
   PubMed Web of Science ®Google Scholar
• Hedberg JJ, Griffiths WJ, Nilsson SJF, Höög JO. (2003). Reduction of S-nitrosoglutathione by human alcohol dehydrogenase is an irreversible reaction as analysed by electrospray mass spectrometry . Eur J Biochem, 270, 1249–56.
   PubMedGoogle Scholar
• HEI. (1987). Special Report: automotive methanol vapors and human health: an evaluation of existing scientific information and issues for further research. Health Effects Institute (HEI), Chapel Hill, NC. http://pubs.healtheffects.org/view.php?id = 15 As cited in U.S. EPA (2011).
   Google Scholar
• Hernandez O, Rhomberg L, Hogan K, Siegel-Scott C, Lai D, Grindstaff G, et al. (1994). Risk assessment of formaldehyde. J Haz Mater, 39, 161–172.
   Web of Science ®Google Scholar
• Hodgson E. (2004). A Textbook of Modern Toxicology, 3rd ed. Hoboken, NJ: Wiley-Interscience, John Wiley & Sons, p. 10.
   Google Scholar
• Hong JY, Yang CS, Lee M, Wang YY, Huang WQ, Tan Y, et al. (1997a). Role of cytochromes P450 in the metabolism of methyl tert-butyl ether in human livers. Arch Toxicol, 71, 266–9.
   PubMed Web of Science ®Google Scholar
• Hong JY, Wang YY, Bondoc FY, Yang CS, Lee M, Huang WQ. (1997b). Rat olfactory mucosa displays a high activity in metabolizing methyl tert-butyl ether and other petrol ethers. Fund Appl Toxicol, 40, 205–10.
   PubMedGoogle Scholar
• Hong JY, Wang YY, Bondoc FY, Lee M, Yang CS, Hu WY, Pan J. (1999a). Metabolism of methyl tert-butyl ether and other petrol ethers by human liver microsomes and heterologously expressed human cytochromes P450: identification of CYP2A6 as a major catalyst. Toxicol Appl Pharmacol, 160, 43–8.
   PubMed Web of Science ®Google Scholar
• Hong JY, Wang YY, Bondoc FY, Yang CS, Gomzales FJ, Pan Z, et al. (1999b). Metabolism of methyl tert-butyl ether and other gasoline ethers in mouse liver microsomes lacking cytochrome P450 2E1. Toxicol Lett, 105, 83–8.
   PubMed Web of Science ®Google Scholar
• Hong JY, Wang YY, Mohr SN, Bondoc FY, Deng C. (2001). Human cytochrome P450 isozymes in metabolism and health effects of gasoline ethers. Res Rep Health Eff Inst, 102, 7–27, discussion 95–109.
   PubMedGoogle Scholar
• Horton VL, Higuchi MA, Rickert DE. (1992). Physiologically based pharmacokinetic model for methanol in rats, monkeys, and humans. Toxicol Appl Pharmacol, 117, 26–36.
   PubMed Web of Science ®Google Scholar
• IARC. (1999). IARC Monographs on the Evaluation Of Carcinogenic Risks to Humans, Vol 73: Some Chemicals that Cause Tumours of The Kidney or Urinary Bladder in Rodents and Some Other Substances. International Agency for Research on Cancer (IARC), Lyon, France, pp. 339–83.
   Google Scholar
• IARC. (2012). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 100f–29: A Review of Human Carcinogens: Chemical Agents and Related Occupations: Formaldehyde. International Agency for Research on Cancer (IARC), Lyon, France. http://monographs.iarc.fr/ENG/Monographs/vol100F/pdf
   Google Scholar
• Iavicoli I, Carelli G, Ardito R, Cittadini A, Sgambato A. (2002). Methyl-tertiary-butyl ether (MTBE) inhibits growth and induces cell transformation in rodent fibroblasts. Anticancer Res, 4, 2173–7.
   Google Scholar
• Imbriani M, Ghittori S, Pezzagno G. (1997). Partition coefficients of methyl tert-butyl ether (MTBE). G Ital Med Lav Ergon, 19, 63–5. As cited in EU 2002.
   PubMedGoogle Scholar
• Ji Z, Li X, Fromowitz M, Mutter-Rottmayer E, Tung J, Smith MT, Zhang L. (2014). Formaldehyde induces micronuclei in mouse erythropoietic cells and suppresses the expansion of human erythroid progenitor cells. Toxicol Lett, 224, 233–9.
   PubMed Web of Science ®Google Scholar
• Jiang S, Yu L, Cheng J, Leng S, Dai Y, Zhang Y, et al. (2010). Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde. Mutat Res, 695, 9–15.
   PubMed Web of Science ®Google Scholar
• Johlin FC, Fortman CS, Ngheim DD, Tephly TR. (1987). Studies on the role of folic acid and folate dependent enzymes in human methanol poisoning. Molec Pharmacol, 31, 557–61.
   PubMed Web of Science ®Google Scholar
• Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, et al. (2014). Complete protection against aflatoxin B1-induced liver cancer with a triterpenoid-DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prev Res, 7, 658–75.
   PubMed Web of Science ®Google Scholar
• Kacew S, Festing MF. (1996). Role of rat strain in the differential sensitivity to pharmaceutical agents and naturally occurring substances. J Toxicol Environ Health, 47, 1–30.
   PubMed Web of Science ®Google Scholar
• Kanki K, Nishikawa A, Masumura K, Umemura T, Imazawa T, Kitamura Y, et al. (2005). In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate. Molec Carcinogenesis, 42, 9–17.
   PubMed Web of Science ®Google Scholar
• Katoh M. (1989). New Energy Development Organization Data. Presented at the Methanol Vapors and Health Effects Workshop: What We Know and What We Need to Know - Summary Report. Washington, DC, ILSI Risk Science Institute/US Environmental Protection Agency/Health Effects Institute/American Petroleum Institute, p A-7. As cited in: WHO IPCS1997.
   Google Scholar
• Khalili L, Gholami S, Maryam Ansari-Lari M. (2015). Evaluation of offspring sex ratio, sex hormones and antioxidant enzymes following exposure to methyl tertiary butyl ether in adult male Sprague-Dawley rats. EXCLI J, 14, 75–82.
   Web of Science ®Google Scholar
• Kim D, Andersen ME, Pleil JD, Nylander-French LA, Prah JD. (2007). Refined PBPK model of aggregate exposure to methyl tertiary-butyl ether. Toxicol Lett, 169, 222–35.
   PubMed Web of Science ®Google Scholar
• Kimbell JS, Overton JH, Subramaniam RP, Schlosser PM, Morgan KT, Conolly RB, Miller FJ. (2001). Dosmetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessment. Toxicol Sci, 64, 111–21.
   PubMed Web of Science ®Google Scholar
• Kimmel CA, Kimmel GL, Euling SY. (2006). Developmental and reproductive toxicity assessment for environmental agents. In: Hood RD, Ed. Developmental and Reproductive Toxicology– A Practical Approach, 2nd ed. Boca Raton, FL: CRC Press, pp. 841–75.
   Google Scholar
• King-Herbert A, Thayer K. (2006). NTP workshop: animal models for the NTP rodent cancer bioassay: stocks and strains—Should we switch? Toxicol Pathol, 34, 802–5.
   PubMed Web of Science ®Google Scholar
• Kirsch-Volders M, Tallon I, Tanzarella C, Sgura A, Hermine T, Parry EM, Parry JM. (1996).Mitotic non-disjunction as a mechanism for in vitro aneuploidy induction by x-rays in primary human cells. Mutagenesis, 11, 307–13.
   PubMed Web of Science ®Google Scholar
• Kitchin KT, Brown JL. Dose-response relationship for rat liver DNA damage caused by 49 rodent carcinogens. Toxicol 1994; 88:31–49.
   PubMed Web of Science ®Google Scholar
• Kitchin KT, Brown JL. Dose-response relationship for rat liver DNA damage caused by 1,2-dimethylhydrazine. Toxicol 1996; 114:113–124.
   PubMed Web of Science ®Google Scholar
• Kleinnijehuis AJ, Stall YC, Duistermaat E, Engel R, Woutersen RA. (2013).The determination of exogenous formaldehyde in blood of rats during and after inhalation exposure. Food Chem Toxicol, 52, 105–12.
   PubMed Web of Science ®Google Scholar
• Koskela S, Hakkola J, Hukkanen J, Pelkonen O, Sorri M, Saranen A, et al. (1999).Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem Pharmacol, 57, 1407–13.
   PubMed Web of Science ®Google Scholar
• Kozlosky J, Bonventre J, Cooper K. (2013). Methyl tert butyl ether is anti-angiogenic in both in vitro and in vivo mammalian model systems. J Appl Toxicol, 33, 820–7.
   PubMed Web of Science ®Google Scholar
• Krishnan K, Andersen ME. (1994). Physiologically based pharmacokinetic modeling in toxicology. In: Hayes AW, Ed. Principles and Methods of Toxicology. New York, NY: Raven Press, pp. 149–88.
   Google Scholar
• Lash LH. (2005). Role of glutathione transport processes in kidney function. Toxicol App Pharmacol, 204, 329–42.
   PubMed Web of Science ®Google Scholar
• Leavens TL, Borghoff SJ. (2009). Physiologically based pharmacokinetic model of methyl tertiary butyl ether and tertiary butyl alcohol dosimetry in male rats based on binding to α2 u-globulin. Toxicol Sci, 109, 321–35.
   PubMed Web of Science ®Google Scholar
• Lee CW, Weisel CP. (1998). Determination of methyl tert-butyl ether and tert-butyl alcohol in human urine by high-temperature purge-and-trap gas chromatography-mass spectrometry. J Anal Toxicol, 22, 1–5.
   PubMed Web of Science ®Google Scholar
• Lee LC, Quintana PJE, de Peyster A. (1998). Comet assay evaluation of the effect of methyl t-butyl ether (MTBE) on rat lymphocytes. Society of Toxicology Abstract, 923. As cited in: EU 2002.
   Google Scholar
• Le Gal A, Dréano Y, Gervasi PG, Berthou F. (2001). Human cytochrome P450 2A6 is the major enzyme involved in the metabolism of three alkoxyethers used as oxyfuels. Toxicol Lett, 124, 47–58.
   PubMed Web of Science ®Google Scholar
• Le Gal A, Dréano Y, Lucas D, Berthou F. (2003). Diversity of selective environmental substrates for human cytochrome P450 2A6: alkoxyethers, nicotine, coumarin, N-nitrosodiethylamine, and N-nitrosobenzylmethylamine. Toxicol Lett, 144, 77–91.
   PubMed Web of Science ®Google Scholar
• Lehman-McKeeman LD, Rodriguez PA, Takigiku R, Caudill D, Fey ML. (1989). d-Limonene-induced male rat-specific nephrotoxicity: evaluation of the association between d-limonene and alpha 2 u-globulin. Toxicol Appl Pharmacol, 99, 250–9.
   PubMed Web of Science ®Google Scholar
• Licata AC, Dekant W, Smith CE, Borghoff SJ. (2001). A physiologically based pharmacokinetic model for methyl tert-butyl ether in humans: implementing sensitivity and variability analyses. Toxicol Sci, 62, 191–204.
   PubMed Web of Science ®Google Scholar
• Liebich HM, Forst C. (1984). Hydroxycarboxylic and oxocarboxylic acids in urine: products from branched-chain amino acid degradation and from ketogenesis. J Chromatogr 309, 225–42. As cited in: EU, 2002.
   PubMed Web of Science ®Google Scholar
• Life Science Research. (1989a). Gene Mutation in Chinese Hamster V79 Cells. Test substance: MTBE. pp, 51. Roma: Life Science Research, Roma Toxicology Centre, S.P.A.R.K. As cited in: EU 2002.
   Google Scholar
• Life Science Research. (1989b). Unscheduled DNA Synthesis (Uds) in Primary Rat Hepatocytes (Autoradiographic Method). pp. 79. Roma: Life Science Research, Roma Toxicology Centre, S.P.A.R.K. As cited in: EU, 2002.
   Google Scholar
• Lindamood C III, Farnell DR, Giles HD, Prejean JD, Collins JJ, Takahashi K, Maronpot RR. (1992). Subchronic toxicity studies of t-butyl alcohol in rats and mice. Fundam Appl Toxicol, 19, 91–100.
   PubMedGoogle Scholar
• Litton Bionetics Inc. (1980). Guinea Pig Sensitization Study: TBME-99. Kensington, Maryland: Litton Bionetics, Inc. As cited in: EU, 2002.
   Google Scholar
• Liu L, Hausladen A, Zeng M, Que L, Heltman J, Stamler JS. (2001). A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. Nature, 401, 490–4.
   Google Scholar
• Liu L, Yan Y, Zeng M, Zhang J, Hanes M, Ahearn G, et al. (2004). Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. Cell, 116, 617–28.
   PubMed Web of Science ®Google Scholar
• Longo V, Citti L, Gervasi PG. (1986). Metabolism of diethylnitrosamine by nasal mucosa and hepatic microsomes from hamster and rat: species specificity of nasal mucosa. Carcinogenesis, 7, 1323–8.
   PubMed Web of Science ®Google Scholar
• Longo V, Mazzaccaro A, Ventura P, Gervasi PG. (1992). Drug-metabolizing enzymes in respiratory nasal mucosa and liver of cynomolgus monkey. Xenobiotica, 22, 427–31.
   PubMed Web of Science ®Google Scholar
• Lu SC. (2009). Regulation of glutathione synthesis. Mol Aspects Med, 30, 42–59.
   PubMed Web of Science ®Google Scholar
• Lu K, Collins LB, Ru H, Bermudez E, Swenberg JA. (2010). Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol Sci, 116, 441–51.
   PubMed Web of Science ®Google Scholar
• Lu K, Moeller B, Doyle-Eisele M, McDonald J, Swenberg JA. (2011). Molecular dosimetry of N2-hydroxymethyl-dG DNA adducts in rats exposed to formaldehyde. Chem Res Toxicol, 24, 159–61.
   PubMed Web of Science ®Google Scholar
• Lu K, Gul H, Upton PB, Moeller BC, Swenberg JA. (2012). Formation of hydroxymethyl DNA adducts in rats orally exposed to stable isotope labeled methanol. Toxicol Sci, 126, 28–38.
   PubMed Web of Science ®Google Scholar
• Lutz WK. (1986a). Endogenous formaldehyde does not produce detectable DNA-protein crosslinks in rat liver. Toxicol Pathol, 14, 462–5.
   PubMedGoogle Scholar
• Lutz WK. (1986b). Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens. J Cancer Res Clin Oncol, 112, 85–91.
   PubMed Web of Science ®Google Scholar
• Lutz WK, Lutz RW. (2009). Statistical model to estimate a threshold dose and its confidence limits for the analysis of sublinear dose-response relationships, exemplified for mutagenicity data. Mutat Res, 678, 118–22.
   PubMed Web of Science ®Google Scholar
• Mackerer CR, Angelosanto FA, Blackburn GR, Schreiner CA. (1996). Identification of formaldehyde as the metabolite responsible for the mutagenicity of methyl tertiary-butyl ether in the activated mouse lymphoma assay. Proc Soc Exper Biol Med, 212, 338–41.
   PubMed Web of Science ®Google Scholar
• Malorny VG. (1969). Die akute und chronische toxizitat der ameisensaure und ihrer formiate. Zeitschrift fuer Ernaehrungswissenschaft (in German), 9, 332–9. As cited in: NTP, 1992.
   PubMedGoogle Scholar
• Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. (2009). Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal, 11, 2685–700.
   PubMed Web of Science ®Google Scholar
• Marsh GM, Youk AO, Buchanich JM, Erdal S, Esmen NA. (2007). Work in the metal industry and nasopharyngeal cancer mortality among formaldehyde-exposed workers. Regul Toxicol Pharmacol, 48, 308–19.
   PubMed Web of Science ®Google Scholar
• Martin-Amat G, McMartin KE, Hayreh SS, Hayreh MS, Tephly TR. (1978). Methanol Poisoning: Ocular Toxicity Produced by Formate. Toxicol Appl Pharmacol, 45, 201–8. As cited in: U.S. EPA 2010.
   PubMed Web of Science ®Google Scholar
• Mascotti K, McCullough J, Burger SR. HPC viability measurement: trypan blue versus acridine orange and propidium iodide. Transfusion, 40, 693–6.
   PubMed Web of Science ®Google Scholar
• Matsushita K, Kijima A, Ishii Y, Takasu S, Ji M, Kuroda K, et al. (2013). Development of a medium-term animal model using gpt Delta rats to evaluate chemical carcinogenicity and genotoxicity. J Toxicol Pathol, 26, 19–27.
   PubMed Web of Science ®Google Scholar
• McComb JA, Goldstein DB. (1979). Quantitative comparison of physical dependence on tertiary butanol and ethanol in mice: correlation with lipid solubility. J Pharmacol Exp Ther, 208, 113–17.
   PubMed Web of Science ®Google Scholar
• McGregor D. (2006). Methyl tertiary-butyl ether: studies for potential human health hazards. Crit Rev Toxicol, 36, 319–58.
   PubMed Web of Science ®Google Scholar
• McGregor D. (2010). Tertiary-butanol: a toxicological review. Crit Rev Toxicol, 40, 697–727.
   PubMed Web of Science ®Google Scholar
• McGregor D, Hard GC. (2001). Renal tubule tumor induction by tertiary-butyl alcohol. Toxicol Sci, 61, 1–3.
   PubMed Web of Science ®Google Scholar
• McGregor DB, Martin R, Riach CG, Caspary WJ. (1985). Optimization of a metabolic activation system for use in the mouse lymphoma L5178Y tk + tk_ mutation system. Environ Mutagen, 7, 10. As cited in: WHO IPCS1997.
   PubMedGoogle Scholar
• McGregor DB, Brown A, Cattanach P, Edwards I, McBride D,Caspary WJ. (1988). Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay II: 18 coded chemicals. Environ Mol Mutagen, 11, 91–118. As cited in: NSF 2003.
   PubMed Web of Science ®Google Scholar
• McGregor D, Cruzan G, Callander R, May K, Banton M. (2005). The mutagenicity of tertiary-butyl alcohol, tertiary-butyl acetate and methyl tertiary-butyl ether in Salmonella typhimurium. Mutat Res, 565, 181–9.
   PubMed Web of Science ®Google Scholar
• McKinnon PJ, Caldecott KW. (2007). DNA strand break repair and human genetic disease. Annu Rev Genomics Hum Genet, 8, 37–55.
   PubMed Web of Science ®Google Scholar
• McMartin KE, Martin-Amat G, Noker PE, Tephly TR. (1979).Lack of a role for formaldehyde in methanol poisoning in the monkey. Biochem Pharmacol, 28, 645–9.
   PubMed Web of Science ®Google Scholar
• Meek ME, Bucher JR, Cohen SM, Dellarco V, Hill RN, Lehman-McKeeman LD, et al. (2003). A framework of human relevance analysis of information on carcinogenic modes of action. Critical Rev Toxicol, 336, 591–653.
   Google Scholar
• Mei N, Arlt VM, Phillips DH, Heflich RH, Chen T. (2006). DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver. Mutat Res, 602, 83–91.
   PubMed Web of Science ®Google Scholar
• Meister A, Anderson ME. (1983). Glutathione. Ann Rev Biochem, 52, 711–60.
   PubMed Web of Science ®Google Scholar
• Melnick RL, Burns KM, Ward JM, Huff J. (2012). Chemically exacerbated chronic progressive nephropathy not associated with renal tubular tumor induction in rats: an evaluation based on 60 carcinogenicity studies by the National Toxicology Program. Toxicol Sci, 128, 346–56.
   PubMed Web of Science ®Google Scholar
• Meng F, Bermudez E, McKinzie PB, Andersen ME, Clewell HJ III, Parsons BL. (2010). Measurement of tumor-associated mutations in the nasal mucosa of rats exposed to varying doses of formaldehyde. Regul Toxicol Pharmacol, 57, 274–83.
   PubMed Web of Science ®Google Scholar
• Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G. (1995). Blood and plasma glutathione measured in healthy subjects by HPLC: relation to sex, aging, biological variables, and life habits. Clin Chem, 41, 1509–17.
   PubMed Web of Science ®Google Scholar
• Miller MJ, Ferdinandi ES, Klan M, Andrews LS, Douglas JF, Kneiss JJ. (1997). Pharmacokinetics and disposition of methyl t-butyl ether in Fischer-344 rats. J Appl Toxicol, 17, S3–12.
   PubMed Web of Science ®Google Scholar
• Moeller B, Lu K, Doyle-Eisele M, McDonald J, Gigliotti A, Swenberg JA. (2011). Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure. Chem Res Toxicol, 24, 162–4.
   PubMed Web of Science ®Google Scholar
• Monticello TM, Swenberg JA, Gross EA, Leininger JR, Kimbell JS, Seilkop S, et al. (1996). Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells. Cancer Res, 56, 1012–22.
   PubMed Web of Science ®Google Scholar
• Moolgavkar SH. (1983). Model for human carcinogenesis: action of environmental agents. Environ Health Perspect, 50, 285–91.
   PubMed Web of Science ®Google Scholar
• Moolgavkar SH. (1988). Biologically motivated two-stage model for cancer risk assessment. Toxicol Lett, 43, 139–50.
   PubMed Web of Science ®Google Scholar
• Moser GJ, Wong BA, Wolf DC, Moss WR, Goldsworthy TL. (1996a). Comparative short-term effects of methyl tertiary butyl ether and unleaded gasoline vapor in female B6C3F1 mice. Fundam Appl Toxicol, 31, 173–83.
   PubMedGoogle Scholar
• Moser GJ, Wong BA, Wolf DC, Fransson-Steen RL, Goldsworthy TL. (1996b). Methyl tertiary butyl ether lacks tumor-promoting activity in N-nitrosodiethylamine-initiated B6C3Fl female mouse liver. Carcinogenesis, 17, 2753–61.
   PubMed Web of Science ®Google Scholar
• Moser GJ, Wolf DC, Wong A, Goldsworthy TL. (1997). Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver. Carcinogenesis, 18, 1075–83.
   PubMed Web of Science ®Google Scholar
• Moser GJ, Wolf DC, Sar M, Gaido KW, Janszen D, Goldsworthy TL. (1998). Methyl tertiary butyl ether-induced endocrine alterations in mice are not mediated through the estrogen receptor. Toxicol Sci, 41, 77–87.
   PubMed Web of Science ®Google Scholar
• Nair B, Anderson FA. (1997). Final report on the safety assessment of formic acid. Intl J Toxicol, 16, 221–34.
   Web of Science ®Google Scholar
• NEDO. (1987). Toxicological Research of Methanol as a Fuel for Power Station: Summary Report on Tests with Monkeys, Rats and Mice. Tokyo, Japan: New Energy Development Organization (NEDO). As cited in: NTP, 2002, U.S. EPA 2009, 2011.
   Google Scholar
• Nihlén A, Wålinder R, Löf A, Johanson G. (1995). Liquid/air partition coefficient of methyl and ethyl T-butyl ethers, T-amyl methyl ether and T-butyl alcohol. J Expos Anal Environ Epidemiol, 5, 573–82.
   PubMedGoogle Scholar
• Nihlén A, Wålinder R, Löf A, Johanson G. (1998). Experimental exposure to methyl tertiary-butyl ether. II. Acute effects in humans.Toxicol Appl Pharmacol, 148, 281–7.
   PubMed Web of Science ®Google Scholar
• Nihlén A, Johanson G. (1999). Physiologically based toxicokinetic modeling of inhaled ethyl tertiary-butyl ether in humans. Toxicol Sci, 51, 184–94.
   PubMed Web of Science ®Google Scholar
• Nihlén A, Sumner SC, Löf A, Johanson G. (1999). 13C2-Labeled methyl tert-butyl ether: Toxicokinetics and characterization of urinary metabolites in humans. Chem Res Toxicol, 12, 822–30.
   Google Scholar
• NRC. (1983). Risk Assessment in the Federal Government: Managing the Process. Washington, DC: National Research Council (NRC). National Academies Press.
   Google Scholar
• NRC. (1994). Science and Judgment in Risk Assessment. Washington, DC: National Research Council (NRC). National Academies Press.
   Google Scholar
• NRC. (1996). Toxicological and Performance Aspects of Oxygenated Motor Vehicle Fuels. Washington, DC: National Research Council (NRC), National Academy Press, pp. 113, 115.
   Google Scholar
• NRC. (2011). Review of the Environmental Protection Agency's Draft Iris Assessment of Formaldehyde. Washington, DC: National Research Council (NRC). National Academies Press. http://www.nap.edu/catalog/13142.html
   Google Scholar
• NSF International. (2003). t-Butanol CAS # 75–65-0, oral risk assessment document. t-Butanol – 06/03, June 2003. Ann Harbor, MI: NSF International. http://www.documents.dgs.ca.gov/bsc/pex/exibit_nsf_t_butanol.pdf
   Google Scholar
• NTP. (1992). NTP Technical Report on Toxicity Studies of Formic Acid (CAS No: 64-18-6) administered by inhalation to F344/N rats and B6C3F1 mice. NIH Publication 92-3342, Toxicity Report Series Number 19. Research Triangle Park, NC: National Toxicology Program (NTP).
   Google Scholar
• NTP. (1995). NTP technical report on the toxicology and carcinogenesis studies of t-butyl alcohol in F344/N rats and B6C3F1 mice (drinking water studies). NTP TR 436. National Toxicology Program, Research Triangle Park, NC. http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr436.pdf
   Google Scholar
• NTP. (1997). NTP technical report on toxicity studies of t-butyl alcohol (CAS No. 75-65-0) administered by inhalation to F344/N rats and B6C3F1 mice. NTP Toxicity Report Series No. 53. National Toxicology Program (NTP), Research Triangle Park, NC. http://ntp.niehs.nih.gov/ntp/htdocs/ST_rpts/tox053.pdf
   Google Scholar
• NTP. (1998). Final Report on Carcinogens Background Document for Methyl Tertiary-Butyl Ether. U.S. National Toxicology Program (NTP), Research Triangle Park, NC. http://ntp.niehs.nih.gov/ntp/newhomeroc/other_background/mtbe1_508.pdf
   Google Scholar
• NTP. (2002). NTP-CERHR Expert Panel Report on the Reproductive and Developmental Toxicity of Methanol. NTP-CERHR-MeOH-02, April 2002. National Toxicology Program (NTP), Research Triangle Park, NC.
   Google Scholar
• NTP. (2011). Summary Report of the National Toxicology Program and Environmental Protection Agency‐Sponsored Review of Pathology Materials from Selected Ramazzini Institute Rodent Cancer Bioassays. November 29, 2011. National Toxicology Program (NTP), Research Triangle Park, NC. ntp.niehs.nih.gov/NTP/About_NTP/Partnerships/International/SummaryPWG_Report_RI_Bioassays.pdf
   Google Scholar
• O’Brien J, Renwick AG, Constable A, Dybing E, Müller DJ, Schlatter J, et al. (2006). Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal. Food Chem Toxicol, 44, 1613–35.
   PubMed Web of Science ®Google Scholar
• OECD. (2013). OECD Guidelines for the Testing of Chemicals: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays. OECD Guideline 488, adopted 26 July. (2013). Organization for Economic Co-Operation and Development (OECD), Paris, France. http://www.oecd-ilibrary.org/docserver/download/9713251e.pdf?expires = 1392250703 & id= id&accname = guest&checksum = CDAA696950A7F98BAA0E9
   Google Scholar
• Ohta T, Watanabe-Akanuma M, Tokishita S, Yamagata H. (1999). Mutation spectra of chemical mutagens determined by Lac + reversion assay with Escherichia coli WP3101P-WP3106P tester strains. Mutat Res, 440, 59–74. As cited in: U.S. EPA 2010.
   PubMed Web of Science ®Google Scholar
• Paini A, Scholz G, Marin-Kuan M, Schilter B, O’Brien J, van Bladeren PJ, Rietjens IM. (2011). Quantitative comparison between in vivo DNA adduct formation from exposure to selected DNA-reactive carcinogens, natural background levels of DNA adduct formation and tumour incidence in rodent bioassays. Mutagenesis, 26, 605–18.
   PubMed Web of Science ®Google Scholar
• Palese M, Tephly TR. (1975). Metabolism of formate in the rat. J Toxicol Environ Health, 1, 13–24. As cited in: NTP 1992.
   PubMed Web of Science ®Google Scholar
• Parry EM, Parry JM, Corso C, Doherty A, Haddad F, Hermine TF, et al. (2002). Detection and characterization of mechanisms of action of aneugenic chemicals. Mutagenesis, 17, 509–21.
   PubMed Web of Science ®Google Scholar
• Pereira MA, Chang LW, McMillan L, Ward JB, Legator MS. (1982). Battery of short-term tests in laboratory animals to corroborate the detection of human population exposures to genotoxic chemicals. Environ Mutagen, 4, 317. As cited in: WHO IPCS1997.
   Google Scholar
• Perkins RA, Ward KW, Pollack GM. (1995a).A pharmacokinetic model of inhaled methanol in humans and comparison to methanol disposition in mice and rats. Environ Health Perspect, 103, 726–33. As cited in: NTP 2002.
   PubMed Web of Science ®Google Scholar
• Perkins RA, Ward KW, Pollack GM. (1995b).Comparative toxicokinetics of inhaled methanol in the female CD-1 mouse and Sprague-Dawley rat. Fundam Appl Toxicol, 28, 245–54. As cited in: NTP 2002.
   PubMedGoogle Scholar
• Phillips S, Palmer RB, Brody A. (2008). Epidemiology, toxicokinetics and health effects of methyl tert-butyl ether (MTBE). Toxicol Rev, 4, 115–26.
   Google Scholar
• Pinkerton LE, Hein MJ, Stayner LT. (2004). Mortality among a cohort of garment workers exposed to formaldehyde: an update. Occup Environ Med, 61, 193–200.
   PubMed Web of Science ®Google Scholar
• Plaut GWE, Betheil JJ, Lardy HA. (1950). The relationship of folic acid to formate metabolism in the rat. J Biol Chem, 184, 795–805.
   PubMed Web of Science ®Google Scholar
• Poet TS, Borghoff SJ. (1997).In vitro uptake of methyl tert-butyl ether in male rat kidney: Use of a two compartment model to describe protein interactions. Toxicol Appl Pharmacol, 145, 340–8.
   PubMed Web of Science ®Google Scholar
• Pogribny IP. (2009). MicroRNA dysregulation during chemical carcinogenesis. Epigenomics, 1, 281–90.
   PubMed Web of Science ®Google Scholar
• Potter DW, Finch L, Udinsky JR. (1995).Glutathione content and turnover in rate nasal epithelia. Toxicol App Pharmacol, 135, 185–91.
   PubMed Web of Science ®Google Scholar
• Prah J, Ashley D, Leavens T, Borghoff S, Case M. (2000). Uptake and elimination of methyl tert. butyl ether (MTBE) and tert. butyl alcohol (TBA) in human subjects by the oral route of exposure. Abstract Toxicol, 54, 57. As cited in: EU 2002.
   Google Scholar
• Prah J, Ashley D, Blount B, Case M, Leavens T, Pleil J, Cardinali F. (2004). Dermal, oral, and inhalation pharmacokinetics of methyl tertiary butyl ether (MTBE) in human volunteers. Toxicol Sci, 77, 195–205.
   PubMed Web of Science ®Google Scholar
• Prentice DE, Meikle AW. (1995). A review of drug-induced Leydig cell hyperplasia and neoplasia in the rat and some comparisons with man. Hum Exp Toxicol, 14, 562–72.
   PubMed Web of Science ®Google Scholar
• Prescott-Mathews JS, Wolf DC, Wong BA, Borghoff SJ. (1997). Methyl tert-butyl ether causes alpha2 u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats. Toxicol Appl Pharmacol, 143, 301–14.
   PubMed Web of Science ®Google Scholar
• Prescott-Mathews JS, Poet TS, Borghoff SJ. (1999). Evaluation of the in vivo interaction of methyl tert-butyl ether with alpha2u-globulin nephropathy in male F-344 rats. Toxicol Appl Pharmacol, 157, 60–7.
   PubMed Web of Science ®Google Scholar
• Pyatt D, Natelson E, Golden R. (2008). Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies? Regul Toxicol Pharmacol, 51, 119–33.
   PubMed Web of Science ®Google Scholar
• Quievryn G, Zhitkovich A. (2000).Loss of DNA-protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydroloysis and an active repair process linked to proteosome function. Carcinogenesis, 21, 1573–80.
   PubMed Web of Science ®Google Scholar
• Rao HV, Ginsberg GL. (1997). A physiologically-based pharmacokinetic model assessment of methyl t-butyl ether in groundwater for a bathing and showering determination. Risk Anal, 17, 583–98.
   PubMed Web of Science ®Google Scholar
• RBM. (1996). Study of the Ability of the Test Article Mtbe to Induce Gene Mutation in Strains of Salmonell Typhimurium. Roma, Italy: Istituto di Ricerche Biomediche ‘Antoine Marxer’ RBM S.p.A. As cited in: EU, 2002.
   Google Scholar
• Recio L, Shepard KG, Hernández LG, Kedderis GL. (2012). Dose-response assessment of naphthalene-induced genotoxicity and glutathione detoxication in human TK6 lymphoblasts. Toxicol Sci, 126, 405–12.
   PubMed Web of Science ®Google Scholar
• Richie JP Jr, Skowronski L, Abraham P, Leutzinger Y. (1996). Blood glutathione concentrations in a large-scale human study. Clin Chem, 42, 64–70.
   PubMed Web of Science ®Google Scholar
• Sanghani PC, Stone CL, Ray BD, Pindel EV, Hurley TD, Bosron WF. (2000).Kinetic mechanism of human glutathione-dependent formFDH (ADH3). Biochem, 39, 10720–9.
   PubMed Web of Science ®Google Scholar
• Schneider K, Oltmanns J, Hassauer M. (2004). Allometric principles for interspecies extrapolation in toxicological risk assessment—empirical investigations. Regul Toxicol Pharmacol, 39, 334–7.
   PubMed Web of Science ®Google Scholar
• Sgambato A, Iavicoli I, De Paola B, Bianchino G, Boninsegna A, Bergamaschi A, et al. (2009). Differential toxic effects of methyl tertiary butyl ether and terTBA on rat fibroblasts in vitro. Toxicol Ind Health, 25, 141–51.
   PubMed Web of Science ®Google Scholar
• Shamsipur M, Miran Beigi AA, Teymouri M, Poursaberi T, Mostafavi SM, Soleimani P, et al. (2012). Biotransformation of methyl tert-butyl ether by human cytochrome P450 2A6. Biodegradation, 23, 311–18.
   PubMed Web of Science ®Google Scholar
• Sipi P, Järventaus H, Norppa H. (1992). Sister-chromatid exchanges induced by vinyl esters and respective carboxylic acids in cultured human lymphocytes. Mutat Res, 279, 75–82.
   PubMed Web of Science ®Google Scholar
• Soffritti M, Maltoni C, Maffei F, Biagi R. (1989).Formaldehyde: an experimental multipotential carcinogen. Toxicol Indust Health, 5, 699–730.
   PubMed Web of Science ®Google Scholar
• Soffritti M, Belpoggi F, Cevolani D, Guarino M, Padovani M Maltoni C. (2002). Results of long-term experimental studies on the carcinogenicity of methyl alcohol and ethyl alcohol in rats. Ann NY Acad Sci, 982, 46–69. As cited in: Cruzan 2009.
   PubMed Web of Science ®Google Scholar
• Sperling F, Maxwell ES, Oettingren WFV. (1953). Comparative excretion and distribution of C14-labeled carbonate and formate in large albino rats. 174, 33–8.
   Google Scholar
• Speit G, Zeller J, Schmid O, Elhajouji A, Ma-Hock L, Neuss S. (2009). Inhalation of formaldehyde does not induce systemic genotoxic effects in rats. Mutat Res, 677, 76–85.
   PubMed Web of Science ®Google Scholar
• Speit G, Gelbke HP, Pallapies D, Morfeld P. (2010). Occupational exposure to formaldehyde, hematotoxicity and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev, 19, 1882–4.
   PubMed Web of Science ®Google Scholar
• Speit G, Schütz P, Weber I, Ma-Hock L, Kaufmann W, Gelbke HP, Durrer S. (2011a). Analysis of micronuclei, histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation. Mutat Res, 721, 127–35.
   PubMed Web of Science ®Google Scholar
• Speit G, Kühner S, Linsenmeyer R, Schütz P. (2011b). Does formaldehyde induce aneuploidy? Mutagenesis, 26, 805–11.
   PubMed Web of Science ®Google Scholar
• Stedman DB, Welsch F. (1989).Inhibit ion of DNA synthesis in mouse whole embryo culture by 2-methoxyetic acid and attenuation of the effects by simple physiological compounds. Toxicol Letters, 45, 111–7. As cited in: Nair and Andersen 1997.
   PubMed Web of Science ®Google Scholar
• Stegink LD, Brummel MC, McMartin KE, Martin-Amat G, Filer LJ Jr, Baker GL, Tephyl TR. (1981). Blood methanol concentrations in normal adult subjects administered abuse doses of aspartame. J Toxicol Environ Health, 7, 281–90.
   PubMed Web of Science ®Google Scholar
• Stegink LD, Brummel MC, Filer LJJ, Baker GL. (1983). Blood methanol concentrations in one-year-old infants administered graded doses of aspartame. J Nutr, 113, 1600–1606.
   PubMed Web of Science ®Google Scholar
• Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR, Mudie LJ, et al. (2011). Massive genomic rearrangement acquired in a single catastrophic event during cancer development. Cell, 144, 27–40.
   PubMed Web of Science ®Google Scholar
• Stindl R. (2008). Defining the steps that lead to cancer: replicative telomere erosion, aneuploidy and an epigenetic maturation arrest of tissue stem cells. Med Hypoth, 71, 126–40.
   PubMed Web of Science ®Google Scholar
• Stover PJ. (2009). One-carbon metabolism–genome interactions in folate-associated pathologies. J Nutr, 139, 2402–5.
   PubMed Web of Science ®Google Scholar
• Stratton MR. (2011). Exploring the genomes of cancer cells: progress and promise. Science, 331, 1153–8.
   Google Scholar
• Stumm-Tegethoff BF. (1969). Formaldehyde-induced mutations in Drosophila melanogaster in dependence of the presence of acids. Theor Appl Genet, 39, 330–4. As cited in: NTP 1992.
   PubMed Web of Science ®Google Scholar
• Sul D, Kim H, Oh E, Phark S, Cho E, Choi S, et al. (2007). Gene expression profiling in lung tissues from rats exposed to formaldehyde. Arch Toxicol, 81, 589–97.
   PubMed Web of Science ®Google Scholar
• Swenberg JA. (1993).Alpha 2u-globulin nephropathy: review of the cellular and molecular mechanisms involved and their implications for human risk assessment. Environ Health Perspect, 101, 39–44.
   PubMed Web of Science ®Google Scholar
• Swenberg JA, Gross EA, Martin J, Popp JA. (1983). Mechanisms of formaldehyde toxicity. In Gibson JE, Ed. Formaldehyde Toxicity, Washington, DC: Hemisphere Publishing Corp.
   Google Scholar
• Swenberg JA, Moeller BC, Lu K, Rager JE, Fry R, Starr TB. (2013). Formaldehyde carcinogenicity research: 30 years and counting for mode of action, epidemiology, and cancer risk assessment. Toxicol Pathol, 41, 181–9.
   PubMed Web of Science ®Google Scholar
• Takahashi K, Morita T, Kawazoe Y. (1985).Mutagenic characteristics of formaldehyde on bacterial systems. Mutat Res, 156, 153–61.
   PubMed Web of Science ®Google Scholar
• Takahashi M, Hasegawa R, Furukawa F, Toyoda K, Sato H, Hayashi Y. (1986).Effects of ethanol, potassium metabisulfite, formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with N-methyl-N’-nitro-N-nitrosoguanidine. Jpn J Cancer Res, 77, 118–24.
   PubMedGoogle Scholar
• Takahashi K, Lindamood C III, Maronpot RR. (1993). Retrospective study of possible alpha-2 mu-globulin nephropathy and associated cell proliferation in male Fischer 344 rats dosed with t-butyl alcohol. Environ Health Perspect, 101, 281–5.
   PubMed Web of Science ®Google Scholar
• Tang G, Wang J, Zhuang Z. (1997). Cytotoxicity and genotoxicity of MTBE & its metabolites to human leukemia cells [Abstract of article in Chinese]. Chinese J Prev Med, 31, 334–7.
   Google Scholar
• Temkin CL. (1941). Four Treatises of Theophrastus Bombastus von Hohenheim Called Paracelsus. Seven Defensiones, The Third Defense. Translation from the German, reprinted in 1979. John Hopkins University Press, Baltimore, MD, p. 22. http://books.google.com/books/about/Four_Treatises_of_Theophrastus_Von_Hohen.html?id = yFbB_dizelAC
   Google Scholar
• TERA. (2010). Report on the Peer Review of Methanol Bioassays: Soffritti et al. (2002) and Apaja (1980). March 5, 2010. Toxicology for Excellence in Risk Assessment (TERA), Cincinnati, OH. http://www.tera.org/peer/meetingreports/MethanolFinalReportRevised.pdf
   Google Scholar
• Tephly TR. (1991). The toxicity of methanol. Life Sci, 48, 1031–41. As cited in: Andersen 1997.
   PubMed Web of Science ®Google Scholar
• Thompson CM, Sonawane B, Grafstrom RC. (2009). The ontogeny, distribution and regulation of alcohol dehydrogenase 3: implications for pulmonary physiology. Drug Metab Dispos, 37, 1565–71.
   PubMed Web of Science ®Google Scholar
• Thornton-Manning JR, Nikula KJ, Hotchkiss JA, Avila KJ, Rohrbacher KD, Ding X, Dahl AR. (1997). Nasal cytochrome P450 2A: identification, regional localization, and metabolic activity toward hexamethylphosphoramide, a known nasal carcinogen. Toxicol Appl Pharmacol, 142, 22–30.
   PubMed Web of Science ®Google Scholar
• Til HP, Woutersen RA, Feron VJ, Hollanders VHM, Falke HE. (1989). Two-year drinking-water study of formaldehyde in rats. Fd Chem Toxicol, 27, 77–87.
   PubMed Web of Science ®Google Scholar
• Torres EM, Williams BR, Amon A. (2008). Aneuploidy: cells losing their balance. Genetics, 179, 737–46.
   PubMed Web of Science ®Google Scholar
• Tulpule K, Dringen R. (2012). Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes. GLIA, 60, 582–93.
   PubMed Web of Science ®Google Scholar
• Turini A, Amato G, Longo V, Gervasi PG. (1998). Oxidation of methyl- and ethyl tertiary-butyl ethers in rat liver microsomes: role of the cytochrome P450 isoforms. Archives of Toxicolog, 72, 207–14.
   PubMed Web of Science ®Google Scholar
• U.S. DOE. (2014). U.S. Exports of MTBE. Release date: 6/27/2014. U.S. Department of Energy (DOE), Energy Information Agency, Washington, DC. http://www.eia.gov/dnav/pet/hist/LeafHandler.ashx?n = PET & s = MMTEX_NUS-Z00_1&f = M
   Google Scholar
• U.S. EPA. (1986). Guidelines for Carcinogen Risk Assessment. EP,A/630/R-00/004, September 1986. Federal Register 51(185, September 24): 33992–34003. U.S. Environmental Protection Agency (EPA), Risk Assessment Forum, Washington, DC.
   Google Scholar
• U.S. EPA. (1991). Alpha 2 μ-Globulin: Association with Chemically Induced Renal Toxicity and Neoplasia in the Male Rat. EPA/625/3–91/019F, September 1991. U.S. Environmental Protection Agency (EPA), Office of Water, Washington, DC.
   Google Scholar
• U.S. EPA. (1992). Draft Report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/kg3/4/Day. U.S. Environmental Protection Agency (EPA), Office of Health and Environmental Assessment, Washington, DC. 57 Federal Regist 1992). 57(109 [Friday, June 5, 1992]):24152–73.
   Google Scholar
• U.S. EPA. (1996). Carcinogenicity Peer Review of Vinclozolin (2nd). Memorandum from Anderson D, Rinde E (Health Effects Division), to Welch C, Sdwell B (Registration Division). September 18, 1996. U.S. Environmental Protection Agency (EPA), Office of Prevention, Pesticides and Toxic Substances, Washington, DC.
   Google Scholar
• U.S. EPA. (2002). Review of the Reference Dose and Reference Concentration Processes. EPA/630/P-02/002F, December 2002. U.S. Environmental Protection Agency (EPA), Risk Assessment Forum, Washington, DC.
   Google Scholar
• U.S. EPA. (2005a). Guidelines for Carcinogen Risk Assessment. EPA/630/P-03/001F, March 2005. U.S. Environmental Protection Agency (EPA), Risk Assessment Forum, Washington, DC.
   Google Scholar
• U.S. EPA. (2005b). Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens. EPA/630/R-03/003F, March 2005. U.S. Environmental Protection Agency (EPA), Risk Assessment Forum, Washington, DC.
   Google Scholar
• U.S. EPA. (2007). State Actions Banning MTBE (Statewide). EPA420-B-07–013, August 2007. U.S. Environmental Protection Agency (EPA), Washington, DC.
   Google Scholar
• U.S. EPA. (2008). Regulatory Determinations Support Document for Selected Contaminants from the Second Drinking Water Contaminant Candidate List (CCL 2). Chapter 13: MTBE. EPA 815-R-08-012, June 2008. U.S. Environmental Protection Agency (EPA), Office of Ground Water and Drinking Water, Washington, DC. http://www.epa.gov/safewater/ccl/pdfs/reg_determine2/report_ccl2-reg2_supportdocument_ch01_introduction.pdf
   Google Scholar
• U.S. EPA. (2009). Toxicological Review of Methanol (CAS No. 67-56-1) in Support of Summary Information on the Integrated Risk Information System (IRIS). Review draft. EPA/635/R-09/013, December 2009. U.S. Environmental Protection Agency (EPA), Washington, DC.
   Google Scholar
• U.S. EPA. (2010). Toxicological Review of Formaldehyde: Inhalation Assessment (CAS No. 50-00-0) in Support of Summary Information on the Integrated Risk Information System (IRIS), Vols. I–IV. EPA/635/R-10/002A, June 2, 2010. U.S. Environmental Protection Agency (EPA), Washington, DC. http://cfpub.epa.gov/ncea/iris_drafts/recordisplay.cfm?deid = 223614
   Google Scholar
• U.S. EPA. (2011). Toxicological Review of Methanol (Non-Cancer) (CAS No. 67-56-1) in Support of Summary Information on the Integrated Risk Information System (IRIS). Review draft. EPA/635/R-11/001A, March 2011. U.S. Environmental Protection Agency (EPA), Washington, DC.
   Google Scholar
• U.S. EPA. (2012a). Update on Ramazzini Institute Data in IRIS Assessments. U.S. Environmental Protection Agency (EPA), Integrated Risk Assessment System (IRIS), Washington, DC. http://www.epa.gov/iris/ramazzini.htm (last updated March 8, 2012).
   Google Scholar
• U.S. EPA. (2012b). MTBE (methyl-t-butyl ether) in Drinking Water. U.S. Environmental Protection Agency (EPA), Office of Water, Washington, DC. http://water.epa.gov/drink/contaminants/unregulated/mtbe.cfm (last updated March 6, 2012).
   Google Scholar
• U.S. EPA. (2012c). Benchmark Dose Technical Guidance. EPA/100/R-12/001, June 2012. U.S. Environmental Protection Agency (EPA), Risk Assessment Forum, Washington, DC. http://www.epa.gov/raf/publications/pdfs/benchmark_dose_guidance.pdf
   Google Scholar
• U.S. EPA. (2013). Integrated Risk information System (IRIS). Compare IRIS Values. http://cfpub.epa.gov/ncea/iris/compare.cfm (last updated August 17, 2013).
   Google Scholar
• van Brabant AJ, Stan R, Ellis NA. (2000). DNA helicases, genomic instability, and human genetic disease. Annu Rev Genomics Hum Genet, 1, 409–59.
   PubMed Web of Science ®Google Scholar
• Waalkes MP, Anver M, Diwan BA. (1999). Carcinogenic effects of cadmium in the Noble (NBL/Cr) rat- Induction of pituitary, testicular, and injection site tumors and intraepithelial proliferative lesions of the dorsolateral plate. Toxicol Sci, 52, 154–61.
   PubMed Web of Science ®Google Scholar
• Wahnschaffe U, Bitsch A, Kielhorn J, Mangelsdorf I. (2005). Mutagenicity testing with transgenic mice. Part II: comparison with the mouse spot test. J Carcinogenesis, 4, 4. doi:10.1186/1477-3163-4-4.
   Google Scholar
• Wang HF, Xu LH, Sun HF, Xue B, Liu YF, Peng SX, et al. (2004). High binding of formic acid to biomacromolecules in mice. Nucl Instrum Methods Phys Res B, 223, 745–9.
   Web of Science ®Google Scholar
• Wang M, Cheng G, Balbo S, Carmella SG, Villalta PW, Hecht SS. (2009). Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. Cancer Res, 69, 7170–4.
   PubMed Web of Science ®Google Scholar
• Wang RS, McDaniel LP, Manjanatha MG, Shelton SD, Doerge DR, Mei N. (2010). Mutagenicity of acrylamide and glycidamide in the testes of big blue mice. Toxicol Sci, 117, 72–80.
   PubMed Web of Science ®Google Scholar
• Williams TM, Borghoff SJ. (2000). Induction of testosterone biotransformation enzymes following oral administration of methyl tert-butyl ether to male Sprague-Dawley rats. Toxicol Sci, 57, 147–55.
   PubMed Web of Science ®Google Scholar
• Williams TM, Borghoff SJ. (2001). Characterization of tert-butyl alcohol binding to alpha2u-globulin in F-344 rats. Toxicol Sci, 62, 228–35.
   PubMed Web of Science ®Google Scholar
• Williams TM, Cattley RC, Borghoff SJ. (2000). Alterations in endocrine responses in male Sprague-Dawley rats following oral administration of methyl tert-butyl ether. Toxicol Sci, 54, 168–76.
   PubMed Web of Science ®Google Scholar
• Williams-Hill D, Spears CP, Prakash S, Olah GA, Shamma T, Moin T, et al. (1999). Mutagenicity studies of methyl-tert-butylether using the Ames tester strain TA102. Mutat Res, 446, 15–21.
   PubMed Web of Science ®Google Scholar
• WHO IPCS. (1997). Environmental Health Criteria 196 – Methanol. World Health Organization (WHO), International Programme on Chemical Safety (IPCS), Geneva, Switzerland. http://www.inchem.org/documents/ehc/ehc/ehc196.htm
   Google Scholar
• WHO IPCS. (1998). Environmental Health Criteria 206 – Methyl Tertiary-Butyl Ether. World Health Organization (WHO), International Programme on Chemical Safety (IPCS), Geneva, Switzerland. http://www.inchem.org/documents/ehc/ehc/ehc206.htm
   Google Scholar
• WHO. (2005). Methyl tertiary-Butyl Ether (MTBE) in Drinking-Water: Background Document for Development of WHO Guidelines for Drinking-Water Quality. WHO/SDE/WSH/05.08/122. World Health Organization (WHO), Geneva, Switzerland. http://www.efoa.eu/documents/document/20100811150614-2005_-_who_guidelines_on_mtbe_in_drinking_water.pdf
   Google Scholar
• Wolfram Research. (2012). Wolfram Mathematica 8 Documentation Center. Wolfram Research, Inc., Champaign, IL (www.wolfram.com). http://reference.wolfram.com/mathematica/guide/Mathematica.html
   Google Scholar
• Ye X, Ji Z, Wei C, McHale CM, Ding S, Thomas R, et al. (2013). Inhaled formaldehyde induces DNA-protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice. Environ Molec Mutagen, 54, 705–18.
   PubMed Web of Science ®Google Scholar
• Yoshikawa M, Arashidani K, Katoh T, Kawamoto T, Kodama Y. (1994). Pulmonary elimination of methyl tertiary-butyl ether after intraperitoneal administration in mice. Arch Toxicol, 68, 517–19.
   PubMed Web of Science ®Google Scholar
• Yu GY, Song XF, Liu Y, Sun ZW. (2014). Inhaled formaldehyde induces bone marrow toxicity via oxidative stress in exposed mice. Asian Pac J Cancer Prev, 15, 5253–37.
   PubMed Web of Science ®Google Scholar
• Yuan Y, Wang HF, Sun HF, Du HF, Xu LH, Liu YF, et al. (2007). Adduction of DNA with MTBE and TBA in mice studied by accelerator mass spectrometry. Environ Toxicol, 22, 630–5.
   PubMed Web of Science ®Google Scholar
• Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. (1987). Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen, 9, 1–110. As cited in: NSF 2003.
   PubMedGoogle Scholar
• Zeller J, Neuss S, Mueller JU, Kühner S, Holzmann K, Högel J, et al. (2011).Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions. Mutagen, 26, 555–61.
   PubMed Web of Science ®Google Scholar
• Zhang H, Xu Y, Kamendulis LM, Klaunig JE. (2000). Morphological transformation by 8-hydroxy-2’-deoxyguanosine in Syrian hamster embryo (SHE) cells. Toxicol Sci, 56, 303–12.
   PubMed Web of Science ®Google Scholar
• Zhang L, Steinmaus C, Eastmond DA, Xin XK, Smith MT. (2009). Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res, 681, 150–68.
   PubMed Web of Science ®Google Scholar
• Zhang L, Tang X, Rothman N, Vermeulen R, Ji Z, Shen M, et al. (2010). Occupational exposure to formaldehyde, hematotoxicity, and leukemia-specific chromosome changes in cultured myeloid progenitor cells. Cancer Epidemiol Biomarkers Prev, 19, 80–8.
   PubMed Web of Science ®Google Scholar
• Zhou W, Yuan D, Huang G, Zhang H, Ye S. (2000). Mutagenicity of methyl tertiary butyl ether. J Environ Pathol Toxicol Oncol, 19, 35–9.
   PubMedGoogle Scholar
• Zhu J, Cheng Y, Sun H, Wang H, Li Y, Liu Y, et al. (2010). Incorporation and/or adduction of formic acid with DNA in vivo studied by HPLC-AMS. Nucl Instr Meth Phys Res B, 268, 1317–20.
   Web of Science ®Google Scholar