Sensory Irritation by Airborne Chemicals

References

• Abe M. Effects of mixed NO2-SO2 gas on human pulmonary functions. Bull. Tokyo Med. Dent. Univ. 1967; 14: 415
   PubMedGoogle Scholar
• Adams D. R. Olfactory and non-olfactory epithelia in the nasal cavity of the mouse. Peromyscus, Am. J. Anat. 1972; 133: 37
   PubMedGoogle Scholar
• Adams J. P., Fee N., Kenmore P. I. Tear gas injuries; clinical study of hand injuries and experimental study of its effects on peripheral nerves and skeletal muscles in rabbits. J. Bones Joint Surg. (Am.) 1966; 48A: 436
   Google Scholar
• Alarie Y. Irritating properties of airborne chemicals, a method for detection and evaluation, Gordon Research Conferences on Toxicology and Safety Evaluation. August, 1965
   Google Scholar
• Alarie Y. Screening method for the determination of irritating properties of airborne materials to the upper respiratory tract, plethysmographic method in mice. Edgewood Arsenal, Md. March, 1966, Research Report under Contract no. DA-18–035-AMC-145(A)
   Google Scholar
• Alarie Y. Irritating properties of airborne materials to the upper respiratory tract. Arch. Environ. Health 1966; 13: 433
   PubMed Web of Science ®Google Scholar
• Alarie Y. Sensory irritation of the upper airways by airborne chemicals. Toxicol. Appl. Pharmacol. 1973; 24: 279
   PubMed Web of Science ®Google Scholar
• Alarie Y., Keller L. W. Sensory irritation by capsaicin. Environ. Physiol. Biochem. 1973; 3, in press
   Google Scholar
• Alarie Y., Wakisaka I., Oka S. Sensory irritation by sulfur dioxide and chlorobenzylidene malononitrile. Environ. Physiol. Biochem. 1973; 3: 53
   Google Scholar
• Alarie Y., Wakisaka I., Oka S. Sensory irritation by sulfite aerosols. Environ. Physiol. Biochem. 1973; 3, in press
   Google Scholar
• Alarie Y., Busey W. M., Krumm A. A., Ulrich C. E. Long-term continuous exposure to sulfuric acid mist in cynomolgxis monkeys and guinea-pigs. Arch. Environ. Health 1973; 27: 16
   PubMed Web of Science ®Google Scholar
• Alarie Y., Ulrich C. E., Busey W. E., Krumm A. A., MacFarland H. N. Long-term continuous exposure to sulfur dioxide in cynomolgus monkeys. Arch. Environ. Health 1972; 24: 115
   PubMed Web of Science ®Google Scholar
• Aldaya F. Les modifications réflexes de la respiration par l'excitation du nerf larynge supérieur. C. R. Soc. Biol. (Paris) 1936; 123: 104
   Google Scholar
• Aldaya F. Le controle réflexe de la respiration par la sensibilité du larynx. C. R. Soc. Biol. (Paris) 1936; 123: 1001
   Google Scholar
• Allen W. F. Effect on respiration, blood pressure, and carotid pulse of various inhaled and insufflated vapors when stimulating one cranial nerve and various combinations of cranial nerves, I. branches of the trigeminus affected by these stimulants. Am. J. Physiol 1928; 87: 319
   Google Scholar
• Allen W. F. Effect on respiration, blood pressure and carotid pulse of various inhaled and insufflated vapors when stimulating one cranial nerve and various combinations of cranial nerves, II, vagus and vagotomy experiments. Am. J. Physiol. 1929; 87: 558
   Google Scholar
• Allen W. F. Effect on respiration, blood pressure and carotid pulse of various inhaled and insufflated vapors when stimulating one cranial nerve and various combinations of cranial nerves, III, olfactory and trigeminal stimulated. Am. J. Physiol. 1929; 88: 117
   Google Scholar
• Allen W. F. Effect of various inhaled vapors on respiration and blood pressure in anesthetized, unanesthetized, sleeping and anosmic subjects. Am. J. Physiol. 1929; 88: 620
   Google Scholar
• Allen W. F. Studies on the level of anesthesia for the olfactory and trigeminal respiratory reflexes in dogs and rabbits. Am. J. Physiol. 1936; 115: 579
   Google Scholar
• Allen W. F. A comparative study of the olfactory and trigeminal reflexes elicited by various vapors in different mammals. J. Wash. Acad. Sci. 1936; 26: 466
   Google Scholar
• Allen W. F. Olfactory and trigeminal conditioned reflexes in dogs. Am. J. Physiol. 1937; 118: 532
   Google Scholar
• Alpert M. H., Flacke W. The peripheral effects of anesthetics. Annu. Rev. Pharmacol. 1969; 9: 273
   Google Scholar
• Alpert S. M., Lewis T. R. Unilateral pulmonary function study of ozone toxicity in rabbits. Arch. Environ. Health 1971; 23: 451
   PubMed Web of Science ®Google Scholar
• Alpert S. M., Lewis T. R. Ozone tolerance studies utilizing unilateral lung exposure. J. Appl. Physiol. 1971; 31: 243
   PubMed Web of Science ®Google Scholar
• Alpert S. M., Gardner D. E., Hurst D. J., Lewis T. R., Coffin D. L. Effects of exposure to ozone on defensive mechanisms of the lung. J. Appl. Physiol. 1971; 31: 247
   PubMed Web of Science ®Google Scholar
• Amdur M. O. The influence of aerosols upon the respiratory response of guinea pigs to sulfur dioxide. Am. Ind. Hyg. Assoc. J. 1957; 18: 149
   Google Scholar
• Amdur M. O. The respiratory response of guinea-pigs to sulfuric acid mist. Arch. Ind. Health 1958; 18: 407
   PubMedGoogle Scholar
• Amdur M. O. The physiological response of guinea-pigs to atmospheric pollutants. Int. J. Air Pollut. 1959; 1: 170
   PubMedGoogle Scholar
• Amdur M. O. The response of guinea-pigs to the inhalation of formaldehyde and formic acid alone and with sodium chloride aerosol. Int. J. Air. Pollut. 1960; 3: 201
   PubMedGoogle Scholar
• Amdur M. O. The respiratory response of guinea-pigs to the inhalation of acetic acid vapor. Am. Ind. Hyg. Assoc. J. 1961; 22: 1
   PubMedGoogle Scholar
• Amdur M. O. The effect of high flow-resistance on the response of guinea-pigs to irritants. Am. Ind. Hyg. Assoc. J. 1964; 25: 564
   PubMed Web of Science ®Google Scholar
• Amdur M. O. Respiratory absorption data and SO2 dose-response curves. Arch. Environ. Health 1966; 12: 729
   PubMed Web of Science ®Google Scholar
• Amdur M. O. The respiratory response of guinea-pigs to histamine aerosol. Arch. Environ. Health 1966; 13: 29
   PubMed Web of Science ®Google Scholar
• Amdur M. O. Toxicologic appraisal of particulate matter, oxides of sulfur, and sulfuric acid. J. Air Pollut. Control Assoc. 1969; 19: 638
   PubMedGoogle Scholar
• Amdur M. O. The impact of air pollutants on physiologic responses of the respiratory tract. Proc. Am. Philos. Soc. 1970; 114: 3
   Web of Science ®Google Scholar
• Amdur M. O. Aerosols formed by oxidation of sulfur dioxide. Arch. Environ. Health 1971; 23: 459
   PubMed Web of Science ®Google Scholar
• Amdur M. O., Corn M. The irritant potency of zinc ammonium sulfate of different particle sizes. Am. Ind. Hyg. Assoc. J. 1963; 24: 326
   PubMedGoogle Scholar
• Amdur M. O., Creasia D. A. The irritant potency of m-terphenyl of different particle sizes. Am. Ind. Hyg. Assoc. J. 1966; 27: 349
   PubMed Web of Science ®Google Scholar
• Amdur M. O., Mead J. A method for studying the mechanical properties of the lungs of unanesthetized animals: application to the study of respiratory irritants. Proc. 3rd Natl Air Pollut. Symp., Pasadena, Calif., 1955, 150
   Google Scholar
• Amdur M. O., Mead J. The respiratory response of guinea-pigs to inhalation of ethylene oxide. Arch. Ind. Health. 1956; 14: 553
   PubMedGoogle Scholar
• Amdur M. O., Mead J. Mechanics of respiration in unanesthetized guinea-pigs. Am. J. Physiol. 1958; 192: 364
   PubMed Web of Science ®Google Scholar
• Amdur M. O., Underhill D. The effect of various aerosols on the response of guinea-pigs to sulfur dioxide. Arch. Environ. Health. 1968; 16: 460
   PubMed Web of Science ®Google Scholar
• Amdur M. O., Underhill D. W. Response of guinea-pigs to a combination of sulfur dioxide and open heart dust. J. Air Pollut. Control Assoc. 1970; 20: 31
   PubMedGoogle Scholar
• Amdur M. O., Melvin W. W., Drinker P. Effects of inhalation of sulphur dioxide by man. Lancet 1953; 265: 758
   PubMed Web of Science ®Google Scholar
• Amdur M. O., Silverman L., Drinker P. Inhalation of sulfuric acid mist by human subjects. Arch. Ind. Hyg. Occ. Med. 1952; 6: 305
   PubMedGoogle Scholar
• Andersen H. T. Factors determining the circulatory adjustments to diving, I. Water immersion. Acta Physiol. Scand. 1963; 58: 173
   PubMedGoogle Scholar
• Andersen H. T. The reflex nature of the physiological adjustments to diving, II, Asphyxia. Acta Physiol. Scand. 1963; 58: 186
   PubMedGoogle Scholar
• Andersen H. T. The reflex nature of the physiological adjustments to diving and their afferent pathway. Acta Physiol. Scand. 1963; 58: 263
   PubMedGoogle Scholar
• Andersen H. T. Physiological adaptations in diving vertebrates. Physiol. Rev. 1966; 46: 212
   PubMed Web of Science ®Google Scholar
• Anderson P. Inhibitory reflexes elicited from the trigeminal and olfactory nerves in rabbits. Acta Physiol Scand. 1953; 30: 137
   Google Scholar
• Andrew B. L. Proprioception at the joint of the epiglottis of the rat. J. Physiol. (Lond.) 1954; 126: 507
   Google Scholar
• Andrew B. L. A functional analysis of the myelinat'ed fibres of the superior laryngeal nerve of the rat. J. Physiol. (Land.) 1956; 133: 420
   PubMed Web of Science ®Google Scholar
• Ariens E. J. Pharmacology of bronchodilating and bronchoconstricting drugs. Bronchitis II, N. G. M. Orie, H. J. Sluiter. Royal Van Grocum Ltd., AssenNetherlands 1964; 209
   Google Scholar
• Ash K. O. Chemical sensing: an approach to biological molecular mechanisms using difference spectroscopy. Science 1968; 162: 452
   PubMed Web of Science ®Google Scholar
• Pharmacology of the Lung, Proceedings of the First International Pharmacological Meeting, D. M. Aviado. MacMillan, New York 1963; Vol. 9: 97
   Google Scholar
• Aviado D. M. The lung circulation. Vol. I. Physiology and Pharmacology. Pergamon Press, New York 1965
   Google Scholar
• Aviado D. M. The lung circulation. Vol. 2. Pathologic Physiology and Therapy of Diseases. Pergamon Press, New York 1965
   Google Scholar
• Aviado D. M., Samanek M. Bronchopulmonary effects of tobacco and related substances, II, Bronchocon-strictionand Bronchodilatation: Influence of lung denervation. Arch. Environ. Health 1965; 11: 141
   PubMed Web of Science ®Google Scholar
• Bacq Z. M. Substances thioloprives. Experientia (Basel) 1946; 2: 349
   PubMedGoogle Scholar
• Bacq Z. M. Substances thioloprives. Experientia (Basel) 1946; 2: 385
   PubMedGoogle Scholar
• Bacq Z. M., Fischer P. Reaction des groupes sulfhydriles de 1 'ovalbumine denaturéd avec les corps vésicants et lacrymogencs. Bull. Soc. R. Sci. Liège 1943; 7: 575
   Google Scholar
• Balchum O. J., Dybicki J., Meneely G. R. The adsorption and distribution of S3 5O2, inhaled through the nose and mouth by dogs. Am. J. Physiol. 1959; 197: 1317
   PubMed Web of Science ®Google Scholar
• Balchum O. J., Dybicki J., Meneely G. R. Pulmonary resistance and compliance with concurrent radioactive sulphur distribution in dogs breathing S3 5 O2. J. Appl. Physiol. 1960; 15: 62
   PubMed Web of Science ®Google Scholar
• Ballantyne B., Callaway S. Inhalation toxicology and pathology of animals exposed to o-chlorobenzylidene malononitrile (CS). Med. Sci. Law 1972; 12: 43
   PubMed Web of Science ®Google Scholar
• Banister J., Fegler G., Hebb C. Initial respiratory responses to the intratracheal inhalation of phosgene and ammonia. Q. J. Exp. Physiol. 1950; 35: 233
   Web of Science ®Google Scholar
• Barker R. Organic Chemistry of Biological Compounds. Prentice Hall, Englewood Cliffs, N. J. 1971; 62
   Google Scholar
• Beidler L. M. Physiology of olfaction and gustation. Ann. Otol. Rhinol. Laryngol 1960; 69: 398
   PubMedGoogle Scholar
• Beidler L. M. Taste receptor stimulation. Progr. Biophys. Biophys. Chem. 1962; 12: 107
   Google Scholar
• Beidler L. M. Comparison of gustatory receptors, olfactory receptors, and free nerve endings. Cold Spring Harbor Symposia on Quantitative Biology, Sensory Receptors 1965; 30: 191
   PubMedGoogle Scholar
• Beidler L. M., Tucker D. Response of nasal epithelium to odor stimulation. Science 1955; 122: 76
   PubMed Web of Science ®Google Scholar
• Benarie M., Menard T., Nonat A. Etude de la transformation de 1′anhydride sulfureux en acide sulfurique en relation avec les données climatologiques, dans un ensemble urbain a caractère industriel, Rouen. Atmos. Environ. 1973; 7: 403
   Google Scholar
• Bennett A., Lockett M. F. Method for recording respiratory changes induced in guinea pigs by aerosols of histamine or of specific antigen, and for assessing drugs which antagonise bronchoconstriction. J. Pharm. Pharmacol. 1964; 16: 241
   Web of Science ®Google Scholar
• Bennett E. D., Jayson M. I. V., Rubenstein D., Campbell E. J. M. The ability of man to detect added nonelastic loads to breathing. Clin. Sci. 1962; 23: 155
   PubMed Web of Science ®Google Scholar
• Bert P. Des effets de l'excitation du nerf pneumogastrique, du nerf layrngé supérieur et du nerf nasal sur la respiration. Arch. Physiol. 1869; 2: 179
   Google Scholar
• Bert P. Des effets de l'excitation du nerf pneumogastrique, du nerf layrngé supérieur et du nerf nasal sur la respiration. Arch. Physiol. 1869; 2: 322
   Google Scholar
• Bickerman H. A., Barach A. L., Itkin S., Drimmer F. The experimental production of cough in human subjects induced by citric acid aerosols. Preliminary studies on the evaluation of antitussive agents. Am. J. Med. Sci. 1954; 228: 156
   PubMed Web of Science ®Google Scholar
• von Biebricher W., Reif E., Ulmer W. T. Untersuchungen der lungen resistance bei isolierter Staubreizung der oberen Luftwege. Med. Thorac. 1963; 20: 163
   PubMedGoogle Scholar
• Binger M. W., Gaarde F. W., Markowitz J. A study of bronchial reflexes in the guinea-pigs. Am. J. Physiol. 1931; 96: 647
   Google Scholar
• Biscoe T. J., Shephard R. J. Some responses to the intravascular injection of o-chlorobenzalmalononitrile in cats and dogs. Arch. Int. Pharmacodyn. Ther. 1962; 138: 389
   PubMedGoogle Scholar
• Booth B. H., Patterson R., Talbot C. H. Immediate type hypersensitivity in dogs: cutaneous, anaphylactic and respiratory responses to ascaris. J. Lab. Clin. Med. 1970; 76: 181
   PubMed Web of Science ®Google Scholar
• Bouhuys A., Jönsson R., Lichtneckert S. E., Lundgreen C., Lundin G., Ringcguist T. R. Effects of histamine on pulmonary ventilation in man. Clin. Sci. 1960; 19: 79
   PubMed Web of Science ®Google Scholar
• Brian P. W., Gove J. F., McGowan J. C. Fungistatic activity of ethylenic and acetylenic compounds. Nature (Lond.) 1946; 158: 876
   PubMed Web of Science ®Google Scholar
• Brimblecombe R. W., Green D. M., Muir A. W. Pharmacology of o-chlorobenzylidene malononitrile (CS). Br. J. Pharmacol. 1972; 44: 561
   PubMed Web of Science ®Google Scholar
• Brodie T. G., Russel A. E. On reflex cardiac inhibition. J. Physiol. (Lond.) 1900; 26: 92
   Google Scholar
• Brown G. L., Gray J. A. B. Some effects of nicotine-like substances and their relation to sensory nerve endings. J. Physiol. (Lond.) 1948; 107: 306
   Google Scholar
• But V. I., Klimova-Cherkasova V. I. The study of afferentation from the upper respiratory tract (Br. nasales n. trigemini). Biu, Eksp. Biol. Med. 1967; 64: 13
   PubMedGoogle Scholar
• Carson B. B., Stoughton R. W. Reaction of alpha, beta-unsaturated dinitriles. J. Am. Chem. Soc. 1928; 50: 2825
   Google Scholar
• Carson S., Goldhamer R., Mackars A., Silson J. E. Effects of cigarette smoke on respiratory function. Arch. Environ. Health 1965; 11: 635
   PubMed Web of Science ®Google Scholar
• Casarett L. J. Toxicology: the respiratory tract. Annu. Rev. Pharmacol. 1971; 11: 425
   PubMedGoogle Scholar
• Cauna N. Light and electron microscopal structure of sensory end-organs in human skin. The Skin Senses, D. R. Kenshalo. Charles C Thomas, Springfield, Ill 1968; 15
   Google Scholar
• Cauna N., Hinderer K. H., Wentges R. T. Sensory receptor organs of the human nasal respiratory mucosa. Am. J. Anat. 1969; 124: 187
   PubMedGoogle Scholar
• Chassain A., Florentin E. Influence de l'inhalation d'air froid sur la ventilation pulmonaire chez l' homme. J. Physiol. (Paris) 1964; 58: 193
   Google Scholar
• Cheney F. W., Butler J. The effects of ultrasonically produced aerosols on airway resistance in man. Anesthesiology 1968; 29: 1099
   PubMed Web of Science ®Google Scholar
• Clarke W. B., Bowsher D. Terminal distribution of primary afferent trigeminal fibers in the rat. Exp. Neurol. 1962; 6: 372
   PubMed Web of Science ®Google Scholar
• Colebatch H. J. H. The humoral regulation of alveolar ducts. Airway Dynamics, Physiology and Pharmacology, A. Bouhuys. Charles C Thomas, Springfield, Ill 1970; 169
   Google Scholar
• Constantine H., Dautrebande L., Kaltreider N., Lovejoy F. W., Morrow P., Perkins P. Influence of carbachol and fine dust aerosols upon the breathing mechanics and the lung volumes of normal subjects and of patients with chronic respiratory disease before and after administering sympathomimetic aerosols. Arch. Int. Pharmacodyn. Ther. 1959; 123: 239
   PubMedGoogle Scholar
• Corn M., Kotsko N., Stanton D., Bell W., Thomas A. P. Response of cats to inhaled mixtures of SO2 and SO2-NaCl aerosol in air. Arch. Environ. Health 1972; 24: 248
   PubMed Web of Science ®Google Scholar
• Craigte H. E. The reflex produced by chemical stimulation of the deeper respiratory passages. Am. J. Physiol. 1922; 59: 346
   Google Scholar
• Crozier W. J. Regarding the existence of the “common chemical sense” in vertebrates. J. Comp. Neurol. 1916; 26: 1
   Google Scholar
• Dalhamn T., Rosengren A., Rylander R. Nasal absorption of organic matter in animal experiments: I. Experimental technique and tobacco smoke absorption. Arch. Environ. Health 1971; 22: 554
   PubMed Web of Science ®Google Scholar
• de Daly M. B., Mount L. E. The origin, course and nature of bronchomotor fibres in the cervical sympathetic nerve of the cat. J. Physiol. 1951; 113: 43
   PubMed Web of Science ®Google Scholar
• DaSilva A. M. T., Hamosh P. Effect of smoking a single cigarette on the the “small airways,”. J. Appl. Physiol. 1973; 34: 361
   PubMed Web of Science ®Google Scholar
• Dastoli F. R., Price S. Sweet sensitive protein from bovine taste buds: isolation and assay. Science 1966; 154: 905
   PubMed Web of Science ®Google Scholar
• Dastoli F. R., Lopiekes D. V., Doig A. R. Bitter sensitive protein from porcine taste buds. Nature (Lond.) 1968; 218: 884
   Web of Science ®Google Scholar
• Dautrebande L. La paralysie périphérique du système vasomoteur par le benzol. La syncope adrénalinobenzolique. Arch. Int. Pharmacodyn. Ther. 1933; 44: 394
   Google Scholar
• Dautrebande L. Microaerosols, Physiology, Pharmacology, Therapeutics. Academic Press, New York 1962
   Google Scholar
• Davis T. R. A., Battista S. P., Kensler C. J. Mechanism of respiratory effects during exposure of guinea-pigs to irritants. Arch. Environ. Health 1967; 15: 412
   PubMed Web of Science ®Google Scholar
• Dawson W. W. Chemical stimulation of the peripheral trigeminal nerve. Nature (Lond.) 1962; 196: 341
   PubMed Web of Science ®Google Scholar
• DeGeus J. P., Heuting J. E., Visser P. The bradycardia reflex on local ammonia stimulation of the mucous membrane of the respiratory tract in rabbits. Acta Physiol. Pharmacol. Neerl. 1956; 5: 216
   PubMedGoogle Scholar
• Deichmann W. B., Keplinger M. L., Lanier G. E. Acute effects of nitro-olefins upon experimental animals. Arch. Ind. Health 1968; 18: 312
   Google Scholar
• DeKock M. A. Mechanism of bronchial obstruction in man. Bronchitis III, Proceedings 3rd International Symposium on Bronchitis, N. G. M. Orie, R. Van Der Lende. Charles C Thomas, Springfield, Ill 1970; 300
   Google Scholar
• Dennis M. W., Douglas J. S. Control of bronchomotor tone in spontaneously breathing, unanesthetized guinea-pigs. Airway Dynamics, Physiology and Pharmacology, A. Bouhuys. Charles C Thomas, Springfield, Ill 1970; 253
   Google Scholar
• Dennis M. W., Douglas J. S., Casby J. U., Stolwijk J. A. J., Bouhuys A. On-line analog computer for dynamic lung compliance and pulmonary resistance. J. Appl. Physiol. 1969; 26: 248
   PubMed Web of Science ®Google Scholar
• Desoubry G., Magné H. Nouvelles expériences concernant la syncope primaire laryngo-réflexe au début de l'anesthésie. Bull. Soc. Ther. 1914; 16: 574
   Google Scholar
• Desreux V., Fredericq E., Fischer P. Recherches sur les fonctions sulfurées des protéines. Bull. Soc. Chim. Biol. 1946; 28: 493
   Google Scholar
• Dixon M. Reactions of lachrymators with enzymes and proteins. Symposium on the Biochemical Reactions of Chemical Warfare Agents, R. T. Williams. Cambridge University Press, 1948; 39, Biochemical Society Symposium No. 2
   Google Scholar
• Dixon M., Needham D. M. Biochemical research on chemical warfare agents. Nature 1946; 158: 432
   PubMed Web of Science ®Google Scholar
• Dixon M., Webb E. C. Enzymes. Academic Press, New York 1964; 341
   Google Scholar
• Dixon W. E., Brodie T. G. Contributions to the physiology of the lungs. Part I. The bronchial muscles, their innervation, and the action of drugs upon them. J. Physiol. (Lond.) 1903; 29: 97
   Google Scholar
• Dixon W. E., Ransom F. Broncho-dilator nerves. J. Physiol. (Lond.) 1913; 45: 413
   Google Scholar
• DuBois A. B., Dautrebande L. Acute effects of breathing inert dust particles and of carbachol on the mechanical characteristics of the lung in man. Changes in response after inhaling sympathomimetic aerosols. J. Clin. Invest. 1958; 37: 1746
   PubMed Web of Science ®Google Scholar
• DuBois A. B., Rogers R. M. Respiratory factors determining the tissue concentrations of inhaled toxic substances. Resp. Physiol. 1968; 5: 34
   PubMedGoogle Scholar
• von Ebbecke U., Knuchel F. Uber den trigeminus-atem-, Schluck- und Herzreflex beir, Kaninchen. Arch. Gesamte Physiol. 1943; 247: 255
   Google Scholar
• Egle J. L. Retention of inhaled formaldehyde propionaldehyde and acrolein in the dog. Arch. Environ. Health 1972; 25: 119
   PubMed Web of Science ®Google Scholar
• Elsberg C. A., Levy I., Brewer E. D. The sense of smell. VI. The trigeminal effects of odorous substances. Bull. N. Y. Neurol. Inst. 1935; 4: 270
   Google Scholar
• Fairchild E. J. II, Tolerance mechanisms. Arch. Environ. Health 1967; 14: 111
   PubMed Web of Science ®Google Scholar
• Farah A., Yamodis N. D., Pesah N. The relation of changes in sodium transport to protein bound disulfide and sulfhydryl groups in the toad bladder epithelium. J. Pharmacol. Exp. Ther. 1969; 170: 132
   PubMed Web of Science ®Google Scholar
• Feniak G. The common chemical sense of the frog. Suffield Experimental Station, Ralston, AlbertaCanada 1966, Suffield Technical Paper No. 310
   Google Scholar
• Feniak G. The common chemical sense of the frog, part III. Homologous series of irritants. Suffield Experimental Station, Ralston, AlbertaCanada 1966, Suffield Technical Paper No. 311
   Google Scholar
• Feniak G., Reesor J. B. The common chemical sense of the frog, part II. On the mode of action of benzalmalononitriles and related compounds. Suffield Experimental Station, Ralston, AlbertaCanada 1966, Suffield Technical Paper No. 329
   Google Scholar
• Fillenz M., Woods R. I. Sensory innervation of the airways. Breathing: Hering-Breuer Centenary Symposium, R. Porter. J. & A. Churchill, London 1970; 101
   Google Scholar
• Fischer P. Inactivation de l'uréase par certains toxiques de guerre et vésicants. Bull. Soc. R. Sci. Liége 1943; 12: 235
   Google Scholar
• Forster R. P., Nyboer J. Effects of induced apnea on cardiovascular renal functions in the rabbits. Am. J. Physiol. 1955; 183: 149
   PubMed Web of Science ®Google Scholar
• Franck F. Recherches expérimentales sur les effets cardiaques, vasculaires et respiratoires des excitations douloureuses. C. R. Acad. Sci. [D] (Paris) 1876; 83: 1109
   Google Scholar
• Frank N. R. Studies on the effects of acute exposure to sulphur dioxide in human subjects. Proc. R. Soc. Med. 1964; 57: 1029
   PubMedGoogle Scholar
• Frank N. R. The effects of inhaled pollutants on nasal and pulmonary flow resistance. Ann. Otol. Rhinol. Laryngol 1970; 79: 540
   PubMed Web of Science ®Google Scholar
• Frank N. R., Speizer F. E. SO2 effects on the respiratory system in dogs. Changes in mechanical behavior at different levels of the respiratory system during acute exposure to the gas. Arch. Environ. Health 1965; 11: 624
   PubMed Web of Science ®Google Scholar
• Frank N. R., Amdur M. O., Whittenberger J. L. A comparison of the acute effects of SO2 administered alone or in combination with NaCl particles on the respiratory mechanics of healthy adults. Int. J. Air Water Pollut. 1964; 8: 125
   Google Scholar
• Frank N. R., Mead J., Whittenberger J. L. Comparative sensitivity of four methods for measuring changes in respiratory flow resistance in man. J. Appl. Physiol. 1971; 31: 934
   PubMed Web of Science ®Google Scholar
• Frank N. R., Amdur M. O., Worcester J., Whittenberger J. L. Effects of acute controlled exposure to SO2 on respiratory mechanics in healthy male adults. J. Appl. Physiol. 1962; 17: 252
   PubMed Web of Science ®Google Scholar
• Frank N. R., Yoder R. E., Brain J. D., Yokoyama E. SO2 (3 5 S labeled) absorption by the nose and mouth under conditions of varying concentration and flow. Arch. Environ. Health 1969; 18: 315
   PubMed Web of Science ®Google Scholar
• Frankenhaeuser B., Lundervold A. A note on an inhibitory reflex from the nose on the rabbit. Acta Physiol. Scand. 1949; 18: 238
   PubMedGoogle Scholar
• Gal E. M., Fung F. H., Greenberg D. M. Studies on the biological action of malononitriles. I. The effect of substituted malononitriles on the growth of transplanted tumors in mice. Cancer Res. 1962; 12: 565
   Google Scholar
• Gaskins J. R., Hehir R. M., McCaulley D. F., Ligon W. E. Lacrimating agents (CS and CN) in rats and rabbits. Acute effects on mouth, eyes and skin. Arch. Environ. Health 1972; 24: 449
   PubMed Web of Science ®Google Scholar
• Gerard M. W. Afferent impulses of the trigeminal nerve. Arch. Neurol. Psychiatr. 1923; 9: 306
   Google Scholar
• Gerard R. W. Recent research on respiratory irritants. Advances in Military Medicine, Vol. II, Gilman, et al. Little Brown, Boston 1948; 565
   Google Scholar
• Gilbert N. C., Fenn G. K., LeRoy G. V., Hobbs T. G. The role of “sympathetic inhibition” in the production of attacks of angina pectoris. Trans. Assoc. Am. Physicians 1941; 56: 279
   Google Scholar
• Gold W. M., Kessler G. F., Yu D. Y. C. Role of vagus nerves in experimental asthma in allergic dogs. J. Appl. Physiol. 1972; 33: 719
   PubMed Web of Science ®Google Scholar
• Gold W. M., Kessler G. F., Yu D. Y. C., Frick O. L. Pulmonary physiologic abnormalities in experimental asthma in dogs. J. Appl. Physiol. 1972; 33: 496
   PubMed Web of Science ®Google Scholar
• Green D. M., Tregear R. T. The action of sensory irritants on the cat's cornea. J. Physiol. (Lond) 1964; 175: 37P
   Google Scholar
• Green J. D., DeGroot J., Sutin J. Trigeminobulbar reflex pathways. Am. J. Physiol. 1957; 189: 384
   PubMed Web of Science ®Google Scholar
• Gunnison A. F., Palmes E. D. Persistence of plasma S-Sulfonates following exposure of rabbits to sulfite and sulfur dioxide. Toxicol. Appl. Pharmacol. 1973; 24: 266
   PubMed Web of Science ®Google Scholar
• Guz A., Noble M. I. M., Eisele J. H., Trenchard D. Experimental results of vagal block in cardiopulmonary disease. Breathing: Hering-Breuer Centenary Symposium, R. Porter. J. & A. Churchill, London 1970; 315
   Google Scholar
• Guz A., Noble M. I. M., Widdicombe J. G., Trenchard D., Mushin W. W., Makey A. R. The role of vagal and glossopharyngeal afferent nerves in respiratory sensation, control of breathing and arterial pressure regulation in conscious man. Clin. Sci. 1966; 30: 161
   PubMed Web of Science ®Google Scholar
• Hainsworth R., Jacobs L., Comroe J. H., Jr. Afferent lung denervation by brief inhalation of steam. J. Appl. Physiol. 1973; 34: 708
   PubMed Web of Science ®Google Scholar
• Hansen K., Zipf H. F. Beziehungen zwischen bronchotonus und lungen-vagusafferenzen und ihre pharmakologische Beeinflussung. Arch. Pharmakol. Exp. Pathol. (Naunyn-Schmiedebergs) 1960; 240: 253
   Google Scholar
• Harris A. S. Cardio-inhibitory and vasomotor reflexes from the nose and throat. Ann. Otol. Rhinol. Laryngol. 1939; 48: 311
   Google Scholar
• Hermann H., Emik L. O., Prindle R. A., Fischer W. M. Progress in medical research on air pollution. U.S. Public Health Sen. Radiol. Health Data Rep. 1958; 73: 1055
   PubMed Web of Science ®Google Scholar
• Henderson Y., Haggard H. W. Naxious Gases and the Principles of Respiration Influencing Their Action. Reinhold, New York 1943
   Google Scholar
• Henkin R. I., Bradley D. F. Regulation of taste acuity by thiols and metal ions. Proc. Natl. Acad. Sci. U.S.A. 1969; 62: 30
   PubMed Web of Science ®Google Scholar
• Hensel H., Kenshalo D. R. Warm receptors in the nasal region of cats. J. Physiol. (Lond.) 1969; 204: 99
   Google Scholar
• Heymans C. Action of drugs on carotid body and sinus. Pharmacol. Rev. 1955; 7: 119
   PubMed Web of Science ®Google Scholar
• Heymans C., Bouckaert J. J., Dauttebande L. Sinus carotidien et réflexes respiratoires, III. Sensibilité des sinus carotidiens aux substances chimiques. Action stimulante respiratoire réflexe du sulfure de sodium, du cyanure de potassium, de la nicotine et de la lobeline. Arch. Int. Pharmacodyn. Ther. 1931; 40: 54
   Google Scholar
• Hilding A. C., Filipi A. N. A method of determining nasal filtration of cigarette smoke: application and results in guinea-pigs, anesthetized and soon after death. Ann. Otol. Rhinol. Laryngol. 1966; 75: 714
   PubMed Web of Science ®Google Scholar
• Hitchcock M., Piscitelli D. M., Bouhuys A. Histamine release from human lung by a component of cotton bracts. Arch. Environ. Health. 1973; 26: 177
   PubMed Web of Science ®Google Scholar
• Holmes H. L. A theory for the action of benzalmalononitriles on nerve endings. Part V. Factors governing the addition of amines to benzalmalononitriles and related products. Oxidation products from model compounds. Suffield Experimental Station, Ralston, AlbertaCanada 1962, Suffield Technical Paper No. 234
   Google Scholar
• Holmes O., Troquet J. Activité électrique de fibres vagales afférentes pendant l'intoxication á l'ozone. J. Physiol. (Paris) 1961; 53: 364
   PubMedGoogle Scholar
• Hubbard Jones M. A study of the common chemical sense. Am. J. Physiol. 1954; 67: 696
   Web of Science ®Google Scholar
• Ivanoo I., Korpas J., Tomari Z. Ein Beitrag zur interozeption der Lufwege. Phyniol Bohemoslov. 1956; 5: 84
   PubMedGoogle Scholar
• Jackson K. E. Sternutators. Chem. Rev. 1935; 17: 251
   Google Scholar
• Jackson K. E., Jackson M. A. Lachrymators. Chem. Rev. 1935; 16: 195
   Google Scholar
• Jancso N. Role of the nerve terminals in the mechanism of inflammatory reactions. Bull. Millard Fillmore Hosp. 1960; 7: 53
   Google Scholar
• Jancso N. Desensitization with capsaicin and related acylamides as a tool for studying the function of pain receptors. Proc. 3rd Int. Pharmacol. Meeting, Vol. 9,Pharmacology of pain. Pergamon Press, New York 1968; 33
   Google Scholar
• Jancso N., Jancso-Gabor A., Szolcsanyi J. Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin. Br. J. Pharmacol Chemother. 1967; 31: 138
   PubMed Web of Science ®Google Scholar
• Jancso N., Jancso-Gaboi A., Szolcsanyi J. The role of sensory nerve endings in neurogenic inflammation induced in human skin and in the eye and paw of the rat. Br. J. Pharmacol Chemother. 1968; 33: 32
   PubMed Web of Science ®Google Scholar
• Jancso N., Jancso-Gabor A., Takats I. Pain and inflammation induced by nicotine, acetylcholine and structurally related compounds and their prevention by desensitizing agents. Acta Physiol. Acad. Scient. Hung. 1961; 19: 113
   PubMedGoogle Scholar
• Jancso-Gaboi A., Szolcsanyi J., Jancso N. Irreversible impairment of thermoregulation induced by capsaicin and similar pungent substances in rats and guinea-pigs. J. Physiol. (Loud.) 1970; 206: 495
   PubMed Web of Science ®Google Scholar
• Karczewski W. The electrical activity of the vagus nerve in anaphylactic shock. Acta Allergol. (Kbh.) 1962; 17: 334
   PubMedGoogle Scholar
• Karczewski W., Dautrebande L. New studies on aerosols, XXII. Electrical responses of pulmonary afferent vagal fibers to carbachol microaerosols administered before and after isoproterenol. Arch. Int. Pharmacodyn. Ther. 1964; 148: 287
   PubMedGoogle Scholar
• Kadin A., Winnik M. Reduction and specific alkylation of the receptor of acetylcholine. Proc. Natl. Acad. Sci., U.S.A. 1968; 60: 668
   PubMed Web of Science ®Google Scholar
• Karlin A., Prives J., Deal W., Winnik M. Counting acetylcholine receptors in the eiectroplax. Molecular Properties of Drug Receptors, R. Porter, M. O'Connor. Williams and Wilkins, Baltimore 1970; 247
   Google Scholar
• Katz S., Hones A. D. Medullary respiratory neuron response to pulmonary emboli and pneumothorax. J. Appl. Physiol. 1972; 33: 390
   PubMed Web of Science ®Google Scholar
• Katz B., Thesleff S. A study of the “desensitization” produced by acetylcholine at the motor end-plate. J. Physiol. (Lond.) 1957; 138: 63
   Google Scholar
• Kaufman J., Wright G. W. The effect of nasal and nasopharyngeal irritation on airway resistance in man. Am. Rev. Resp. Dis. 1969; 100: 626
   PubMed Web of Science ®Google Scholar
• Keele C. A. The common chemical sense and its receptors. Arch. Int. Pharmacodyn. Ther. 1962; 139: 547
   PubMedGoogle Scholar
• Kenshalo D. R., Hensel H., Gnziadei P., Fruhstorfer H. On the anatomy, physiology, and psychophysics of the cat's temperature-sensing system. Oral-facial Sensory and Motor Mechanisms, R. Dubner, Y. Kawamura. Appleton-Century-Crofts, New York 1971; 23–43
   Google Scholar
• Kice J. L. The sulfur-sulfur bond. Sulfur In Organic and Inorganic Chemistry, Vol. 1, A. Senning. Dekker, New York 1971; 153
   Google Scholar
• King B., Elder J., Proctor D. F., Dripps R. D. Reflex circulatory responses to tracheal intubation performed under topical anesthesia. Anesthesiology 1954; 15: 231
   PubMed Web of Science ®Google Scholar
• King R. B., Barnett J. C. Studies of trigeminal nerve potentials. Overreaction to tactile facial stimulation in acute laboratory preparation. J. Neurosurg. 1957; 14: 617
   PubMed Web of Science ®Google Scholar
• King R. B., Meagher J. N. Studies of trigeminal nerve potentials. J. Neurosurg. 1955; 12: 393
   PubMed Web of Science ®Google Scholar
• King R. B., Meagher J. N., Barnett J. C. Studies of trigeminal nerve potentials, in normal compared to abnormal experimental preparations. J. Neurosurg. 1956; 13: 176
   PubMed Web of Science ®Google Scholar
• Kisch B. The heart rate and the electrocardiogram of small animals. Exper. Med. Surg. 1953; 11: 117
   PubMedGoogle Scholar
• Kisch B., Yuceoglu Y. Z. Cardiac reflexes elicited from the respiratory tract. Exper. Med. Surg. 1955; 13: 378
   PubMedGoogle Scholar
• Knoll P. Uber die Wirkung von chloroform und ather auf athmung und Blutkreislauf. Aca. Sci. Vienne, Sci: Med. 1879; 233
   Google Scholar
• Koller E. A. Atmung und Kreislauf im anaphylaktischen Asthma bronchiale des meerschweinchens. Helv. Physiol. Acta 1968; 26: 153
   PubMedGoogle Scholar
• Koller E. A., Ferrer P. Discharge patterns of the lung stretch receptors and activation of deflation fibres in anaphylactic bronchial asthma. Resp. Physiol. Pharmacol. 1973; 17: 113
   PubMedGoogle Scholar
• Kratschmer F. Uber Reflexe von der Nasenschleimbaut auf ahtmung und Kreislauf. Akad. Wiss. Lit. Abh. Math.-Naturwiss. Kl (Mainz) 1870; v, 62: 147
   Google Scholar
• Kruger L., Michell F. A morphological and somatotopic analysis of single unit activity in the trigeminal sensory complex of the cat. Exp. Neurol. 1962; 5: 139
   PubMed Web of Science ®Google Scholar
• Lampe K. F., Meude T. J., Deichmann W. B., Eye M. G., Palmer L. F. Evaluation of conjugated nitro-olefins as eye irritants in air pollution. Ind. Med. Surg. 1958; 27: 375
   PubMedGoogle Scholar
• Laqueur E., Magnus R. Uber Kampfgasvergiftugen III. Experimentelle Pathologie des Phosgenvergiftung, Z. Gesamte Exp. Med. 1921; 13: 31
   Google Scholar
• Larsell O., Burget G. E. The effects of mechanical and chemical stimulation of the tracheo-bronchial mucous membrane. Am. J. Physiol. 1924; 70: 311
   Google Scholar
• Lawther P. J. Effects of inhalation of sulphur dioxide on respiration and pulse-rate in normal subjects. Lancet 1955; 269: 745
   PubMedGoogle Scholar
• Lazarus J. Ueber reflexe von des Nasenschleimhaut auf die bronchiallumina. Arch. f.A.u. Physiol. Klin, Med. 1891; 15: 19
   Google Scholar
• Lele P. P., Weddell G. Sensory nerves of the cornea and cutaneous sensibility. Exp. Neurol. 1959; 1: 334
   PubMed Web of Science ®Google Scholar
• Leong K. J., MacFarland H. N. Pulmonary dynamics and retention of toxic gases. I. Sulfur dioxide: concentration and duration effects in rat. Arch. Environ. Health 1965; 11: 555
   PubMed Web of Science ®Google Scholar
• Lough C. E., Currie D. J. The reaction of n-butyl-amine and benzylamine with some β-nitrostyrenes, diethyl benzalmalonates, and cinnamalmalononitriles. Can. J. Chem. 1966; 44: 1563
   Web of Science ®Google Scholar
• Macklem P. T. Airway obstruction and collateral ventilation. Physiol. Rev. 1971; 51: 368
   PubMed Web of Science ®Google Scholar
• Mackworth J. F. The inhibition of thiol enzymes by lachrymators. Biochem. J. 1948; 42: 82
   PubMed Web of Science ®Google Scholar
• Magne H., Mayer A., Plantefol L. Recherches sur les actions réflexes produites par l'irritation des voies respiratoires. Ann. Physiol. 1925; 1: 394
   Google Scholar
• Magne H., Mayer A., Plantefol L. La mort par inhibition et l'irritation des premiéres voies respiratoires. Ann. Physiol. 1925; 1: 428
   Google Scholar
• Makara G. B., Stark E., Mihaly K. Sites at which formalin and capsaicin act to stimulate corticotropin secretion. Can. J. Physiol. Pharmacol. 1967; 45: 669
   PubMedGoogle Scholar
• Massion J., Meulders M., Gijbels J. Etude des réflexes respiratoires provoqués par l'excitation de la muqueuse nasale. Arch. Int. Physiol. Biochem. 1954; 62: 127
   PubMed Web of Science ®Google Scholar
• McNally W. D. Treatment of eye burns produced by tear gas, (chloracetophenone). J. A. M. A. 1932; 98: 45
   Google Scholar
• Melville G. N. Cold II: Nervous pathways in the respiratory response to facial cold. Environ. Physiol Biochem. 1972; 2: 179
   Google Scholar
• Melville G. N., Morris D. Cold I: Effect on airway resistance in health and disease. Environ. Physiol. Biochem. 1972; 2: 107
   Google Scholar
• Meyrick B., Reid L. Nerves in rat intra-acinar alveoli: an electron microscopic study. Resp. Physiol. 1971; 11: 367
   PubMedGoogle Scholar
• Midtbo A. Eye injury from tear gas. Acta Ophthalmol. (Kbh) 1964; 42: 672
   PubMed Web of Science ®Google Scholar
• Mills J. E., Sellick H., Widdicombe J. G. Activity of lung irritant receptors in pulmonary microembolism, anaphylaxis and drug-induced bronchoconstrictions. J. Physiol (Lond) 1969; 203: 337
   Google Scholar
• Mills J. E., Sellick H., Widdicombe J. G. Epithelial irritant receptors in the lungs. Breathing: Hering-Breur Centenary Symposium, R. Porter. J. & A. Churchill, London 1970; 77
   Google Scholar
• Mitchell C. A., Gandevia B. Respiratory symptoms and skin reactivity in workers exposed to proteolytic enzymes in the detergent industry. Am. Rev. Resp. Dis. 1971; 104: 1
   PubMed Web of Science ®Google Scholar
• Miyamoto T., Reynolds L. B., Patterson R., Cugell D. W., Kettel L. J. Respiratory changes in passively sensitized dogs and monkeys as models of allergic asthma. Am. Rev. Resp. Dis. 1968; 97: 76
   PubMed Web of Science ®Google Scholar
• Molnar J. Die pharmakologischen Wirkungen des capsaisins, des scharf schmeckenden Wirkstoffes im paprika. Arzneim. Forsch. 1965; 7: 718
   Google Scholar
• Molnar J. Effect of capsaicin on the cat's nictating membrane. Acta Physiol. Acad. Sci. Hung. 1966; 30: 183
   PubMedGoogle Scholar
• Moncrief R. W. The Chemical Senses. Leonard Hill, London 1967; 298
   Google Scholar
• Moulton D. G. The interrelations of the chemical senses. The Chemical Senses and Nutrition, M. R. Kare, O. Mailer. The Johns Hopkins Press, Baltimore 1967; 249
   Google Scholar
• Murphy S. D., Ulrich C E. Multi-animal test system for measuring effects of irritant gases and vapors on respiratory function of guinea-pigs. Am. Ind. Hyg. Assoc. J. 1964; 25: 28
   PubMedGoogle Scholar
• Murphy S. D., Kingshirm D. A., Ulrich C. E. Respiratory response of guinea-pigs during acrolein inhalation and its modification by drugs. J. Pharmacol. Exp. Ther. 1963; 141: 79
   PubMed Web of Science ®Google Scholar
• Murphy S. D., Ulrich C. E., Leng C. K. Altered function in animals inhaling conjugated nitro-olefins. Toxicol. Appl. Pharmacol. 1963; 5: 319
   PubMed Web of Science ®Google Scholar
• Murphy S. D., Leng J. K., Ulrich C. E., Davis H. V. Effects on animals of exposure to auto exhaust. Arch. Environ. Health 1963; 7: 60
   PubMed Web of Science ®Google Scholar
• Murphy S. D., Ulrich C. E., Frankowitz S. H., Xintaras C. Altered function in animals inhaling low concentrations of ozone and nitrogen dioxide. Am. Ind. Hyg. Assoc. J. 1964; 25: 246
   PubMedGoogle Scholar
• Nadel J. A. Structure-function relationships in the airways: Bronchoconstriction mediated via vagus nerves or bronchial arteries; peripheral lung constriction mediated via pulmonary arteries. Med. Thorac. 1965; 22: 231
   PubMedGoogle Scholar
• Nadel J. A., Widdicombe J. G. Reflex effects of upper airway irritation on total lung resistance and blood pressure. J. Appl. Physiol. 1962; 17: 861
   PubMed Web of Science ®Google Scholar
• Nadel J. A., Salem H., Tamplin B., Tokiwa Y. Mechanism of bronchoconstriction. During inhalation of sulfur dioxide, reflex involving vagus nerves. Arch. Environ. Health 1965; 10: 175
   PubMed Web of Science ®Google Scholar
• Nadel J. A., Salem H., Tamplin B., Tokiwa Y. Mechanism of bronchoconstriction during inhalation of sulfur dioxide. J. Appl. Physiol. 1965; 20: 164
   PubMed Web of Science ®Google Scholar
• Nagaishi C. Functional Anatomy and Histology of the Lung. University Park Press, Baltimore 1972
   Google Scholar
• Nicholls P. J., Evans E., Valic F., Zuskin F. Histamine-releasing activity and bronchoconstricting effects of sisal. Br. J. Ind. Med. 1973; 30: 142
   PubMedGoogle Scholar
• Noble M. I. M., Eisele J. H., Trenchard D., Guz A. Effect of selective peripheral nerve blocks on respiratory sensations. Breathing: Hering-Breuer Centenary Symposium, R. Porter. J. & A. Churchill, London 1970; 233
   Google Scholar
• Paintal A. S. The location and excitation of pulmonary deflation receptors by chemical substances. Q. J. Exp. Physiol. 1957; 42: 56
   PubMedGoogle Scholar
• Paintal A. S. Vagal afferent fibres. Ergebn. Physiol. 1963; 52: 74–156
   PubMedGoogle Scholar
• Paintal A. S. Mechanism of stimulation of type J pulmonary receptors. J. Physiol. (Land) 1969; 203: 511
   PubMed Web of Science ®Google Scholar
• Paintal A. S. The mechanism of excitation of type J receptors, and the J reflex. Breathing: Hering-Breuer Centenary Symposium, R. Porter. J. & A. Churchill, London 1970; 59
   Google Scholar
• Paintal A. S. Vagal sensory receptors and their reflex effects. Physiol. Rev. 1973; 53: 159
   PubMed Web of Science ®Google Scholar
• P'an A. Y. S., Jegier Z. The effect of sulfur dioxide and ozone on acetylcholinesterase. Arch. Environ. Health 1970; 21: 498
   PubMed Web of Science ®Google Scholar
• Parker A. J., Kharasch N. The scission of the sulfur-sulfur bond. Chem. Rev. 1959; 59: 583
   Web of Science ®Google Scholar
• Parker G. H. The relation of Smell, Taste and the Common Chemical Sense in Vertebrates. J. Acad. Natl. Sci. Phila. 1912; 15: 219
   Google Scholar
• Parker G. H. Smell, Taste and Allied Senses in the Vertebrates. J. B. Lippincott, Philadelphia 1922; 102
   Google Scholar
• Pepys J. Hypersensitivity disease of the lungs due to fungi and organic dusts. Monographs in Allergy, Vol. 4. Karger, New York 1969; 147
   Google Scholar
• Peters J. M., Murphy R. L. H., Pagnotto L. D., Whittenberger J. L. Respiratory impairment in workers exposed to “safe” levels of toluene diisocyanate (TDI). Arch. Environ. Health 1970; 20: 364
   PubMedGoogle Scholar
• Peters R. A. Biochemical Lesions and Lethal Synthesis. Pergamon Press, Oxford 1963
   Google Scholar
• Porcelli R. J., Bergofsky E. H. Adrenergic receptors in pulmonary vasoconstrictor responses to gaseous and humoral agents. J. Appl. Physiol. 1973; 34: 483
   PubMed Web of Science ®Google Scholar
• Poulos D. A. Trigeminal temperature mechanisms. Oral-Facial Sensory and Motor Mechanisms, R. Dubner, Y. Kawamura. Appleton-Century-Crofts, New York 1971; 47
   Google Scholar
• Prosser C. L., Brown F. A. Comparative Animal Physiology. Saunders, Philadelphia 1962; 319
   Google Scholar
• Pryor W. A. Mechanisms of Sulfur Reactions. McGraw Hill, New York 1962
   Google Scholar
• Punte C. L., Owens E. J., Gutentag P. J. Exposures to ortho-chlorobenzylidene malononitrile, Controlled human exposures. Arch. Environ. Health 1963; 6: 366
   PubMed Web of Science ®Google Scholar
• Punte C. L., Gutentag P. J., Owens E. J., Gongwer L. E. Inhalation studies with chloracetophenone, diphenyl- aminochloroarsine and pelargonic morpholide, II, Human exposures. Am. Ind. Hyg. Assoc. J. 1962; 23: 199
   PubMedGoogle Scholar
• Punte C. L., Weimer J. T., Ballard T. A., Wilding J. L. Toxicologic studies on o-chlorobenzylidene malononitrile. Toxicol. Appl. Pharmacol. 1962; 4: 656
   PubMed Web of Science ®Google Scholar
• Rall J. E., Gilbert N. C., Trump R. Certain aspects of the bronchial reflexes obtained by stimulation of the nasopharynx. J. Lab. Clin. Med. 1945; 30: 953
   Web of Science ®Google Scholar
• Ramos J. G. On the integration of respiratory movements, III. The fifth nerve afferent. Acta Physiol. Lat. Am. 1959; 10: 104
   Google Scholar
• Rang H. P., Ritter J. M. On the mechanism of desensitization at cholinergic receptors. Mol Pharmacol. 1970; 6: 357
   PubMed Web of Science ®Google Scholar
• Ranson S. W. Afferent paths for visceral reflexes. Physiol. Rev. 1921; 1: 477
   Google Scholar
• Ratner B., Jackson H. C., Gruehl H. L. Respiratory anaphylaxis. Sensitization, shock, bronchial asthma and death induced in the guinea-pig by the nasal inhalation of dry horse dander. Am. J. Dis. Child. 1927; 34: 23
   Google Scholar
• Read E. A. A contribution to the knowledge of the olfactory apparatus in dog, cat and man. Am. J. Anat. 1908; 8: 17
   Google Scholar
• Reid L. C., Brace D. E. Irritation of the respiratory tract and its reflex effect upon the heart. Surg. Gynccol. Obstet. 1940; 70: 157
   Google Scholar
• Reinhardt C. F., Azar A., Maxfield M. E., Smith P. E., Mullin L. S. Cardiac arrhythmias and aerosol “sniffing.”. Arch. Environ. Health 1971; 22: 265
   PubMed Web of Science ®Google Scholar
• Riddiford L. M. Antennal proteins of saturniid moths: their possible role in olfaction. J. Insect Physiol. 1970; 16: 653
   Web of Science ®Google Scholar
• Rijlant P. Le controle réflexe de la respiration par le nerf trijumeau. C. R. Soc. Biol. (Paris) 1941; 135: 398
   Google Scholar
• Roberts J. D., Caserio M. C. Basic Principles of Organic Chemistry. W. A. Benjamin, New York 1965; 265
   Google Scholar
• Robinson J. D. Interaction between protein sulfhydryl groups and lipid double bonds in biological membranes. Nature 1966; 212: 199
   PubMed Web of Science ®Google Scholar
• Rodarte J. R., Hyatt R. E. Effect of acute exposure to CO2 on lung mechanics in normal man. Resp. Physiol. 1973; 17: 135
   PubMedGoogle Scholar
• Roldanus A. Sur l'influence de substances odorantes sur le coeur du lapin. Acta Biol. Neerl. 1948; 16: 15
   Google Scholar
• Rossing R. G. Physiologic effects of chronic exposure to phosgene in dogs. Am. J. Physiol. 1964; 207: 265
   PubMed Web of Science ®Google Scholar
• Roy A. B., Trudinger P. A. The Biochemistry of Inorganic Compounds of Sulphur. Cambridge University Press, Cambridge 1970
   Google Scholar
• Sakada S. Response of Golgi-Mazzoni corpuscles in the cat periostea to mechanical stimulation. Oral-facial Sensory and Motor Mechanism, R. Dubner, Y. Kawamura. Appleton-Century-Crofts, New York 1971; 105
   Google Scholar
• Sakai H. Quantitative microdetermination of total SH groups in proteins. Anal Biochem. 1968; 26: 269
   PubMed Web of Science ®Google Scholar
• Scherf D. Cardiac reflexes originating in the respiratory tract. N. Y. State J. Med. 1945; 45: 1647
   Google Scholar
• Schneider D. Insect olfaction: Deciphering system for chemical messages. Science 1969; 163: 1031
   PubMed Web of Science ®Google Scholar
• Scholander P. F. The master switch of life. Am. Sci. 1963; 209: 92
   Google Scholar
• Schroeter L. Sulfur dioxide. Applications in Food, Beverages, and Pharmaceuticals. Pergamon Press, New York 1966
   Google Scholar
• Sedlak J., Lindsay R. H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's Reagent. Anal. Biochem. 1968; 25: 192
   PubMed Web of Science ®Google Scholar
• Linke W. F. Solubilities of Inorganic and Metal Organic Compounds. The American Chemical Society, Washington, D. C. 1965; Vol. 2: 1413, Seidell, revised by
   Google Scholar
• Sellick H., Widdicombe J. G. The activity of lung irritant receptors during pneumothorax, hyperpnoea and pulmonary vascular congestion. J. Physiol. (Lond.) 1969; 203: 359
   Google Scholar
• Sellick H., Widdicombe J. G. Stimulation of lung irritant receptors by cigarette smoke, carbon dust and histamine aerosols. J. Appl. Physiol. 1971; 3: 15
   Google Scholar
• Shaw R. K., Holmes H. L. The action of benzalmalononitriles on nerve endings, Part VII. Excitation of the frog flexor reflex as an index of sternutatory activity. Suffield Experimental Station, Ralston, AlbertaCanada 1963, Suffield Technical paper No. 233
   Google Scholar
• Sim V. M., Pattle R. E. Effect of possible smog irritants on human subjects. J. A. M. A. 1957; 165: 1908
   PubMed Web of Science ®Google Scholar
• Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airways disease. J. Clin. Invest. 1967; 46: 1812
   PubMed Web of Science ®Google Scholar
• Sobrino J. A., Del Castillo G. Activation of the cholinergic end plate receptors by oxidizing reagents. Int. J. Neurosci. 1972; 3: 251
   PubMed Web of Science ®Google Scholar
• Speizer F. E., Frank N. R. The uptake and release of SO2 by the human nose. Arch. Environ. Health 1966; 12: 725
   PubMed Web of Science ®Google Scholar
• Speizer F. E., Frank N. R. A comparison of changes in pulmonary flow resistance in healthy volunteers acutely exposed to SO2 by mouth and by nose. Br. J. Ind. Med. 1966; 23: 75
   PubMedGoogle Scholar
• Stein A. A., Kirwan W. E. Chloracetophenone (tear gas) poisoning: clinicopathologic report. J. Forensic Sci. 1964; 9: 374
   PubMedGoogle Scholar
• Stein M., Schiavi R. C., Ottenberg P., Hamilton C. The mechanical properties of the lungs in experimental asthma in the guinea-pigs. J. Allergy 1961; 32: 8
   Google Scholar
• Sterling G. M. The mechanism of decreased specific airway conductance in man during hypercapnia caused by inhalation of 7% CO2. Clin. Sci. 1969; 37: 539
   PubMed Web of Science ®Google Scholar
• Sterling G. M., Batten J. C. Effect of aerosol propellants and surfactants on airway resistance. Thorax 1969; 24: 228
   PubMed Web of Science ®Google Scholar
• Stone H., Carregal E. J. A., Williams B. The olfactory-trigeminal response to odorants. Life Sci. [1] 1966; 5: 2195
   Google Scholar
• Stone H., Williams B., Carregal E. J. A. The role of the trigeminal nerve in olfaction. Exp. Neurol. 1968; 21: 11
   PubMed Web of Science ®Google Scholar
• Strandberg L. G. SO2, absorption in the respiratory tract. Arch. Environ. Health 1964; 9: 160
   PubMed Web of Science ®Google Scholar
• Swan J. M. Chemical modification of thiol and disulfide groups in proteins and peptides. Sulfur In Proteins. Academic Press, New York 1959; 3
   Google Scholar
• Tatantino P. A., Sass S. Polarographic measurement of the reaction between o-chlorobenzalmalononitrile and 2-Diethyl aminoethyl Mercaptan (DEAEM). J. Electrochem. Soc. 1969; 116: 430
   Web of Science ®Google Scholar
• Tarantino P. A., Sass S. Structure activity relationships of some arylidenemalononitriles and β-nitro-styrenes as sensory irritants. Toxicol Appl. Pharmacol., (in press)
   Google Scholar
• Tauc L. Transmission action on synaptic neuronal receptor membranes. Handbook of Sensory Physiology, Vol 1, Principles of receptor physiology, W. R. Loewenstein. Springer-Verlag, New York 1971; 103
   Google Scholar
• Thompson R. H. S. The reactions of arsenicals in living tissues. Symposium on the Biochemical Reactions of Chemical Warfare Agents, Biochemical Society Symposium No. 2, R. T. Williams. Cambridge University Press. 1948; 28
   Google Scholar
• Ton C. C., Lee T. S., Kiang A. K. The pharmacological actions of capsaicin and analogues. Br. J. Pharmacol. 1955; 10: 175
   Web of Science ®Google Scholar
• Tomori Z., Widdicombe J. G. Muscular, bronchomotor and cardiovascular reflexes elicited by mechanical stimulation of the respiratory tract. J. Physiol. (Lond.) 1969; 200: 25
   Google Scholar
• Torvik A. Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures. J. Comp. Neurol. 1956; 106: 51
   PubMed Web of Science ®Google Scholar
• Tucker D. Olfactory, vomeronasal and trigeminal receptor responses to odorants. Proceedings First International Symposium on Olfaction and Taste, Stockholm, 1962, 45
   Google Scholar
• Tucket D. Nonolfactory responses from the nasal cavity: Jacobson's organ and the trigeminal system. Handbook of Sensory Physiology, Vol. IV. Chemical Senses, Part I: Olfaction, L. M. Beidler. Springer-Verlag, New York 1971; 151
   Google Scholar
• Ulrich C. E., Haddock M. P., Alarie Y. Airborne chemical irritants, role of the trigeminal nerve. Arch. Environ. Health 1972; 24: 37
   PubMed Web of Science ®Google Scholar
• Upshall D. G. Effects of o-chlorobenzylidene malononitrile (CS) and the stress of aerosol inhalation upon rat and rabbit embryonic development. Toxicol. Appl. Pharmacol. 1973; 24: 45
   PubMed Web of Science ®Google Scholar
• Vincent S., Cameron A. T. A note on an inhibitory respiratory reflex in the frog and other animals. J. Comp. Neural. 1920; 31: 283
   Google Scholar
• Weigand D. A. Cutaneous reaction to the riot control agent CS. Milit. Med. 1969; 134: 437
   Web of Science ®Google Scholar
• Weill H., Waddel L. C., Ziskind M. A study of workers exposed to detergent enzymes. J. A. M. A. 1971; 217: 425
   PubMed Web of Science ®Google Scholar
• Wenzel B. M. Olfaction in birds. Handbook of Sensory Physiology, Vol IV, Chemical Senses Part I: Olfaction, L. M. Beidler. Springer-Verlag, New York 1971; 432
   Google Scholar
• Whitear M. An electron microscope study of the cornea in mice, with special reference to the innervation. J. Anat. 1960; 94: 387
   PubMed Web of Science ®Google Scholar
• Whitteridge D. The action of phosgene on the stretch receptors of the lung. J. Physiol. (Lond.) 1948; 107: 107
   Google Scholar
• Whitteridge D. Effect of anaesthetics on mechanical receptors. Br. Med. Bull. 1958; 14: 5
   PubMed Web of Science ®Google Scholar
• Whitteridge D., Bulbring E. Changes in activity of pulmonary receptors in anesthesia and their influence on respiratory behaviour. J. Pharmacol. 1944; 81: 340
   Google Scholar
• Widdicombe J. G. Respiratory reflexes from the trachea and bronchi of the cat. J. Physiol. (Lond.) 1954; 123: 55
   Google Scholar
• Widdicombe J. G. Receptors in the trachea and bronchi of the cat. J. Physiol. (Lond.) 1954; 123: 71
   Google Scholar
• Widdicombe J. G. Action potentials in vagal efferent nerve fibres to the lungs of the cat. Arch. Exp. Pathol. Pharm. 1961; 241: 415
   PubMedGoogle Scholar
• Widdicombe J. G. Respiratory reflexes in man and other mammalian species. Clin. Sci. 1961; 163
   Google Scholar
• Widdicombe J. G. The activity of pulmonary stretch receptors during bronchoconstriction, pulmonary oedema, atelectasis and breathing against a resistance. J. Physiol. (Lond.) 1961; 159: 436
   Google Scholar
• Widdicombe J. G. Clinical significance of reflexes from the respiratory system. Anesthesiology 1962; 23: 434
   PubMed Web of Science ®Google Scholar
• Widdicombe J. G. Regulation of tracheobronchial smooth muscle. Physiol. Rev. 1963; 43: 1
   PubMed Web of Science ®Google Scholar
• Widdicombe J. G. Respiratory reflexes. Handbook of Physiology, Section 3: Respiration, Vol. I, W. O. Fenn, H. Rahn. American Physiological Society, Washington, D.C. 1964; 585
   Google Scholar
• Widdicombe J. G. Action potentials in parasympathetic and sympathetic afferent fibres to the trachea and lungs of dogs and cats. J. Physiol. (Lond.) 1966; 186: 56
   Google Scholar
• Widdicombe J. G. Reflex mechanisms in bronchial obstruction. Bronchitis, III. Proceedings Third International Symposium on Bronchitis, N. G. M. Orie, R. Van Der Lende. Charles C Thomas, Philadelphia 1970; 288
   Google Scholar
• Widdicombe J. G., Sterling G. M. The autonomic nervous system and breathing. Arch. Intern. Med. 1970; 126: 311
   PubMedGoogle Scholar
• Widdicombe J. G., Kent D. C., Nadel J. A. Mechanism of bronchoconstriction during inhalation of dust. J. Appl. Physiol. 1962; 17: 613
   PubMed Web of Science ®Google Scholar
• Windle W. F. The distribution and probable significance of unmyelinated nerve fibers in the trigeminal nerve of the cat. J. Comp. Neurol. 1926; 41: 453
   Google Scholar
• Woolcock A. J., Macklem P. T., Hogg J. C., Wilson M. J., Nadel J. A., Frank N. R., Brain J. Effect of vagal stimulation on central and peripheral airways in dogs. J. Appl. Physiol. 1969; 26: 806
   PubMed Web of Science ®Google Scholar
• Wyss O. A. M., Rivkin E. A. Les fibres afférentes du nerf vague participant aux réflexes respiratoires. Helv. Physiol. Acta 1950; 8: 87
   Google Scholar
• Zagari J. Wirkung des chloroforms, des ammoniaks und des bromaethyls auf die athmung mit besonder Beziehung auf den durch die Kohlensaure bedingten inspiratorischen Reflex von Seiten der Hauptbronchien. Beitrag zur Lehre der dyspnoeformen. Arch. f.A.u. Physiol. 1891; 15: 37
   Google Scholar
• Glogowska M., Widdicombe J. G. The role of vagal reflexes in experimental lung oedema, bronchoconstriction and inhalation of halothane. Resp. Physiol. 1973; 18: 116
   PubMedGoogle Scholar
• Reynolds L. B., Jr. The function of the reflex deep breath in pulmonary congestion. Resp. Physiol. 1973; 18: 129
   PubMedGoogle Scholar
• Szereda-Przestaszewska M., Widdicombe J. G. Reflex effects of chemical irritation of the upper airways on the laryngeal lumen in cats. Resp. Physiol. 1973; 18: 107
   PubMedGoogle Scholar