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Research Article

Peripheral Neuropathy Caused by Chemical Agents

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Pages 365-417 | Published online: 26 Sep 2008

References

  • Sharkey S. J. On peripheral neuritis. Br. Med. J. 1896; 1: 457
  • Peters R. A. Lethal synthesis. Proc. R. Soc. Lond. (Biol) 1952; 139: 143
  • Albert A. Selective Toxicity, 4th ed. Methuen, London 1968
  • Cavanagh J. B., Passingham R. J., Vogt J. A. Staining of sensory and motor nerves in muscles with Sudan black B. J. Pathol. Bacteriol. 1964; 88: 89
  • Glees P., Marsland T. A. Degeneration of pyramidal fibres studied by a paraffin silver method. J. Physiol. (Lond.) 1952; 118: 51p
  • Armstrong J., Stephens P. R. A modified chrome-silver paraffin-wax technique for staining neural end-feet. Stain Technol. 1960; 35: 71
  • Young J. Z. Functional repair of nervous tissue. Physiol. Rev. 1942; 22: 318
  • Guth L. Regeneration in the mammalian peripheral nerve. Physiol. Rev. 1956; 36: 441
  • Nicholas J. S. Experimental approaches to problems of early development in the rat. Q. Rev. Biol. 1947; 22: 179
  • Sperry R. W., Hibberd E. Regulative factors in the orderly growth of retinotectal connexions. Growth of the Nervous System, G. W. E. Wolstenholme, M. O'Connor. J. & A. Churchill, London 1968; 41
  • Gaze R. M. Growth and differentiation. Annu. Rev. Physiol. 1967; 29: 59
  • Chambers W. W., Liu C-N. Fate of cells of Clarke's nucleus following axon section in cat with evidence of spinal collaterals from dorsal spinocerebellar tract. Anat. Rec. 1953; 115: 342
  • Watson W. E. An autoradiographic study of the incorporation of nucleic-acid precursors by neurones and glia during nerve regeneration. J. Physiol. (Lond.) 1965; 180: 741
  • Watson W. E. Observations on the nucleolar and total cell body nucleic acid of injured nerve cells. J. Physiol. (Lond) 1968; 196: 655
  • Torvik A., Skjörten F. Electron microscopic observations on nerve cell regeneration and degeneration after axon lesions. Acta Neuropathol. (Berl) 1971; 17: 248
  • Pannese E. Investigations on the ultrastructural changes of the spinal ganglion neurons in the course of axon regeneration and cell hypertrophy. I. Changes during axon regeneration. Z. Zellforsch. Mikrosk. Anat. 1963; 60: 711
  • Brattgard S-O., Edström J. E., Hyden H. The chemical changes in regenerating neurones. J. Neurochem. 1957; 1: 316
  • Watson W. E. The response of motor neurones to intramuscular injection of botulinum toxin. J. Physiol. (Lond.) 1969; 202: 611
  • Davies D. R. Neurotoxicity of organophosphorus compounds. Handbuch der Experimentellen Pharmakologie, Ergänzungwerk, G. B. Koelle. Springer-Verlag, Berlin 1963; Vol. XV, chap. 19
  • Cavanagh J. B. The significance of the “dying back” process in experimental and human neurological disease. Int. Rev. Exp. Pathol. 1964; 3: 219
  • O'Brien R. D. Toxic Phosphorus Esters. Academic Press, New York 1960
  • Valaer P. J. Adulterated ginger—responsible for recent paralysis epidemic. J. Am. Pharm. Assoc. 1930; 19: 948
  • Vonderahe A. R. Pathological changes in paralysis caused by drinking Jamaica ginger. Arch. Neurol. Psychiatr. (Chicago) 1931; 25: 29
  • Burley B. T. Polyneuritis from tri-ortho -cresyl phosphate. J. A. M. A. 1931; 98: 298
  • Smith M. T., Elvove E., Valaer P. J., Frazier W. H., Mallory G. E. Pharmaceutical and chemical studies of the causes of the so-called ginger jake paralysis. Public Health Rep. 1930; 45: 1703
  • Smith H., Spalding J. M. K. Outbreak of paralysis in Morocco due toortho -cresyl phosphate poisoning. Lancet 1959; 2: 1019
  • Geoffroy H., Slomic A., Benebadji M., Pascal P. Myelo-polynevrites tri-cresyl phosphates. World Neurol. 1960; 1: 294
  • Bidstrup P. L., Bonnell J. A., Beckett A. G. Paralysis following poisoning by a new organic phosphorus insecticide (mipafox). Br. Med. J. 1953; 1: 1068
  • Svennilson E. Studies of triortho cresyl phosphate neuropathy, Morocco, 1960. Acta Psychiatr. Neurol. Scand. Suppl. 1961; 150: 36, 334
  • Bjorklund N. E., Erne K., Hallgren W., Sevelius F. Trixylylfosfat som forgiftmingsorsak hos kov. Nord. Vet. Med. 1961; 5: 225
  • Smith M. I., Lillie R. D. The histopathology of triorthoocresyl phosphate poisoning. Arch. Neurol. Psychiatr. (Chicago) 1931; 26: 976
  • Cavanagh J. B. The toxic effects of tri-ortho-cresyl phosphate poisoning on the nervous system. J. Neurol. Neurosurg. Psychiatry 1954; 17: 163
  • Cavanagh J. B. Peripheral nerve changes inortho-cresyl phosphate poisoning in the cat. J. Pathol. Bacteriol. 1964; 87: 365
  • Cavanagh J. B., Patangia G. N. Changes in the central nervous system in the cat as the result of tri-o-cresyl phosphate poisoning. Brain 1965; 88: 165
  • Bischoff A. Ultrastructure of triorthocresyl phosphate poisoning in the chicken. II. Studies on spinal cord alterations. Acta Neuropathol. (Berl.) 1970; 15: 142
  • Prineas J. The pathogenesis of dying back polyneuropathies. Part I. An ultrastructural study of experimental tri-ortho-ctesyl phosphate intoxication in the cat. J. Neuropathol. Exp. Neurol. 1969; 28: 571
  • Iilis L., Patangia G. N., Cavanagh J. B. Boutons terminaux and tri-ortho-cresyl phosphate neurotoxicity. Exp. Neurol. 1966; 14: 160
  • Blakemore W. F., Cavanagh J. B. ‘Neuraxonal dystrophy’ occurring in an experimental ‘dying back’ process in the rat. Brain 1969; 92: 789
  • Davies D. R., Cavanagh J. B., unpublished observations
  • Johnson M. K., Barnes J. M. Age and the sensitivity of chicks to the delayed neurotoxic effects on some organophosphorus compounds. Biochem. Pharmacol. 1970; 19: 3045
  • Cavanagh J. B., unpublished observations
  • Hine C. H., Dunlap M. K., Rice E. G., Coursey M. M., Gross R. M., Anderson H. H. The neurotoxicity and anticholinesterase properties of some substituted phenyl phosphates. J. Pharmacol. Exp. Ther. 1956; 116: 227
  • Henschler D. Die trikresylphosphatvergiftung. Klin. Wochenschr. 1958; 36: 663
  • Bondy H. F., Field E. J., Worden A. N., Hughes J. P. W. A study of the acute toxicity of the tri-aryl phosphates used as plasticisers. Br. J. Ind. Med. 1960; 17: 190
  • Aldridge W. N., Barnes J. M. Neurotoxic and biochemical properties of some triaryl phosphates. Biochem. Pharmacol. 1961; 6: 177
  • Aldridge W. N. Tricresyl phosphates and cholinesterase. Biochem. J. 1954; 56: 185
  • Myers D. K., Rekel J. B. J., Veeger C., Kemp A., Simons E. G. L. Metabolism of triaryl phosphates in rodents. Nature (Lond) 1955; 176: 259
  • Casida J. E., Eto M., Baron R. L. Biological activity of a tri-o-cresyl phosphate metabolite. Nature (Lond.) 1961; 191: 1396
  • Eto M., Casida J. E., Eto E. Hydroxylation and cyclization reactions involved in the metabolism of tri-o-cresyl phosphate. Biochem. Pharmacol. 1962; 11: 337
  • Baron R. L., Bennett D. R., Casida J. E. Neurotoxic syndrome produced in chickens by a cyclic phosphate metabolite of tri-o-cresyl phosphate—a clinical and pathological study. Br. J. Pharmacol. 1962; 18: 465
  • Taylor J. D. A neurotoxic syndrome produced in cats by a cyclic phosphate metabolite of tri-o-cresyl phosphate. Toxicol Appl. Pharmacol. 1967; 11: 538
  • Baron R. L., Casida J. E. Enzymatic and antidotal studies on the neurotoxic effect of certain organophosphates. Biochem. Pharmacol. 1962; 11: 1129
  • Earl C. J., Thompson R. H. S. Cholinesterase levels in the nervous system in tri-ortho-cresyl phosphate poisoning. Br. J. Pharmacol. 1952; 7: 685
  • Cavanagh J. B., Davies D. R., Holland P., Lancaster M. Comparison of the functional effects of Dyflos, tri-o-cresyl phosphate and tri-p-ethyl-phenyl phosphate in chickens, ifr. J. Pharmacol. 1961; 17: 21
  • Aldridge W. N., Barnes J. M. Further observations on the neurotoxicity of organophosphorus compounds. Biochem. Pharmacol. 1966; 15: 541
  • Johnson M. K. A phosphorylation site in brain and the delayed neurotoxic effect of some organophosphorus compounds. Biochem. J. 1969; 111: 487
  • Johnson M. K. Organophosphorus and other inhibitors of brain ‘neurotoxic esterase’ and the development of delayed neurotoxicity in hens. Biochem. J. 1970; 120: 523
  • Johnson M. K., personal communication
  • Diezel P. B., Quadbeck G. Nervenschädigung durch p-bromphenylacetyl-harnstoff. Naunyn Schmiedeberg's Arch. Pharmakol. Exp. Pathol. 1960; 238: 534
  • Toman J. E. P., Goodman L. S. Anticonvulsants. Physiol. Rev. 1948; 28: 409
  • Swinyard E. A., Brown W. C., Goodman L. S. Comparative assays of antiepileptogenic drugs in mice and rats. J. Pharmacol Exp. Ther. 1952; 106: 319
  • Everett G. M., Richards R. K. Pharmacological studies of phenylacetylurea (Phenurone), an anticonvulsant drug. J. Pharmacol Exp. Ther. 1952; 106: 303
  • Chen F. C-K., Cavanagh J. B. Factors affecting neurotoxicity byp-bromophenylacetylurea in rats. Br. J. Exp. Pathol. 1971; 52: 315
  • Cavanagh J. B., Chen F. C-K., Kyu M. H., Ridley A. The experimental neuropathy in rats caused by p-bromophenylacetylurea. J. Neurol. Neurosurg. Psychiatry 1968; 31: 471
  • Zamora A. J., Chen F. C-K., Cavanagh J. B., unpublished findings
  • Cavanagh J. B., Chen F. C-K. Amino acid incorporation into protein during the “silent phase” before organomercury andp -bromophenylacetylurea neuropathy in the rat. Acta Neuropathol. (Berl) 1971; 19: 216
  • Chen F. C-K., Cavanagh J. B., unpublished observations
  • Pegum J. S. Nicotinic acid and burning feet. Lancet 1952; 2: 536
  • Jones W. A., Jones G. P. Peripheral neuropathy due to isoniazid. Lancet 1953; 1: 1073
  • Gammon G. D., Burge F. W., King G. Neural toxicity in tuberculous patients treated with isoniazid (iso -nicotinic acid hydrazide). Arch. Neurol. Psychiatr. (Chicago) 1953; 70: 64
  • Biehl J. P., Skavlem J. H. Toxicity of isoniazid. Am. Rev. Tuberc. 1953; 68: 296
  • Evans D. A. P., Manley K. A., McKusick V. A. Genetic control of isoniazid metabolism in man. Br. Med. J. 1960; 2: 485
  • Harris H. W., Knight R. A., Selin M. J. Comparison of isoniazid concentrations in the blood of people of Japanese and European descent. Am. Rev. Tuberc 1958; 78: 944
  • Boone I. U., Woodward K. T. Relationships of pyridoxine and its derivatives to the mechanism of action of isoniazid. Proc. Soc. Exp. Biol. Med. 1953; 84: 292
  • Biehl J. P., Vilter R. W. Effect of isoniazid on vitamin B6 metabolism, its possible significance in producing isoniazid neuritis. Proc. Soc. Exp. Biol. Med. 1954; 85: 389
  • Zbinden G., Studer A. Experimenteller beitrage zur frage der isoniazid-neuritis ihrer beeinflussung durch pyridoxin. Z. Tuberk. Erkr. Thoraxorgane 1955; 107: 97
  • Zbinden G., Studer A. Zur wirkung von vitaminen der B-gruppe auf die experimentelle isoniazid-neuritis. Schweiz. Z. Allg. Pathol. Bakteriol. 1955; 18: 1198
  • Klinghardt G. W. Experimentelle degenerative nervenschadigungen durch verbindungen des hydrazins und hydroxylamins. Naturwissenschaften 1961; 48: 381
  • Cavanagh J. B. On the pattern of change in peripheral nerves produced by isoniazid intoxication in rats. J. Neurol. Neurosurg. Psychiatry 1967; 30: 26
  • Schlaepfer W. W., Hager H. Ultrastructural studies of INH-induced neuropathy in rats. I. Early axonal changes. Am. J. Pathol. 1964; 45: 209
  • Schlaepfer W. W., Hager H. Ultrastructural studies of INH-induced neuropathy in rats. II. Alteration and decomposition of the myelin sheaths. Am. J. Pathol. 1964; 45: 423
  • Smith B. The myenteric plexus in drug-induced neuropathy. J. Neurol. Neurosurg. Psychiatry 1967; 30: 506
  • Metzler D. E., Ikawa M., Snell E. E. A general mechanism for vitamin B6—catalysed reactions. J. Am. Chem. Soc. 1954; 76: 648
  • McCormick D. B., Snell E. E. Pyridoxal kinase of human brain and its inhibition by hydrazine derivatives. Proc. Natl. Acad. Sci. U.S.A. 1959; 45: 1371
  • McCormick D. B., Snell E. E. Comparative inhibition of pyridoxal kinase and glutamic acid decarboxylase by carbonyl reagents. Proc. Soc. Exp. Biol. Med. 1960; 104: 554
  • McCormick D. B., Snell E. E. Pyridoxal phospho-kinases. II. Effects of inhibitors. J. Biol. Chem. 1961; 236: 2085
  • Holtz P., Palm D. Pharmacological aspects of vitamin B6. Pharmacol. Rev. 1964; 16: 113
  • Tower D. B. Neurochemical aspects of pyridoxine metabolism and function. Am. J. Clin. Nutr. 1956; 4: 329
  • Killam K. F., Bain J. A. Convulsant hydrazides. I.In vitro andin vivo inhibition of vitamin B6 enzymes by convulsant hydrazides. J. Pharmacol. Exp. Ther. 1957; 119: 255
  • Sauberlich H. E. Human requirements for vitamin B6. Vitam. Horn. 1964; 22: 807
  • Palmer A. C., Noel P. R. B. Neuropathological effects of dosing dogs with isonicotinic hydrazide, and with its methanesulphonate derivative. Nature (Lond.) 1965; 205: 506
  • Carlton W. W., Kreutzberg G. Isonicotinic acid-hydrazide—induced spongy degeneration of the white matter in the brains of Pekin ducks. Am. J. Pathol. 1966; 48: 91
  • Carlton W. W. Neural toxicity of isonicotinic acid hydrazide (isoniazid) for chickens. Avian Dis. 1967; 11: 241
  • Coursin D. B. The present status of vitamin B6 metabolism. Am. J. Clin. Nutr. 1961; 9: 414
  • Munck B. G. Amino acid transport by the small intestine of the rat. Biochim. Biophys. Acta 1965; 94: 136
  • Cavanagh J. B., Chen F. C-K., unpublished observations
  • Wilson J. E., Vigneaud V. L-Penicillamine as a metabolic antagonist. Science 1948; 107: 653
  • Kirkendahl W. M., Page E. B. Polyneuritis occurring during hydralazine therapy. J.A.M.A. 1958; 167: 427
  • Poole G. W., Schneeweiss J. Peripheral neuropathy due to ethionamide. Am. Rev. Resp. Dis. 1961; 84: 890
  • Cavanagh J. B., Mellick R. S. On the nature of the peripheral nerve lesions associated with acute intermittent porphyiia. J. Neurol. Neurosurg. Psychiatry 1965; 28: 320
  • Cavanagh J. B., Ridley A. The nature of the neuropathy complicating acute intermittent porphyria. Lancet 1967; 2: 1023
  • Ridley A. The neuropathy of acute intermittent porphyria. Q. J. Med. 1969; 38: 307
  • Mason V. R., Courville C., Ziskind E. The porphyrins in human disease. Medicine 1933; 12: 355
  • Denny-Brown D., Sciarra D. Changes in the nervous system in acute porphyria. Brain 1945; 68: 1
  • Hierons R. Changes in the nervous system in acute porphyria. Brain 1957; 80: 176
  • Ridley A., Hierons R., Cavanagh J. B. Tachycardia and the neuropathy of porphyria. Lancet 1968; 2: 708
  • Kezdi P. Neurogenic hypertension in man in porphyria. Arch. Intern. Med. 1954; 94: 122
  • Rimington C. Haems and porphyrins in health and disease. Acta Med. Scand. 1952; 143: 161
  • De Matteis F., Rimington C. The biochemical disturbance in acute intermittent porphyria. Lancet 1962; 1: 1332
  • De Matteis F. Disturbances of liver porphynn metabolism caused by drugs. Pharmacol. Rev. 1967; 19: 523
  • Asbury A. K., Sidman R. L., Wolf M. K. Drug induced porphynn accumulation in the nervous system. Neurology (Minneap.) 1966; 16: 320
  • Price J. M., Brown R. R., Peters H. A. Tryptophan metabolism in porphyria. schizophrenia, and a variety of neurological and psychiatric diseases. Neurology (Minneap.) 1959; 9: 456
  • Hamfelt A., Wetterberg L. Neuropathy in porphyria. Lancet 1968; 1: 50
  • Davidson M., Feinleib M. Carbon disulfide poisoning, a review. Am. Heart J. 1972; 83: 100
  • Tiller J. R., Schilling R. S. F., Morris J. N. Occupational toxic factor in mortality from coronary heart disease. Br. Med. J. 1968; 2: 407
  • Hernberg S., Postanen T., Nordman C. H., Sumari P. Coronary heart disease among workers exposed to carbon disulphide. Br. J. Ind. Mod. 1970; 27: 313
  • Lewey F. M. Neurological, medical and biochemical signs and symptoms indicating chronic industrial carbon disulfide absorption. Ann. Intern. Med. 1941; 15: 869
  • Vigliani E. C. Carbon disulphide poisoning in viscose rayon factories. Br. J. Ind. Med. 1954; 11: 235
  • Brieger H. Chronic carbon disulfide poisoning. J. Occup. Med. 1961; 3: 302
  • Ferraro A., Jervis G., Flicker D. Neuropathological changes in experimental carbon disulfide poisoning in cats. Arch. Pathol. 1941; 32: 723
  • Richter R. Degeneration of the basal ganglia in monkeys from chronic carbon disulfide poisoning. J. Neuropathol. Exp. Neurol. 1945; 4: 324
  • Cohen A. E., Scheel L. D., Kopp J. F., Stockwell F. R., Keenan R. G., Mountain J. T., Paulus H. J. Biochemical mechanisms in chronic carbon disulfide poisoning. Am. Ind. Hyg. Assoc. J. 1959; 20: 303
  • Alpers B. J., Lewey F. H. Changes in the nervous system following carbon disulfide poisoning in animals and man. Arch. Neurol. Psychiatr. 1940; 44: 725
  • Gordy S. T., Trumper M. Carbon disulfide poisoning. Report of 21 cases. Ind. Med. 1940; 9: 231
  • Lewey F. H. Experimental chronic carbon disulfide poisoning in dogs. J. Ind. Hyg. 1941; 23: 415
  • Eldjarn L. Metabolism of tetraethyl thiuramdisulphide (antabuse. aversan) in the rat, investigated by means of radioactive sulphur. Scand. J. Clin. Lab. Invest. 1950; 2: 198
  • Eldjarn L. Metabolism of tetraethyl thiuramdisulphide in man. investigated by means of radioactive sulphur. Scand. J. Clin. Lab. Invest. 1950; 2: 202
  • Stromme J. H. Metabolism of disulfiram and diethyl dithiocarbamate in rats with demonstration of anin vivo ethanol-induccd inhibition of the glucuronic acid conjugation of the thiol. Biochem. Pharmacol. 1965; 14: 353
  • Kane F. J. Carbon disulfide intoxication from overdosage of disulfiram. Am. J. Psychiatry 1970; 127: 690
  • Gardner-Thorpe C., Benjamin S. Peripheral neuropathy alter disulfiram administration. J. Neurol. Ncurosurg. Psychiatry 1971; 34: 253
  • Anon. Peripheral neuropathy and disulfiram. Lancet 1971; 2: 649
  • Melson F., Weigelt H. The influence of tetramethyl thiuram and carbon disulphide on the enzymes monoamine oxidase and alcohol dehydrogenase. Toxicology of Carbon Disulphide, H. Brieger, J. Teisinger. Excerpta Medica foundation. Elsevier, Amsterdam 1967; 100
  • McHowell J. C., Edington N. The neurotoxicity of sodium diethyldithiocarbamate in the hen. J. Neuropathol. Exp. Neurol. 1968; 27: 464
  • Edington N., McHowell J. C. The neurotoxicity of sodium diethyldithiocarbamate in the rabbit. Acta Neuropathol. (Berl) 1969; 12: 339
  • Rasul A. R., McHowell J. C. A comparison of the effect of sodium diethyldithiocarbamate on the central nervous system of young and domestic adult fowl. Acta Neuropathol. (Berl) 1973; 24: 68
  • Rasul A. R., McHowell J. C. Further observations on the response of the peripheral and central nervous system of the rabbit to sodium diethyldithiocarbamate. Acta Neuropathol. (Berl) 1973; 24: 161
  • Sunderman F. W., Sunderman F. W., Jr. Dithiocarb. A new therapeutic agent for persons exposed to nickel carbonyl. Am. J. Med. Sci. 1958; 236: 26
  • Sunderman F. W., White J. C., Sunderman F. W., Jr. Dithiocarbamates in the treatment of Wilson's disease. Am. J. Med. 1963; 34: 875
  • Sunderman F. W. Diethyldithiocarbamate therapy of thallotoxicosis. Am. J. Med. Sci. 1967; 253: 209
  • Kamerbeek A., Rauws A. G., ten Ham M. G., Van Heijst A. N. P. Dangerous redistribution of thallium by treatment with sodium diethyldithiocarbamate. Acta Med. Scand. 1971; 189: 149
  • Van Steenis G., Van Logten M. J. Neurotoxic effect of the dithiocarbamatetectoram on the chick embryo. Toxicol Appl. Pharmacol. 1971; 19: 675
  • McKee R., Kiper C., Fountain J. H., Riskin A. M., Drinker P. A solvent vapour carbon disulfide -absorption, elimination metabolism and mode of action. J.A.M.A. 1943; 122: 217
  • Thorne G. D., Ludwig R. A. The Dithiocarbamates and Related Compounds. Excerpta Medica Foundation, Elsevier, Amsterdam 1962
  • Scheel L. D. Experimental carbon disulfide poisoning in rabbits, its mechanism and similarities with human case reports. Toxicology of Carbon Disulphide, H. Brieger, K. Teisinger. Excerpta Medica Foundation, Elsevier, Amsterdam 1967; 107
  • Edington N., McHowell J. C. Changes in the nervous system of rabbits following the administration of sodium diethyldithiocarbamate. Nature (Lond.) 1966; 210: 1060
  • Vašák V., Kopecky J. On the role of pyridoxamine in the mechanism of the toxic action of carbon disulphide. Toxicology of Carbon Disulphide, H. Brieger, J. Teisinger. Excerpta Medica Foundation, Elsevier, Amsterdam 1967; 35
  • Abramova J. I. The questions of pathogenesis, specific prevention and therapy of carbon disulphide intoxication. Toxicology of Carbon Disulphide, H. Brieger, J. Teisinger. Excerpta Medica Foundation, Elsevier, Amsterdam 1967; 32
  • Magos L. The effects of carbon disulphide exposure on brain catecholamines in rats. Br. J. Pharmacol 1970; 39: 26
  • Magos L., Jervis J. A. E. Effects of diethyldithiocarbamate and carbon disulphide on brain tyrosine. J. Pharm. Pharmacol. 1970; 22: 936
  • Tarkowski S., Ctemer J. E. Metabolism of glucose and free amino acids in brain, studied with14 C-labelled glucose and butyrate in rats intoxicated with carbon disulphide. J. Neurochem. 1972; 19: 2631
  • Chamberlain W. P., Bloombergh H. D., Kilbourne E. D. A study of the influence of rice diet and of inanition on the production of multiple neuritis of fowls and the bearing thereof on the aetiology of beri-beri. Philipp. J. Sci. 1911; 6: 177
  • Vedder E. B., Clark E. A study of polyneuritis gallinarum. Philipp. J. Sci. 1912; 7: 423
  • Swank R. L., Prados M. Avian thiamine deficiency. Arch. Neurol. Psychiatr. 1942; 47: 97
  • Swank R. L. Avian thiamine deficiency, correlation of pathology and clinical behaviour. J. Exp. Med. 1940; 71: 683
  • Follis R. H. Pathology of Nutritional Disease. Charles C Thomas, Springfield, Ill 1948
  • Stevenson M. J. The effects of a thiamine analogue on the histopathology of rat tissues. Am. J. Vet. Res. 1950; 11: 105
  • Eaton Laboratories. The nitrofurans. Introduction to the Nitrofurans. Norwich, N.Y. 1958; Vol. 1
  • Collings H. Polyneuropathy associated with nitrofuran therapy. Arch. Neurol 1960; 3: 656
  • Ellis F. G. Acute polyneuritis after nitrofurantoin therapy. Lancet 1962; 2: 1136
  • Robertson D. H. H. Nitrofurazone. T. rhodesiense sleeping sickness. 1959; 41, Report of the East African Trypanosome Research Organization
  • Paul M. F., Paul G. E., Kopko F., Bryson M. J., Harrington C. Inhibition by furacin of citrate formation in testis preparations. J. Biol. Chem. 1954; 206: 491
  • Loughridge L. W. Peripheral neuropathy due to nitrofurantoin. Lancet 1962; 2: 1133
  • Behar A., Rachmilewitz E., Rahamimoff R., Demau M. Experimental nitrofurantoin neuropathy in rats. Arch. Neurol. 1965; 13: 160
  • Robertson D. H. H., Knight R. H. Observations on the polyneuropathy and disordered pyruvate metabolism induced by nitrofurazone in cases of sleeping sickness due to T. rhodesiense. Acta Trop. (Basel) 1964; 21: 239
  • Hassin G. B. Symptomatology of arsenical polyneuritis. J. Nerv. Ment. Dis. 1930; 72: 628
  • Gringschgl G. Demonstration vier fälle von Arsenikvergiftung in einer Familie. Wien. Med. Wochenschr. 1956; 10: 248
  • Harding J. D. J., Lewis G., Done J. T. Experimental arsenilic acid poisoning in pigs. Vet. Rec. 1968; 83: 560
  • Joiner C. L., McArdle B., Thompson R. H. S. Blood pyruvate estimations in the diagnosis and treatment of polyneuritis. Brain 1950; 73: 431
  • Tucker A. The Toxic Metals. Pan-Ballantine, London 1972
  • McAlpine D., Araki S. Minamata Disease. An unusual neurological disorder caused by contaminated fish. Lancet 1958; 2: 629
  • McAlpine D., Araki S. Minamata disease. Arch. Neurol. 1959; 1: 522
  • Hunter D., Bomford R. R., Russell D. S. Poisoning by methyl-mercury compounds. Q. J. Med., N.S. 1940; 9: 193
  • Hunter D., Russell D. S. Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds. J. Neurol. Neurosurg. Psychiatry 1954; 17: 235
  • Kurland L. F., Faro S. N., Siedler H. Minamata disease. World Neurol. 1960; 1: 370
  • Takeuchi T., Morikawa N., Matsumato H., Shiraishi Y. A pathological study of Minamata disease in Japan. Acta Neuropathol. (Berl.) 1962; 2: 40
  • Bakir F., Damluji S. F., Amin-Zaki L., Murtadha M., Khalidi A., Al-Rawi N. Y., Tikriti S., Dhahir H. I., Qarkson T. W., Smith J. C., Doherty R. A. Methyl-mercury poisoning. Iraq Sci. 1973; 181: 230
  • Okinaka, et al. Encephalopathy due to an organic mercury compound. Neurology (Minneap.) 1964; 14: 69
  • Matsumoto H., Koya G., Takeuchi T. Fetal Minamata disease. A neuropathological study of two cases of intrauterine intoxication by a methyl mercury compound. J. Neuropathol. Exp. Neurol. 1965; 24: 563
  • Miyakawa T., Deshimaru M. Electron microscopic study of experimentally induced poisoning due to organic mercury compound. Acta Neuropathol. (Berl.) 1969; 14: 126
  • Miyakawa T., Deshimaru M., Sumiyoshi S., Teraoka A., Udo N., Haltori E., Tatetsu S. Experimental organic mercury poisoning—pathological changes in peripheral nerves. Acta Neuropathol. (Berl.) 1970; 15: 45
  • Cavanagh J. B., Chen F. C-K. The effects of methyl-mercury dicyandiamide on the peripheral nerves and spinal cord of rats. Acta Neuropathol. (BerL) 1971; 19: 208
  • Chang L. W., Hartmann H. A. Ultrastructural studies of the nervous system after methyl mercury. Acta Neuropathol. (BerL) 1972; 20: 122
  • Cavanagh J. B., Jacobs J. M. 1973, unpublished observations
  • Chang L. W., Desnoyers P. A., Hartmann H. A. Quantitative cytochemical studies of RNA in experimental mercury poisoning. I. Changes in RNA content. J. Neuropathol. Exp. Neurol. 1972; 31: 489
  • Berglund F., et al. Report from an expert group. Methyl mercury in fish. A toxicologic-epidemiologic evaluation of the risks. Nord. Hyg. Tidskr. 1971, Suppl., 4
  • Norseth T., Qarkson F. W. Studies on the biotransformation of2 0 3 Hg-labelled methyl-mercury chloride in rats. Arch. Environ. Health 1970; 21: 717
  • Swensson A. Investigation on the toxicity of some organic mercury compounds which are used as seed disinfectants. Acta Med. Scand. 1954; 143: 365
  • Brown I. H. Chronic mercurialism. A cause of the clinical syndrome of amyotrophic lateral sclerosis. Arch. Neurol. Psychiatr. 1954; 72: 674
  • Hunter D. Diseases of Occupations. English University Press, London 1969
  • Noetzel H. Schädigung und verkalkung der Kornerschicht des Kleinhirns bei chronischer experimenteller Sublimatvergiftung. Beitr. Pathol. Anat. 1955; 226: 115
  • Paterson D., Greenfield J. G. Erythroedema polyneuritis (the so-called Pink Disease). Q. J. Med. 1923; 17: 6–24
  • Wyllie W. G., Stern R. O. Pink Disease. Its morbid anatomy with a note on treatment. Arch. Dis. Child. 1931; 6: 137
  • Warkany J., Hubbard D. M. Mercury in the urine of children with acrodynia. Lancet 1948; 1: 829
  • Colver T. Pink disease and mercury in Sheffield, 1947–55. Br. Med. J. 1956; 1: 897
  • Annotation. Teething powders. Lancet 1953; 2: 1247, 1321
  • Gritzka T. L., Trump B. F. Renal tubular lesions caused by mercuric chloride. Am. J. Pathol. 1968; 52: 1225
  • Mustakallio K. K., Telkkä A. Histochemical localization of the mercurial inhibition of succininc dehydrogenase in rat kidney. Science 1953; 118: 320
  • Telkkä A., Mustakallio K. K. Proximal and distal mercurial inhibition of succinic dehydrogenase in kidney tubules of rat. Science 1955; 121: 146
  • Bergstrand A., Friberg L., Odeblad E. Localization of mercury in kidneys after subcutaneous administration. Arch. Ind. Health 1958; 17: 253
  • Fiiberg L. Studies on the accumulation, metabolism and excretion of inorganic mercury (Hg203) after prolonged subcutaneous administration to rats. Acta Pharmacol. Toxicol. (Kbh.) 1956; 12: 411
  • Magos L. Mercury-blood interactions and mercury uptake by the brain after vapor exposure. Environ. Res. 1967; 1: 322
  • Magos L., Butler W. H. Cumulative effects of methyl-mercury dicyandiamide given orally to rats. Food Cosmet. Toxicol. 1972; 10: 513
  • Magos L., Cavanagh J. B. 1973, unpublished observations
  • Yoshino Y., Mozai T., Nakao K. Biochemical changes in rat brain poisoned with an alkyl mercury compound with special reference to the inhibition of protein synthesis in brain cortex slices. J. Neurochem. 1966; 13: 1223
  • Cavanagh J. B., Chen F. C-K. Amino acid incorporation in protein during the ‘silent phase’ before organomercury andp -bromophenylacetylurea neuropathy in the rat. Acta Neuropathol. (Berl.) 1971; 19: 216
  • Leek J. M., Millar E. L. M. Incidence of malformations since the introduction of thalidomide. Br. Med. J. 1962; 2: 16
  • Florence A. L. Is thalidomide to blame?. Br. Med. J. 1960; 2: 1954
  • Fullerton P. M., Kremer M. Neuropathy after intake of thalidomide (distaval). Br. Med. J. 1961; 2: 855
  • Hafström T. Polyneuritis after neurosedyn (thalidomide), and its prognosis. Acta Neurol. Scand. 1967; 43(Suppl. 32)1
  • Gebbels E. Die Thalidomid-Polyneuritis. Geo. Thieme Verlag, Stuttgart 1968
  • Fullerton P. M., O'Sullivan D. J. Thalidomide neuropathy: a clinical, electrophysiological and histological follow-up study. J. Neurol. Neurosurg. Psychiatry 1968; 31: 543
  • Klinghaidt G. W. 1965, quoted by Fullerton, P. M. and O'Sullivan, D. J., Thalidomide neuropathy: a clinical, electrophysiological and histological follow-up study. J. Neurol. Neurosurg. Psychiatry 1968; 31: 543
  • Staemmler M., Lagler F. Tierexperimenteller untersuchungen zur Frage Thalidomid und Nervenschadigungen. Arzneim. Forsch. 1965; 15: 504
  • Diezel P. B. Morphologische veränderungen bei experimenteller Thalidomid-Neuropathic und thalidomidbedingten Extremitatenmissbildungen. Munch. Med. Wochenschr. 1963; 105: 2265
  • McColl J. D., Globus M., Robinson S. An attempted reversal of thalidomide embryopathy in the rat by glutamine. Can. J. Physiol. Pharmacol. 1965; 43: 69
  • Schumacher H., Smith R. L., Williams R. T. The metabolism of thalidomide. The spontaneous hydrolysis of thalidomide in solution. Br. J. Pharmacol. 1965; 25: 304
  • Schumacher H., Smith R. L., Williams R. T. The metabolsim of thalidomide. The fate of thalidomide and some of its hydrolysis products in various species. Br. J. Pharmacol. 1965; 25: 338
  • Fabro S., Schumacher H., Smith R. L., Stagg B. L., Williams R. T. The metabolism of thalidomide. Some biological effects of thalidomide and its metabolites. Br. J. Pharmacol. 1965; 25: 352
  • Gillette J. R. Acylation as a possible mechanism of thalidomide-induced teratogenicity. The Teratological Society 7th Annual Meeting, Estes Park, Colorado, 1967, Quoted by Becker, B. A., inDevelopmental Neurobiology, Himwich, W. A., Ed., Charles C Thomas, Springfield, Ill., 1970, 621.
  • Fabro S., Smith R. L., Williams R. T. Thalidomide as a possible acylating agent. Nature (Lond) 1965; 208: 1208
  • Champy-Hatem S. Action de l'imidazole sur les premiers metabolites de la thalidomide. Arzneim. Forsch. 1965; 15: 508
  • Gross P. R. RNA metabolism in embryonic development and differentiation. N. Engl. J. Med. 1967; 276: 1239
  • Zillig W., Krone W., Albers M. Untersuchungen Zur Biosynthese der Proteine. III. Beitrage zur Kenntnis der Zusammensetzung und struktur der Ribosomen. Z. Physiol. Chem. 1959; 317: 131
  • Cohen S. S., Lichtenstein J. Polyamines and ribosome structure. J. Biol Chem. 1960; 235: 2112
  • Tissières A., Hopkins J. W. Factors affecting amino acid incorporation into proteins byEscherichia coli ribosomes. Proc. Natl. Acad. Sci. U.S.A. 1961; 47: 2015
  • Hirschberg E., Osnos M., Bryant S., Ultman S. E. Thalidomide. Effects on enzymes of glutamic acid metabolism in mice. Science 1964; 143: 1343
  • Lamy, Sur les effets toxique du thallium. J. Pharmac. Chim. 1863; 44: 285
  • Munch J. C. Human thaliotoxicosis. J.A.M.A. 1934; 102: 1929
  • Heyroth F. F. Thallium, a review and summary of the medical literature. U.S. Public Health Serv. Public Health Rep. 1947, Suppl.: 197
  • Matthys R. Neuf observations d'empoisonnement Criminel par le thallium. Ann. Med. Lég. 1955; 35: 237
  • Prick J. J. G., Smith W. G. S., Muller L. Thallium Poisoning. Elsevier, Amsterdam 1955
  • Reed D., Crawley J., Faro S. N., Pieper S. J., Kurland L. T. Thaliotoxicosis. Acute manifestations and sequelae. J.A.M.A. 1963; 183: 510
  • Zook B. C., Holzworth J., Thornton G. W. Thallium poisoning in cats. J. Am. Vet. Med. Assoc. 1968; 153: 285
  • Zook B. C., Gilmore C. E. Thallium poisoning in dogs. J. Am. Vet. Med. Assoc. 1967; 151: 204
  • Council on Drugs. Thaliotoxicosis—a recurring problem. J.A.M.A. 1957; 165: 1566
  • Rogers J. H. Thallium poisoning in N. S. Wales. Aust. Police J. 1957; 11: 125
  • Cavanagh J. B., Fuller N. H., Johnson H. M., Rudge P. The effects of thallium salts, with particular reference to the nervous system changes. A report of three cases. Q. J. Med. 1973, in press
  • Thyresson N. Experimental investigations on thallium. Acta Derm. Venereal. (Stockh.) 1950; 30: 417
  • Truhaut R. Recherche sur la Toxicologie de Thallium. Institut Nationale de Securité pour la Prévention des Accidents de Travail, Paris 1959
  • Lund A. Distribution of thallium in the organism and its elimination. Acta Pharmacol Toxicol. (Kbh.) 1956; 12: 251
  • Allsopp J. L. Thallium poisoning. Australas. Ann. Med. 1953; 2: 144
  • Grunfeld O., Hinostroza G. Thallium poisoning. Arch. Intern. Med. 1964; 114: 132
  • Passarge C., Wiecke H. H. Thallium polyneuritis. Fortschr. Neurol. Psychiatr. 1965; 33: 477
  • Kamerbeek H. H., Rauws A. G., ten Ham M., Van Heijst A. N. P. Dangerous redistribution of thallium by treatment with sodium diethyldithiocarbamate. Acta Med. Scand. 1971; 189: 149
  • Banks W. J., Pleasure D. E., Suzuki K., Nigro M., Katz R. Thallium poisoning. Arch. Neurol. 1972; 26: 456
  • Peterson E. L., Murray M. R. Patterns of peripheral demyelinationin vitro. Ann. N. Y. Acad. Sci. 1965; 122: 39
  • Spencer P. S., Peterson E. R., Ricardo Madrid A., Raine C. S. Effects of thallium salts on neuronal mitochondria in organotypic cord-ganglia-muscle combination cultures. J. Cell Biol. 1973, in press
  • Greving R., Gegel O. Pathologisch-anatomische Befunde am Nervensystem nach Experimenteller Thallium-veigiftung. Z. Gesamte Neurol. Psychiatr. 1929; 120: 805
  • Scharrer E. Histopathologische Befunde in Zentralnervensystem bei Thallium Vergiftung. Z. Gesamte Neurol. Psychiatr. 1933; 145: 454
  • Gettler A. O., Weiss L. Thallium poisoning. III. Clinical toxicology of thallium. Am. J. Clin. Pathol. 1943; 13: 422
  • Moeschlin S. Klinik und Therapie der Vergiftungen. Geo. Thieme Verlag, Stuttgart 1952
  • Kaeser H. E., Lambert E. H. Nerve function studies in experimental polyneuritis. Electroencephalogr. Clin. Neurophysiol. Suppl. 1962; 22: 29
  • Herman M. M., Bensch K. G. Light and electronmicroscopic studies of acute and chronic thallium intoxication in rats. Toxicol. Appl. Pharmacol. 1967; 10: 199
  • Gehring P. J., Hammond P. B. Mechanism for the increase in thallium excretion during the administration of potassium. Pharmacology 1966; 8: 218
  • Gehring P. J., Hammond P. B. The interrelationship between thallium and potassium in animals. J. Pharmacol. Exp. Ther. 1967; 155: 187
  • Britten J. S., Blank M. Thallium activation of the (Na+ + K+) -activated ATPase. Biochim. Biophys. Acta 1968; 159: 160
  • Rusnyak I., Györgi L., Ormai S., Millner T. On some potassium-like qualities of the thallium ion. Experientia 1968; 24: 809
  • Inturrisi C. E. Thallium activation of K+ -activated phosphatases from beef brain. Biochim. Biophys. Acta 1969; 173: 567
  • Inturrisi C. E. Thallium-induced dephosphorylation of a phosphorylated intermediate of the (sodium + thallium)-activated ATPase. Biochim. Biophys. Acta 1969; 173: 630
  • Flesch P. Inhibition of keratinizing structures by systemic drugs. Pharmacol. Rev. 1963; 15: 653
  • Lund A. The effect of various substances on the excretion and the toxicity of thallium in the rat. Acta Pharmacol. Toxicol. (Kbh.) 1956; 12: 260
  • Papp J. P., Gay P. C., Dodson V. N., Pollard H. M. Potassium chloride treatment in thallotoxicosis. Ann. Intern. Med. 1969; 71: 119
  • McCollister D. D., Oyen F., Rowe V. K. Toxicology of acrylamide. Toxicol. Appl. Pharmacol. 1964; 6: 172
  • Auld R. B., Bedwell S. F. Peripheral neuropathy with sympathetic overactivity from industrial contact with acrylamide. Can. Med. Assoc. J. 1967; 96: 652
  • Garland T. O., Patterson W. H. Six cases of acrylamide poisoning. Br. Med. J. 1967; 4: 134
  • Kupperman S. S. Effects of acrylamide on the nervous system of the cat. J. Pharmacol. Exp. Ther. 1958; 123: 180
  • Leswing R. J., Ribelin W. E. Physiologic and pathologic changes in acrilamide neuropathy. Arch. Environ. Health 1969; 18: 22
  • Fullerton P. M., Barnes J. M. Peripheral neuropathy in rats produced by acrylamide. Br. J. Ind. Med. 1966; 23: 210
  • Hopkins A. The effect of acrylamide on the peripheral nervous system of the baboon. J. Neurol. Neurosurg. Psychiatry 1970; 33: 805
  • Hopkins A., Gilliatt R. W. Motor and sensory nerve conduction velocity in the baboon: normal values and changes during acrylamide neuropathy. J. Neurol. Neurosurg. Psychiatry 1971; 34: 415
  • Princeas J. The pathogenesis of dying back polyneuropathies. Part II. An ultrastructural study of experimental acrylamide intoxication in the rat. J. Neuropathol. Exp. Neurol. 1969; 28: 598
  • Pleasure D., Engel W. K. Axonal flow in experimental neuropathies. J. Neuropathol. Exp. Neurol. 1970; 29: 140
  • Hashimoto K., Ando K. Alterations of amino acid incorporation into proteins of the nervous systemin vitro after administration of acrylamide to rats. Biochem. Pharmacol. 1973; 22: 1057
  • Hashimoto K., Aldridge W. N. Biochemical studies on acrylamide. A neurotoxic agent. Biochem. Pharmacol. 1970; 19: 259
  • Neuss N., Gorman M., Boaz H. E., Cone N. J. Vinca alkaloids. X. Structure of leurocristine (LCR) and vincaleukoblastine (VLB). J. Am. Chem. Soc. 1962; 84: 1508
  • Moress G. R., D'Agostino A. N., Jardio L. W. The neuropathy in lymphoblastic leukemia treated with vincristine. Arch. Neurol. 1967; 16: 377
  • Gottschalk P. G., Dyck P. J., Kiely J. M. Vinca alkaloid neuropathy: nerve biopsy studies in rats and man. Neurology (Minneap.) 1968; 11: 875
  • Shelanski M. L., Wiśniewski H. Neurofibrillary degeneration induced by vincristine neuropathy. Arch. Neurol. 1969; 20: 199
  • Bradley W. G., Lassman L. P., Pearce G. W., Walton J. N. The neuromyopathy of vincristine in man: clinical, electrophysiological and pathological studies. J. Neurol Sci. 1970; 10: 107
  • Uy Q. L., Moen T. H. Vincristine neurotoxicity in rodents. Johns Hopkins Med. J. 1967; 121: 349
  • Slotwiner P., Song S. K., Anderson P. J. Spheromembraneous degeneration of muscle induced by vincristine. Arch. Neurol. 1966; 15: 172
  • Bradley W. G. The neuropathy of vincristine in the guinea pig. An electrophysiological and pathological study. J. Neurol. Sci. 1970; 10: 133
  • Prineas J. Tri-ortho -cresyl phosphate myopathy. Arch. Neurol. 1969; 21: 150
  • Robbins E., Gonotas N. K. Histochemical and ultrastructural studies on HeLa cultures exposed to spindle inhibitors with special reference to the interphase cell. J. Histochem. Cytochem. 1964; 12: 704
  • Behnke O. Microtubules in disk-shaped blood cells. Int. Rev. Exp. Pathol. 1970; 91: 1
  • Porter K. R. Cytoplasmic microtubules and their functions. Principles of Biomolecular Organisation, G. E. W. Wolstenholme, M. O'Connor. J. & A. Churchill, London 1966; 308
  • Behnke O., Forer A. Evidence for four classes of microtubules in individual cells. J. Cell Sci. 1967; 21: 169
  • James K. A. C., Bray J. J., Morgan I. G., Austin L. The effect of colchicine on the transport of axonal protein in the chicken. Biochem. J. 1970; 117: 767
  • Fernandez H. L., Huneeus F. C., Davison P. F. Studies on the mechanism of axoplasmic transport in the crayfish cord. J. Neurobiol. 1970; 1: 395
  • Borisy G. G., Taylor E. W. The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and their mitotic apparatus. J. Cell Biol. 1967; 34: 535
  • Borisy G. G., Taylor E. W. The mechanism of action of colchicine. Binding of colchicine-3 H to cellular protein. J. Cell Biol. 1967; 34: 525
  • Wiśniewski H., Terry R. D., Hirano A. Neurofibrillary pathology. J. Neuropathol. Exp. Neurol., 29: 163
  • Cavanagh J. B., Blakemore W. F., Kyu M. H. Fibrillary accumulations in oligodendrocytle processes of rats subjected to portocaval anastomosis. J. Neurol. Sci. 1971; 14: 143
  • Mottet N. K., Hammar S. P. Ribosome crystals in necrotizing cells from the posterior necrotic zone of the developing chick limb. J. Cell Sci. 1972; 11: 403
  • Jacobs J. M., Cavanagh J. B. Aggregations of filaments in Schwann cells of spinal roots of the normal rat. J. Neurocytol. 1972; 1: 161
  • Wisniewski H., Terry R. D. Experimental colchicine encephalopathy. I. Induction of neurofibrillary degeneration. Lab. Invest. 1967; 17: 577
  • Cline M. J. Effect of vincristine on synthesis of ribonucleic acid and protein in leukaemic leucocytes. Br. J. Haematol. 1968; 14: 21
  • Creasey W. A., Markiw M. E. Biochemical effects of vinca alkaloids. II. A comparison of the effects of colchicine, vinblastine and vincristine on the synthesis of ribonucleic acids in Ehrlich ascites carcinoma cells. Biochim. Biophys. Acta 1964; 87: 601
  • Agustin B. M., Creasey W. A. Vinca alkaloids and the synthesis of RNA in mouse brain. Nature (Lond.) 1967; 215: 965
  • Tsubaki T., Honma Y., Hoshi M. Neurological syndrome associated with clioquinol. Lancet 1971; 1: 696
  • Annotation. Only in Japan. Lancet 1971; 1: 690
  • Nakae K., Yamamoto S-I., Shigematsu I., Kono R. Relation between subacute myelo-optico-neuropathy (S.M.O.N.) and clioquinol. Nationwide survey. Lancet 1973; 1: 171
  • Marsden P. D., Knight R. Halogenated oxyquinoline derivatives. Lancet 1971; 1: 854
  • Inoue Y. K., Nishibe G., Nakamura Y. Virus associated with S.M.O.N. in Japan. Lancet 1971; 1: 853
  • Schmidt I. G., Schmidt L. H. Neurotoxicity of the 8-aminoquinolines. I. Lesions in the central nervous system of the rhesus monkey induced by administration of plasmocid. J. Neuropathol. Exp. Neurol. 1948; 7: 369
  • Schmidt I. G., Schmidt L. H. Neurotoxicity of 8-aminoquinolines. II. Reactions of various experimental animals to plasmocid. J. Comp. Neurol. 1949; 91: 337
  • Acton H. W. An investigation into the causation of lathyrism in man. Indian Med. Gaz. 1922; 57: 241
  • Filimonoff I. N. Zur pathologisch-anatomischen charakteristik des Lathyrismus. Z. Gesamte Neurol. Psychiatr. 1926; 105: 76
  • Singh M., Singh G. Lathyrism. J. Nerv. Ment Dis. 1952; 116: 923
  • Stockman R. The poisonous principle ofLathyrus and some other leguminous plants. J. Hyg. 1931; 31: 550
  • Acton H. W., Chopra R. N. The production and pharmacological action of Khesari amine. Indian Med. Gaz. 1922; 52: 412
  • Stockman R., Johnson J. M. Cereal food poisoning and its relation to the etiology of pellagra. J. Hyg. 1933; 33: 204
  • Gopalan S. C. The Lathyrus syndrome. Trans. R. Soc. Trop. Med. Hyg. 1950; 44: 333
  • Geiger B. J., Steenbock H., Parsons H. T. Lathyrism in the rat. J. Nutr. 1933; 3: 427
  • Vivanco F., Jimenez Diaz C. Nuevos estudios sobre los effectos de la proteinas de las legumbres (leguminismos). El laterismo odorato (odoratismo). Rev. Clin. Esp. 1951; 40: 157
  • McKay G. F., Lalich J. J., Schilling E. D., Strong F. M. A crystalline “lathyrus factor” from Lathyrus odoratus. Arch. Biochem. Biophys. 1954; 52: 313
  • Backhuber T. E., Lalich J. J., Angevine D. M., Schilling E. D., Strong F. M. Lathyius factor activity of beta-amino-propionitrilo and related compounds. Proc. Soc. Exp. Biol. Med. 1955; 89: 294
  • Hartmann H. A., Lalich J. J., Akert K. Lesions in the anterior motor horn cells of rats after the administration of bis-β-cyanoethylamine. J. Neuropathol. Exp. Neurol. 1958; 17: 298
  • Ule G. Zur ultrastruktur derGhost cells beim Experimentcllen Neurolathyrismus der Ratte, Z. Zellforsch. Mikrosk. Anat. 1962; 56: 130
  • Chou S-M., Hartmann H. A. Axonal lesions and waltzing syndrome after IDPN administration in rats, with a concept “axostasis,”. Acta Neuropathol. (Berl.) 1964; 3: 428
  • Chou S-M., Hartmann H. A. Electron microscopy of focal neuroaxonal lesions produced by ββ'-imino-pro-prionitrile in rats. Acta Neuropathol. (Berl.) 1965; 4: 590
  • Mollitor H., Graessle O. E., Kuna S., Mushett C. W., Sibler R. H. Some toxicological and pharmacological properties of streptomycin. J. Pharmacol. Exp. Ther. 1946; 86: 151
  • Stevenson L. D., Alvord E. C., Correll J. W. Degeneration and necrosis of neurones in eighth cranial nuclei caused by streptomycin. Proc. Soc. Exp. Biol. Med. 1947; 65: 86
  • Wersäll J., Hawkins J. E., Jr. The vestibular sensory epithelia in the cat and their reactions in chronic streptomycin intoxication. Acta Otolaryngol. (Slockh.) 1962; 54: 1
  • Tyberghein J. Influence of some streptomyces antibiotics on the cochlea microphonics in the ginuea-pig. Acta Otolaryngol. (Stockh.) 1962, Suppl., 171
  • Duvall A. J., Wersäll J. Site of action of streptomycin upon inner ear sensory cells. Acta Otolaryngol. (Stockh.) 1964; 57: 581
  • Buxton P. H., Hayward M. Polyneuritis cranialis associated with industrial trichlorethylene poisoning. J. Neural. Neurosurg. Psychiatry 1967; 30: 511
  • Feldman R. G., Meyer R. M., Taub A. Evidence for peripheral neurotoxic effect of trichloroethylene. Neurology (Minneap.) 1970; 20: 599
  • Broser F., Henschler D., Hopf H. C. Chlorierte Acetylene als Ursache enier irreparablen Trigeminusstörung bei zwei Patienten. Dtsch. Z. Nervenheilkd. 1970; 197: 163
  • Herskowitz A., Lshii N., Schaumberg H. n -Hexane neuropathy. N. Engl. J. Med. 1971; 285: 82
  • Murai Y., Kuroiwa Y. Peripheral neuropathy in chlorobiphenyl poisoning. Neurology (Minneap.) 1971; 21: 1173
  • Magee P. N., Stoner H. B., Barnes J. M. The experimental production of oedema in the central nervous system of the rat by triethyl tin compounds. J. Pathol. Bacteriol. 1957; 73: 107
  • Aleu F. P., Katzman R., Terry R. D. Fine structure and electrolyte analysis of cerebral oedema induced by alkyl-tin intoxication. J. Neuropathol. Exp. Neurol. 1963; 22: 403
  • Katzman R., Aleu F. P., Wilson C. Further observations on triethyltin edema. Arch. Neurol. 1963; 9: 178
  • Torak R., Gordon J., Prokop J. Pathophysiology of acute triethyl tin intoxication. Int. Rev. Neurobiol. 1970; 12: 45
  • Aldridge W. N., Cremer J. E. The biochemistry of organotin compounds: diethyltin chloride and triethyltin sulphate. Biochem. J. 1955; 61: 406
  • Gump W. S. Toxicological properties of hexa-chlorophene. J. Soc. Cosmet. Chem. 1969; 20: 173
  • Kimbrough R. D., Gaines T. B. Hexachlorophene effects upon the rat brain. Environ. Health 1971; 23: 114
  • Carlton W. W. Studies on the induction of hydrocephalus and spongy degeneration by cuprizone feeding and attempts to antidote the toxicity. Life Sci. 1967; 6: 11
  • Blakemore W. F. Observations on oligodendrocyte degeneration, the resolution of status spongiosus and remyelination in cuprizone intoxication in mice. J. Neurocytol. 1973; 1: 413
  • Pope C. G. Diphtheria toxin and anti-toxin. A short review of progress since the work of Ehrlich. Int. Arch. Allergy Appl. Immunol. 1954; 5: 115
  • Barksdale L. Lysogenic conversions in bacteria. Bacteriol. Rev. 1959; 23: 202
  • Lwoff A. The dynamics of viral functions. Proc. R. Soc. Lond. (Biol) 1961; 154: 1
  • Cavanagh J. B., Jacobs J. M. Some quantitative aspects of diphtheritic neuropathy. Br. J. Exp. Pathol. 1964; 45: 309
  • Walshe F. M. R. On the pathogenesis of diphtheritic neuropathy. Q. J. Med. 1918; 12: 14–19
  • Gaskill H. S., Korb M. Occurrence of multiple neuritis in cases of diphtheria. Arch. Neurol. Psychiatr. (Chicago) 1946; 55: 559
  • Vizoso A. D., Young J. Z. Internode length and fibre diameter in developing and regenerating nerves. J. Anat. 1948; 82: 110
  • Vizoso A. D. The relationship between internodal length and growth in human nerves. J. Anat. 1950; 84: 342
  • Jacobs J. M., Cavanagh J. B., Mellick R. S. Intraneural injection of diphtheria toxin. Br. J. Exp. Pathol. 1966; 47: 507
  • Allt G., Cavanagh J. B. Ultrastructural changes in the region of the node of Ranvier in the rat caused by diphtheria toxin. Brain 1969; 92: 459
  • Waksman B. H., Adams R. D., Mansmann H. C. Experimental study of diphtheritic polyneuritis in the rabbit and guinea-pig. J. Exp. Med. 1957; 105: 591
  • McDonald W. I. Conduction in muscle afferent fibres during expermental demyelination in cat nerve. Acta Neuropathol. (Berl.) 1962; 1: 425
  • Meyer P. Anatomische Untersuchungen über Diphtheritische Lähmung. Virchow's Arch. Pathol. Anat. 1881; 85: 181
  • Fisher C. M., Adams R. D. Diphtheritic paralysis: a pathological study. J. Neuropathol. Exp. Neurol. 1956; 15: 243
  • Papenheimer A. M., Jr., Williams C. M. The effects of diphtheria toxin on thececropia silkworm. J. Gen. Physiol. 1951–52; 35: 727
  • Strauss N., Hendee E. D. The effect of diphtheria toxin on the metabolism of HeLa cells. J. Exp. Med. 1959; 109: 145
  • Collier R. J., Pappenheimer A. M., Jr. Studies on the mode of action of diphtheria toxin. I. Phosphorylated intermediates in normal and intoxicated HeLa cells. J. Exp. Med. 1964; 120: 1007
  • Collier R. J., Pappenheimer A. M., Jr. Studies on the mode of action of diphtheria toxin. II. Effect of toxin on amino acid incorporation in cell free systems. J. Exp. Med. 1964; 120: 1019
  • Kato I. Mode of action of diphtheria toxin on protein synthesis. I. Effect of diphtheria toxin on C14 amino acid incorporation into microsomes and mitrochondriain vitro. Jap. J. Exp. Med. 1962; 32: 335
  • Strauss N. The effect of diphtheria toxin on the metabolism of HeLa cells. II. Effect on nucleic acid metabolism. J. Exp. Med. 1960; 112: 351
  • Bonventre P. F., Imhoff J. G. Studies on the mode of action of diphtheria toxin. I. Protein synthesis in guinea pig tissues. J. Exp. Med. 1966; 124: 1107
  • Matheson D. F. Incorporation of (14C)-glycine into protein of the adult rat peripheral nerve: effects of inhibitors. J. Neurochem. 1968; 15: 179
  • Collier R. J. Effect of diphtheria toxin on protein synthesis: inactivation of one of the transfer factors. J. Mol. Biol. 1967; 25: 83
  • Pleasure D. E., Feldman B., Prockup D. J. Diphtheria toxin inhibits the synthesis of myelin proteolipid and basic proteins by peripheral nervesin vitro. J. Neurochem. 1973; 20: 81
  • Fullerton P. M. Chronic peripheral neuropathy produced by lead poisoning in guinea pigs. J. Neuropathol. Exp. Neurol. 1966; 25: 214
  • Shimazono J. Ueber das Verhalter der zentralen und peripheren Nervensubstanz bei verschiedenen Vergiftungen und Ernåhrungstörungen. Arch. Psychiatr. 1914; 53: 972
  • De Villaverde J. M. Sur l'avenir des parties constitutives de la fibre nerveuse dans l'intoxication expérimentale par le plomb. Trav. Lab. Recherches Biol. Univ. Madr. 1929; 26: 163–30
  • McHowell J. C. Nutrition and the nervous system in farm animals. World Rev. Nutr. Diet. 1970; 12: 377
  • Blakemore W. F. 1972, personal communication
  • Schlaepfer W. W. Experimental lead neuropathy: disease of the supporting cells in the peripheral nervous system. J. Neuropathol. Exp. Neurol. 1969; 28: 401
  • Ord M. G., Stocken L. A. Metabolic properties of histones from rat liver and thymus gland. Biochem. J. 1966; 98: 888
  • Pogo B. G. T., Pogo A. O., Allfrey V. G., Mirsky A. E. Changing patterns of histone alkylation and RNA synthesis in regeneration of the liver. Proc. Natl. Acad. Sci. U.S.A. 1968; 59: 1337
  • Baldwin G. S., Carnegie P. R. Specific enzymic methylation of an arginine in the experimental allergic encephalomyelitis protein from human myelin. Science 1971; 171: 579

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